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Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi hao Jianjian Chu Tinglin Zhang Tong yin yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang yan Liu Jie Gao you yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

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Decomposition solutions and Bäcklund transformations of the B-type and C-type Kadomtsev-Petviashvili equations

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Communications in Theoretical Physics 2024年第6期76卷 34-44页

作者： Xiazhi hao S y Lou College of Science Zhejiang University of TechnologyHangzhou 310014China School of Physical Science and Technology Ningbo UniversityNingbo 315211China

This paper introduces a modified formal variable separation approach,showcasing a systematic and notably straightforward methodology for analyzing the B-type Kadomtsev-Petviashvili(BKP)*** the application of this approach,we successfully ascertain decomposition solutions,Bäcklund transformations,the Lax pair,and the linear superposition solution associated with the aforementioned ***,we expand the utilization of this technique to the C-type Kadomtsev-Petviashvili(CKP)equation,leading to the derivation of decomposition solutions,Bäcklund transformations,and the Lax pair specific to this *** results obtained not only underscore the efficacy of the proposed approach,but also highlight its potential in offering a profound comprehension of integrable behaviors in nonlinear ***,this approach demonstrates an efficient framework for establishing interrelations between diverse systems.

关键词： decomposition solution Backlund transformation Lax pair linear superposition solution

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Higher-dimensional integrable deformations of the modified KdV equation

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Communications in Theoretical Physics 2023年第7期75卷 15-21页

作者： Xiazhi hao S y Lou College of Science Zhejiang University of TechnologyHangzhouChina School of Physical Science and Technology Ningbo UniversityNingbo315211China

The derivation of nonlinear integrable evolution partial differential equations in higher dimensions has always been the holy grail in the field of *** well-known modified Kd V equation is a prototypical example of an integrable evolution equation in one spatial *** there exist integrable analogs of the modified Kd V equation in higher spatial dimensions?In what follows,we present a positive answer to this *** particular,rewriting the(1+1)-dimensional integrable modified Kd V equation in conservation forms and adding deformation mappings during the process allows one to construct higher-dimensional integrable ***,we illustrate this idea with examples from the modified Kd V hierarchy and also present the Lax pairs of these higher-dimensional integrable evolution equations.

关键词： higher-dimensional integrable equation conservation form deformation mapping Lax integrability symmetry integrability

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First-principles calculation on the electronic structures, phonon dynamics, and electrical conductivities of Pb_(10)(PO_(4))_(6O) and Pb_(9)Cu(PO_(4))_(6O) compounds

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Journal of Materials Science & Technology 2024年第6期173卷 218-224页

作者： L.y.hao E.G.Fu State Key Laboratory of Nuclear Physics and Technology Department of Technical PhysicsSchool of PhysicsPeking UniversityBeijing 100871China

Superconducting materials with high critical temperature have the potential to revolutionize many fields,including military,electronic communications,and power ***,scientists around the world have been tirelessly working with the ultimate goal of achieving high-temperature *** 2023,a preprint by Lee et *** South Korea claimed the discovery of ultra-high-temperature superconductivity with a critical temperature of up to 423 K in Cu-doped lead-apatite(LK-99)(arXiv:2307.12008,arXiv:2307.12037),which caused a worldwide sensation and ***,the electronic structures,phonon dynamics,and electrical conductivities of LK-99 and its parent compound lead-apatite have been calculated using first-principles *** results show that the lead-apatite compound and the LK-99 compound are insulator and half-metal *** flat band characteristic is consistent with previous *** electrical conductivity of the LK-99 compound shows two extreme points,and the electrical conductivity along the C-axis increases significantly after 400 *** phonon dispersion spectra of the compounds were investigated,demonstrating their dynamic instability.

关键词： Superconductivity LK-99 Lead-apatite First-principles calculation

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稀土元素Er、yb和y掺杂ZrO_(2)的第一性原理研究

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原子与分子物理学报 2025年第1期42卷 156-162页

作者：熊威任浩重庆交通大学航空学院重庆402247 重庆交通大学绿色航空技术研究院重庆401147

氧化锆具有声子能量低,介电常数高和带隙较宽等优良特性,并且立方相的氧化锆(cZrO_(2))透光率高,适合作为上转换发光材料的基质.采用基于密度泛函理论(DFT)的第一性原理平面波赝势法研究了稀土元素Er、yb和y掺杂cZrO_(2)的电子结构和光... 详细信息

氧化锆具有声子能量低,介电常数高和带隙较宽等优良特性,并且立方相的氧化锆(cZrO_(2))透光率高,适合作为上转换发光材料的基质.采用基于密度泛函理论(DFT)的第一性原理平面波赝势法研究了稀土元素Er、yb和y掺杂cZrO_(2)的电子结构和光学性质.计算结果显示,掺入y元素后,cZrO_(2)转变为直接带隙材料,继续掺入Er和yb原子后,费米能级移动到价带内,带隙显著减小.y和Er混掺后,增强了cZrO_(2)在近红外波段的吸收能力.继续掺入yb后,cZrO_(2)对近红外波段的吸收能力有了进一步地增加.

