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High glucose reduces Nrf2-dependent cRAGE release and enhances inflammasome-dependent IL-1βproduction in monocytes:the modulatory effects of EGCG

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Food Science and Human Wellness 2024年第3期13卷 1531-1542页

作者： Chi-hao Wu Yin-Hsuan chang chin-Lin Hsu Sheng-Yi Chen Gow-chin Yen Graduate Programs of Nutrition Science School of Life ScienceTaiwan Normal UniversityTaipei 106209TaiwanChina Department of Food Science and Biotechnology Chung Hsing UniversityTaichung 40227TaiwanChina School of Nutrition Chung Shan Medical UniversityTaichung 40201TaiwanChina

Soluble receptor for advanced glycation end products(sRAGE)acts as a decoy sequestering of RAGE ligands,thus preventing the activation of the ligand-RAGE axis linking human ***,the molecular mechanisms underlying sRAGE remain *** this study,THP-1 monocytes were cultured in normal glucose(NG,5.5 mmol/L)and high glucose(HG,15 mmol/L)to investigate the effects of diabetesrelevant glucose concentrations on sRAGE and interleukin-1β(IL-1β)*** modulatory effects of epigallocatechin gallate(EGCG)in response to HG challenge were also *** enhanced intracellular reactive oxygen species(ROS)generation and RAGE *** secretion of sRAGE,including esRAGE and cRAGE,was reduced under HG conditions,together with the downregulation of a disintegrin and metallopeptidase 10(ADAM10)and nuclear factor erythroid 2-related factor 2(Nrf2)nuclear ***,the HG effects were counteracted by siRAGE and exacerbated by *** immunoprecipitation results showed that Nrf2 binding to the ADAM10 promoter and HG interfered with this *** data reinforce the notion that RAGE and Nrf2 might be sRAGE-regulating *** HG conditions,the treatment of EGCG reduced ROS generation and RAGE ***-stimulated cRAGE release was likely caused by the upregulation of the Nrf2-ADAM10 *** inhibited HG-mediated NLRP3 inflammasome activation at least partly by stimulating sRAGE,thereby reducing IL-1βrelease.

关键词： Epigallocatechin gallate(EGCG) Inflammasome Nuclear factor erythroid 2-related factor 2(Nrf2) Receptor for advanced glycation end products(RAGE) Soluble RAGE(sRAGE)

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MLDA:a multi-level k-degree anonymity scheme on directed social network graphs

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Frontiers of Computer Science 2024年第2期18卷 199-215页

作者： Yuanjing hao Long LI Liang chang Tianlong GU Guangxi Key Laboratory of Trusted Software Guilin University of Electronic TechnologyGuilin 541004China Engineering Research Center of Trustworthy AI(Ministry of Education) Jinan UniversityGuangzhou 510632China

With the emergence of network-centric data,social network graph publishing is conducive to data analysts to mine the value of social networks,analyze the social behavior of individuals or groups,implement personalized recommendations,and so ***,published social network graphs are often subject to re-identification attacks from adversaries,which results in the leakage of users’***-anonymity technology is widely used in the field of graph publishing,which is quite effective to resist re-identification ***,the current researches still exist some issues to be solved:the protection of directed graphs is less concerned than that of undirected graphs;the protection of graph structure is often ignored while achieving the protection of nodes’identities;the same protection is performed for different users,which doesn’t meet the different privacy requirements of ***,to address the above issues,a multi-level-degree anonymity(MLDA)scheme on directed social network graphs is proposed in this ***,node sets with different importance are divided by the firefly algorithm and constrained connectedness upper approximation,and they are performed different-degree anonymity protection to meet the different privacy requirements of ***,a new graph anonymity method is proposed,which achieves the addition and removal of edges with the help of fake *** addition,to improve the utility of the anonymized graph,a new edge cost criterion is proposed,which is used to select the most appropriate edge to be ***,to protect the community structure of the original graph as much as possible,fake nodes contained in a same community are merged prior to fake nodes contained in different *** results on real datasets show that the newly proposed MLDA scheme is effective to balance the privacy and utility of the anonymized graph.

