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Chinese Chemical Letters 2024年第9期35卷 351-355页

作者： Yun-Xin Huang Lin-qian Yu Ke-Yu Chen hao Wang Shou-Yan Zhao Bao-Cheng Huang ren-Cun Jin School of Engineering Hangzhou Normal UniversityHangzhou 311121China Zhejiang Provincial Key Laboratory of Urban Wetlands and Regional Change Hangzhou 311121China

Environmental endocrine disruptors,represented by bisphenol A(BPA),have been widely detected in the environment,bringing potential health risks to human ***-containing biocarbon catalyst can activate peroxymonosulfate(PMS)to degrade BPA in water,but its active sites remain ***,in this work,nitrogen-containing biochar,i.e.,C–Nedge,enriched with graphitic-N defects at the edges was prepared by one-pot co-pyrolysis of chitosan and potassium *** results showed that the C–Nedge/PMS system can effectively degrade 98%of BPA(50 mg/L).The electron transfer based non-radical oxidation mechanism was responsible for BPA *** graphitic-N doping endows biochar with strong electron transfer *** catalyst had good recovery and reuse *** catalytic oxidation was also feasible for other refractory pollutants removal and worked well for treating practical *** work may provide valuable information in unraveling the N doping configurationactivity relationship during activating PMS by biochar.

关键词： Peroxymonosulfate Carbon-based catalysts Edge graphitic-N Non-radicals Bisphenol A

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基于多模态关系建模的三维形状识别方法

软件学报 2024年第5期35卷 2208-2219页

作者：陈浩楠朱映映赵骏骐田奇深圳大学计算机与软件学院广东深圳518060 华为技术有限公司广东深圳518172

为了充分利用点云和多视图两种模态数据之间的局部空间关系以进一步提高三维形状识别精度,提出一个基于多模态关系的三维形状识别网络,首先设计多模态关系模块(multimodal relation module,MRM),该模块可以提取任意一个点云的局部特征... 详细信息

为了充分利用点云和多视图两种模态数据之间的局部空间关系以进一步提高三维形状识别精度,提出一个基于多模态关系的三维形状识别网络,首先设计多模态关系模块(multimodal relation module,MRM),该模块可以提取任意一个点云的局部特征和一个多视图的局部特征之间的关系信息,以得到对应的关系特征.然后,采用由最大池化和广义平均池化组成的级联池化对关系特征张量进行处理,得到全局关系特征.多模态关系模块分为两种类型,分别输出点-视图关系特征和视图-点关系特征.提出的门控模块采用自注意力机制来发现特征内部的关联信息,从而将聚合得到的全局特征进行加权来实现对冗余信息的抑制.详尽的实验表明多模态关系模块可以使网络获得更优的表征能力;门控模块可以让最终的全局特征更具判别力,提升检索任务的性能.所提网络在三维形状识别标准数据集ModelNet40和ModelNet10上分别取得了93.8%和95.0%的分类准确率以及90.5%和93.4%的平均检索精度,在同类工作中处于先进水平.

关键词：三维形状识别关系建模多模态学习

The p38/MAPK pathway as a therapeutic target to prevent therapeutic escape of breast cancer stem cells

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Science China(Life Sciences) 2024年第9期67卷 1867-1880页

作者： Weixiao Yan Xiaotong Wang Wenjing Wang qi Guo Na Huang hao Chen Xing-Jie Liang Yu Han Dandan Liu Jinchao Zhang State Key Laboratory of New Pharmaceutical Preparations and Excipients/Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education/College of Chemistry and Materials Science Chemical Biology Key Laboratory of Hebei ProvinceHebei UniversityBaoding 071002China CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and TechnologyBeijing 100190China

Cancer stem cells(CSCs)play an important role in metastasis development,tumor recurrence,and treatment resistance,and are essential for the eradication of ***,therapies fail to eradicate CSCs due to their therapeutic stress-induced cellular escape,which leads to enhanced aggressive behaviors compared with CSCs that have never been ***,the underlying mechanisms regulating the therapeutic escape remain *** this end,we established a model to isolate the therapeutic escaped CSCs(TSCSCs)from breast CSCs and performed the transcription profile to reveal the ***,we demonstrated that the behavior of therapeutic escape was regulated through the p38/MAPK signaling pathway,resulting in TSCSCs exhibiting enhanced motility and ***,blocking the p38/MAPK signaling pathway effectively reduced motility and metastasis ability both in vitro and in vivo,which were further supported by downregulated motility-related genes and epithelial-mesenchymal transition(EMT)-related proteins vimentin and *** obtained findings reveal the p38/MAPK pathway as a potential therapeutic target for TSCSCs and would provide profound implications for cancer therapy.

