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NLRP3 activation in macrophages promotes acute intestinal injury in neonatal necrotizing enterocolitis

World Journal of Pediatrics 2024年第2期20卷 153-164页

作者： Bo Shi Cheng-jie Lyu Zhen-Kai Le hao-sen ji Yi Xiao Yuan-Yuan Zhang Shou-jiang Huang Lin-Jun Yu Qiang Shu jin-Fa Tou Deng-Ming Lai Department of Neonatal Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Thoracic and Cardiovascular Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China

Background Macrophages are involved in various immune inflammatory disease *** study aimed to investigate the role and mechanism of macrophages in regulating acute intestinal injury in neonatal necrotizing enterocolitis(NEC).Methods CD68,nucleotide-binding oligomerization domain,leucine-rich repeat,and pyrin domain-containing 3(NLRP3),cysteine aspartate-specific protease-1(caspase-1),and interleukin-1β(IL-1β)in paraffin sections of intestinal tissues from NEC and control patients were detected with immunohistochemistry,immunofluorescence,and western *** pet milk,hypoxia and cold stimulation were used to establish a mouse(wild type and Nlrp3^(-/-))model of *** mouse macrophage(RAW 264.7)and rat intestinal epithelial cell-6 lines were also cultured followed by various ***,intestinal epithelial cell injuries,and IL-1β release were *** Compared to the gut“healthy”patients,the intestinal lamina propria of NEC patients had high macrophage infiltration and high NLRP3,caspase-1,and IL-1β ***,in vivo,the survival rate of Nlrp3^(-/-)NEC mice was dramatically improved,the proportion of intestinal macrophages was reduced,and intestinal injury was decreased compared to those of wild-type NEC ***3,caspase-1,and IL-1β derived from macrophages or supernatant from cocultures of macrophages and intestinal epithelial cells also caused intestinal epithelial cell *** Macrophage activation may be essential for NEC ***3/caspase-1/IL-1β cellular signals derived from macrophages may be the underlying mechanism of NEC development,and all these may be therapeutic targets for developing treatments for NEC.

关键词： Caspase-1 Interleukin-1β Macrophage Necrotizing enterocolitis NLRP3

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Cooperative Covert Communication in Multi-Antenna Broadcast Channels

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China Communications 2024年第6期21卷 246-260页

作者： Qiao sen Liu Guangjie ji Xiaopeng Liu Weiwei School of Electrical and Information Engineering Nanjing University of Information Science and TechnologyNanjing 210044China School of Automation Nanjing University of Science and TechnologyNanjing 210094China

With the gradual popularization of 5G communications,the application of multi-antenna broadcasting technology has become ***,this study aims to investigate the wireless covert communication in the two-user cooperative multi-antenna broadcast *** focus on the issue that the deteriorated reliability and undetectability are mainly affected by the transmission *** tackle this issue,we design a scheme based on beamforming to increase the reliability and undetectability of wireless covert communication in the multi-antenna broadcast *** first modeled and analyzed the cooperative multi-antenna broadcasting system,and put forward the target *** we use the SCA(successive convex approximation)algorithm to transform the target problem into a series of convex *** the convex problems are solved and the covert channel capacity is *** order to verify the effectiveness of the scheme,we conducted simulation *** simulation results show that the proposed beamforming scheme can effectively improve the reliability and undetectability of covert communication in multi-antenna broadcast channels.

关键词： beamforming covert communication multi-antenna broadcast channels OFDM

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Activity promotion of Rh_(1)Ca_(x)/Al_(2)O_(3) single-atom catalyst in 1-octene hydroformylation:a volcano curve exists between Ca adding ratio and catalytic activity

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Science China Chemistry 2024年第4期67卷 1187-1192页

作者： hao Zhang Xingcong Zhang Xilun Wang Qingdi Sun hao Liu Hongbing ji Xiaohui He Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education Fine Chemical Industry Research InstituteSchool of ChemistryIGCMESun Yat-sen UniversityGuangzhou 510275China Huizhou Research Institute Sun Yat-sen UniversityHuizhou 516081China State Key Laboratory Breeding Base of Green-Chemical Synthesis Technology Institute of Green Petroleum Processing and Light Hydrocarbon ConversionCollege of Chemical EngineeringZhejiang University of TechnologyHangzhou 310014China

Single-atom catalysts(SACs)are considered the best candidates for olefin hydroformylation due to their combined advantages of homogeneous and heterogeneous *** conventional organo-phosphine modification,Rh SAC is modified by introducing Ca,resulting in a significant increase in activity(maximum~5.7-fold)and ***,a volcano curve between Ca addition ratio and catalytic activity is *** Ca significantly increases activity by decreasing the energy barrier,but excessive Ca decreases activity due to hindering substrate adsorption and reaction.