关键词： directed social network graph graph publishing k-degree anonymity community structure graph utility

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Effect of tubastatin A on NLRP3 inflammasome activation in macrophages under hypoxia/ reoxygenation conditions

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World Journal of Emergency Medicine 2024年第4期15卷 289-296页

作者： hao Li chang Liu Ying Cui Panpan chang Wei Chong Department of Emergency Medicine the First Hospital of China Medical UniversityShenyang 110001China Trauma Medicine Center Peking University People's HospitalBeijing 100871China Key Laboratory of Trauma and Neural Regeneration Peking UniversityBeijing 100871China National Center for Trauma Medicine of china Beijing 100871China

BACKGROUND:There are currently no effective drugs to mitigate the ischemia/reperfusion injury caused by fluid resuscitation after hemorrhagic shock(HS).The aim of this study was to explore the potential of the histone deacetylase 6(HDAC6)-specific inhibitor tubastatin A(TubA)to suppress nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome activation in macrophages under hypoxia/reoxygenation(H/R)***:The viability of RAW264.7 cells subjected to H/R after treatment with different concentrations of TubA was assessed using a cell-counting kit-8(CCK8)***,2.5μmol/L TubA was used with RAW264.7 cells under H/R ***264.7 cells were divided into three groups,namely the control,H/R,and TubA *** levels of reactive oxygen species(ROS)in the cells were detected using fluorescence *** protein expression of HDAC6,heat shock protein 90(Hsp90),inducible nitric oxide synthase(iNOS),NLRP3,gasdermin-D(GSDMD),Caspase-1,GSDMD-N,and Caspase-1 p20 was detected by western *** levels of interleukin-1β(IL-1β)and IL-18 in the supernatants were detected using enzyme-linked immunosorbent assay(ELISA).RESULTS:HDAC6,Hsp90,and iNOS expression levels were significantly higher(P<0.01)in the H/R group than in the control group,but lower in the TubA group than in the H/R group(P<0.05).When comparing the H/R group to the control group,ROS levels were significantly higher(P<0.01),but significantly reduced in the TubA group(P<0.05).The H/R group had higher NLRP3,GSDMD,Caspase-1,GSDMD-N,and Caspase-1 p20 expression levels than the control group(P<0.05),however,the TubA group had significantly lower expression levels than the H/R group(P<0.05).IL-1βand IL-18 levels in the supernatants were significantly higher in the H/R group compared to the control group(P<0.01),but significantly lower in the TubA group compared to the H/R group(P<0.01).CONCLUSION:TubA inhibited the expression of HDAC6,Hsp90,and iNOS in macrophages

关键词： Hemorrhagic shock Hypoxia/reoxygenation Macrophage NLRP3 Tubastatin A

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Optimizing the Double Inverted Pendulum′s Performance via the Uniform Neuro Multiobjective Genetic Algorithm

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International Journal of Automation and computing 2017年第6期14卷 686-695页

作者： Dony Hidayat Al-Janan hao-chin chang Yeh-Peng Chen Tung-Kuan Liu Institute of Engineering Science and Technology National Kaohsiung First University of Science and TechnologyTaiwanChina Mechanical Engineering Departement Engineeering FacultySemarang State UniversitySemarangCenter of JavaIndonesia Institute of Engineering Science and Technology National Kaohsiung First University of Science and TechnologyTaiwanChina

An inverted pendulum is a sensitive system of highly coupled parameters, in laboratories, it is popular for modelling nonlinear systems such as mechanisms and control systems, and also for optimizing programmes before those programmes are applied in real situations. This study aims to find the optimum input setting for a double inverted pendulum（DIP）, which requires an appropriate input to be able to stand and to achieve robust stability even when the system model is unknown. Such a DIP input could be widely applied in engineering fields for optimizing unknown systems with a limited budget. Previous studies have used various mathematical approaches to optimize settings for DIP, then have designed control algorithms or physical mathematical *** study did not adopt a mathematical approach for the DIP controller because our DIP has five input parameters within its nondeterministic system model. This paper proposes a novel algorithm, named Uni Neuro, that integrates neural networks（NNs） and a uniform design（UD） in a model formed by input and response to the experimental data（metamodel）. We employed a hybrid UD multiobjective genetic algorithm（HUDMOGA） for obtaining the optimized setting input parameters. The UD was also embedded in the HUDMOGA for enriching the solution set, whereas each chromosome used for crossover, mutation, and generation of the UD was determined through a selection procedure and derived individually. Subsequently, we combined the Euclidean distance and Pareto front to improve the performance of the algorithm. Finally, DIP equipment was used to confirm the settings. The proposed algorithm can produce 9 alternative configured input parameter values to swing-up then standing in robust stability of the DIP from only 25 training data items and 20 optimized simulation results. In comparison to the full factorial design, this design can save considerable experiment time because the metamodel can be formed by only 25 experiments using the UD. Furth

关键词： Double inverted pendulum(DIP) Uni Neuro-hybrid UD multiobjective genetic algorithm(HUDMOGA) uniform design(UD) metamodel euclidean distance

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Designing a Secure and Scalable Data Sharing Mechanism Using Decentralized Identifiers(DID)

