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Performance-Oriented Layout Synthesis for Quantum Computing

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Computer Systems Science & Engineering 2024年第6期48卷 1581-1594页

作者： Chi-Chou kao Hung-Yi Lin Department of Computer Science and Information Engineering National University of TainanTainan700301TaiwanChina Department of Electrical Engineering National University of KaohsiungKaohsiung811TaiwanChina

Layout synthesis in quantum computing is crucial due to the physical constraints of quantum devices where quantum bits(qubits)can only interact effectively with their nearest *** constraint severely impacts the design and efficiency of quantum algorithms,as arranging qubits optimally can significantly reduce circuit depth and improve computational *** tackle the layout synthesis challenge,we propose an algorithm based on integer linear programming(ILP).ILP is well-suited for this problem as it can formulate the optimization objective of minimizing circuit depth while adhering to the nearest neighbor interaction *** algorithm aims to generate layouts that maximize qubit connectivity within the given physical constraints of the quantum *** experimental validation,we outline a clear and feasible setup using real quantum *** includes specifying the type and configuration of the quantum hardware used,such as the number of qubits,connectivity constraints,and any technological *** proposed algorithm is implemented on these devices to demonstrate its effectiveness in producing depth-optimal quantum circuit *** integrating these elements,our research aims to provide practical solutions to enhance the efficiency and scalability of quantum computing systems,paving the way for advancements in quantum algorithm design and implementation.

关键词： Quantum computing layout placement and routing scheduling allocation optimality

Finite Element Analysis of Graphite/Epoxy Composite Pressure Vessel

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Journal of Materials Science and Chemical Engineering 2017年第7期5卷 19-28页

作者： Meng-kao Yeh Tai-Hung Liu Department of Power Mechanical Engineering National Tsing Hua University Taiwan

Shell structure is widely used in industrial applications, such as in machinery, aerospace, ship and building fields, as well as containers of pressurized chemicals or liquefied natural gas. Graphite/epoxy composites has advantages of light weight, high strength, corrosion resistance, low expansion, low shrin kage and are often used in the form of composite pressure vessel for various engineering applications. In this study, the stress distributions of composite pressure vessel were analyzed. The finite element code ANSYS was used in analysis, in which the eight-node element SHELL 281 was adopted. The internal pressure 20 MPa, as in container of compressed natural gas, was applied inside the symmetrical cross-ply graphite/epoxy composite pressure vessel. The finite element model was established with suitable mesh size and boundary conditions. The stress distributions are discussed for the composite pressure vessel, especially for the inner two layers at the junction of semis pherical part. The Tsai-Hill criterion was used to assess the failure of composite pressure vessel.

关键词： Finite Element Analysis Stress Analysis Composite Pressure Vessel Tsai-Hill Failure Criterion

Povacoat affecting solid-state polymorphic changes of indomethacin after co-evaporation from different types of solvents via conventional and microwave drying techniques

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Asian Journal of Pharmaceutical Sciences 2016年第3期11卷 376-384页

作者： Shan-Yang Lin Hong-Liang Lin Ying-Ting Chi Ru-Ying Hung Yu-Ting Huang Chi-Yu kao Wei-Hsien Hsieh Department of Biotechnology and Pharmaceutical Technology Yuanpei University of Medical Technology

The effect of Povacoat on the solid state characteristics and polymorphic transformation of γ-form of indomethacin(γ-IMC) after solvent co-evaporation via two drying methods was investigated by thermoanalytical and FTIR spectroscopic studies. The types of solvents(water,ethanol, and water:ethanol(1:9 ～ 2:8, v/v)), weight ratios of Povacoat:IMC(4:1 ～ 4:10, w/w),and drying methods(air-drying and microwave-drying) were selected as variables in this study. A physical mixture of Povacoat and γ-IMC was also carried out by neat grinding *** results indicate that there was no interaction between Povacoat and γ-IMC or no polymorphic change of γ-IMC after the neat co-grinding process. Since Povacoat was only soluble in water or <30% ethanol aqueous solution but γ-IMC was only soluble in organic solvents,different solvents and drying methods might significantly influence the solid-state characteristics of IMC formed in the presence of Povacoat. It was found that the amorphous IMC was formed in the Povacoat/IMC evaporates after dissolving both Povacoat and γ-IMC in water:ethanol(mixed ratio=1:9 and 2:8, v/v) and co-evaporation via microwave-drying, whereas the α-IMC was formed in the Povacoat/IMC evaporates via the air-drying method. In addition, the predominate α-IMC formation was only found in all the Povacoat/IMC evaporates with different weight ratios prepared by previously dissolving in water:ethanol(1:9, v/v) and co-evaporation via air-drying, but the amorphous IMC formation after co-evaporation via microwave-drying was obtained except the 4:10(w/w) weight ratio. The thermal effect of microwave irradiation and the presence of Povacoat might be responsible for the amorphous IMC formation in the Povacoat/IMC evaporates.

