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Myocardial bridging phenomenon is not invariable:A case report

World Journal of Clinical Cases 2022年第29期10卷 10721-10727页

作者： hao-hao li Ming-Wang liu Yang-Fang Zhang Bo-Ce Song Zheng-Chuan Zhu Fu-Hai Zhao Graduate School of Beijing University of Chinese Medicine Beijing 100029China Department of Cardiology Xiyuan HospitalChinese Academy of Chinese Medicine ScienceNational Clinical Research Center for Chinese Medicine CardiologyBeijing 100091China

BACKGROUND Myocardial bridging is a common anatomical malformation,and the milking effect is a characteristic phenomenon of myocardial bridging in coronary angiography.Generally,the phenomenon is invariable.However,this article reports an inconceivably rare myocardial bridging phenomenon that breaks through our conventional views.The milking effect changed obviously in two coronary angiography examinations,which subverted the traditional deep-rooted view of the myocardial bridging phenomenon and revealed the limitations of coronary angiography in diagnosing myocardial bridging and judging the prognosis of it.CASE SUMMARY A 63-year-old man was diagnosed with ST-segment elevation myocardial infarction and received primary percutaneous coronary intervention on December 26,2019.His heart rate was 104 beats per minute,and blood pressure was 15.3/10.3 kPa.A severe milking effect was found in the left anterior descending coronary artery during his index coronary angiography on January 14,2020.The patient was given intensive medical management,including aβ1-adrenergic receptor blocker,during hospitalization and after discharge.Unexpectedly,coronary angiography showed that the previous impressive milking effect was dramatically alleviated(close to normal)at the follow-up on October 13,2020.At that moment,the patient’s heart rate was 83 beats per minute,and blood pressure was 12.7/8.0 kPa.CONCLUSION The myocardial bridging phenomenon is not invariable and,in certain circumstances,may vary.Furthermore,the autonomic nervous system may be involved in the myocardial bridging phenomenon.

关键词： Myocardial bridging Milking effect Autonomic nervous system Endocrine system Coronary angiography Case report

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Development and evaluation of psychometric properties of a common module for the quality of life scale of living organ donors(QLSLOD-CM V1.0)based on liver donors

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Chinese Medical Journal 2020年第12期133卷 1473-1475页

作者： Yue-Xian Shi Hai-Ming Zhang Jing Chen hao-hao li Ming-Ming Yu Yin-Hui Jin Ya-Qi Huang Meng Sun Wei Gao Shao-Mei Shang School of Nursing Peking UniversityBeijing 100161China liver Transplantation Center Clinical Center for Pediatric Liver TransplantationNational Clinical Research Center for Digestive DiseasesBeijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of liver Transplantation Tianjin First Center HospitalTianjin 300192China Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China Center for Evidence-Based and Translational Medicine Wuhan UniversityWuhanHubei 430071China School of Nursing Tianjin Medical UniversityTianjin 300070China

A living donor is by definition a healthy person without significant medical problems.However,procedures involved with donation expose living donors to risks from a number of complications and donor safety remains an issue of concern.[1]Complications can affect the donor’s quality of life(QoL)to varying degrees and scales or questionnaires are commonly used to assess their QoL.Based on existing literature,we found three types of instruments for assessing living donors’QoL:(1)generic instruments,(2)disease-specific instruments,and(3)selfdeveloped instruments(scales,questionnaires,survey lists).Generic instruments(eg,36-item short form health survey),[2]may not adequately measure some specific problems and/or minor issues associated with the organ transplant surgery.Disease-specific instruments,(eg,chronic liver disease questionnaire),originally developed for use with particular diseases,[3]may lack precision and comprehensiveness in assessing the QoL of donors from healthy individuals.Self-developed instruments can resolve some of the deficiencies associated with generic and disease-specific instruments.[4,5]In China,there remains a lack of consensus with regard to an effective scale that is specific for assessing the QoL of living organ donors.

