检索结果-南通市图书馆

Constitutive Relationship and Hot Processing Maps of Mg-Gd-Y-Nb-Zr Alloy

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2017年第7期33卷 637-644页

作者： Zhaohui Zhou Qichao Fan Zhihui Xia Aiguo hao Wenhua yang Wei ji Haiqiao Cao Institute of Machinery Manufacturing Technology Chinese Academy of Engineering Physics Mianyang 621900 China

The hot working behavior of Mg-Gd-Y-Nb-Zr alloy was investigated using constitutive model and hot processing maps in this work. Isothermal compression tests were conducted with temperature and strain rate range of 703-773 K and 0.01-5 s^（-1）, respectively. Improved Arrhenius-type equation incorporated with strain compensations was used to predict flow behavior of the alloy, and the predictability was evaluated using correlation coefficient, root mean square error and absolute relative error. Processing maps were constructed at different strains for Mg-Gd-Y-Nb-Zr alloy based on dynamic materials *** processing maps are divided into three domains and the corresponding microstructure evolutions are referred to the forming of straight grain boundaries, twinning, dynamic recrystallization and grain growth. Instability occurred mainly at the strain rate range of 0.3s^（-1）-0.5s^（-1）. The optimum processing domain is mainly at the temperature range of 703-765 K with the strain rate range of 0.01-0.1 s^（-1）.

关键词： Magnesium alloy Recrystallization Constitutive model Processing maps Hot deformation

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi hao jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo ji jianhua Zhuang Yan Liu jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

FTIR Spectroscopic Study of Crystallization of Uniaxial Drawn Syndiotactic Polystyrene/Carbon Nanotube Nanocomposite Films

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2012年第1期28卷 153-155页

作者： ZHANG jin-hao1,2, yang ji-ping1, YUAN Cui-ping1,2 and CHEN Guang-ming2 1. School of Materials Science and Engineering, Beihang University, Beijing 100191, P. R. China 2. Beijing National Laboratory for Molecular Sciences(BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China Beihang Univ Sch Mat Sci & Engn Beijing 100191 Peoples R China Chinese Acad Sci Inst Chem BNLMS Beijing 100190 Peoples R China

The crystallization of uniaxial hot drawn syndiotactic polystyrene/multi-walled carbon nanotube （sPS/MWCNT） nanocomposite films was studied by FTIR spectroscopy. The effects of MWCNT content, draw ratio and drawing temperature on the sPS crystallinity were investigated. The sPS/MWCMT nanocomposite films show reduced crystallinities with the increase of MWCNT content. In addition, with the increase of draw ratio, both the pure sPS and the sPS/MWCNT nanocomposite drawn films exhibit increased crystallinity. The effect of drawing temperature on the sPS crystallization is complex. In a temperature range of 100―135 °C, the crystallinity decreases with drawing temperature, whereas it increases at 140 °C for both pure sPS and its nanocomposite films.

关键词： Carbon nanotube Crystallization FTIR spectroscopy Nanocomposite Syndiotactic polystyrene

A versatile synthetic strategy towards rare earth based metal-organic frameworks

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Quan Shi Yun-hao Xu Ming-Hui Chen Peng Zhao Wen-Bo Deng ji Xiong Kai Guo Ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

关键词：

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-jie Quan hao Liang Yong-Hong Tang Li jiang Xiong-Ying ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

新型双螺旋双电源电磁干燥机在钼精矿干燥中的应用

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

煤矿现代化 2010年第4期19卷 71-72页

作者：时涛杨浩基李翔王志强河南煤化集团栾川龙宇钼业有限公司河南栾川471500

基于双螺旋双电源电磁干燥的工作原理,对我厂新型双螺旋双电源电磁干燥机的使用情况进行了详细的测量与能耗分析,通过与闪蒸干燥机能耗结果的对比,详细阐述了双螺旋双电源电磁干燥机的环保、节能效果,为该产品的推广应用及选矿厂干燥设... 详细信息

基于双螺旋双电源电磁干燥的工作原理,对我厂新型双螺旋双电源电磁干燥机的使用情况进行了详细的测量与能耗分析,通过与闪蒸干燥机能耗结果的对比,详细阐述了双螺旋双电源电磁干燥机的环保、节能效果,为该产品的推广应用及选矿厂干燥设备的节能改造,提供重要的参考依据。

关键词：电磁干燥机变频电源节能减排经济效益

k_(eff)uncertainty quantification and analysis due to nuclear data during the full lifetime burnup calculation for a small-sized prismatic high temperature gas-cooled reactor

