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Prognostic significance of SOX2 for chemotherapeutic patients with oral squamous cell carcinoma

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Journal of Pharmaceutical Analysis 2024年第4期14卷 619-621页

作者： Xuefeng Zhang hao Xu Tong Zhou Xiaodong Feng Qianming Chen State Key Laboratory of Oral Diseases National Center of StomatologyNational Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu610041China

Oral squamous cell carcinoma(OSCC)is the most common oral cancers worldwide,accounting for over 90%of all oral malignancies[1].Despite encouraging improvements in therapeutic approaches,including surgical resection,chemotherapy,and radiotherapy,the five-year overall survival rate of OSCC has not been improved significantly over the past decades,mainly due to the high ratio of tumor recurrence and metastasis.

关键词： SOX2 therapeutic squamous

Electricity resonance-induced phase transition of water confined in nanochannels

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Communications in Theoretical Physics 2024年第5期76卷 159-165页

作者： Yunqiu Ma Zhigao Zhao Shaoqian hao Jianlong Kou Jiang-Xing Chen Institute of Condensed Matter Physics Zhejiang Institute of Photoelectronics&Zhejiang Institute for Advanced Light SourceZhejiang Normal UniversityJinhua 321004China Department of Physics Inner Mongolia UniversityHohhot 010021China Department of Physics Hangzhou Normal UniversityHangzhou 311121China

The phase transition of water molecules in nanochannels under varying external electric fields is studied by molecular dynamics *** is found that the phase transition of water molecules in nanochannels occurs by changing the frequency of the varying electric *** molecules maintain the ice phase when the frequency of the varying electric field is less than 16 THz or greater than 30 THz,and they completely melt when the frequency of the varying electric field is 24 *** phenomenon is attributed to the breaking of hydrogen bonds when the frequency of the varying electric field is close to their inherent resonant ***,the study demonstrates that the critical frequency varies with the confinement *** new mechanism of regulating the phase transition of water molecules in nanochannels revealed in this study provides a perspective for further understanding of the phase transition of water molecules in nanochannels,and has great application potential in preventing icing and deicing.

关键词： electricity resonance phase transition water molecules molecular dynamics simulations

Bidirectional Optimization Coupled Ligh tweight Net works for Efficient and Robust Multi-Person 2D Pose Estimation

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Journal of Computer Science & Technology 2019年第3期34卷 522-536页

作者： Shnai Li Zheng Fang Wen-Feng Song Ai-Min hao Hong Qin State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing 100191China Beihang University Qingdao Research Institute Qingdao 266000China Department of Computer Science Stony Brook UniversityStony Brook 11790U.S.A.

For multi-person 2D pose estimation,current deep learning baised methods have exhibited impressive performance,but the trade-offs among efficiency,robustness,and accuracy in the existing approaches remain *** principle,bottom-up methods are superior to top-down methods in efficiency,but they perform worse in *** make full use of their respective advantages,in this paper we design a novel bidirectional optimization coupled lightweight network(BOCLN)architecture for efficient,robust,and general-purpose multi-person 2D(2-dimensional)pose estimation from natural *** the BOCLN framework,the bottom-up network focuses oil global features,while the top-down net work places emphasis on det ailed *** entire framework shares global features along the bottom-up data stream,while the top-down data stream aims to accelerate the accurate pose *** particular,to exploit the priors of human joints'relationship,we propose a probability limb heat map to represent the spatial context of the joints and guide the overall pose skeleton prediction,so that each person's pose estimation in cluttered scenes(involving crowd)could be as accurate and robust as ***,benefiting from the novel BOCLN architecture,the tinie-consuming refinement procedure could be much simplified to an efficient lightweight *** experiments and evaluations on public benchmarks have confirmed that our new method is more efficient and robust,yet still attain competitive accuracy performance compared with the state-of-the-art *** BOCLN shows even greater promise in online applications.

关键词： bidirectional optimization computer vision deep learning probability limb heat map 2D multi-person pose estimation

Highly efficient labelling of extracellular vesicles for enhanced detection on a microfluidic platform

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Chinese Chemical Letters 2024年第2期35卷 441-445页

作者： Shi Hu Rui hao Zitong Yu Huitao Zhang Hui Yang Bionic Sensing and Intelligence Center Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Developing precise extracellular vesicles(EVs)labelling techniques with minimal disturbance is of great importance to the follow-up EVs detection and ***,currently available methods such as using probes to conjugate phospholipids or membrane proteins have certain limitations due to EV steric hindrance,dye aggregation,***,we present a microfluidic platform to enhance EVs’labelling efficiency and improve their *** platform provides excellent sample throughput and high-efficiency EV labelling at lower label concentrations with an optimized flowing *** cytometry analysis(FCM)and cellular uptake results show that EV labelling by utilizing this platform possesses the merits of a higher labelling efficiency with 64.1%relative improvement than conventional co-incubation method and a lower background ***,this technique maintains EVs’size,morphology and biological *** the recipient cells uptake the EVs treated by the microfluidic platform,the spatial and temporal distribution of EVs in the cells are clearly *** results demonstrate that our method holds great potential in efficient labelling of EVs,which is essential to subsequent EV quantification and analysis.

