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Optimal decision-making in relieving global high temperature-related disease burden by data-driven simulation

Infectious Disease Modelling 2024年第2期9卷 618-633页

作者： Xin-Chen Li hao-ran qian Yan-Yan Zhang Qi-Yu Zhang Jing-Shu Liu Hong-Yu Lai Wei-Guo Zheng Jian Sun Bo Fu Xiao-Nong Zhou Xiao-Xi Zhang School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiPeople's Republic of China Institute of One Health Shanghai Jiao Tong UniversityShanghaiPeople's Republic of China School of Public Health Shanghai Jiao Tong University School of MedicineShanghaiPeople's Republic of China School of Data Science Fudan UniversityShanghaiPeople's Republic of China

The rapid acceleration of global warming has led to an increased burden of high temperature-related diseases(HTDs),highlighting the need for advanced evidence-based management *** have developed a conceptual framework aimed at alleviating the global burden of HTDs,grounded in the One Health *** framework refines the impact pathway and establishes systematic data-driven models to inform the adoption of evidence-based decision-making,tailored to distinct *** collected extensive national-level data from authoritative public databases for the years 2010–*** burdens of five categories of disease causes–cardiovascular diseases,infectious respiratory diseases,injuries,metabolic diseases,and non-infectious respiratory diseases–were designated as intermediate outcome *** cumulative burden of these five categories,referred to as the total HTD burden,was the final outcome *** evaluated the predictive performance of eight models and subsequently introduced twelve intervention measures,allowing us to explore optimal decision-making strategies and assess their corresponding *** model selection results demonstrated the superior performance of the Graph Neural Network(GNN)model across various *** simulations driven by the GNN model,we identified a set of optimal intervention strategies for reducing disease burden,specifically tailored to the seven major regions:East Asia and Pacific,Europe and Central Asia,Latin America and the Caribbean,Middle East and North Africa,North America,South Asia,and Sub-Saharan *** mitigation and adaptation measures,acting upon our categories of Infrastructure&Community,Ecosystem Resilience,and Health System Capacity,exhibited particularly strong performance for various regions and *** out of twelve interventions were included in the optimal intervention package for each region,including raising low-carbon energy use,increasing energy intensity,improving

关键词： High temperature-related diseases Data-driven simulation Optimal intervention Disease burden Graph neural network Global warming

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Worldvolume fermions as baryons in holographic quantum chromodynamics with instantons

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Communications in Theoretical Physics 2025年第1期77卷 106-121页

作者： Si-wen Li hao-qian Li Yi-peng Zhang Department of Physics School of ScienceDalian Maritime UniversityDalian 116026China

In this study,we investigated worldvolume fermions on the flavor brane in the D0-D4/D8 model,which is holographically equivalent to four-dimensional quantum chromodynamics with instantons or equivalently with a theta *** action involving the worldvolume fermions was obtained by the T-duality rules in string theory,and we accordingly derived their effective five-dimensional and canonical four-dimensional forms by using the systematic dimensional reduction and decomposition of the ***,we used the AdS/CFT dictionary to evaluate the two-point correlation function as the spectral function for the worldvolume fermions and interpreted the fermions as baryons by analyzing their quantum number with the baryon vertex in *** this sense,the interacted action involving the worldvolume fermions and gauge field on the flavor brane was finally derived in holography,which describes the various interactions of mesons and baryons with instantons in the large-N ***,this study provides a holographic picture to describe baryons and their interactions based on string theory,particularly in the presence of instantons or a theta angle.

关键词： gauge-gravity duality AdS/CFT holographic QCD

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New poly-types of LPSO structures in a non-equilibrium Mg_(97)Zn_(1)Y_(1.6)Ca_(0.4)alloy

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China Foundry 2025年第1期22卷 83-89页

作者： qian-qian Jin Zi-hui Tang Wen-long Xiao Xiu-yu Qu Xu-hao Han Lin Mei Xiao-hong Shao Xiu-liang Ma School of Biological and Chemical Engineering Guangxi University of Science and TechnologyLiuzhou 545006GuangxiChina Center for the Structure of Advanced Matter School of Electronic EngineeringGuangxi University of Science and TechnologyLiuzhou 545006GuangxiChina Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Bay Area Center for Electron Microscopy Songshan Lake Materials LaboratoryDongguan 523808GuangdongChina