关键词： therapeutic escape breast cancer stem cells motility p38/MAPK signaling pathway molecular mechanism

Frameworked electrolytes:Ionic transport behavior and high mobility for solid state batteries

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InfoMat 2024年第2期6卷 76-89页

作者： Jianguo Sun hao Yuan Jing Yang Tuo Wang Yulin Gao qi Zhao Ximeng Liu Haimei Wang Yong-Wei Zhang John Wang Department of Materials Science and Engineering National University of SingaporeSingaporeSingapore Institute of High Performance Computing(IHPC) Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore ST Engineering Advanced Material Engineering Pte.Ltd. SingaporeSingapore National University of Singapore(Chongqing)Research Institute Chongqing Liang Jiang New AreaChongqingthe People's Republic of China Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore

All solid-state batteries(ASSBs)are the holy grails of rechargeable batteries,where extensive searches are ongoing in the pursuit of ideal solid-state ***,there is still a long way off to the satisfactorily high(enough)ionic conductivity,long-term stability and especially being able to form compatible interfaces with the solid ***,we have explored ionic transport behavior and high mobility in the sub-nano pore networks in the framework ***,the frameworked electrolyte behaves as a solid,and however in the(sub)-nano scales,the very limited number of solvent molecules in confinement makes them completely different from that in liquid *** from a liquid-electrolyte counterpart,the interactions between the mobile ions and surrounding molecules are subject to dramatic changes,leading to a high ionic conductivity at room temperature with a low activation ***+ions in the sub-nano cages of the network structure are highly mobile and diffuse rather independently,where the rate-limiting step of ions crossing cages is driven by the local concentration gradient and the electrostatic interactions between Li^(+)*** new class of frameworked electrolytes(FEs)with both high ionic conductivity and desirable interface with solid electrodes are demonstrated to work with Li-ion batteries,where the ASSB with LiFePO_(4)shows a highly stable electrochemical performance of over 450 cycles at 2℃ at room temperature,with an almost negligible capacity fade of 0.03‰ each *** addition,the FE shows outstanding flexibility and anti-flammability,which are among the key requirements of large-scale applications.

关键词： frameworked electrolyte macroscopically solid with 3D ionic channels in sub-nano-scales solid-state battery space confinement of Li ions

Data-driven systematic analysis of waterborne viruses and health risks during the wastewater reclamation process

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Environmental Science and Ecotechnology 2024年第3期19卷 80-90页

作者： Jia-Xin Ma Xu Wang Yi-Rong Pan Zhao-Yue Wang Xuesong Guo Junxin Liu Nan-qi ren David Butler Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing100085China State Key Laboratory of UrbanWater Resource and Environment School of Civil and Environmental EngineeringHarbin Institute of TechnologyShenzhenShenzhen518055China University of Chinese Academy of Sciences Beijing100049China Centre for Water Systems College of EngineeringMathematics and Physical SciencesUniversity of ExeterExeterEX44QFUnited Kingdom

Waterborne viral epidemics are a major threat to public *** interest in wastewater reclamation highlights the importance of understanding the health risks associated with potential microbial hazards,particularly for reused water in direct contact with *** study focused on identifying viral epidemic patterns in municipal wastewater reused for recreational applications based on long-term,spatially explicit global literature data during 2000e2021,and modelled human health risks from multiple exposure pathways using a well-established quantitative microbial risk assessment *** median viral loads in municipal wastewater ranged from 7.92×10^(4)to 1.4×10^(6)GC L^(-1)in the following ascending order:human adenovirus(HAdV),norovirus(NoV)GII,enterovirus(EV),NoV GI,rotavirus(RV),and severe acute respiratory syndrome coronavirus 2(SARSCoV-2).Following secondary or tertiary wastewater treatment,NoV GI,NoV GII,EV,and RV showed a relatively higher and more stable log reduction value with medians all above 0.8(84%),whereas SARSCoV-2 and HAdV showed a relatively lower reduction,with medians ranging from 0.33(53%)to 0.55(72%).A subsequent disinfection process effectively enhanced viral removal to over 0.89-log(87%).The predicted event probability of virus-related gastrointestinal illness and acute febrile respiratory illnesses in reclaimed recreational water exceeded the World Health Organization recommended recreational risk benchmark(5%and 1.9%,respectively).Overall,our results provided insights on health risks associated with reusing wastewater for recreational purposes and highlighted the need for establishing a regulatory framework ensuring the safety management of reclaimed waters.