关键词： Microfluidic platform Extracellular vesicles Labelling PKH dye Flow cytometry

Weighted Particle Swarm Clustering Algorithm for Self-Organizing Maps

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Journal of Quantum Computing 2020年第2期2卷 85-95页

作者： Guorong Cui hao Li Yachuan Zhang Rongjing Bu Yan kang Jinyuan Li Yang Hu Department of Software Yunnan UniversityKunming650500China

The traditional K-means clustering algorithm is difficult to determine the cluster number,which is sensitive to the initialization of the clustering center and easy to fall into local *** paper proposes a clustering algorithm based on self-organizing mapping network and weight particle swarm optimization SOM&WPSO(Self-Organization Map and Weight Particle Swarm Optimization).Firstly,the algorithm takes the competitive learning mechanism of a self-organizing mapping network to divide the data samples into coarse clusters and obtain the clustering ***,the obtained clustering center is used as the initialization parameter of the weight particle swarm optimization *** particle position of the WPSO algorithm is determined by the traditional clustering center is improved to the sample weight,and the cluster center is the“food”of the particle *** particle moves toward the nearest cluster *** iteration optimizes the particle position and velocity and uses K-means and K-medoids recalculates cluster centers and cluster partitions until the end of the algorithm convergence *** a lot of experimental analysis on the commonly used UCI data set,this paper not only solves the shortcomings of K-means clustering algorithm,the problem of dependence of the initial clustering center,and improves the accuracy of clustering,but also avoids falling into the local *** algorithm has good global convergence.

关键词： Self-organizing map weight particle swarm K-means K-medoids global convergence

A general quantum minimum searching algorithm with high success rate and its implementation

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Science China(Physics,Mechanics & Astronomy) 2023年第4期66卷 49-60页

作者： Yi Zeng Ziming Dong hao Wang Jin He Qijun Huang Sheng Chang School of Physics and Technology Wuhan UniversityWuhan 430072China Key Laboratory of Artificial Micro-and Nano-Structures of Ministry of Education Wuhan UniversityWuhan 430072China

Finding a minimum is a fundamental calculation in many quantum ***,challenges are faced in demonstrating it effectively in real quantum *** practice,the number of solutions is unknown,and there is no universal encoding *** that,current quantum computers have limited *** alleviate these problems,this paper proposes a general quantum minimum searching *** adaptive estimation method is adopted to calculate the number of solutions,and a quantum encoding circuit for arbitrary databases is presented for the first time,which improves the universality of the algorithm and helps it achieve a nearly 100%success rate in a series of random ***,gate complexity is reduced by our simplified Oracle,and the realizability of the algorithm is verified on a superconducting quantum *** algorithm can serve as a subroutine for various quantum algorithms to promote their implementation in the Noisy IntermediateScale Quantum era.

关键词： quantum minimum searching algorithm quantum circuit superconducting quantum computer quantum encoding

Enhancing energy storage density of poly(arylene ether nitrile)via incorporating modified barium titanate nanorods and hotstretching

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Nano Research 2024年第8期17卷 7574-7584页

作者： Zhengjiao Zhang Lingyun Zhou Lingling Wang Qingqing hao Xiufu Hua Renbo Wei School of Chemical Engineering Northwest UniversityXi’an 710069China Yangtze Delta Region Institute Tsinghua UniversityJiaxing 314006China

