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Effective-constituent compatibility-based analysis of Bufei Yishen formula, a traditional herbal compound as an effective treatment for chronic obstructive pulmonary disease

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Journal of Integrative Medicine 2020年第4期18卷 351-362页

作者： Jian-sheng Li Xue-fang Liu hao-ran dong Wan-chun Zheng Su-xiang Feng Yan-ge Tian Peng Zhao Jin-di Ma Zhou-xin Ren Yang Xie Henan Key Laboratory of Chinese Medicine for Respiratory Disease Henan University of Chinese MedicineZhengzhou 450046Henan ProvinceChina Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan&Education Ministry of P.R.China Henan University of Chinese MedicineZhengzhou 450046Henan ProvinceChina

Objective:Critical effective constituents were identified from Bufei Yishen formula(BYF),a traditional herbal compound and combined as effective-constituent compatibility(ECC)of BYF I,which may have potential bioactive equivalence to ***:The active constituents of BYF were identified using four cellular models and categorised into Groups 1(Bufeiqi),2(Bushen),3(Huatan)and 4(Huoxue)according to Chinese medicinal *** orthogonal design and a combination method were used to determine the optimal ratios of effective constituents in each group and the ratios of‘‘Groups 1 to 4"according to their pharmacological *** also comprehensively assessed bioactive equivalence between the BYF and the ECC of BYF I in a rat model of chronic obstructive pulmonary disease(COPD).Results:We identified 12 active constituents in *** numbers of constituents in Groups 1 to 4 were 3,2,5 and 2,*** identified the optimal ratios of effective constituents within each *** Group1,total ginsenosides:Astragalus polysaccharide:astragaloside IV ratio was 9:5:*** Group 2,icariin:schisandrin B ratio was 100:*** Group 3,nobiletin:hesperidin:peimine:peiminine:kaempferol ratio was4:30:6.25:0:*** Group 4,paeoniflorin:paeonol ratio was 4:*** orthogonal design was then used to establish the optimal ratios of Group 1,Group 2,Group 3 and Group 4 in ECC of BYF *** ratio for total ginsenosides:Astragalus polysaccharide:astragaloside IV:icariin:schisandrin B:nobiletin:hesperidin:peimine:paeoniflorin:paeonol was determined to be 22.5:12.5:5:100:12.5:4:30:6.25:25:6.25.A comprehensive evaluation confirmed that ECC of BYF I presented with bioactive equivalence to the original ***:Based on the ECC of traditional Chinese medicine formula method,the effective constituents of BYF were identified and combined in a fixed ratio as ECC of BYF I that was as effective as BYF itself in treating rats with COPD.

关键词： Effective-constituent compatibility Bufei Yishen formula Chronic obstructive pulmonary disease

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Precise separation and efficient recovery of Pd(Ⅱ)from high-level liquid waste by XAD-based adsorbents

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Rare Metals 2024年第10期43卷 5372-5390页

作者： hao-ran dong Shun-Yan Ning Zeng-Yuan Li Si-Zhi Xu Feng-Tao Hu Feng Gao You-Bin Wang Li-Feng Chen Xiang-Biao Yin Toyohisa Fujita Mohammed FHamza Yue-Zhou Wei School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China School of Nuclear Science and Technology University of South ChinaHengyang 421001China

Efficient separation of palladium(Pd(Ⅱ))from high-level liquid waste(HLLW)not only helps the safe disposal of nuclear waste,but also is a vital importan supplement to Pd(Ⅱ)***,16 kinds of nove Amberlite XAD resins-based adsorbents were prepared by vacuum impregnation method for the separation of Pd(Ⅱ)from simulated HLLW,and the MMBT/XAD7HP prepared using 4-methyl-2-mercaptobenzothiazole(MMBT)as ligand and Amberlite XAD7HP resin(XAD7HP)as the carrier was selected as the optimal research *** analysis experiments proved the successful preparation of MMBT/XAD7HP,which exhibited ultrahigh adsorption selectivity for Pd(Ⅱ)(distribution coefficient(K_d)≥12584.5 ml·g^(-1),separation factor(SF_(Pd/M))≥2818.4)and superior adsorption capacity(Q≥130.1 mg·g^(-1)).The adsorption kinetics and adsorption isotherms for Pd(Ⅱ)matched with pseudo-secondorder(PSO)kinetics model and Langmuir model,indicating that the adsorption mode for Pd(Ⅱ)by MMBT/XAD7 HP was monolayer chemical *** dynamic column experiments showed that MMBT/XAD7 HP achieved efficiently separation of Pd(Ⅱ)from simulated HLLW,and the recovery rate was nearly 100% The adsorption mechanism was analyzed by Fourier transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS)and density functional theory(DFT),and the ultrahigh selectivity of MMBT/XAD7 HP is attributed to the preferred affinity of the soft-N,S donor atoms in MMBT for Pd(Ⅱ).MMBT has the shortest frontline molecular orbital energy band gap(HOMO-LUMO)among the four ligands,which makes it easier to become an electron donor to attract Pd^(2+)to participate in ***_(3)^(-)participates in the adsorption to keep charge *** summary,MMBT/XAD7 HP has broad application prospects for the treatment of Pd(Ⅱ)in HLLW.

