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Pectolinarin inhibited LPS-stimulated inflammation in microglial BV_(2) cells via NF-κB signaling pathway

Traditional Medicine Research 2024年第6期9卷 12-18页

作者： Bin-Feng Cheng Xiao Feng yu-Qian Dong Shao-Qin Jian hao-heng yu Jing-Jing Li Ting Ma Jun Zhang Yao-Dong Zhang Hai-Jie Yang Lei Wang Xinxiang Key Laboratory of Stress Cell Biology School of Life Sciences and TechnologyXinxiang Medical UniversityXinxiang 453003China Henan Neural Development Engineering Research Center Henan Children’s HospitalZhengzhou 410000China

Background:Neuro-inflammation is regarded as one of the critical pathogenesis in neurodegenerative diseases,which is characterized by the activated microglial ***(Pec),a natural flavonoid that exists in many Chinese herbal medicines,has been reported to have various biological ***,the effects and mechanisms on neuro-inflammation are not ***:In this study,the inhibitory effects and mechanisms of Pec on neuro-inflammation were investigated in the LPS-stimulated microglial BV_(2) ***_(2) microglial cells were treated with Pec or vehicle,followed by ***-linked immunosorbent assay,real-time quantitative PCR,nitric oxide and reactive oxygen species assay,and western blot were performed to examine the effects of Pec on neuro-inflammatory ***:We showed that Pec significantly inhibited the expression of tumor necrosis factorαand interleukin 6 in mRNA and protein levels induced by ***,the production of nitric oxide,iNOS,reactive oxygen species,and COX-2 were suppressed by Pec in LPS-stimulated microglial BV_(2) *** addition,Pec inhibited LPS-induced inflammation via nuclear factor kappa B signaling pathway,as evidenced by the reduction of the phosphorylation of inhibitor of nuclear factor kappa-B kinase,the degradation of IκBα,and the nuclear translocation of ***:Taken together,Pec exhibited anti-inflammatory effects in LPS-stimulated microglial BV_(2) cells via nuclear factor kappa B signaling pathway,which might provide therapeutic potential for neuro-inflammation and neurodegenerative diseases.

关键词： neuroinflammation microglial cells pectolinarin NF-κB

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Equivalent linear model for seismic damage evaluation of single-degree-of-freedom systems representing reinforced concrete structures considering cyclic degradation behavior

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 637-648页

作者： Lulu Yan Ding-hao yu Research Center for Geotechnical and Structural Engineering Technology of Liaoning Province Dalian UniversityDalian116622China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

In this study,a novel equivalent damping ratio model that is suitable for reinforced concrete(RC)structures considering cyclic degradation behavior is developed,and a new equivalent linearization analysis method for implementing the proposed equivalent damping ratio model for use in seismic damage evaluation is *** this end,Ibarra’s peak-oriented model,which incorporates an energy-based degradation rule,is selected for representing hysteretic behavior of RC structure,and the optimized equivalent damping for predicting the maximum displacement response is presented by using the empirical method,in which the effect of cyclic degradation is ***,the relationship between the hysteretic energy dissipation of the inelastic system and the elastic strain energy of the equivalent linear system is established so that the proposed equivalent linear system can be directly integrated with the Park-Ang seismic model to implement seismic damage *** to the simplicity of the equivalent linearization method,the proposed method provides an efficient and reliable way of obtaining comprehensive insight into the seismic performance of RC *** verification demonstrates the validity of the proposed method.