关键词： Reclaimed water Waterborne virus Recreational Human health Data-driven analysis

Transcriptomic Landscape Analysis Reveals a Persistent DNA Damage Response in Metabolic Dysfunction-associated Steatohepatitis Post-dietary Intervention

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 765-779页

作者： Zi-Yuan Zou tian-Yi ren Jia-qi Li Ting-Ying Jiao Meng-Yu Wang Lei-Jie Huang Shuang-Zhe Lin Yuan-Yang Wang Xiao-Zhen Guo Ye-Yu Song Rui-Xu Yang Cen Xie Jian-Gao Fan Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina University of Chinese Academy of Sciences BeijingChina Human Phenome Institute School of Life SciencesFudan UniversityShanghaiChina Department of Gastroenterology Ningbo No.2 HospitalNingboZhejiangChina Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition ShanghaiChina

Background and Aims:Metabolic dysfunction-associated steatotic liver disease(MASLD)and its more advanced form,metabolic dysfunction-associated steatohepatitis,have emerged as the most prevalent liver diseases ***,lifestyle modification is the foremost guidelinerecommended management strategy for ***,it remains unclear which detrimental signals persist in MASLD even after disease ***,we aimed to examine the persistent changes in liver transcriptomic profiles following this ***:Male C57BL/6J mice were divided into three groups:Western diet(WD)feeding,chow diet(CD)feeding,or diet reversal from WD to *** 16 weeks of feeding,RNA sequencing was performed on the mice’s livers to identify persistent alterations characteristic of ***,RNA sequencing databases containing high-fat diet-fed P53-knockout mice and human MASLD samples were ***:WD-induced MASLD triggered persistent activation of the DNA damage response(DDR)and its primary transcription factor,P53,long after the resolution of the hepatic phenotype through dietary *** levels of P53 might promote apoptosis,thereby exacerbating metabolic dysfunction-associated steatohepatitis,as they strongly correlated with hepatocyte ballooning,an indicator of apoptosis ***,P53 knockout in mice led to downregulated expression of apoptosis signaling in the ***,P53 may regulate apoptosis by transcriptionally activating the expression of apoptosis-enhancing nuclease(AEN).Consistently,P53,AEN,and the apoptosis process all exhibited persistently elevated expression and showed a strong inter-correlation in the liver following dietary ***:The liver demonstrated upregulation of DDR signaling and the P53-AEN-apoptosis axis both during and after exposure to *** findings provide new insights into the mechanisms of MASLD relapse,highlighting DDR signaling as a promising target to prevent MASLD recu

关键词： Apoptosis DNA Damage Metabolic dysfunction-associated steatotic liver disease RNA-Seq Tumor suppressor protein P53 Western Diets

MAL2 DNA methylation serves as a biomarker for the diagnosis and prognosis of glioma

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Genes & Diseases 2024年第5期11卷 36-39页

作者： hao Luo Xing Xiao Weiliang Hou Jing Cai Ming Chen qisheng Tang Yusheng Tong Zengxin qi Kaicheng Li Liang Chen Department of Neurosurgery Huashan HospitalShanghai Medical CollegeState Key Laboratory of Medical NeurobiologyMOE Frontiers Center for Brain Science and Institutes of Brain ScienceFudan UniversityShanghai 200040China National Center for Neurological Disorders Shanghai 200040China Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration Shanghai 200040China tianqiao and Chrissy Chen Institute Clinical Translational Research Center Shanghai 200040China Shanghai QuietD Biotechnology Co. Ltd.Shanghai 201210China

Glioma is a common and malignant brain tumor,and molecular diagnostics for glioma have received increasing attention.1,2 Previous studies have suggested that the MAL2 gene may be involved in the transcytosis of various cancers.3 This study aimed to investigate the potential of MAL2 as a biomarker for *** candidate MAL2 CpG sites were validated by pyrosequencing and used to construct a diagnostic model for *** analysis was also conducted to determine the relationship between highly methylated MAL2-specific CpG sites and the prognosis of *** findings also showed that MAL2 was more highly methylated in glioma than in other *** constructed diagnostic model can distinguish glioma from other cancers with high sensitivity(93.3%)and specificity(86.5%).Additionally,a risk score model was built based on MAL2 methylation to assess the prognosis of glioma。

关键词： glioma diagnosis MAL

An all-metallic nanovesicle for hydrogen oxidation

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National Science Review 2024年第6期11卷 233-242页