关键词： XAD Palladium HLLW Adsorption Column experiments

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Lipid levels and insulin resistance markers in patients with colorectal cancer:Propensity score matching analysis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 130-142页

作者： Ren-hao Hu dong-Yi Yan Ke-Hui Zhang Di Zhang Xi-Mao Cui Xiao-Hua Jiang Shun Zhang Department of Gastrointestinal Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China School of Medicine Tongji UniversityShanghai 200092China Department of Emergency Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

BACKGROUND Colorectal cancer(CRC)is a prevalent malignant neoplasm characterized by subtle early *** To investigate the correlation among serum lipid profiles,the triglyceride-glucose(TyG)index,and the atherosclerotic index(AI)in patients with ***,it explored the clinical diagnostic utility of combining serum lipids with cancer antigens in the context of *** A retrospective analysis encompassed 277 patients with CRC and 1034 healthy *** Following propensity score matching,patients with CRC exhibited significantly reduced levels of serum triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol(LDL-C),as well as a diminished TyG ***,they displayed elevated AI levels compared to their healthy *** in advanced stages exhibited lower serum levels of TG,TC,and LDL-C compared to those in early *** with positive lymph node metastasis demonstrated reduced levels of TG,LDL-C,and the TyG *** operating characteristic analysis revealed that the combination of the TyG index,carcinoembryonic antigen,and carbohydrate antigen 19-9 yielded the highest positive prediction rate for CRC at 75.3%.CONCLUSION Preoperative serum lipid profiles exhibit a robust association with patients with *** concurrent assessment of multiple serum lipids and cancer antigens effectively enhances the diagnostic accuracy for CRC.

关键词： Colorectal cancer Serum lipids Triglyceride-glucose index Atherosclerotic index Diagnostic marker

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亚甲基蓝对黄颡鱼鱼卵高卵壳裂解酶(HCE)表达的影响

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淡水渔业 2017年第5期47卷 53-57页

作者：李浩然董亚萍杨柳胡鲲杨先乐国家水生动物病原库水产动物遗传育种中心上海市协同创新中心水产科学国家级实验教学示范中心(上海海洋大学) 上海201306 上海长峰房地产开发有限公司上海200042

鱼卵高卵壳裂解酶(HCE)是鱼类孵化酶中的一种,在水生生物胚胎发育过程中起非常重要的作用,其表达可能会受到化学药物的影响。以黄颡鱼(Pelteobagrus fulvidraco)受精卵为研究对象,采用免疫组织化学方法研究了亚甲基蓝对黄颡鱼鱼卵高卵... 详细信息

鱼卵高卵壳裂解酶(HCE)是鱼类孵化酶中的一种,在水生生物胚胎发育过程中起非常重要的作用,其表达可能会受到化学药物的影响。以黄颡鱼(Pelteobagrus fulvidraco)受精卵为研究对象,采用免疫组织化学方法研究了亚甲基蓝对黄颡鱼鱼卵高卵壳裂解酶表达的影响。以15 mg/L亚甲基蓝浸泡黄颡鱼受精卵,同时设置不做任何药物处理的空白对照组,分别在受精后0、1、2、4、8、12、24 h取黄颡鱼受精卵或胚胎,4%多聚甲醛固定,石蜡切片,免疫组织化学方法染色,倒置显微镜观察,Image-Pro Plus6.0软件分析每张照片的累积光密度值。结果表明,亚甲基蓝实验组与空白对照组中均有HCE表达,但是亚甲基蓝实验组中HCE的相对表达量显著高于其相应的空白对照组。不同受精时间的对照组和实验组之间HCE的相对表达量无统计学差异。亚甲基蓝明显促进HCE的分泌,可能与鱼卵的代偿或应激反应有关,由此推测亚甲基蓝对胚胎有一定的毒性。

关键词：亚甲基蓝黄颡鱼胚胎鱼卵高卵壳裂解酶免疫组织化学

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颗粒特性对离心泵叶轮叶片的磨损分析

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水动力学研究与进展（A辑） 2022年第2期37卷 181-189页

作者：王田田池晓清杨具瑞谢汭之董浩然喻黎明昆明理工大学农业与食品学院昆明650500

为了预测离心泵叶轮叶片的磨损位置和计算磨损量的大小,利用有限元软件Ansys-FLUENT和离散元软件EDEM基于计算流体动力学(CFD)和离散单元法(DEM)耦合的方法,探究了颗粒体积分数(2%、3%和4%)、粒径(1 mm、2 mm和3 mm)、形状(球形、类球... 详细信息