关键词： degrading system equivalent linear system equivalent damping seismic damage RC structures

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Study of the multi-physics field-coupled model of the two-stage electrostatic precipitator

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Building Simulation 2024年第3期17卷 387-398页

作者： Wenjia hao yu Guo yukun Wang Tao yu hao Gao Zhengwei Long Tianjin Key Laboratory of Indoor Air Environmental Quality Control School of Environmental Science and EngineeringTianjin UniversityWeijin Road 92Tianjin300072China Wuhan Second Ship Design and Research Institute WuhanChin

The two-stage electrostatic precipitator is widely used to purify oil mist ***,there is limited research on the influences of relative humidity,particle deposition characteristics,and the generation of gaseous ***,this paper established a numerical model of the electrostatic oil mist purifier and applied it to a two-stage electrostatic *** the model was used to investigate the corona discharge characteristics under different relative humidity conditions in the charged zone,the particle deposition characteristics,the purification efficiency,the ozone concentration distribution,and the oil vapor concentration distribution in the collection *** results indicate that,with a constant temperature,the corona current decreases as relative humidity increase,and there is a quadratic relationship between relative humidity and *** variation in relative humidity has little impact on the purification *** maximum ozone concentration occurs near the electrode line,and its concentration is influenced by the discharge current and inlet airflow *** oil vapor concentration reaches its maximum value at the side plates,with a value of 19 ppb,while it reaches the minimum value at the collecting zone electrode plate,with a value of 2 *** temperature is the main factor affecting the volatilization of the oil film,with higher temperatures resulting in higher oil vapor.

关键词： two-stage ESPs particle deposition corona discharge oil vapor

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Finite Groups with Some Bounded Codegrees

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1778-1784页

作者： Dong Fang YANG yu ZENG heng LV School of Mathematics and Statistics Southwest UniversityChongqing400715P.R.China Department of Mathematics Changshu Institute of TechnologyChangshu215500P.R.China

For a characterχof a finite group G,the number cod(χ) := ∣G:ker(χ)∣/χ(1)is called the codegree ofχ.In this paper,we give a solvability criterion for a finite group G depending on the minimum of the ratioχ(1)^(... 详细信息

关键词： Finite group codegree degree simple group

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Studies on the temporal,structural,and interacting features of the clubroot resistance gene Rcr1 using CRISPR/Cas9-based systems

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Horticultural Plant Journal 2024年第4期10卷 1035-1048页

作者： hao Hu Fengqun yu Agriculture and Agri-Food Canada Saskatoon Research and Development Centre107 Science PlaceSaskatoonSKS7N OX2Canada

Clubroot disease is a severe threat to Brassica crops globally,particularly in western *** resistance,achieved through pyramiding clubroot resistance(CR)genes with different modes of action,is the most important strategy for managing the ***,studies on the CR gene functions are quite *** this study,we have conducted investigations into the temporal,structural,and interacting features of a newly cloned CR gene,Rcr1,using CRISPR/Cas9 *** temporal functionality,we developed a novel CRISPR/Cas9-based binary vector,pHHIGR-Hsp18.2,to deliver Rcr1 into a susceptible canola line(DH12075)and observed that early expression of Rcr1 is critical for conferring *** structural functionality,several independent mutations in specific domains of Rcr1 resulted in loss-offunction,highlighting their importance for CR *** the study of the interacting features of Rcr1,a cysteine protease gene and its homologous allele in canola were successfully disrupted via CRISPR/Cas9 as an interacting component with Rcr1 protein,resulting in the conversion from clubroot resistant to susceptible in plants carrying intact *** results indicated an indispensable role of these two cysteine proteases in Rcr1-mediated resistance *** study,the first of its kind,provides valuable insights into the functionality of ***,the new vector p HHIGR-Hsp18.2 demonstrated an inducible feature on the removal of add-on traits,which should be useful for functional genomics and other similar research in brassica crops.

