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China Ocean Engineering 2024年第3期38卷 394-407页

作者： HU Ze-bo LIU Zhen LI Peng GUO Hai-yan REN Xiao-hui HOU hao hao Lian-hong College of Civil Engineering and Architecture Shandong University of Science and TechnologyQingdao 266590China Qingdao Key Laboratory of Marine Civil Engineering Materials and Structures Qingdao 266590China College of Engineering Ocean University of ChinaQingdao 266100China

In order to study the response law of vortex-induced vibration(VIV)of marine risers under the combined action of roughness and interference effects,and to reveal the coupling mechanism of roughness and interference effects on the riser,a VIV experiment of rough risers in tandem arrangement was conducted in a wave−current combined *** experiment characterized the risers’roughness by arranging different specifications of attachments on the surface of the *** rough risers with different roughness and smooth risers were arranged in tandem arrangement,with the rough risers arranged *** experimental results indicate that the suppression of the attachments on the downstream risers’vibration are more significant both in the CF and IL directions as the reduced velocity *** the downstream riser,the amplitude response of rough riser is more significantly weakened compared with the smooth one at high reduced *** the upstream risers,changes in the roughness and spacing ratio have an impact on their‘lock-in’*** the roughness of downstream risers is relatively large(0.1300)and the spacing between risers is small(S/D=4.0),the reduced velocity range of‘lock-in’region in the CF direction of upstream risers is obviously expanded,and the displacement in the‘lock-in’region is severer.

关键词： marine riser vortex-induced vibration tandem arrangement roughness interference effect

Experimental research on the launching system of auxiliary charge with filter cartridge structure

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Defence Technology（防务技术） 2024年第1期31卷 41-48页

作者： Zi-Jun Chen Ze He hong-hao Ma Lu-Qing Wang Zhao-Wu Shen CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern MechanicsUniversity of Science and Technology of ChinaHefeiAnhui230027PR China State Key Laboratory of Fire Science University of Science and Technology of ChinaHefeiAnhui230026PR China

A launching system with a filter cartridge structure was proposed to improve the muzzle velocity of the *** combustion chamber of the launching system is divided into two fixed chambers,one is located in the breech chamber,and the other is arranged in the *** breech chamber charge was ignited first,and the charges in the auxiliary chambers were ignited by the high-temperature,highpressure combustible gas trailing the *** this way,the combustible gas in the auxiliary chambers could compensate for the pressure drop caused by the movement of the *** proposed device features the advantage of launching a projectile with high muzzle velocity without exceeding the maximum pressure in the *** order to obtain some internal ballistic characteristics of the launch system,some critical structure,such as the length of the filter cartridge auxiliary charge,the combustion degree of the propellant in the chamber,and the length of the barrel,are *** experimental results show that with the increased auxiliary charge length,a pressure plateau or even a secondary peak pressure can be formed,which is less than the peak *** projectile velocity increased by 23.57%,14.64%,and 7.65%when the diaphragm thickness was 0 mm,1 mm,and2 mm,*** muzzle velocity of the projectile can be increased by 13.42%by increasing the length of the *** the same charge condition,with the increase of barrel length,the energy utilization rate of propellant increases by 28.64%.

关键词： Interior ballistics Charge structures Launch system Charge design

Evidence of abnormal hot carrier thermalization at van Hove singularity of twisted bilayer graphene

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Science Bulletin 2024年第16期69卷 2522-2528页

作者： Nianze Shang Chen Huang Qing Chen Chang Liu Guangjie Yao Zhipei Sun Sheng Meng Kaihui Liu hao hong State Key Laboratory for Mesoscopic Physics Frontiers Science Center for Nano-optoelectronicsSchool of PhysicsPeking UniversityBeijing 100871China QTF Centre of Excellence Department of Electronics and NanoengineeringAalto UniversityEspoo 02150Finland Institute of Physics Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Lab Institute of PhysicsChinese Academy of SciencesDongguan 523808China Interdisciplinary Institute of Light-Element Quantum Materials and Research Centre for Light-Element Advanced Materials Peking UniversityBeijing 100871China

Interlayer twist evokes revolutionary changes to the optical and electronic properties of twisted bilayer graphene(TBG)for electronics,photonics and *** the ground state responses in TBG have been vastly and clearly studied,the dynamic process of its photoexcited carrier states mainly remains ***,we unveil the photoexcited hot carrier dynamics in TBG by time-resolved ultrafast photoluminescence(PL)autocorrelation *** demonstrate the unconventional ultrafast PL emission between the van Hove singularities(VHSs)with a~4 times prolonged relaxation *** intriguing photoexcited carrier behavior is ascribed to the abnormal hot carrier thermalization brought by bottleneck effects at VHSs and interlayer charge distribution *** study on hot carrier dynamics in TBG offers new insights into the excited states and correlated physics of graphene twistronics systems.

