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A genomic association study revealing subphenotypes of childhood steroid-sensitive nephrotic syndrome in a larger genomic sequencing cohort

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Genes & Diseases 2024年第4期11卷 400-410页

作者： Han Chan Fenfen Ni Bo Zhao Huimin Jiang Juanjuan Ding Li Wang Xiaowen Wang Jingjing Cui Shipin Feng Xiaojie Gao Xueying Yang Huan Chi hao lee Xuelan Chen Xiaoqin Li Jia Jiao Daoqi Wu Gaofu Zhang Mo Wang Yupeng Cun Xiongzhong Ruan Haiping Yang Qiu Li Department of Nephrology Children's Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of PediatricsChongqing 400014China Department of Nephrology Shenzhen Children's HospitalShenzhenGuangdong 518034China Department of Nephrology Kunming Children's HospitalKunming Medical UniversityKunmingYunnan 650228China Department of Nephrology Wuhan Children's HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhanHubei 430015China Department of Nephrology Chengdu Women and Children Central HospitalChengduSichuan 610073China Pediatric Research Institute Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Department of Nephrology John Moorhead Research LaboratoryUniversity College London Medical SchoolRoyal Free CampusUniversity College LondonLondon NW32PFUnited Kingdom

Dissecting the genetic components that contribute to the two main subphenotypes of steroid-sensitive nephrotic syndrome(SSNS)using genome-wide association studies(GWAS)strategy is important for understanding the *** conducted a multicenter cohort study(360 patients and 1835 controls)combined with a GWAS strategy to identify susceptibility var-iants associated with the following two subphenotypes of ssNS:steroid-sensitive nephrotic syn-drome without relapse(SSNswR,181 patients)and steroid-dependent/frequent relapse nephrotic syndrome(SDNS/FRNS,179 patients).The distribution of two single-nucleotide poly-morphisms(SNPs)in ANKRD36 and ALPG was significant between SSNSWR and healthy controls,and that of two SNPs in GAD1 and HLA-DQA1 was significant between SDNS/FRNS and healthy ***,rs1047989 in HLA-DQA1 was a candidate locus for SDNS/FRNS but not for *** significant SNPs were observed between SSNSWR and SDNS/***,chromosome 2:171713702 in GAD1 was associated with a greater steroid dose(>0.75 mg/kg/d)upon relapse to first remission in patients with SDNS/FRNS(odds ratio=3.14;95%confidence interval,0.97-9.87;P=0.034).rs117014418 in APOL4 was significantly associated with a decrease in eGFR of greater than 20%compared with the baseline in SDNS/FRNS patients(P=0.0001).Protein-protein intersection network construction suggested that HLA-DQA1 and HLA-DQB1 function together through ***,SSNSWR belongs to non-HLA region-dependent nephropathy,and the HLA-DQA/DQB region is likely strongly associated with dis-ease relapse,especially in SDNS/*** study provides a novel approach for the GWAS strategy of SsNS and contributes to our understanding of the pathological mechanisms of SSNSWRandSDNS/FRNS.

关键词： Frequentrelapse Genome-wide association study Human leukocyte antigen region Steroid-sensitive nephrotic syndrome

The onset of surface-enhanced Raman scattering for single-particle detection of submicroplastics

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Journal of Environmental Sciences 2022年第11期34卷 58-64页

作者： Cheng-hao lee James Kar-Hei Fang Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityKowloonHong Kong SARChina Institute of Textiles and Clothing The Hong Kong Polytechnic UniversityKowloonHong Kong SARChina Research Institute for Future Food The Hong Kong Polytechnic UniversityKowloonHong Kong SARChina State Key Laboratory of Marine Pollution City University of Hong KongKowloonHong Kong SARChina

Microplastics represent an emerging environmental problem worldwide, raising ecological and food safety concerns. Compared to microplastics, there is growing evidence of an even higher abundance of submicro-and nanoplastics in the environment, but a reliable monitoring method for detecting these smaller-sized plastics is lacking. Herein we presented the application of surface-enhanced Raman scattering(SERS) for this purpose. Particles of polystyrene(PS;600 nm) were used as the probe analyte. Gold nanourchins(Au NU;50 nm),i.e. urchin-shaped nanoparticles with irregular spikes around the core, were used as the SERS-active substrate. The effectiveness of SERS on PS was evaluated at a single-particle level with different numbers of Au NU in order to determine the minimum conditions required for the onset of the SERS effect. Our findings suggest that SERS of a single particle of PS can be induced by as few as 1–5 particles of Au NU, and that the use of excitation wavelength at 785 nm is appropriate to meet the red-shifted surface plasmon resonance of Au NU upon aggregation. These specifications provide additional information for the development of SERS-based tools for detecting plastic particles < 1 μm in food and environmental samples.