关键词： Clubroot resistance Brassica crops Canola Rcr1 CRISPR/Cas9 system Gene knock-out Timing control Non-synonymous mutation Protein-protein interaction

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A new liquid membrane diffusion model for characterizing the adsorption kinetics of europium by using a continuous measurement of adsorption platform

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Nuclear Science and Techniques 2024年第1期35卷 59-72页

作者： hao-Qi yu Tao yu Jian-Hua Ye State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China CGN Cangnan Nuclear Power Co. Ltd.Cangnan 325800China Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices East China University of TechnologyNanchang 330013China School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

To explore the kinetic adsorption under continuous and nonequilibrium states, an integration of continuous measurement and adsorption platform kinetics method was proposed, which was initially called the ICM-AP kinetics method, and a corresponding kinetic adsorption experimental method was developed. Adsorption experiments of europium(Eu) on Ca-bentonite,Na-bentonite, and the D231 cation exchange resin were performed using the ICM-AP kinetics method and continuous measurements. Because the kinetic experimental results observed in this study were different from those of traditional batch adsorption data, pseudo-first-order or pseudo-second-order kinetic models were unsuitable for fitting the experimental ***, a liquid membrane diffusion(LMD) model was developed based on the assumption of simultaneous adsorption/desorption to discuss the mechanism of kinetic adsorption. The kinetic adsorption mechanism was also studied by using *** results indicated that the proposed adsorption model can fit the experimental data more suitably, and the adsorption/desorption behaviors of Eu on bentonite and the D231 resin were simultaneously observed, suggesting that the adsorption kinetics of Eu(Ⅲ) was mainly dominated by hydrated Eu(Ⅲ) ions on the liquid membrane.

关键词： ICM-AP method LMD model Adsorption mechanism Eu(Ⅲ)

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Multi-Robot Cooperative Localization: Time-Varying Unobservable Subspace Analysis and Consistent Algorithm Design

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Journal of Systems Science & Complexity 2024年第5期37卷 1937-1955页

作者： hao Ning HE Fenghua YAO yu School of Astronautics Harbin Institute of Technology

This paper investigates the problem of cooperative localization(CL) for a multi-robot system(MRS) under dynamic measurement topology, which involves a group of robots collectively estimating their poses with respect to a common reference frame using ego-motion measurements and robot-to-robot relative measurements. The authors provide a theoretical analysis of the time-varying unobservable subspace and propose a consistent cooperative localization algorithm. First, the authors introduce the relative measurement graph(RMG) to represent the relative pose measurements obtained by the MRS at each instant. Then, the authors derive the local observability matrix over a time *** equivalent relationship is established between the local observability matrix and the spectral matrices of the RMG. Moreover, the authors present a method for constructing the unobservable subspace based on the RMG under different topology conditions. Based on this analysis, the authors design a consistent cooperative localization algorithm that satisfies the constraints of the time-varying unobservable subspace. An analytical optimal solution is derived for the constrained optimization *** Carlo numerical simulations are conducted to demonstrate the consistency and accuracy of the proposed method.

关键词： Consistency cooperative localization multi-robot system null space relative measurement graph time-varying unobservable subspace

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New model of linkage evolution for the transtensional fault systems in the Nanpu Sag of Bohai Bay Basin: Insight from seismic interpretation and analogue modelling

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Petroleum Science 2024年第4期21卷 2287-2310页

作者： yu-heng Wang Fu-Sheng yu Bao-Yin Zhao Ling-Jian Meng College of Geosciences China University of Petroleum (Beijing) State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum (Beijing) Jidong Oilfield Company PetroChina Limited Company

The evolution of faults within the same stress field is frequently influenced by numerous factors,involving the reactivation of pre-existing structures, stress transmission through ductile detachment layers, and the growth, interaction, as well as linkage of new fault segments. This study analyses a complex multi-phase oblique extension fault system in the Nanpu Sag(NPS) of the Bohai Bay Basin(BBB),China. High-resolution three-dimensional(3D) seismic data and analogue modelling indicate that the oblique extensional reactivation of pre-existing structures governs the sequential arrangement of fault segments in the caprock, and they dip synthetically to the reactivated fault at depth. During the NW-SE extension in the Eocene, the predominant movement of the pre-existing fault is strike-slip. Subsequently,during the N-S extension since the Oligocene, inclined at *** the pre-existing fault, forming splay fault segments and ultimately creating large en-echelon arcuate faults linked by relay ramps. Using fault throw-distance(T-D) and laser scanning, we reconstructed the fault evolution model of oblique extension reactivation in the presence of a ductile detachment basement. Our study illustrates that the arcuate faults can be categorized into linear master fault segments controlled by pre-existing structures, bending splay faults in the termination zone, and normal fault segments responding to the regional stress *** interaction between faults occurs among normal faults and strike-slip faults, and the kinematic unification of the two fault systems is accomplished in the intersection zone. As the faults continue to evolve, the new fault segments tend to relinquish the control of pre-existing structures and concentrate more on the development of planar and continuous major faults. The ductile detachment layer significantly contributes to the uniform distribution of strain, resulting in narrow shear zones and discontinuous normal faults in its absence.