关键词： donor life instruments

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A High Order Accurate Bound-Preserving Compact Finite Difference Scheme for Two-Dimensional Incompressible Flow

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Communications on Applied Mathematics and Computation 2024年第1期6卷 113-141页

作者： hao li Xiangxiong Zhang Department of Mathematics Purdue University150 N.University StreetWest LafayetteIN47907-2067USA

For solving two-dimensional incompressible flow in the vorticity form by the fourth-order compact finite difference scheme and explicit strong stability preserving temporal discretizations,we show that the simple bound-preserving limiter in li et al.(SIAM J Numer Anal 56:3308–3345,2018)can enforce the strict bounds of the vorticity,if the velocity field satisfies a discrete divergence free constraint.For reducing oscillations,a modified TVB limiter adapted from Cockburn and Shu(SIAM J Numer Anal 31:607–627,1994)is constructed without affecting the bound-preserving property.This bound-preserving finite difference method can be used for any passive convection equation with a divergence free velocity field.

关键词： Finite difference Monotonicity Bound-preserving Discrete maximum principle Passive convection Incompressible flow Total variation bounded limiter

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Influence of carbides and pores on the localized deformation of nickel-based single-crystal superalloys

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Progress in Natural Science:Materials International 2024年第3期34卷 562-568页

作者： Rengeng li Yu Zhang haoyi Niu hao Wang hao Wu Key Laboratory for light-weight Materials Nanjing Tech University College of Materials Science and Engineering Chongqing University CRRC Qishuyan Institute Co.Ltd.

The carbides and pores play a critical role in the cracking tendencies of nickel-based single-crystal superalloys during deformation. In the present study, the deformation mechanism and local strain evolution behavior around carbides and pores were studied through in-situ tensile deformation experiments. The findings indicate that multiple slip systems are easily activated during tensile deformation in single-crystal alloys. Furthermore, the strain localization in carbides is influenced by their morphology, with rod-like and flake-like carbides demonstrating an increased likelihood of cracking during deformation. The strain localization adjacent to pores is markedly more intense, rendering these areas particularly susceptible to cracking. Our work therefore offers a theoretical foundation for enhancing the mechanical properties of nickel-based single-crystal superalloys by controlling carbide morphology and pore formation.

关键词： Carbides In-situ tensile Nickel-based single-crystal Pores Strain evolution

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Investigation on UV-curing Reprocessable Thermosets Bearing Hindered Urea Bonds and Their Composites with Modified Zinc Oxide Nanoparticles

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Chinese Journal of Polymer Science 2024年第6期42卷 751-765页

作者： Jun-hao Zhou li-Ming Tang Key Laboratory of Advanced Materials of Ministry of Education of China Department of Chemical EngineeringTsinghua UniversityBeijing100084China

In this study,a series of hindered urea bond(HUB)containing polyurethane-urea methacrylate prepolymers and a none HUB containing polyurethane methacrylate prepolymer were prepared using isobornyl methacrylate as the reactive diluent via one-pot procedure.The prepolymers were characterized fully by various techniques.Then,their thermosets were fabricated via UV curing in presence of a photo initiator,and their mechanical property and thermal behavior were investigated and compared.Different from the none HUB containing thermoset,the HUB containing thermosets(defined as PUT)could be recycled and reprocessed by hot press under relatively mild conditions with high recovery ratio of mechanical property.Furthermore,zinc oxide(ZnO)nanoparticles were modified with 3-(trimethoxysilyl)propyl methacrylate and the modified ZnO(defined as ZnO-TPM)was dispersed and polymerized into PUT matrix to prepare their nanocomposites.The influence of ZnO-TPM on the mechanical performance of the composites was evaluated,which indicated that the Young’s modulus and tensile strength increased gradually to the maximum values at ZnO-TPM content of 1 wt%and then decreased.The composites also displayed good reprocessability with improved recovery ratio compared to the pure PUT sample.In addition,the composite materials exhibited strong UV absorption capacity,implying their potential application in the circumstance where UV-shielding was required.