为了预测离心泵叶轮叶片的磨损位置和计算磨损量的大小,利用有限元软件Ansys-FLUENT和离散元软件EDEM基于计算流体动力学(CFD)和离散单元法(DEM)耦合的方法,探究了颗粒体积分数(2%、3%和4%)、粒径(1 mm、2 mm和3 mm)、形状(球形、类球形和三角形)对离心泵叶轮叶片的磨损影响。结果表明离心泵内部压强最大处为隔舌部位,出口管道的滞留区域与大涡量区域分布一致,管道涡具有滞留作用;随着颗粒体积分数的增加,颗粒最大速度增加,最小速度减小,叶轮叶片磨损量增大,磨损分布不变;当粒径增大时,颗粒最大速度与最小速度同时增大,磨损增加,磨损最严重的位置由尾部变为头部,颗粒尖锐程度的增加也使得磨损加剧。

关键词： CFD-DEM 离心泵颗粒特性磨损

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Correlations of the expression of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in colon cancer tissues

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 207-213页

作者： Rong-Gang Luan Ming-Da Liu Zi-Feng Deng Cong-Lan Lu Mei-Ling Yu Ming-Yu Zhang Rong Liu ran An You-Liang Yao dong-Bei Guo Yong-Xing Zhang Lei Zhao Department of Gastrointestinal Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen 361102Fujian ProvinceChina Trauma Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina Department of Orthopaedics Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina

BACKGROUND Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ***,reduced expression results in a loss of this capacity to facilitate cyclin E *** ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein,with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical *** To investigate the correlation between expression of Cx43,SKP1/Cullin1/F-box(SCF)FBXW7,p-cyclin E1(ser73,thr77,thr395)and clinicopathological indexes in colon *** Expression levels of Cx43,SCFFBXW7,p-cyclin E1(ser73,thr77,thr395)in 38 clinical colon cancer samples were detected by immunohistochemistry and were analyzed by statistical methods to discuss their *** Positive rate of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in detected samples were 76.32%,76.32%,65.79%,5.26%and 55.26%*** expressions of these proteins were not related to the tissue type,degree of tissue differentiation or lymph node ***43 and SCFFBXW7(r=0.749),p-cyclin E1(Ser73)(r=0.667)and p-cyclin E1(Thr395)(r=0.457),SCFFBXW7 and p-cyclin E1(Ser73)(r=0.703)and p-cyclin E1(Thr395)(0.415)were correlated in colon cancer(P<0.05),and expressions of the above proteins were positively correlated in colon *** Cx43 may facilitate the phosphorylation of cyclin E1 at the Ser73 and Thr195 sites through its interaction with SCFFBXW7,thereby influencing the ubiquitination and degradation of cyclin E1.

关键词： Colon cancer Cx43 SCFFBXW7 Phosphorylation of cyclin E1 Sites of cyclin E1 Correlation analysis

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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第01期 369-376页

作者： Song-Meng Wang hao Nian Yan-Fang Wang Li-Shuo Zheng Yu-Tao Zheng Yi-Wei dong Liping Huang Xiaoping Wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent LiCoO_(2)cathode material

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： Junjie Shi Changle Hou Jingjing dong dong Chen Jianzhong Li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(LIBs),properly recycling spent LIBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of LIB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to LiCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/LiCoO_(2)mass ratio of 3:1,the leaching efficiency of Li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in LiCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of LIB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy

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Effect of N and Zr on as-cast microstructure and properties after annealing of a high-speed steel

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Journal of Iron and Steel Research International 2018年第4期25卷 460-468页

作者： hao-ran Cui Jian-ping Lai Qing-lin Pan Xiang-dong Wang School of Materials Science and Engineering Central South University Changsha 410083 Hunan China

Effects of N and Zr on the as-cast microstructure and properties after annealing of high-speed steel （HSS） were investigated by using electronic probe micro-analysis, Rockwell hardness test, X-ray diffractometry and differential scanning calorimetry with combination of microstructure analysis. The results indicate that the addition of N and Zr will refine the eutectic structures and enhance the stability of carbides which are mainly MC, M2C and M7C3. The coarse dendritic structures decrease significantly and most of the carbides are distributed in the microstructure uniformly. Moreover, a kind of Zr-Si compound which only exists in VC is discovered, and this new phase is speculated to be related with the spheroidization of VC. The annealing process is set up to 6 different time periods which are 1, 3, 6, 10, 15 and 20 h, respectively. In different annealing processes at 750 ℃ which is lower than austenitizing temperature, the addition of N and Zr makes the decrease of hardness more obvious and restrains the precipitation of secondary carbides with the extension of time. Moreover, when the annealing time reaches 20 h, some clusters appear in the matrix of the two samples, and the density of clusters in HSS1 is lower, but the matrix of HSS1 contains more C and alloying elements which indicate more carbides precipitate.

关键词： N addition Zr addition High-speed steel As-cast microstructure Precipitation Annealing

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