Dielectric energy storage materials that are extensively employed in capacitors and other electronic devices have attracted increasing attentions amid the rapid progress of electronic ***,the commercialized polymeric and ceramic dielectric materials characterized by low energy storage density face numerous limitations in practical *** this study,we report the simultaneous enhancement of dielectric properties of poly(arylene ether nitrile)(PEN)through the incorporating of sulfonated PEN(SPEN)modified barium titanate nanorods(BTNR)(SPEN@BTNR)and *** is synthesized using a two-step hydrothermal method,aminated with KH550,and then reacted with SPEN to form the cladding-modified SPEN@*** to the intrinsic high permittivity of barium titanate(BT)and enhanced compatibility between SPEN@BTNR and PEN stemming from the cladding of SPEN,the dielectric constant and breakdown strength of SPEN@BTNR/PEN composite are as high as 14.0 at 103 Hz and 198.1 kV/mm at the doping amount of 15 wt.%,*** a result,the energy storage density of SPEN@BTNR/PEN is increased to 2.43 J/cm^(3),compared with that of 0.82 J/cm^(3)for *** addition,derived from the rearrangement of SPEN@BTNR and orientation of PEN after hot-stretching,the dielectric constant and breakdown strength of SPEN@BTNR/PEN with 15 wt.%fillers are further enhanced to 17.1 and 204.8 kV/mm,respectively,resulting in an energy storage density of 3.36 J/cm^(3).The boosting of energy storage density up to 310%provides a new idea for improving the performances of dielectric energy storage materials.

关键词： barium titanate nanorods poly(arylene ether nitrile) dielectric constant breakdown strength energy density

Metal-ceramic Bond Mechanism of the Co-Cr Alloy Denture with Original Rough Surface Produced by Selective Laser Melting

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Chinese Journal of Mechanical Engineering 2014年第1期27卷 69-78页

作者： ZHANG Sheng LI Yong hao Liang XU Tian WEI Qingsong SHI Yusheng State Key Lab of Materials Processing and Die&Mold Technology Huazhong University of Science and Technology Hospital of Stomatology WuHan University School of Engineering Computing and Mathematics University of Exeter

The porcelain fracture caused by low metal-ceramic bond strength is a critical issue in porcelain fused to metal（PFM） restorations. Surface roughening methods, such as sand blasting, acid etching and alkaline degreasing for the metal matrix are used to increase bond strength. However, the metal matrix of PFM processed by selective laser melting（SLM） has natural rough surface. To explore the effect of the original roughness on metal-ceramic bond strength, two groups of specimen are fabricated by SLM. One group of specimen surface is polished smooth while another group remains the original rough surface. The dental porcelain is fused to the specimens＇ surfaces according to the ISO 9693：1999 standard. To gain the bond strength, a three-point bending test is carried out and X ray energy spectrum analysis（EDS）, scanning electron microscope（SEM） are used to show fracture mode. The results show that the mean bond strength is 116.5 16 MPa of the group with rough surface（Ra= 17.2）, and the fracture mode is cohesive. However, when the surface is smooth （Ra =3.8）, the mean bond strength is 74.5 MPa _＋ 5 MPa and the fracture mode is mixed. The original surface with prominent structures formed by the partly melted powder particles, not only increases surface roughness but also significantly improves the bond strength by forming strong mechanical lock effect. Statistical analysis （Student＇s t-test） demonstrates a significant difference （p〈0.05） of the mean value of bond strength between the two groups. The experiments indicate the natural rough surface can enhance the metal-ceramic bond strength to over four times the minimum value （25 MPa） of the ISO 9693：1999 standard. It is found that the natural rough surface of SLM-made PFM can eliminate the porcelain collapse defect produced by traditional casting method in PFM restorations.

关键词： selective laser melting(SLM) Co-Cr alloy metal-ceramic bond strength

Optimized Mid-bond Order for 3D-Stacked ICs Considering Failed Bonding

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Chinese Journal of Electronics 2015年第2期24卷 223-228页

作者： LIANG Huaguo CHANG hao LI Yang WANG Wei CHEN Tian XU Hui School of Electronic Science & Applied Physics Hefei University of Technology School of Computer and Information Hefei University of Technology Department of Computer Science & Technology Anhui University of Finance & Economics

One notable difference between 3D test flow and 2D test flow mainly lies in the mid-bond test, in which the stacking yield can be further enhanced through optimized bonding arrangement. In contrast to the existing sequential stacking, this paper proposes a novel rearranged stacking scheme which estimates the probability and cost of failed bonding in each stacking step and optimizes the mid-bond order to screen out the failed component as early as possible. The effect of the rearranged stacking has been extensively analyzed using the yield model and cost model of 3D-SICs considering different process parameters such as die yield, stacking size, failure rate and redundancy degree of TSVs. Experimental results demonstrate that the proposed rearranged stacking method is only a half of the sequential stacking in terms of Failed area ratio(FAR).

关键词： 3D-Stacked ICs Through silicon via(TSV) 3D-SICs test Sequential stacking Rearranged stacking Abort on fail