关键词：氧化锆第一性原理电子结构光学性质

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Structure and species composition of tree stands on verges and slopes along a major highway in Hong Kong

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Journal of Forestry Research 2023年第5期34卷 1347-1358页

作者： Louis Shing Him Lee hao Zhang Kathy Tze Kwun ng Shun Cheong Lo Alan Siu Lun yu Faculty of Design and Environment Technological and HigherEducation Institute of Hong KongHong KongPeople’s Republic of China Landscape Division Highways DepartmentHong KongPeople’s Republic of China Greening Landscape and Tree Management SectionDevelopment BureauHong KongPeople’s Republic of China

Arboricultural research focusing on transport land use was lacking in Hong *** highway slopes were registered in the Systematic Identification of Maintenance Responsibility of Slopes in the Territory(SIMAR),abbreviated as SIMAR *** aimed to analyze patterns in the structure and species composition of the tree stock along a highway in Hong Kong and examined how a slope registration system could help explain the characteristics of urban *** 53 slopes and 52 verges along San Tin Highway,Hong Kong were randomly *** trees on each slope and verge were collectively sampled as a tree *** variables,namely tree abundance,species richness,maximum tree height,Shannon-Wiener diversity,Simpson's dominance,and Pielou's evenness were measured for each *** addition,a limited visual tree risk assessment was *** 7,209 trees in 23 species were *** richness was low,ranging from one to eight species per *** and non-SIMAR slopes were *** slopes had significantly higher species richness,diversity,evenness but lower dominance,with mean difference of 1.41 species,0.17,0.17 *** slopes were associated with lower tree risk *** training regression models,boosting as an ensemble method arbitrarily raised the explanatory power and the predictive accuracy of some *** height,length,angle and area could be significant predictors of the biodiversity-related *** research can sample more habitat characteristics related to the structure and species composition of slopes and verges which were important components of urban forestry.

关键词： Highway greenery Roadside tree management Tree risk assessment Monospecific urban forest Slope geophysical environment Urban forests

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Laboratory characterization of temperature induced reflection cracks

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第5期7卷 668-677页

作者： Richard y.Ji Tirupan Mandal hao yin William J.Hughes Technical Center Airport Technology R&D BranchFederal Aviation AdministrationAtlantic CityNJ 08234USA Gemini Technologies Inc.Atlantic CityNJ 08234USA

A hot-mix asphalt(HMA) overlay is one of the primary strategy for rehabilitating existing HMA pavements and Portland cement concrete(PCC) pavements. The current design program, FAARFIELD, does not address reflective cracking for asphalt-overlaid concrete pavements due to its mechanism complexity. The bending, shearing, and thermal are three crucial factors to successfully model reflective cracking. To implement this failure mode in flexible over rigid design procedure, a series of full-scale test pavements were constructed, instrumented, and tested in the condition of extreme cooling temperature at the FAA National Airport Pavement Test Facility. The purpose was to assess cooling effects on the propagation of reflection cracks for airport AC over PCC pavements. In preparation for reflective cracking phase VI test, the FAA is conducting laboratory experiment on field extracted hot mix asphalt(HMA) cores. In order to test these field HMA cores, the Texas Overlay Tester(OT) was customized to get data similar to the full-scale tests. This paper discusses finite element analysis on the full-scale testing, development of the customized Texas OT, and a laboratory testing suite using the customized Texas OT, including preliminary tests, instrumentation, experiment design, and test results. Data obtained from this research effort will be used to develop a rational testing procedure to simulate extreme cooling cycles through full-scale testing.

关键词： Reflection cracks Customized Texas overlay tester Overlay Strain properties Fracture properties

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Tectonic framework of China and its relation with mineral resources——Cognition from geophysical data

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Chinese Science Bulletin 1997年第2期42卷 89-95页

作者： Liu, GD hao, Ty Liu, y Institute of Geophysics Chinese Academy of Sciences Beijing China

TECTONIC and its evolution are theoretical basis of geology and summation in geosciences from investigation of the earth’s structure, composition, motion and history. Therefore, they are of great importance to the industrial activities. Various geological maps have been compiled in different scales after long-time observation of rock outcrops in mountains and torrents. These tectonic maps, which are obtained based upon the cognition and judgment of tectonic movements in different ages, are summarization regarding the regularity of geological phenomenon in terms of theory, and provide service of exploration and references for environmental protection and prevention and control of disaster.