关键词： hydroformylation bimetallic single-atom catalysts rhodium heterogeneous catalyst

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Characteristics,origins,and significance of pyrites in deep-water shales

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Science China Earth Sciences 2024年第2期67卷 313-342页

作者： Chao LIANG Shichao ji Yingchang CAO Keyu LIU jing WU Fang hao National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580China School of Geosciences China University of PetroleumQingdao266000China Laboratory for Marine Mineral Resource Qingdao National Laboratory for Marine Science and TechnologyQingdao266071China College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao266590China

As important metal sulfides in the geochemical cycle of sulfur,the characteristics and formation processes of pyrites can provide useful clues regarding their *** on previous findings,shale pyrites were divided into three major classes(euhedral pyrites,framboidal pyrites(framboids)and metasomatic pyrites)and six sub-classes in this *** the microscopic scale,each type of pyrite is associated with a different formation *** are formed by burst nucleation in environments with a homogeneous distribution of nutrients while euhedral pyrites are usually formed on pre-existing sites(such as=FeS on the minerals surface)in the heterogeneous *** pyrites formed by the replacement of other ions in accountable material by iron ions and hydrogen sulfide ions in hydrothermal *** morphology and isotope value of pyrite provide information to track the origins of their nutrient and characteristics of sulfur and iron *** addition,the trace element content of pyrite can serve as a proxy for paleo-ocean trace element abundance,indicating changes in atmospheric oxygen ***,pyrite can also serves as an indicator of shale gas reservoirs.

关键词： Shale Pyrite Sulfate reduction reaction Isotope fractionation Pyrite element

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Uncertainty and sensitivity analysis of in-vessel phenomena under severe accident mitigation strategy based on ISAA-SAUP program

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Nuclear Science and Techniques 2024年第1期35卷 108-123页

作者： hao Yang ji-Shen Li Zhi-Ran Zhang Bin Zhang jian-Qiang Shan School of Nuclear Science and Technology Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an 710049China

The phenomenology involved in severe accidents in nuclear reactors is highly ***,integrated analysis programs used for severe accident analysis heavily rely on custom empirical parameters,which introduce considerable ***,in recent years,the field of severe accidents has shifted its focus toward applying uncertainty analysis methods to quantify uncertainty in safety assessment programs,known as“best estimate plus uncertainty(BEPU).”This approach aids in enhancing our comprehension of these programs and their further development and *** study concentrates on a third-generation pressurized water reactor equipped with advanced active and passive mitigation *** an Integrated Severe Accident Analysis Program(ISAA),numerical modeling and uncertainty analysis were conducted on severe accidents resulting from large break loss of coolant *** uncertainty parameters of the ISAA program were meticulously *** Wilks'formula,the developed uncertainty program code,SAUP,was employed to carry out Latin hypercube sampling,while ISAA was employed to execute batch *** analysis was then conducted on two figures of merit,namely hydrogen generation and the release of fission products within the pressure *** calculations revealed that hydrogen production and the fraction of fission product released exhibited a normal distribution,ranging from 182.784 to 330.664 kg and from 15.6 to 84.3%,*** ratio of hydrogen production to reactor thermal power fell within the range of 0.0578–0.105.A sensitivity analysis was performed for uncertain input parameters,revealing significant correlations between the failure temperature of the cladding oxide layer,maximum melt flow rate,size of the particulate debris,and porosity of the debris with both hydrogen generation and the release of fission products.