关键词： Twisted bilayer graphene van Hove singularity Ultrafast photoluminescence Hot carrier dynamics

坚持和发展民主集中制原则推进新时代中国刑事诉讼制度现代化

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政法论丛 2024年第1期 37-52页

作者：洪浩武汉大学法学院湖北武汉430072

全国人大已将《刑事诉讼法》的修改列入本届人大的工作规划之中。作为规范刑事诉讼程序、约束诉讼主体行为的基本法律,应该明确刑事诉讼中公权力机关之间职能分工的工作原则。民主集中制是我国《宪法》规定的国家机构组织和活动原则,同... 详细信息

全国人大已将《刑事诉讼法》的修改列入本届人大的工作规划之中。作为规范刑事诉讼程序、约束诉讼主体行为的基本法律,应该明确刑事诉讼中公权力机关之间职能分工的工作原则。民主集中制是我国《宪法》规定的国家机构组织和活动原则,同时也是我国现行刑事诉讼确立的公权力机关之间职能分工的指导原则,具体表现为公检法等机关在刑事诉讼中“分工负责、互相配合、互相制约”的工作原则。民主集中制决定了我国刑事诉讼中权力的集中本位及其分工的相对性。新时代应该发展刑事诉讼中的民主集中制原则,顺应权力本位向权利本位转变的时代潮流,以实现民主集中制原则与刑事诉讼制度的根本自洽,推进刑事诉讼现代化。

关键词：刑事诉讼权力分工权力本位权利本位司法民主

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 945-997页

作者： Jian Sheng Loh Wen Qi Mak Li Kar Stella Tan Chu Xin Ng hong hao Chan Shiau Hueh Yeow Jhi Biau Foo Yong Sze Ong Chee Wun How Kooi Yeong Khaw School of Pharmacy Monash University MalaysiaJalan Lagoon Selatan47500 Bandar SunwaySelangorMalaysia School of Pharmacy Faculty of Health&Medical SciencesTaylor’s University1Jalan TaylorsSubang Jaya 47500 SelangorMalaysia Digital Health&Medical Advancements Taylor’s University1Jalan TaylorsSubang Jaya 47500 SelangorMalaysia School of Biosciences Faculty of Health&Medical SciencesTaylor’s University1Jalan TaylorsSubang Jaya 47500 SelangorMalaysia UCL School of Pharmacy University College London29-39 Brunswick SquareLondon WC1N 1AXUK

The human gastrointestinal tract is populated with a diverse microbial *** vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect of human biology,including health maintenance,development,aging,and *** advent of new sequencing technologies and culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations to shed light on microbiome–host *** has unveiled the bidirectional communication between the gut microbiome and the central nervous system,referred to as the“microbiota–gut–brain axis”.The microbiota–gut–brain axis represents an important regulator of glial functions,making it an actionable target to ameliorate the development and progression of neurodegenerative *** this review,we discuss the mechanisms of the microbiota–gut–brain axis in neurodegenerative *** the gut microbiome provides essential cues to microglia,astrocytes,and oligodendrocytes,we examine the communications between gut microbiota and these glial cells during healthy states and neurodegenerative ***,we discuss the mechanisms of the microbiota–gut–brain axis in neurodegenerative diseases using a metabolite-centric approach,while also examining the role of gut microbiota-related neurotransmitters and gut ***,we examine the potential of targeting the intestinal barrier,blood–brain barrier,meninges,and peripheral immune system to counteract glial dysfunction in ***,we conclude by assessing the pre-clinical and clinical evidence of probiotics,prebiotics,and fecal microbiota transplantation in neurodegenerative diseases.A thorough comprehension of the microbiota–gut–brain axis will foster the development of effective therapeutic interventions for the management of neurodegenerative diseases.

关键词： degenerative therapeutic diseases

3D seismic forward modeling from the multiphysical inversion at the Ketzin CO_(2) storage site

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Applied Geophysics 2024年第3期21卷 593-605,620页

作者： Yi-kang Zheng Chong Wang hao-hong Liang Yi-bo Wang Rong-shu Zeng Key Laboratory of Petroleum Resource Research Institute of Geology and GeophysicsChinese Academy of Sciences100029 BeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Shale Gas and Geoengineering Institute of Geology and GeophysicsChinese Academy of Sciences100029 BeijingChina

From June 2008 to August 2013,approximately 67 kt of CO_(2) was injected into a deep saline formation at the Ketzin pilot CO_(2) storage *** injection,3D seismic surveys have been performed to monitor the migration of sequestered CO_(2).Seismic monitoring results are limited by the acquisition and signal-to-noise ratio of the acquired *** multiphysical reservoir simulation provides information regarding the CO_(2) fluid behavior,and the approximated model should be calibrated with the monitoring *** this work,property models are delivered from the multiphysical model during 3D repeated seismic *** simulated seismic data based on the models are compared with the real data,and the results validate the effectiveness of the multiphysical inversion ***-lapse analysis shows the trend of CO_(2) migration during and after injection.