In this study,a comprehensive analysis of microstructural features,morphology,crystal structures,and interface structures of long-period stacking ordered(LPSO)structures in a non-equilibrium Mg_(97)Zn_(1)Y_(16)Ca_(0.4)alloy cast in a steel mold was carried *** addition of Ca element plays an important role in the refinement of LPSO *** result reveals new poly-types including 20H F2F2F4,60R(F2F3F3)_(3),and 66H F2F3F3F2(F6)_(4)featuring a 6-Mg structure,alongside the prevalent 18R and 14H LPSO *** incoherent interface between 20H and the Mg matrix is split into two dislocation arrays,leading to the formation of a segment of 60R_(1).Moreover,the superstructure 116L,designated as(F2)_(18)F4,is formed through the ordered distribution of F4 stacking faults in 18R.

关键词： LPSO structures crystal structure Mg alloys heterogeneous interface

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Leucine-Rich Repeat Protein Family Regulates Stress Tolerance and Development in Plants

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Rice science 2025年第1期32卷 32-43页

作者： hao Zhiqi WANG Tingyi CHEN Dongdong SHEN Lan ZHANG Guangheng qian qian ZHU Li State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 310006China Yazhouwan National Laboratory Sanya 572024China National Nanfan Research Institute(Sanya) Chinese Academy of Agricultural SciencesSanya 572024China

The leucine-rich repeat(LRR)protein family is involved in a variety of fundamental metabolic and signaling processes in plants,including growth and defense *** proteins can be divided into two categories:those containing LRR domains along with other structural elements,which are further subdivided into five groups,LRR receptor-like kinases,LRR receptor-like proteins,nucleotide-binding site LRR proteins,LRR-extensin proteins,and polygalacturonase-inhibiting proteins,and those containing only LRR ***,various LRR proteins are primarily involved in plant development and responses to environmental ***,the LRR protein family plays a central role in signal transduction pathways related to stress *** this review,we classify and analyze the functions of LRR proteins in *** extensive research has been conducted on the roles of LRR proteins in disease resistance signaling,these proteins also play important roles in abiotic stress *** review highlights recent advances in understanding how LRR proteins mediate responses to biotic and abiotic *** upon these insights,further exploration of the roles of LRR proteins in abiotic stress resistance may aid efforts to develop rice varieties with enhanced stress and disease tolerance.

关键词： leucine-rich repeat classification function stress tolerance plant development

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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China(Life Sciences) 2025年第1期68卷 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie qian hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China Department of Oncology First Affiliated Hospital of Nanchang UniversityNanchang 330006China Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Beijing 100069China Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)Institutes of Biomedical SciencesFudan UniversityShanghai 200032China

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies,including WEE1 *** that p53 activation can also lead to multiple types of cell death,the role of this tumor suppressor in WEE1 inhibitor-based therapies remains *** this study,we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer *** findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake,an action similar to that of ***,inhibition of WEE1 by the WEE1 inhibitors or siRNAs induced compensatory upregulation of SLC7A11,which conferred resistance to ***,AZD1775 prevented the enrichment of H3K9me3,a histone marker of transcriptional repression,on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1,thereby enhancing NRF2-mediated SLC7A11 *** finding was also validated using the H3K9me3 inhibitor ***,we found that the nucleolar stress-inducing agent Actinomycin D(Act.D)inhibited SLC7A11 expression by activating p53,thus augmenting AZD1775-induced ***,the combination of AZD1775 and Act.D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in ***,our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription,and inhibition of SLC7A11 by Act.D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词： p53 NRF2 SLC7A11 WEE1 AZD1775 ferroptosis nucleolar stress

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Influence of heat treatment on microstructure of a newβ-solidifyingγ-TiAl alloy

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Journal of Iron and Steel Research International 2025年第1期32卷 239-248页

作者： Li Quan Xiao-bing Li Peng Xue Jun-jie hao Kun qian Bo Chen Jian-zhong Li Kui Liu School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina Department of Materials Science and Technology Ji Hua LaboratoryFoshan528200GuangdongChina