关键词： Gen-III PWR Severe accident mitigation Wilks’formula Hydrogen Fission products Uncertainty and sensitivity analysis

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Self‑Assembly of Binderless MXene Aerogel for Multiple‑Scenario and Responsive Phase Change Composites with Ultrahigh Thermal Energy Storage Density and Exceptional Electromagnetic Interference Shielding

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Nano-Micro Letters 2024年第3期16卷 367-382页

作者： Chuanbiao Zhu Yurong hao hao Wu Mengni Chen Bingqing Quan Shuang Liu Xinpeng Hu Shilong Liu Qinghong ji Xiang Lu jinping Qu Key Laboratory of Material Chemistry for Energy Conversion and Storage of Ministry of Education School of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China Qingdao Mental Health Center Qingdao 266034People’s Republic of China Hubei Engineering Research Center for Biomaterials and Medical Protective Materials Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Hubei Key Laboratory of Material Chemistry and Service Failure School of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China National Engineering Research Center of Novel Equipment for Polymer Processing Key Laboratory of Polymer Processing Engineering(South China University of Technology)Ministry of EducationGuangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced ManufacturingSchool of Mechanical and Automotive EngineeringSouth China University of TechnologyGuangzhou 510641People’s Republic of China

The severe dependence of traditional phase change materials(PCMs)on the temperature-response and lattice deficiencies in versatility cannot satisfy demand for using such materials in complex application ***,we introduced metal ions to induce the self-assembly of MXene nanosheets and achieve their ordered arrangement by combining suction filtration and rapid ***,a series of MXene/K^(+)/paraffin wax(PW)phase change composites(PCCs)were obtained via vacuum impregnation in molten *** prepared MXene-based PCCs showed versatile applications from macroscale technologies,successfully transforming solar,electric,and magnetic energy into thermal energy stored as latent heat in the ***,due to the absence of binder in the MXene-based aerogel,MK3@PW exhibits a prime solar-thermal conversion efficiency(98.4%).Notably,MK3@PW can further convert the collected heat energy into electric energy through thermoelectric equipment and realize favorable solar-thermal-electric conversion(producing 206 mV of voltage with light radiation intensity of 200 mw cm^(−2)).An excellent Joule heat performance(reaching 105℃with an input voltage of 2.5 V)and responsive magnetic-thermal conversion behavior(a charging time of 11.8 s can achieve a thermal insulation effect of 285 s)for contactless thermotherapy were also demonstrated by the MK3@***,as a result of the ordered arrangement of MXene nanosheet self-assembly induced by potassium ions,MK3@PW PCC exhibits a higher electromagnetic shielding efficiency value(57.7 dB)than pure MXene aerogel/PW PCC(29.8 dB)with the same MXene *** work presents an opportunity for the multi-scene response and practical application of PCMs that satisfy demand of next-generation multifunctional PCCs.

关键词： Self-assembly Multiple-scenario Phase change composites Thermal energy storage Electromagnetic interference shielding

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Span-based joint entity and relation extraction augmented with sequence tagging mechanism

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Science China(Information Sciences) 2024年第5期67卷 84-98页

作者： Bin ji Shasha LI hao XU jie YU Jun MA Huijun LIU jing YANG College of Computer National University of Defense Technology

Span-based joint extraction simultaneously conducts named entity recognition(NER) and relation extraction(RE) in a text span form. However, since previous span-based models rely on span-level classifications, they cannot benefit from token-level label information, which has been proven advantageous for the task. In this paper, we propose a sequence tagging augmented span-based network(STSN), a spanbased joint model that can make use of token-level label information. In STSN, we construct a core neural architecture by deep stacking multiple attention layers, each of which consists of three basic attention *** the one hand, the core architecture enables our model to learn token-level label information via the sequence tagging mechanism and then uses the information in the span-based joint extraction; on the other hand, it establishes a bi-directional information interaction between NER and RE. Experimental results on three benchmark datasets show that STSN consistently outperforms the strongest baselines in terms of F1,creating new state-of-the-art results.