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 809-822页

作者： Iuon-chang Lin I-Ling Yeh ching-Chun chang Jui-Chuan Liu chin-Chen chang Department of Management Information Systems National Chung Hsing UniversityTaichung402Taiwan Information and Communication Security Research Center Feng Chia UniversityTaichung407Taiwan Department of Information Engineering and Computer Science Feng Chia UniversityTaichung407Taiwan

Centralized storage and identity identification methods pose many risks,including hacker attacks,data misuse,and single points of ***,existing centralized identity management methods face interoperability issues and rely on a single identity provider,leaving users without control over their ***,this paper proposes a mechanism for identity identification and data sharing based on decentralized *** scheme utilizes blockchain technology to store the identifiers and data hashed on the chain to ensure permanent identity recognition and data *** is stored on InterPlanetary File System(IPFS)to avoid the risk of single points of failure and to enhance data persistence and *** the same time,compliance with World Wide Web Consortium(W3C)standards for decentralized identifiers and verifiable credentials increases the mechanism’s scalability and interoperability.

关键词： Self-sovereign identity decentralized identifier blockchain

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Stage separation of recoverable liquid launch vehicle by using moving pulsating ball analogue for propellant sloshing

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chinese Journal of Aeronautics 2024年第2期37卷 360-370页

作者： Yu LU Baozeng YUE Bailong hao Bole MA Feng LIU Yuanyuan chang School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Beijing Institute of Astronautical Systems Engineering Beijing 100076China

In the process of stage separation of recoverable liquid launch vehicles,because of the large amount of residual fuel in the storage tanks,the influence of liquid sloshing on separation safety must be *** calculation simplicity and operation practicability,the Moving Pulsating Ball Model(MPBM)of large amplitude liquid sloshing is introduced into the calculation of launch vehicle stage *** the dynamic equation of the model with the energy relationship during"breathing movement",the formula calculating the force of liquid on the rigid body is *** with the calculations of commercial CFD calculation software,the accuracy of MPBM model is ***,all the external forces and moments are applied to the rigid body of the stages,so that the translational and rotational dynamic equations of the stages are obtained *** to the relative position of the two stages,the geometric shape of the interstage section and the engine of the second stage,the minimum clearance in the separation process can be decided to guarantee that the separation process is safe.

关键词： Moving Pulsating Ball Model(MPBM) Dynamics of stage separation Large amplitude sloshing Recoverable liquid launch vehicle Flight dynamics

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Observation of gapless corner modes of photonic crystal slabs in synthetic translation dimensions

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Photonics Research 2024年第3期12卷 444-455页

作者： WEN-JIN ZHANG hao-chang MO WEN-JIE CHEN XIAO-DONG CHEN JIAN-WEN DONG School of Physics&State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen UniversityGuangzhou 510275China

Second-order topological photonic crystals support localized corner modes that deviate from the conventional bulk-edge ***,the frequency shift of corner modes spanning the photonic band gap has not been experimentally ***,we observe the gapless corner modes of photonic crystal slabs within a parameter space by considering translation as an additional synthetic *** corner modes,protected by topological pumping in synthetic translation dimensions,are found to exist independently of the specific corner *** gapless corner modes are experimentally imaged via the near-field scanning measurement and validated numerically by full-wave *** propose a topological rainbow with gradient translation,demonstrating the ability to extract and separate specific frequency components of light into different spatial *** work contributes to the advancement of topological photonics and provides valuable insights into the exploration of gapless corner modes in synthetic dimensions.

关键词： translation dimensions corner

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Investigation on Degradation Path of SF_(6)in Packed-bed Plasma:Effect of Plasma-generated Radicals

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1231-1241页

作者： Zhaolun Cui chang Zhou Amin Jafarzadeh Xiaoxing Zhang Peng Gao Licheng Li Yanpeng hao School of Electric Power Engineering South China University of TechnologyGuangzhou 510630China School of Electrical and Electronic Engineering Hubei University of TechnologyWuhan 430068China Research group PLASMANT Department of ChemistryUniversity of AntwerpUniversiteitsplein 1BE-2610 Wilrijk-AntwerpBelgium CSEE

SF_(6)degradation mechanism in non-thermal plasma(NTP)systems is not fully understood due to the formation of a complex physico-chemical reaction network,especially when reactive gases and packing materials are *** this work,we conduct a combined experimental and theoretical study to unravel the SF_(6)degradation path in a-Al_(2)O_(3)packed plasma in the presence of H_(2)O or O_(2).Our experimental results show that both H_(2)O and O_(2)have a synergetic effect with-Al_(2)O_(3)packing on promoting SF_(6)degradation,leading to higher stable gas yields than typical spark or corona discharges.H_(2)O or O_(2)addition promotes SO_(2)or SO_(2)F_(2)selectivity,*** functional theory(DFT)calculations reveal that SO_(2)generation corresponding with the highest activation barrier is the most critical step toward SF_(6)*** like H and O generated from H_(2)O or O_(2)discharge can significantly promote the degradation process via Eley-Rideal mechanism,affecting key reactions of stable product generation,advancing degradation *** results of this work could provide insights on further understanding SF_(6)degradation mechanism especially in packed-bed plasma systems.