关键词： Polyurethane-urea methacrylate Hindered urea bond ZnO nanoparticles Reprocessing UV curing

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Experimental Investigation and X-Ray Computed Microtomography Simulation on Thermal Physical Properties of Foundation Materials after Molten Salt Leakage in the Storage Tank

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Journal of Thermal Science 2024年第2期33卷 591-601页

作者： WANG Zhaowen ZHOU hao LUO Jiawei li Yawei FANG hao liU Tianxiao State Key Laboratory of Clean Energy Utilization Institute for Thermal Power EngineeringZhejiang UniversityHangzhou310027China

This paper studied the thermal physical properties of foundation materials in the molten salt tank of thermal energy storage system after molten salt leakage by Transient plane source experiment and X-ray computed microtomography simulation methods.The microstructure,thermal properties and pressure resistance with different particle diameters were addressed.The measured heat conductivities from Transient plane source experiment for three cases are 0.49 W/(m·K),0.48 W/(m·K),and 0.51 W/(m·K),and the porosity is 30.1%,30.7%,and 31.2% respectively.The heat conductivity simulating results of three cases are 0.471 W/(m·K),0.482W/(m·K),and 0.513 W/(m·K).The ratio of difference between the results of simulation and Transient plane source measurement is as low as 1.2%,verifying the reliability of experimental and simulation results to a certain degree.Compared with the heat conductivity of 0.097-0.129 W/(m·K) and porosity of 71.6%-78.9% without leaking salt,the porosity is reduced by more than 50% while the heat conductivity increased by 4 to 5 times after molten salt leakage.This significant increase in heat conductivity has a great impact on security operation,structure design,and modeling of the tank foundation for solar power plants.

关键词： heat conductivity X-ray computed microtomography foundation materials three-phase threshold algorithm molten salt leakage

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Visualizing Wallerian degeneration in the corticospinal tract after sensorimotor cortex ischemia in mice

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Neural Regeneration Research 2024年第3期19卷 636-641页

作者： Jiao Mu liufang hao Zijue Wang Xuyang Fu Yusen li Fei hao Hongmei Duan Zhaoyang Yang Xiaoguang li Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina

Stroke can cause Wallerian degeneration in regions outside of the brain,particularly in the corticospinal tract.To investigate the fate of major glial cells and axons within affected areas of the corticospinal tract following stroke,we induced photochemical infarction of the sensorimotor cortex leading to Wallerian degeneration along the full extent of the corticospinal tract.We first used a routine,sensitive marker of axonal injury,amyloid precursor protein,to examine Wallerian degeneration of the corticospinal tract.An antibody to amyloid precursor protein mapped exclusively to proximal axonal segments within the ischemic cortex,with no positive signal in distal parts of the corticospinal tract,at all time points.To improve visualization of Wallerian degeneration,we next utilized an orthograde virus that expresses green fluorescent protein to label the corticospinal tract and then quantitatively evaluated green fluorescent protein-expressing axons.Using this approach,we found that axonal degeneration began on day 3 post-stroke and was almost complete by 7 days after stroke.In addition,microglia mobilized and activated early,from day 7 after stroke,but did not maintain a phagocytic state over time.Meanwhile,astrocytes showed relatively delayed mobilization and a moderate response to Wallerian degeneration.Moreover,no anterograde degeneration of spinal anterior horn cells was observed in response to Wallerian degeneration of the corticospinal tract.In conclusion,our data provide evidence for dynamic,pathogenic spatiotemporal changes in major cellular components of the corticospinal tract during Wallerian degeneration.

关键词： corticospinal tract green fluorescent protein microglia spinal anterior horn cells stroke virus trace Wallerian degeneration

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Highly Thermoconductive,Strong Graphene‑Based Composite Films by Eliminating Nanosheets Wrinkles

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Nano-Micro Letters 2024年第1期16卷 328-340页

作者： Guang Xiao hao li Zhizhou Yu haoting Niu Yagang Yao College of Engineering and Applied Sciences Jiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNational Laboratory of Solid State MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China Institute of Laser Manufacturing Henan Academy of SciencesZhengzhou 450052People’s Republic of China Center for Quantum Transport and Thermal Energy Science School of Physics and TechnologyNanjing Normal UniversityNanjing 210023People’s Republic of China

Graphene-based thermally conductive composites have been proposed as effective thermal management materials for cooling high-power electronic devices.However,when flexible graphene nanosheets are assembled into macroscopic thermally conductive composites,capillary forces induce shrinkage of graphene nanosheets to form wrinkles during solution-based spontaneous drying,which greatly reduces the thermal conductivity of the composites.Herein,graphene nanosheets/aramid nanofiber(GNS/ANF)composite films with high thermal conductivity were prepared by in-plane stretching of GNS/ANF composite hydrogel networks with hydrogen bonds andπ-πinteractions.The in-plane mechanical stretching eliminates graphene nanosheets wrinkles by suppressing inward shrinkage due to capillary forces during drying and achieves a high in-plane orientation of graphene nanosheets,thereby creating a fast in-plane heat transfer channel.The composite films(GNS/ANF-60 wt%)with eliminated graphene nanosheets wrinkles showed a significant increase in thermal conductivity(146 W m^(−1)K^(−1))and tensile strength(207 MPa).The combination of these excellent properties enables the GNS/ANF composite films to be effectively used for cooling flexible LED chips and smartphones,showing promising applications in the thermal management of high-power electronic devices.