关键词： joint extraction named entity recognition relation extraction span sequence tagging mechanism

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Spin chiral anisotropy of diamagnetic chiral mesostructured In_(2)O_(3)films

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Nano Research 2024年第8期17卷 7756-7761页

作者： Ting ji Quanzheng Deng hao Chen Lu Han Zhibei Qu Shunai Che Yingying Duan Frontiers Science Center for Transformative Molecules State Key Laboratory of Metal Matrix CompositesShanghai Key Laboratory for Molecular Engineering of Chiral DrugsSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Chemical Science and Engineering Tongji UniversityShanghai 200092China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China

Spin chiral anisotropy(SChA)refers to the occurrence of different spin polarization in antipodal chiral ***,we report the SChA in diamagnetic chiral mesostructured In2O3 films(CMIFs)with manifestation of chirality-dependent magnetic circular dichroism(MCD)*** were grown on fluorine-doped tin dioxide conductive glass(FTO)substrates,which were synthesized via a hydrothermal route,with malic acid used as the symmetry-breaking *** levels of chirality have been identified in CMIFs:primary nanoflakes with atomically twisted crystal lattices and secondary helical stacking of the *** exhibit chirality-dependent asymmetric MCD signals due to the different interactions of chirality-induced effective magnetic field and external magnetic field,which distinguish from the commonly observed external magnetic fielddependent symmetric MCD *** findings provide insights into spin manipulation of spin-paired diamagnets.

关键词： chiral inorganics mesostructure diamagnet spin chiral anisotropy(SChA) magnetic circular dichroism(MCD)

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Identifying Three New AGNs among Fermi Unidentified Gigaelectronvolt Sources

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Research in Astronomy and Astrophysics 2024年第7期24卷 260-270页

作者： Shun-hao ji Zhong-Xiang Wang Qiang-Meng Huang Ruo-Heng Yang Department of Astronomy School of Physics and AstronomyYunnan University Shanghai Astronomical Observatory Chinese Academy of Sciences

We report our identification of three gigaelectronvolt γ-ray sources, 4FGL J0502.6+0036, 4FGL J1055.9+6507,and 4FGL J1708.2+5519, as Active Galactic Nuclei(AGNs). They are listed in the latest Fermi-Large Area Telescope source catalog as unidentified ones. We find that the sources all showed γ-ray flux variations in recent years. Using different survey catalogs, we are able to find a radio source within the error circle of each source's position. Further analysis of optical sources in the fields allows us to determine the optical counterparts, which showed similar variation patterns to those seen in γ-rays. The optical counterparts have reported redshifts of 0.6,1.5, and 2.3, respectively, estimated from photometric measurements. In addition, we also obtain an X-ray spectrum of 4FGL J0502.6+0036 and a flux upper limit on the X-ray emission of 4FGL J1055.9+6507 by analyzing the archival data. The broadband spectral energy distributions of the three sources from radio to γ-rays are constructed. Comparing mainly the γ-ray properties of the three sources with those of different sub-classes of AGNs, we tentatively identify them as blazars. Followup optical spectroscopy is highly warranted for obtaining their spectral features and thus verifying the identification.

关键词： (galaxies:) BL Lacertae objects: general (galaxies:) quasars: general gamma-rays: galaxies

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Resistance-capacitance model of the capillary heat exchanger in subway tunnels

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Energy and Built Environment 2024年第1期5卷 1-8页

作者： Zhen Tong hao Wu Yiming Guan Yongming ji Songtao Hu School of Environmental and Municipal Engineering Qingdao University of TechnologyQingdao 266033China

The subway operation generates a large amount of waste heat,which will lead to a disruption of the underground thermal *** remove the heat,a ground source heat pump system adopting capillary net as the front-end heat exchanger can be built in the tunnels to recycle the waste heat and use it for building *** simulation method was used to analyze the heat transfer process in the tunnel and the surrounding *** existing simulation method usually takes a long time for calculation and can not be used for a real-time regulation of the *** on the concept of thermoelectric analogy,a resistance-capacitance(RC)model was proposed for rapid prediction and analysis on the heat transfer of the capillary net in subway *** annual thermal response in the tunnel was analyzed,and the influence of the tunnel air temperature and the capillary inlet water temperature was examined using this *** maximum heat transfer flux of the capillary in summer(release heat)and in winter(extract heat)was 55.27 W/m 2 and 38.33 W/m 2,*** effect of capillary inlet water temperature was more remarkable than that of the tunnel air temperature on the capillary heat exchange process.

关键词： Subway tunnel Heat pump Capillary heat exchanger Resistance-capacitance model

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