关键词： Seismic forward modeling reservoir simulation CO_(2)storage time-lapse analysis

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战略性新兴领域拔尖创新人才的早期成长机制

高等教育研究 2024年第4期45卷 68-78页

作者：金红昊华中科技大学教育科学研究院

基于“全国高校教学质量与学生发展监测追踪调查”数据中的资优学生样本，从高中与大学教育衔接视角切入，实证考察战略性新兴领域拔尖创新人才的早期成长机制发现，在战略性新兴领域相关专业，资优学生高中阶段的超前探究、生涯规划与... 详细信息

基于“全国高校教学质量与学生发展监测追踪调查”数据中的资优学生样本，从高中与大学教育衔接视角切入，实证考察战略性新兴领域拔尖创新人才的早期成长机制发现，在战略性新兴领域相关专业，资优学生高中阶段的超前探究、生涯规划与综合实践学习体验均能显著促进其在大学阶段的综合发展。高考成绩可有效预测资优学生的大学学业表现，但在大学专业兴趣和通用能力发展方面，高考选拔效果尚未彰显。因此，战略性新兴领域的拔尖创新人才培养应突破“强筛选、晚起点、弱衔接”的传统模式，构建贯通式育人机制，以促进高层次人才的动态成长与系统涌现。

关键词：战略性新兴领域拔尖创新人才早期成长机制

Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain

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Science China(Life Sciences) 2024年第1期67卷 67-82页

作者： Chun-Kui Zhang Pan Wang Yuan-Yuan Ji Jian-Shuai Zhao Jun-Xiang Gu Xian-Xia Yan hong-Wei Fan Ming-Ming Zhang Yu Qiao Xiao-Die Liu Bao-Juan Li Ming-Hui Wang Hai-Long Dong hao-hong Li Peng-Cheng Huang Yun-Qing Li Wu-Gang Hou Jin-Lian Li Tao Chen Department of Anatomy and K.K.Leung Brain Research Centre Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Basic Medical Sciences Beijing 100850China Key Laboratory of Ministry of Public Health for Forensic Science Xi’an Jiaotong UniversityXi’an 710061China Department of Anesthesiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Neurosurgery the Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China School of Biomedical Engineering Fourth Military Medical UniversityXi’an 710032China Affiliated Mental Health Centre and Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhou 310013China The MOE Frontier Research Center of Brain&Brain-machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou 310058China Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Anatomy School of MedicineNorthwest UniversityXi’an 710069China

Chronic pain often develops severe mood changes such as ***,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely *** we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1%of mice with depression *** determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA ***,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic *** of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic *** study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.

关键词： chronic pain depression lateral habenula ventral tegmental area dopamine susceptibility

Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

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Military Medical Research 2024年第1期11卷 50-79页

作者： Shuai Liu Jiang-Ming Yu Yan-Chang Gan Xiao-Zhong Qiu Zhe-Chen Gao Huan Wang Shi-Xuan Chen Yuan Xiong Guo-Hui Liu Si-En Lin Alec McCarthy Johnson V.John Dai-Xu Wei hong-hao Hou Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedics and Traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional Materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA Mary&Dick Holland Regenerative Medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative *** contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative *** paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future *** highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ***,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE ***,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic Scaffold Biosynthesis Natural biomaterial Tissue engineering

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基于计算机视觉的工业金属表面缺陷检测综述

自动化学报 2024年第7期50卷 1261-1283页

作者：伍麟郝鸿宇宋友北京航空航天大学软件学院北京100191

针对平面及三维结构金属材料的工业表面缺陷检测,概述了视觉检测技术的基本原理和研究现状,并总结出视觉自动检测系统的关键技术包括光学成像技术、图像预处理技术与缺陷检测器.首先介绍了如何根据检测对象的光学特性选择合适的二维、... 详细信息

针对平面及三维结构金属材料的工业表面缺陷检测,概述了视觉检测技术的基本原理和研究现状,并总结出视觉自动检测系统的关键技术包括光学成像技术、图像预处理技术与缺陷检测器.首先介绍了如何根据检测对象的光学特性选择合适的二维、三维光学成像技术;其次介绍了图像降噪、特征提取、图像分割和拼接等预处理技术的重要作用;然后根据缺陷检测器的实现原理将其分为模板匹配、图像分类、图像语义分割、目标检测和图像异常检测五类,并对其中的经典算法进行了归纳分析.最后,探讨了工业场景下金属表面缺陷检测技术实施中的关键问题,并对该技术的发展趋势进行了展望.

关键词：表面缺陷检测计算机视觉金属表面缺陷自动化检测