关键词： Graphene Aramid nanofiber Wrinkles elimination In-plane stretching Thermal conductivity

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A core scientific problem in the treatment of central nervous system diseases:newborn neurons

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Neural Regeneration Research 2024年第12期19卷 2588-2601页

作者： Peng hao Zhaoyang Yang Kwok-Fai So Xiaoguang li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

It has long been asserted that failure to recover from central nervous system diseases is due to the system's intricate structure and the regenerative incapacity of adult neurons.Yet over recent decades,numerous studies have established that endogenous neurogenesis occurs in the adult central nervous system,including humans'.This has challenged the long-held scientific consensus that the number of adult neurons remains constant,and that new central nervous system neurons cannot be created or renewed.Herein,we present a comprehensive overview of the alterations and regulatory mechanisms of endogenous neurogenesis following central nervous system injury,and describe novel treatment strategies that to rget endogenous neurogenesis and newborn neurons in the treatment of central nervous system injury.Central nervous system injury frequently results in alterations of endogenous neurogenesis,encompassing the activation,proliferation,ectopic migration,diffe rentiation,and functional integration of endogenous neural stem cells.Because of the unfavorable local microenvironment,most activated neural stem cells diffe rentiate into glial cells rather than neurons.Consequently,the injury-induced endogenous neurogenesis response is inadequate for repairing impaired neural function.Scientists have attempted to enhance endogenous neurogenesis using various strategies,including using neurotrophic factors,bioactive materials,and cell reprogramming techniques.Used alone or in combination,these therapeutic strategies can promote targeted migration of neural stem cells to an injured area,ensure their survival and diffe rentiation into mature functional neurons,and facilitate their integration into the neural circuit.Thus can integration re plenish lost neurons after central nervous system injury,by improving the local microenvironment.By regulating each phase of endogenous neurogenesis,endogenous neural stem cells can be harnessed to promote effective regeneration of newborn neurons.This offers a novel approach for treating central ne

关键词： bioactive materials brain trauma endogenous neurogenesis hippocampal dentate gyrus neural stem cells neurotrophic factors newborn neurons spinal cord injury stroke subventricular zone

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Path-Following Control With Obstacle Avoidance of Autonomous Surface Vehicles Subject to Actuator Faults

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 956-964页

作者： li-Ying hao Gege Dong Tieshan li Zhouhua Peng the School of Marine Electrical Engineering Dalian Maritime UniversityDalian 116026China the School of Automation Engineering University of Electronic Science and Technology of ChinaChengdu 611731the Navigation CollegeDalian Maritime UniversityDalian 116026 the Yangtze Delta Region Institute(Huzhou) Huzhou 313001China

This paper investigates the path-following control problem with obstacle avoidance of autonomous surface vehicles in the presence of actuator faults,uncertainty and external disturbances.Autonomous surface vehicles inevitably suffer from actuator faults in complex sea environments,which may cause existing obstacle avoidance strategies to fail.To reduce the influence of actuator faults,an improved artificial potential function is constructed by introducing the lower bound of actuator efficiency factors.The nonlinear state observer,which only depends on measurable position information of the autonomous surface vehicle,is used to address uncertainties and external disturbances.By using a backstepping technique and adaptive mechanism,a path-following control strategy with obstacle avoidance and fault tolerance is designed which can ensure that the tracking errors converge to a small neighborhood of zero.Compared with existing results,the proposed control strategy has the capability of obstacle avoidance and fault tolerance simultaneously.Finally,the comparison results through simulations are given to verify the effectiveness of the proposed method.

关键词： Actuator faults autonomous surface vehicle(ASVs) improved artificial potential function nonlinear state observer obstacle avoidance

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