作者： Juntao Zhang Lujie Jin hao Sun Xiaozhi Liu Yujin Ji Youyong Li Wei Liu Dong Su Xuerui Liu zhongbin Zhuang Zhiwei Hu qi Shao Xiaoqing Huang State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering Xiamen University Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Key Laboratory for Special Functional Materials of Ministry of Education National &Local Joint Engineering Research Center for High-efficiency Display and Lighting Technology School of Materials Science and EngineeringCollaborative Innovation Center of Nano Functional Materials and Applications Henan University Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials& Devices Soochow University State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences State Key Lab of Organic-Inorganic Composites Beijing University of Chemical Technology Max Planck Institute for Chemical Physics of Solids College of Chemistry and Chemical Engineering and Materials Science Soochow University

Vesicle, a microscopic unit that encloses a volume with an ultrathin wall, is ubiquitous in ***, it remains a huge challenge to create its inorganic metal-based artificial counterparts. Here,inspired by the formation of biological vesicles, we proposed a novel biomimetic strategy of curling the ultrathin nanosheets into nanovesicles, which was driven by the interfacial strain. Trapped by the interfacial strain between the initially formed substrate Rh layer and subsequently formed RhRu overlayer, the nanosheet begins to deform in order to release a certain amount of strain. Density functional theory（DFT）calculations reveal that the Ru atoms make the curling of nanosheets more favorable in thermodynamics applications. Owing to the unique vesicular structure, the RhRu nanovesicles/C displays excellent hydrogen oxidation reaction（HOR） activity and stability, which has been proven by both experiments and DFT calculations. Specifically, the HOR mass activity of RhRu nanovesicles/C are 7.52 A mg（Rh+Ru）-1at an overpotential of 50 m V at the rotating disk electrode（RDE） level; this is 24.19 times that of commercial Pt/C(0.31 m A mgPt-1). Moreover, the hydroxide exchange membrane fuel cell（HEMFC） with RhRu nanovesicles/C displays a peak power density of 1.62 W cm-2in the H2-O2condition, much better than that of commercial Pt/C(1.18 W cm-2). This work creates a new biomimetic strategy to synthesize inorganic nanomaterials, paving a pathway for designing catalytic reactors.

关键词： biomimetic synthesis nanovesicle interfacial strain hydrogen oxidation reaction

lmpact of non-canonical ALK fusion on the efficacy of targeted therapy in non-small cell lung cancer

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Chinese Medical Journal 2024年第12期137卷 1468-1470页

作者： hao Zeng qi Wei Yuan Tang Yuanyuan Zhang Sihan Tan qin Huang Xin Pu Yalun Li Panwen tian Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Department of Pathology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Pulmonary and Critical Care Medicine Lung Cancer CenterWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Pulmonary and Critical Care Medicine State Key Laboratory of Respiratory Health and MultimorbidityPrecision Medicine Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduSichuan 610041China

To the Editor:With the wide application of next-generation sequencing(NGS),a number of EML4-ALK fusion partners or coexisting(non)-EML4-ALK and non-EML4-ALK have been detected in non-small cell lung cancer(NSCLC).Although targeted therapies for patients with metastatic NSCLC and actionable mutations dramatically change how these patients are treated,studies have demonstrated differences in progression-free survival(PFS)among patients based on different ALK fusion partners.

关键词： targeted lung NSCLC

NEATmap: a high-efficiency deep learning approach for whole mouse brain neuronal activity trace mapping

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National Science Review 2024年第5期11卷 202-216页

作者： Weijie Zheng Huawei Mu Zhiyi Chen Jiajun Liu Debin Xia Yuxiao Cheng qi Jing Pak-Ming Lau Jin Tang Guo-qiang Bi Feng Wu hao Wang AHU-IAI AI Joint Laboratory Anhui University Anhui Province Key Laboratory of Biomedical Imaging and Intelligent Processing Institute of Artificial IntelligenceHefei Comprehensive National Science Center National Engineering Laboratory for Brain-inspired Intelligence Technology and Application School of Information Science and TechnologyUniversity of Science and Technology of China Division of Life Sciences and Medicine University of Science and Technology of China Interdisciplinary Center for Brain Information Brain Cognition and Brain Disease InstituteShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions Shenzhen Institute of Advanced Technology Chinese Academy of Sciences

Quantitative analysis of activated neurons in mouse brains by a specific stimulation is usually a primary step to locate the responsive neurons throughout the brain. However, it is challenging to comprehensively and consistently analyze the neuronal activity trace in whole brains of a large cohort of mice from many terabytes of volumetric imaging data. Here, we introduce NEATmap, a deep learning–based high-efficiency,high-precision and user-friendly software for whole-brain neuronal activity trace mapping by automated segmentation and quantitative analysis of immunofluorescence labeled c-Fos+neurons. We applied NEATmap to study the brain-wide differentiated neuronal activation in response to physical and psychological stressors in cohorts of mice.

关键词： whole-brain imagingneuronal activity trace mapping deep learning quantitative analysis