关键词： Povacoat Indomethacin (IMC) Air-drying Microwave-drying α-IMC Amorphous IMC

GLOBAL ROBUST STABILITY OF INTERVAL HOPFIELD NEURAL NETWORKS WITH CONTINUOUSLY DISTRIBUTED DELAYS

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Annals of Differential Equations 2007年第4期23卷 427-432页

作者： kao Yonggui Gao Cunchen Liu Guanfeng Dept. of Math. Ocean University of China Qingdao 266071 China Dept. of Math. Zaozhuang University Zaozhuang 277160 Shandong College of Resources and Environment Engineering Wuhan University of Science and Technology Wuhan 430081

In this paper, we implement topological degree theory and Lyapunov-functional methods to obtain the existence and uniqueness of the equilibrium point and its global robust stability for interval Hopfield neural networks with continuously distributed delays. Moreover, the methods used in judging the robust stability are proven practical and easily verifiable.

关键词： global robust stability neural networks distributed delays topological degree

Increase in apoptosis by combination of metformin with silibinin in human colorectal cancer cells

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World Journal of Gastroenterology 2015年第14期21卷 4169-4177页

作者： Cheng-Chia Tsai Tang-Wei Chuang Li-Jen Chen Ho-Shan Niu Kun-Ming Chung Juei-Tang Cheng kao-Chang Lin Department of Surgery Mackay Memorial Hospital Graduate Institute of Disease Prevention and Control College of MedicineTaipei Medical University Division of Hepatogastroenterology Department of Internal MedicineChi Mei Medical Center Institute of Basic Medical Science College of MedicineNational Cheng Kung University Department of Nursing Tzu Chi College of Technology Division of Gastroenterology Department of Internal MedicineChi-Mei Medical Center Institute of Medical Sciences Chang Jung Christian University Department of Neurology Chi Mei Medical Center Department of Medical Research Chi Mei Medical Center Institute of Biotechnology Southern Taiwan University

AIM: To investigate the effect of metformin on silibinin-induced apoptosis in human colorectal cancer(COLO 205) ***: MTT assays were performed to quantify cell *** blot assays were applied to identify the expression of signaling ***: The combined treatment of COLO 205 cells with metformin and silibinin decreased cell survival at a dose insufficient to influence the non-malignant cells [Human colonic epithelial cells(HCo Epi C)].Silibinin and metformin increased phosphatase and tensin homolog and 5'-adenosine monophosphate-activated protein kinase expression in COLO 205 cells and inhibited the phosphorylation of mammol/Lalian target of *** combined treatment resulted in an increase in the expression of activated caspase 3 and apoptosis inducing factor, indicating ***: The combined treatment of human colorectal cancer cells with silibinin and metformin may induce apoptosis at a dose that does not affect HCo Epi *** finding reveals a potential therapeutic strategy for the treatment of colorectal cancer.

关键词： Silibinin Metformin COLO 205 Mammol/ Lalian target

LOW-VALENT TITANIUM INDUCED REDUCTIVE COUPLING OF AROMATIC NTTRILES TO 1,2-ARYLETHANONES

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Chinese Chemical Letters 1991年第5期2卷 351-352页

作者： Wei Xing CHEN Jian Xie CHEN Jian Ping JIANG Tsi Yu kao Department of Chemistry Nanjing UniversityNanjing210008

Reductive coupling of aromatic nitriles 1 by titanium tetrachloride/zinc provides an efficient general synthesis of 1,2-arylethanones.

关键词： Chen LOW-VALENT TITANIUM INDUCED REDUCTIVE COUPLING OF AROMATIC NTTRILES TO 1,2-ARYLETHANONES SH Wang Am OCH

Relationship between genetic polymorphisms of alcohol and aldehyde dehydrogenases and esophageal squamous cell carcinoma risk in males

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World Journal of Gastroenterology 2005年第33期11卷 5103-5108页

作者： Chia-Fang Wu Deng-Chyang Wu Hon-Ki Hsu Ein-Long kao Jang-Ming Lee Cheng-Chieh Lin Ming-Tsang Wu Graduate Institute of Occupational Safety and Health and Department of Occupational Medicine kaohsiung Medical University Kaohsiung Taiwan China Department of Chest Surgery kaohsiung Veterans General Hospital KaohsiungTaiwan China Department of Chest Surgery kaohsiung Medical University Hospital Kaohsiung Taiwan China Department of Surgery National Taiwan University Hospital Taipei Taiwan China Department of Family Medicine China Medical University and Hospital Taichung 404Taiwan China