关键词： Microplastics Nanoplastics Gold nanourchins SERS Food contamination

Intraocular lens exchange-removing the optic intact

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International Journal of Ophthalmology(English edition) 2016年第6期9卷 925-928页

作者： Matthew hao lee Diane Lesley Webster Department of Ophthalmology Alfred HospitalMelbourneVIC 3004Australia Royal Victorian Eye and Ear Hospital East MelbourneVIC3002Australia

Current practice for intraocular lens （IOL） exchange is to cut the optic of the posterior chamber intraocular lens （PCIOL） prior to removing it. Great care must be taken during this maneuver to avoid a posterior capsular tear. Removing the haptics from the fibrosed capsule can also be hazardous, as it may result in zonular stress and dehiscence. A technique is described for performing foldable （one-piece acrylic） IOL removal without cutting the optic. Careful visco-dissection of the haptics with a low viscosity ophthalmic viscosurgical device （OVD） in the fibrosed peripheral capsular tunnel avoids zonular or capsular stress. Internal wound enlargement permits foldable IOL removal in one piece, whilst preserving a self-sealing sutureless corneal wound. This technique may enhance the safety and efficacy of foldable IOL exchange.

关键词： intraocular lens exchange viscodissection posterior capsular tear

Leveraging generative adversarial networks to create realistic scanning transmission electron microscopy images

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npj Computational Materials 2023年第1期9卷 1492-1500页

作者： Abid Khan Chia-hao lee Pinshane Y.Huang Bryan K.Clark Department of Physics University of Illinois Urbana-ChampaignUrbanaIL 61801USA Department of Materials Science and Engineering University of Illinois Urbana-ChampaignUrbanaIL 61801USA Materials Research Laboratory University of Illinois Urbana-ChampaignUrbanaIL 61801USA Institute for Condensed Matter Theory and IQUIST and NCSA Center for Artificial Intelligence Innovation University of Illinois Urbana-ChampaignUrbanaIL 61801USA

The rise of automation and machine learning(ML)in electron microscopy has the potential to revolutionize materials research through autonomous data collection and processing.A significant challenge lies in developing ML models that rapidly generalize to large data sets under varying experimental *** address this by employing a cycle generative adversarial network(CycleGAN)with a reciprocal space discriminator,which augments simulated data with realistic spatial frequency *** allows the CycleGAN to generate images nearly indistinguishable from real data and provide labels for ML *** showcase our approach by training a fully convolutional network(FCN)to identify single atom defects in a 4.5 million atom data set,collected using automated acquisition in an aberration-corrected scanning transmission electron microscope(STEM).Our method produces adaptable FCNs that can adjust to dynamically changing experimental variables with minimal intervention,marking a crucial step towards fully autonomous harnessing of microscopy big data.

关键词： autonomous adjust network

Biogeochemical reductive release of soil embedded arsenate around a crater area (Guandu) in northern Taiwan using X-ray absorption near-edge spectroscopy

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Journal of Environmental Sciences 2013年第3期25卷 626-636页

作者： Kai-Ying Chiang Tsan-Yao Chen Chih-hao lee Tsang-Lang Lin Ming-Kuang Wang Ling-Yun Jang Jyh-Fu lee Department of Agricultural Chemistry "National" Taiwan University Department of Engineering and System Science "National" Tsing Hua University "National" Synchrotron Radiation Research Center

This study investigates biogeochemical reductive release of arsenate from beudantite into solution in a crater area in northern Taiwan,using a combination of X-ray absorption near-edge structure （XANES） and atomic absorption *** arsenic （As） concentrations in the soil were more than 200 mg/*** four months of laboratory experiments,less than 0.8% As was released into solution after reduction *** 71% to 83% As was chemically reduced into arsenite （As（III）） and partially weathering into the soluble *** kinetic dissolution and re-precipitation of As,Fe,Pb and sulfate in this area of paddy soils merits further study.

关键词： agricultural rice soils arsenic arsenate reduction release

Petrology and geochemistry at the Lower zone-Middle zone transition of the Panzhihua intrusion,SW China:Implications for differentiation and oxide ore genesis

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Geoscience Frontiers 2013年第5期4卷 517-533页

作者： Kwan-Nang Pang Mei-Fu Zhou Liang Qi Sun-Lin Chung Chiu-Hong Chu hao-Yang lee Department of Geosciences National Taiwan University Department of Earth Sciences The University of Hong Kong Institute of Geochemistry Chinese Academy of Sciences