关键词： Analogue modelling Transtensional deformation Fault linkage Fault intersection zone Nanpu Sag of Bohai Bay basin

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UiO-66-NH_(2)nanoparticles supported on layered double hydroxides as an excellent adsorbent for levofloxacin capture

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Particuology 2024年第9期92卷 155-165页

作者： Yan Li heng Lin Qiaolan yu Na Ma Wei Dai College of Geography and Environmental Sciences Zhejiang Normal UniversityJinhua321004China Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua321004China

The adsorption performances of individual adsorbent such as UiO-66-NH_(2)and MgAl-layered double hydroxides(MgAl-LDH)toward levofloxacin(LVX)is less satisfactory due to the disappointing uptake capacity and adsorption ***,a 3D flower-like composite adsorbent prepared via iterative hydrothermal synthesis method anchoring UiO-66-NH_(2)nanoparticles onto the MgAl-LDH *** to the synergistic effects of UiO-66-NH_(2),and MgAl-LDH,the MgAl-LDH@UiO-66-NH_(2)exhibits an outstanding adsorption performance toward ***,the maximum LVX uptake capacity over MgAl-LDH@UiO-66-NH_(2)reached 268 mg/g,which was higher than that of the individual adsorption materials UiO-66-NH_(2)(41 mg/g),MgAl-LDH(140 mg/g),and some adsorbents reported in previous *** rapid adsorption process can reach equilibrium within 20 min,which conformed well to the pseudo-second-order kinetics and the Langmuir isotherm *** thermodynamic result also indicated that the adsorption was spontaneous and exothermic,simultaneous coexisting physical and chemical adsorption ***,the MgAl-LDH@UiO-66-NH_(2)still maintained excellent adsorption capacity with a slightly decrease after fifth cycle,exhibiting a remarkable reuse and stable *** work provides a highly novel strategy to prepare recyclable composite adsorbent for the LVX capture from aqueous solution.

关键词： Layered double hydroxides UiO-66-NH_(2) LVX Adsorption

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A proteomic landscape of pharmacologic perturbations for functional relevance

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Journal of Pharmaceutical Analysis 2024年第1期14卷 128-139页

作者： Zhiwei Liu Shangwen Jiang Bingbing hao Shuyu Xie Yingluo Liu yuqi Huang heng Xu Cheng Luo Min Huang Minjia Tan Jun-yu Xu State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing210023China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshanGuangdong528400China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing210023China

Pharmacological perturbation studies based on protein-level signatures are fundamental for drug discovery. In the present study, we used a mass spectrometry (MS)-based proteomic platform to profile the whole proteome of the breast cancer MCF7 cell line under stress induced by 78 bioactive compounds. The integrated analysis of perturbed signal abundance revealed the connectivity between phenotypic behaviors and molecular features in cancer cells. Our data showed functional relevance in exploring the novel pharmacological activity of phenolic xanthohumol, as well as the noncanonical targets of clinically approved tamoxifen, lovastatin, and their derivatives. Furthermore, the rational design of synergistic inhibition using a combination of histone methyltransferase and topoisomerase was identified based on their complementary drug fingerprints. This study provides rich resources for the proteomic landscape of drug responses for precision therapeutic medicine.

关键词： Proteomics Drug Perturbation Drug target Drug combination

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