关键词： tectonic geophysics macroscopic framework.

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Synthesis, Crystal Structure and Luminescence Properties of a Cadmium(Ⅱ) Complex Based on 2-Hydroxy-6-methylisonicotinic Acid

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Chinese Journal of Structural Chemistry 2016年第2期35卷 279-285页

作者： ZHAng Tian TIAN Ai-Qin FEng Xun Seik Weng ng TIAN Pan-hao WAng y.ng College of Chemistry and Chemical Engineering Luoyang Normal University Basic Courses Education Department Henan Forestry Vocational College Department of Chemistry University of Malaya Chemistry Department Faculty of ScienceKing Abdulaziz University

A new cadmium（Ⅱ） complex[Cd（Hminic）（IP）]n（1,Hminic = 2-hydroxy-6-methylisonicotinic acid,IP = imidazo[4,5-f]-l,10-phenanthroline）,has been synthesized by the reaction of a Hminic and auxiliary N-containing ligands with Cd（Ⅱ） ion under hydrothermal *** complex was studied by elemental analysis,IR spectroscopy and X-ray *** is formulated as C（20）H（13）CdN5O3,crystallizes in monoclinic system,space group C2/c with α=9.6764（8）,b = 26.767（2）,c = 14.1332（11） A and β= 97.4510（10）°.V= 3629.7（5） A^3,Z = 8,Mr=483.75,Dc = 1.770 g/cm^3,F（000） = 1484 and μ= 1.237 mm^（-1）.The final refinement gave R = 0.0309 and wR = 0.0703 for 4151 reflections with I 〉2σ（I）.In the structure of 1,two Cd（Ⅱ） atoms are joined by a pair of μ2-hydroxyl oxygen atoms giving rise to a dinuclear Cd（Ⅱ） unit which is bridged by Hminic linkers to form a 1D ladder-like polymer *** chelating ligand IP coordinated to the Cd（Ⅱ） atom,and alternately attached to both sides of the ladder-like polymer *** chains are further bound together by strong intermolecular hydrogen bonds and face-to-face π…πinteractions,resulting in the formation of a 3D supramolecular ***,the thermal stability and luminescent properties of this complex and the free ligands have been investigated.

关键词： luminescent property 2-hydroxy-6-methylisonicotinic acid cadmium(Ⅱ) complex

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MICROSTRUCTURE ANALySIS AND MECHANICAL PROPERTIES OF Zn-Al ALLOy ROD PRODUCED By HEATED MOLD CONTINUOUS CASTIng

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Acta Metallurgica Sinica(English Letters) 2003年第3期16卷 241-248页

作者： y.Ma y.hao F.y.yan H.J.Liu State Key Laboratory of Advanced Nonferrous Materials Lanzhou University of Science & Technology Lanzhou 730050 ChinaState Key Laboratory of Advanced Nonferrous Materials Lanzhou University of Science & Technology Lanzhou 730050 ChinaState Key Laboratory of Advanced Nonferrous Materials Lanzhou University of Science & Technology Lanzhou 730050 ChinaSchool of Mechano-Electronic EngineeringHua Qian University Quanzhou 362011China

The new technology of continuous casting by heated mold was used to produce directional solidification ZA alloy lines to eliminate the inter defects of these lines and increase their mechanical properties. The results are as follows: (1) The microstruc-ture of the ZA alloy lines is the parallel directional dendritic columnar crystal. Every dendritic crystal of eutectic alloy ZA5 was composed of many layer eutectic β and η phases. The micro structure of hypereutectic ZA alloys is primary dendritic crystal and interdendritic eutectic structure. The primary phase of ZA8 and ZA12 is β, among them, but the primary phase of ZA22 and ZA27 is a. (2) Through the test to the as-cast ZA alloy lines made in continuous casting by heated mold, it is found that the tensile strength and hardness increase greatly, but the elongation decreases. With the increase of aluminum amount from ZA 5 to ZA 12, ZA22 and ZA27, the tensile strength increases gradually. ZA27 has the best comprehensive mechanical properties in these four kinds of ZA alloys. (3) Heat treatment can decrease the dendritic segregation and improve the elongation of ZA alloy, but make their strength decrease slightly.

关键词： zinc-aluminum alloy heated mold continuous casting mechanical properties heat treatment

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