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2021年第11期32卷 105-118页

作者： Rong-Rui yang Yuan Yuan Chen hao ji Ma Guang-hao Liu Fundamental Science on Nuclear Safety and Simulation Technology Laboratory College of Nuclear Science and TechnologyHarbin Engineering UniversityHarbin 150001China Department of Reactor Technology Beijing Institute of Nuclear EngineeringChina Nuclear Power Engineering Co.LtdBeijing 100089China

To benefit from recent advances in modeling and computational algorithms,as well as the availability of new covariance data,sensitivity and uncertainty analyses are needed to quantify the impact of uncertain sources on the design parameters of small prismatic high-temperature gascooled reactors(HTGRs).In particular,the contribution of nuclear data to the k_(eff)uncertainty is an important part of the uncertainty analysis of small-sized HTGR physical *** this study,a small-sized HTGR designed by China Nuclear Power Engineering Co.,*** selected for k_(eff)uncertainty analysis during full lifetime burnup *** of the cold zero power(CZP)condition and full lifetime burnup process were constructed using the Reactor Monte Carlo Code RMC for neutron transport calculation,depletion calculation,and sensitivity and uncertainty *** the sensitivity analysis,the Contribution-Linked eigenvalue sensitivity/Uncertainty estimation via Track length importance Characterization(CLUTCH)method was applied to obtain sensitive information,and the "sandwich" method was used to quantify the k_(eff)*** also compared the k_(eff)uncertainties to other typical *** results show that ^(235)U is the largest contributor to k_(eff)uncertainty for both the CZP and depletion conditions,while the contribution of ^(239)Pu is not very significant because of the design of low discharge *** is worth noting that the radioactive capture reaction of ^(28)Si significantly contributes to the k_(eff)uncertainty owing to its specific fuel ***,the k_(eff)uncertainty during the full lifetime depletion process was relatively stable,only increasing by 1.12%owing to the low discharge burnup design of small-sized *** numerical results are beneficial for neutronics design and core parameters optimization in further uncertainty propagation and quantification study for small-sized HTGR.

关键词： Small-sized HTGR SU analysis Nuclear data Burnup

Bifurcation control of solid angle car-following model through a time-delay feedback method

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2023年第9期24卷 828-840页

作者： Qun ji hao LYU Hang yang Qi WEI Rongjun CHENG Faculty of Maritime and Transportation Ningbo UniversityNingbo 315211China Ningbo University of Finance&Economics Ningbo 315175China

In order to alleviate unstable factor-caused bifurcation and reduce oscillations in traffic flow,a feedback control with consideration of time delay is designed for the solid angle model(SAM).The stability and bifurcation condition of the new SAM is derived through linear analysis and bifurcation analysis,and then accurate range of stable region is *** order to explore the mechanism of the influence of multiple parameter combinations on the stability of controlled systems,a definite integral stabilization method is provided to determine the stable interval of time delay and feedback *** simulations are explored to verify the feasibility and effectiveness of the proposed model,which also demonstrate that feedback gain and delay are two key factors to alleviate traffic congestion in the SAM.

关键词： Solid angle model(SAM) Time-delay Hopf bifurcation Feedback control Parameter calibration

表阿霉素对人肝癌SMMC-7721细胞bcl-2蛋白表达的影响

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

苏州大学学报（医学版） 2005年第3期25卷 454-456页

作者：危少华吴浩荣杨吉成盛伟华邢春根苏州大学附属第二医院普外科江苏苏州215004

目的探讨表阿霉素诱导SMMC7721细胞凋亡的可能分子机制。方法采用流式细胞仪间接免疫荧光法检测表阿霉素作用于人肝癌SMMC7721细胞后bcl2蛋白的表达。结果随着表阿霉素的浓度增加,作用于SMMC7721细胞时间的延长,细胞bcl2蛋白的表达逐渐... 详细信息

目的探讨表阿霉素诱导SMMC7721细胞凋亡的可能分子机制。方法采用流式细胞仪间接免疫荧光法检测表阿霉素作用于人肝癌SMMC7721细胞后bcl2蛋白的表达。结果随着表阿霉素的浓度增加,作用于SMMC7721细胞时间的延长,细胞bcl2蛋白的表达逐渐降低,SMMC7721细胞bcl2蛋白的表达与表阿霉素作用浓度EY时间呈负相关。结论Bcl2基因表达下调可能是表阿霉素诱导人肝癌SMMC7721细胞凋亡的重要机制之一。

关键词：表阿霉素 bcl-2蛋白细胞凋亡人肝癌SMMC-7721细胞