A sequence of gabbros showing isotropic,layered and fine-grained textures is exposed in the Nalaqing mine at the southern tip of the～260 Ma Panzhihua intrusion,SW *** field relations,structure,texture and mineralogy of the rocks indicate that the sequence represents the transition between the Lower zone and Middle zone of the *** gabbros characteristic of the Lower zone pass upward to layered gabbros of the Middle zone through a～5 m-thick microgabbro sheet,within and close to which small-scaled, concordant Fe-Ti oxide ore horizons are *** fractionation between HFSE and REE in a subset of samples is ascribed to cumulus titanomagnetite into which HFSE are preferentially incorporated over REE,as reflected in the parallel relations between Nb/La,Hf/Sm and Ti/Ti＊.Both the isotropic and layered gabbros display cumulate textures and have similar mineral compositions（Mg# of clinopyroxene =～76-79 and An59-61）,isotopic compositions[（87Sr/86Sr）i = 0.7044-0.7045 andεNd（t） = ＋2.4 to ＋3.9]and trapped liquid contents inferred from Zr abundance（～17-34 ppm）.However,there are substantial variations in elemental abundances（V,Cr and PGE） and ratios（Ti/V,La/Yb,Ba/Y and Cu/Pd） between the two types of gabbros,features that cannot be explained by cumulate formation from a common magma in a closed *** microgabbros generally resemble high-Ti Emeishan basalts in major element compositions,but their low trace element abundances indicate some lost of residual liquid is inevitable despite rapid nucleation and *** with available data and observations,we propose a model involving in-situ crystallization,followed by magma recharge and closed-system fractionation to explain the formation of texturally distinctive gabbros at Nalaqing and the evolution of the lower part of the Panzhihua intrusion.

关键词： Fe-Ti oxides Layered intrusion Microgabbro Panzhihua Emeishan

A series solution for surface motion amplification due to underground group cavities:Incident P waves

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Acta Seismologica Sinica(English Edition) 2004年第3期17卷 296-307页

作者： LIANG Jian-wen(梁建文) ZHANG hao(张浩) Vincent W lee Tianjin University Tianjin 300072 China Tianjin University Tianjin 300072 China University of Southern California Los Angeles CA 90089-2531 U S A

A series solution for surface motion amplification due to underground group cavities for incident plane P waves is derived by Fourier-Bessel series expansion method. It is shown that underground group cavities significantly am-plify the surface ground motion nearby. It is suggested that the effect of subways on ground motion should be con-sidered when the subways are planned and designed.

关键词： underground group cavities surface motion plane P wave scattering series solution CLC number: P315.3 Document code: A

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World Journal of Clinical Cases 2024年第1期12卷 176-179页

作者： Hsin-Chia Angela Lin Kam-Fai lee Tzu hao Huang Division of General Surgery Department of SurgeryChang Gung Memorial HospitalChiayi 613Taiwan Department of Anatomic Pathology Chang Gung Memorial HospitalChiayi 613Taiwan

BACKGROUND Gastric IgG4-related disease(IgG4-RD)is rarely encountered in clinical practice,and especially more so among pediatric *** our knowledge,this is the first report of IgG4-RD presenting as a calcifying gastric mass in a *** describe how this entity was difficult to differentiate from a gastrointestinal stromal tumor(GIST)imaging-based ***,this case highlights the importance of considering IgG4-RD in the differential diagnosis of gastric tumor before performing surgical resection,especially to distinguish it from malignancy to avoid unnecessary *** SUMMARY The patient suffered from epigastric pain for several *** and computed tomography scan revealed a submucosal *** diagnoses included GIST,leiomyoma,teratoma,and mucinous ***,laparoscopic proximal gastrectomy allowed for the definitive diagnosis of IgG4-related stomach *** We emphasize the importance of considering IgG4-RD in the differential diagnosis of gastric submucosal tumors before performing surgical resection.

关键词： IgG4-related disease Gastrointestinal stromal tumor Child Pediatric Case report

A NORMAL YIELD TABLE FOR LARIX GMELINII INDAXIN GANLING BASED ON THE MAXIMUM GROWTH RATE METHOD

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Journal of Northeast Forestry University 1990年第1期1卷 61-64页

作者： Weng Guoqing hao Wenkang lee LongchangNortheast Forestry University, Harbin 150040 P. R. China

Normal yield tables for Larix gmelimii(Rupr) Rupr were constructed from 228 tem-porary sample plois.A normal stand was defined as having the maximum growh rate parameter,based on the theory of forest *** area growth curves were described with Richard’s equa-tion according to Von-Bertalanfy’s growth theory and allometric *** growth rate parameterwas found to be K,so a normal stand had maximum *** the basal area growth curve of a nor-mal stand was obtaied simply by increasing K.A normal yield table for *** of Daxinganlingnatural forest was then constructed.

关键词： Larix gmelinii. Normal vield table