关键词： Degradation mechanism packed-bed plasma radicals SF_(6)

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Abnormal mechanochemical effect in ultraprecision machining of an additively manufactured precipitation-strengthened high-entropy alloy

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Journal of Materials Science & Technology 2024年第3期170卷 221-237页

作者： Long Xu Yuchao Bai Yunfa Guo chang Ren Xiaohua Tan Yandong Jia Gang Wang hao Wang Institute of Materials Shanghai UniversityShanghai 200444China Zhejiang Institute of Advanced Materials Shanghai UniversityJiashan 314100China Department of Mechanical Engineering National University of SingaporeSingapore 117575Singapore

Recently,researchers have explored the use of precipitation strengthening and finer microstructures with high-density dislocations in additive manufacturing to produce high-entropy alloys(HEAs)with adjustable ***,the inherent surface roughness and lack of machinability research in AMed HEAs limit their engineering *** this study,we systematically investigated the microstructural characteristics,mechanical properties,and machinability of Fe_(29.3)Co_(28.7)Ni_(28.6)Al_(6.8)Ti_(6.6)(at.%)HEAs with three different structures:single FCC phase cellular(SPC),dual precipitation-strengthened(DPS),and single precipitation-strengthened(SPS).These structures were fabricated by selective laser melting and isothermally annealing at 780 and 940℃.Compared to SPC HEA,DPS HEA exhibits a significant increase in yield strength and ultimate tensile strength but with a dramatic sacrifice in *** HEA exhibits similar mechanical properties to SPC HEA due to the pronounced coarsening of L21 *** ultraprecision machining micro-cutting test showed that SPC HEA had a significant mechanochem-ical effect,as evidenced by a sharp drop in cutting force for inked workpieces,but not DPS *** abnormal finding was that the negligible reflection of cutting force for SPS HEAs suggested a negative mechanochemical effect,even though SPS HEA had equally excellent plasticity like SPC *** was found that nanocrystallization-induced strength enhancement and ductility reduction of SPS HEA lead to chips’deformation dominated by shear avalanche rather than chip folding of SPC HEA,which involves the reduction of surface energy and friction of chips’***,these results and our research findings may guide the machining of AMed precipitation-strengthened HEAs and accelerate their engineering ap-plication.

关键词： High-entropy alloy Selective laser melting Precipitation strengthening Machinability Mechanochemical effect

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Intermittent Theta Burst Stimulation Attenuates Cognitive Deficits and Alzheimer’s Disease-Type Pathologies via ISCA1-Mediated Mitochondrial Modulation in APP/PS1 Mice

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Neuroscience Bulletin 2024年第2期40卷 182-200页

作者： Yang Zhu hao Huang Zhi Chen Yong Tao Ling-Yi Liao Shi-hao Gao Yan-Jiang Wang chang-Yue Gao Department of Rehabilitation Medicine Daping HospitalArmy Medical UniversityChongqing 400042China Department of Neurology and Center for Clinical Neuroscience Daping HospitalArmy Medical UniversityChongqing 400042China Department of Special Medicine Daping HospitalArmy Medical UniversityChongqing 400042China

Intermittent theta burst stimulation(iTBS),a time-saving and cost-effective repetitive transcranial magnetic stimulation regime,has been shown to improve cognition in patients with Alzheimer’s disease(AD).However,the specific mechanism underlying iTBS-induced cognitive enhancement remains *** studies suggested that mitochondrial functions are modulated by magnetic ***,we showed that iTBS upregulates the expression of iron-sulfur cluster assembly 1(ISCA1,an essential regulatory factor for mitochondrial respiration)in the brain of APP/PS1 *** vivo and in vitro studies revealed that iTBS modulates mitochondrial iron-sulfur cluster assembly to facilitate mitochondrial respiration and function,which is required for ***,iTBS rescues cognitive decline and attenuates AD-type pathologies in APP/PS1 *** present study uncovers a novel mechanism by which iTBS modulates mitochondrial respiration and function via ISCA1-mediated iron-sulfur cluster assembly to alleviate cognitive impairments and pathologies in *** provide the mechanistic target of iTBS that warrants its therapeutic potential for AD patients.

关键词： Intermittent theta burst stimulation Alzheimer’s disease Iron-sulfur cluster assembly 1 Mitochondrial dysfunction Neurodegeneration

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