AIM： To investigate the association between the genetic polymorphisms of ADH2 and ALDH2, lifetime alcohol consumption and esophageal cancer risk in the Taiwan Residents men. METHODS： Between August 2000 and June 2003, 134 pathologically-proven esophageal squamous cell carcinoma male patients and 237 male controls were recruited from kaohsiung Medical University Hospital and kaohsiung Veterans General Hospital in southern Taiwan. ADH2 and ALDH2 polymorphisms were genotyped using PCR-RFLP. RESULTS： Compared to those with ADH2＊2/＊2, individuals with ADH2＊1/＊2 and ADH2＊1/＊1 had 2.28- and 7.14-fold, respectively, increased risk of developing esophageal cancer （95%CI = 1.11-4.68 and 2.76-18.46） after adjusting for alcohol consumption and other covariates. The significant increased risk was also noted among subjects with ALDH2＊1/＊2 （adjusted OR （AOR） = 5.25, 95%CI = 2.47-11.19）, when compared to those with ALDH2＊1/＊1. The increased risk of esophageal cancer was made greater, when subjects carried both ADH2＊1/＊1 and ALDH2＊1/＊2, compared to those with ADH2＊1/＊2 or ADH2＊2/＊2 and ALDH2＊1/＊1 （AOR = 36.79,95%a = 9.36-144.65）. Furthhermore, we found a multipticative effect of lifetime alcoholic consumption and genotypes （ADH2 and ALDH2） on esophageal cancer risk. CONCLUSION： Our findings suggest that polymorphisms of ADH2 and ALDH2 can modify the influence of alcoholic consumption on esophageal cancer risk.

关键词： Esophageal cancer Alcohol Alcoholdehydrogenase Aldehyde dehydrogenase Geneticpolymorphisms

Microscopic colitis:A large retrospective analysis from a health maintenance organization experience

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World Journal of Gastroenterology 2009年第25期15卷 3122-3127页

作者： Kevin T kao Benito A Pedraza Amy C McClune David A Rios Yi-Qiong Mao Robert H Zuch Michael H Kanter Sony Wirio Chris N Conteas Department of Gastroenterology Kaiser PermanenteLos Angeles Medical Center Los Angeles California 90027United States Department of Internal Medicine Kaiser Permanente Los Angeles Medical Center Los Angeles California 90027 United States Department of Pathology Southern California Kaiser Permanente Medical Group California 90027 United States

AIM： To examine the demographic data on a large multi-ethnic population of patients with microscopic colitis （MC） in Southern California and to determine the association of MC with inflammatory bowel disease （IBD） and colorectal cancer. METHODS： All patients diagnosed with MC by co- Ionic biopsy from 1996-2005 were identified utilizing a pathology database. All biopsies were reviewed by experienced pathologists utilizing standard histologic criteria. Patients＇ medical records were reviewed and data regarding patient age, co-morbidities, sex, ethnic- ity, and medications were analyzed. An age- and sex- matched standard control group was also generated. Chi-square test was used to evaluate the associations of co-morbidities between lymphocytic colitis （LC）, col- lagenous colitis （CC） and the control group. RESULTS： A total of 547 cases of MC were identified, 376 patients with LC and 171 patients with CC. The fe- male/male ratio was 3：1 in CC and 2.7：1 in LC patients. Celiac disease （P 〈 0.001）, irritable bowel syndrome （IBS）（P 〈 0.001）, and thyroid diseases （P 〈 0.001） were found to have a higher occurrence in MC com- pared to the control group. No statistical differences in the occurrence of colorectal cancer, diabetes and IBD were found between the MC group and the control group. CONCLUSION： This is the largest group of patients with MC known to the authors that has been studied to date. Conditions such as celiac disease, IBS, and thyroid diseases were found to be related to MC. Fur- thermore, neither an increased risk of colorectal cancer nor IBD was associated with MC in this study.

关键词： Collagenous colitis Inflammatory bowel disease Lymphocytic colitis Microscopic colitis

基于MCR模型的村庄“三生空间”格局优化研究

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水土保持研究 2021年第5期28卷 362-367页

作者：郑洋郝润梅吴晓光王考内蒙古师范大学地理科学学院呼和浩特010022 内蒙古自治区土地整治中心呼和浩特010020

探究村庄"三生空间"布局的重构与优化,以空间理念研究村庄布局,对推动城乡一体化进程、加快乡村转型及实现乡村振兴具有重要意义。运用GIS软件功能和MCR模型分析等方法研究内蒙古和林格尔县迭力素村国土空间开发利用的适宜性分区及村域... 详细信息

探究村庄"三生空间"布局的重构与优化,以空间理念研究村庄布局,对推动城乡一体化进程、加快乡村转型及实现乡村振兴具有重要意义。运用GIS软件功能和MCR模型分析等方法研究内蒙古和林格尔县迭力素村国土空间开发利用的适宜性分区及村域"三生空间"格局优化问题。结果表明:(1)迭力素村空间适宜性以圈层呈现,中心位置建设适宜性最佳,生态适宜性由中心向四周逐渐增强,周边生态适宜性较好。(2)根据MCR模型模拟结果将村域国土空间适宜性划分为5种类型,分别为:生态保护区、生态优化区、禁止开发区、限制开发区和适宜开发区。(3)基于功能重要性、生态敏感性原则,兼顾土地利用类型和适宜性评价结果,将生态保护区确定为生态空间;将生态优化区、禁止开发区和限制开发区确定为生产空间;将适宜开发区确定为生活空间。(4)结合村庄发展定位及内部要素,提出生态空间重功能、生产空间重规模、生活空间重品质的迭力素村"三生空间"格局优化途径。研究可为村庄规划的编制提供理论依据。

关键词：土地资源管理 “三生”空间 MCR模型格局优化村庄规划