The high strength and stability of the full-lamellar structure guarantee the industrial application of theβ-solidifyingγ-TiAl ***,it is a huge challenge to design an alloy with good hot-deformability as well as the full-lamellar *** low-cost Ti-42.5Al-2Mn-0.4Mo-0.1B-0.1C(at.%)alloy was designed,which undergoes bothβandαsingle-phase region during the *** is found that the full-lamellar structure can be obtained by the solution heat treatment at 1230℃ for 20 min and then aging treatment at 800℃ for 3 ***,a new microstructure,namely,the pearlitic-like microstructure(PM)induced by theα_(2)/γ→βo+γcellular reaction was observed when the aging temperature is increased to above 800℃.The volume fraction of the PM is gradually increased from 0%to 25.5%,65%,and 94%according to elevated aging temperature from 800 to 900,1000,and 1050℃,*** mechanism of the reducedα_(2)/γlamellae and PM formation was discussed regarding the heterogeneous distribution ofβstabilizing elements and the interface energy stored inα_(2)/γlamellae.

关键词： β-γ-TiAl Alloy design Two-step heat treatment Full-lamellar structure Cellular reaction

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Efficacy and Safety of Juan Bi Pill with Add-on Methotrexate in Active Rheumatoid Arthritis:A 48-Week,Multicentre,randomized,Double-Blind,and Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2025年第2期31卷 99-107页

作者： JIA Qing-yun WANG Yi-ru SUN Da-wei MAO Jian-chun XUE Luan GU Xiao-hua YU Xiang PIAO Xue-mei XU hao LIANG qian-qian Spine Institute Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai(200032)China Spine Institute Shanghai University of Traditional Chinese MedicineShanghai(200032)China Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of Education(Shanghai University of Traditional Chinese Medicine)Shanghai(201203)China Department of Orthopedics Linyi People's HospitalLinyiShandong Province(273000)China Department of Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese MedicineShanghai(200437)China Department of Orthopedics the Seventh People's Hospital of Shanghai University of Traditional Chinese MedicineShanghai(200137)China

Objective:To explore the efficacy and safety of Juan Bi Pill(JBP)in treatment of active rheumatoid arthritis(RA).Methods:From February 2017 to May 2018,115 participants from 4 centers were randomly divided into JBP group(57 cases)and placebo group(58 cases)in a 1:1 ratio using a random number table *** received a dose of JBP(4 g,twice a day,orally)combined with methotrexate(MTX,10 mg per week)or placebo(4 g,twice a day,orally)combined with MTX for 12 *** were required with follow-up visits at 24 and 48 weeks,attending 7 assessment *** were undergo disease activity assessment 7 times(at baseline and 2,4,8,12,24,48 weeks)and safety assessments 6 times(at baseline and 4,8,12,24,48 weeks).The primary endpoint was 28-joint Disease Activity Score(DAS28-ESR and DAS28-CRP).The secondary endpoints included American College of Rheumatology(ACR)criteria for 20%and 50%improvement(ACR20/50),Health Assessment Questionnaire Disability Index(HAQ-DI),clinical disease activity index(CDAI),visual analog scale(VAS),Short Form-36(SF-36)score,Medial Outcomes Study(MOS)sleep scale score,serum erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),tender joint count,swollen joint count,and morning *** adverse reactions were observed during the ***:After 12 weeks of treatment,DAS28-ESR and DAS28-CRP scores in both groups were lower than before treatment(both P<0.01),while the remission rate of DAS28-ESR and DAS28-CRP and low disease activity of JBP group were higher than those in the placebo group(both P<0.01).JBP demonstrated better efficacy on ACR20 and ACR50 compliance rate at 12 and 48 weeks comparing to placebo(all P<0.05).The CDAI and HAQ-DI score,pain VAS and global VAS change of RA patients and physicians,the serum ESR and CRP levels,and the number of tenderness and swelling joints were lower than before treatment at 4,8,12,24,48 weeks in both groups(P<0.05 or P<0.01),while the reduction of above indices in

关键词： Chinese medicine Juan Bi Pill methotrexate active rheumatoid arthritis randomized controlled trial

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Impact of sodium-glucose cotransporter-2 inhibitors on pulmonary vascular cell function and arterial remodeling

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World Journal of Cardiology 2025年第1期17卷 28-46页

作者： Jing-Jing Zhang Xue-Rui Ye Xue-Song Liu hao-Ling Zhang qian Qiao Chinese Academy Medical Sciences Fuwai Yunnan HospitalKunming 650000Yunnan ProvinceChina Kunming Medical University Affiliated Cardiovascular Hospital of Kunming Medical UniversityKunming 650000Yunnan ProvinceChina Department of Biochemistry Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia

Sodium-glucose cotransporter-2(SGLT-2)inhibitors represent a cutting-edge class of oral antidiabetic therapeutics that operate through selective inhibition of glucose reabsorption in proximal renal tubules,consequently augmenting urinary glucose excretion and attenuating blood glucose *** clinical investigations have demonstrated their profound cardiovascular *** basic science research has elucidated the mechanistic pathways through which diverse SGLT-2 inhibitors beneficially modulate pulmonary vascular cells and arterial ***,these inhibitors exhibit promising potential in enhancing pulmonary vascular endothelial cell function,suppressing pulmonary smooth muscle cell proliferation and migration,reversing pulmonary arterial remodeling,and maintaining hemodynamic *** comprehensive review synthesizes current literature to delineate the mechanisms by which SGLT-2 inhibitors enhance pulmonary vascular cell function and reverse pulmonary remodeling,thereby offering novel therapeutic perspectives for pulmonary vascular diseases.

关键词： Sodium-glucose cotransporter-2 inhibitors Pulmonary vascular endothelial cells Pulmonary vascular smooth muscle cells Pulmonary artery remodeling Right heart dysfunction Cardiovascular disease

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Global patterns of taxonomic and phylogenetic endemism in liverwort assemblages

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Plant Diversity 2025年第1期47卷 82-88页

作者： Hong qian Shenhua qian Research and Collections Center Illinois State Museum1011 East Ash StreetSpringfieldIL 62703USA Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment Ministry of EducationChongqing UniversityChongqing 400045China College of Environment and Ecology Chongqing UniversityChongqing 400045China

Exploring the worldwide patterns of endemism and the processes that lead to the formation of highendemism centers is crucial in *** study examines the geographic distribution and ecological influences on the endemism of liverworts across 390 regions *** assess phylogenetic endemism and relative phylogenetic endemism in relation to eleven environmental factors,which represent current and Quaternary climate variations,as well as topographic and environmental *** with higher endemism in liverworts tend to have higher temperatures,precipitation,and environmental heterogeneity,but lower temperature seasonality and lesser impacts from Quaternary climate *** exhibiting notably high endemism are predominantly found in tropical Asia,Madagascar,eastern Australia,and the Andes,while those with notably low endemism are generally in temperate Eurasia and North America,parts of Africa,and eastern South *** of neo-endemism are mainly in southern Africa,whereas centers of paleo-endemism are in southern South America,tropical Asia,and New *** variability is a more significant predictor of phylogenetic endemism than current climate conditions,which are themselves more predictive than variables related to Quaternary climate ***,these three types of explanatory variables combined explain only about one-third of the variance in phylogenetic endemism.

关键词： Bryophyte Quaternary climate change Current climate Topographic heterogeneity Endemism

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Recent advances in exploring new blood-based biomarkers for the early diagnosis of gastric cancer

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Science China Chemistry 2025年第1期68卷 35-45页

作者： Xinyu Peng qian Ma Da Han School of Life Science Shanghai UniversityShanghai 200444China Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and NanomedicineState Key Laboratory of Oncogenes and Related GenesRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Research and Development Intellinosis Biotechnologies Co.Ltd.Shanghai 201112China

Gastric cancer(GC)is a prevalent and lethal malignancy worldwide,and the 5-year survival rate is less than 30%.The absence of distinctive symptoms often leads to late-stage diagnosis,contributing to a grim *** detection is pivotal for improving the survival rates and outcomes of GC *** diagnostic methods,including gastroscopy and histopathological examination,are restricted in the early diagnosis of *** protein biomarkers,such as carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9),and carbohydrate antigen 72-4(CA72-4),exhibit insufficient sensitivity and specificity for GC screening,which diminishes their clinical ***,novel circulating biomarkers,such as circulating tumor cells(CTCs),circulating tumor cell DNA(ct DNA),and circulating free RNA(cf RNA),have emerged as promising candidates in the burgeoning field of liquid biopsy due to their superior sensitivity and *** review focuses on the latest research on blood-based biomarkers for GC diagnosis and examines the clinical potentials and challenges associated with these emerging biomarkers.

关键词： gastric cancer early diagnosis blood

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