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High glucose reduces Nrf2-dependent cRAGE release and enhances inflammasome-dependent IL-1βproduction in monocytes:the modulatory effects of EGCG

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Food Science and Human Wellness 2024年第3期13卷 1531-1542页

作者： chi-hao Wu Yin-Hsuan Chang chin-Lin Hsu Sheng-Yi Chen Gow-chin Yen Graduate Programs of Nutrition Science School of Life ScienceTaiwan Normal UniversityTaipei 106209TaiwanChina Department of Food Science and Biotechnology Chung Hsing UniversityTaichung 40227TaiwanChina School of Nutrition Chung Shan Medical UniversityTaichung 40201TaiwanChina

Soluble receptor for advanced glycation end products(sRAGE)acts as a decoy sequestering of RAGE ligands,thus preventing the activation of the ligand-RAGE axis linking human ***,the molecular mechanisms underlying sRAGE remain *** this study,THP-1 monocytes were cultured in normal glucose(NG,5.5 mmol/L)and high glucose(HG,15 mmol/L)to investigate the effects of diabetesrelevant glucose concentrations on sRAGE and interleukin-1β(IL-1β)*** modulatory effects of epigallocatechin gallate(EGCG)in response to HG challenge were also *** enhanced intracellular reactive oxygen species(ROS)generation and RAGE *** secretion of sRAGE,including esRAGE and cRAGE,was reduced under HG conditions,together with the downregulation of a disintegrin and metallopeptidase 10(ADAM10)and nuclear factor erythroid 2-related factor 2(Nrf2)nuclear ***,the HG effects were counteracted by siRAGE and exacerbated by *** immunoprecipitation results showed that Nrf2 binding to the ADAM10 promoter and HG interfered with this *** data reinforce the notion that RAGE and Nrf2 might be sRAGE-regulating *** HG conditions,the treatment of EGCG reduced ROS generation and RAGE ***-stimulated cRAGE release was likely caused by the upregulation of the Nrf2-ADAM10 *** inhibited HG-mediated NLRP3 inflammasome activation at least partly by stimulating sRAGE,thereby reducing IL-1βrelease.

关键词： Epigallocatechin gallate(EGCG) Inflammasome Nuclear factor erythroid 2-related factor 2(Nrf2) Receptor for advanced glycation end products(RAGE) Soluble RAGE(sRAGE)

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Risk of cardiovascular death in patients with hepatocellular carcinoma based on the Fine-Gray model

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 844-856页

作者： Yu-Liang Zhang Zi-Rong Liu Zhi Liu Yi Bai hao chi Da-Peng Chen Ya-Min Zhang Zi-Lin Cui First Central Clinical College Tianjin Medical UniversityTianjin 300070China Department of Hepatobiliary Surgery Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)is one of the most common types of cancers worldwide,ranking fifth among men and seventh among women,resulting in more than 7 million deaths *** the development of medical tech-nology,the 5-year survival rate of HCC patients can be increased to 70%.How-ever,HCC patients are often at increased risk of cardiovascular disease(CVD)death due to exposure to potentially cardiotoxic treatments compared with non-HCC ***,CVD and cancer have become major disease burdens ***,further research is needed to lessen the risk of CVD death in HCC patient *** This study was conducted on the basis of the Surveillance,Epidemiology,and End Results database and included HCC patients with a diagnosis period from 2010 to *** independent risk factors were identified using the Fine-Gray model.A nomograph was constructed to predict the CVM in HCC *** nomograph performance was measured using Harrell’s concordance index(C-index),calibration curve,receiver operating characteristic(ROC)curve,and area under the ROC curve(AUC)***,the net benefit was estimated via decision curve analysis(DCA).RESULTS The study included 21545 HCC patients,of whom 619 died of ***(5 cm:2.090(1.543-2.830),P<0.001],surgery(no)[0.376(0.297-0.476),P<0.001],and chemotherapy(none/unknown)[0.578(0.472-0.709),P<0.001]were independent risk factors for CVD death in HCC *** discrimination and calibration of the nomograph were *** C-index values for the training and validation sets were 0.736 and 0.665,*** AUC values of the ROC curves at 2,4,and 6 years were 0.702,0.725,0.740 in the training set and 0.697,0.710,0.744 in the validation set,*** calibration curves showed that the

关键词： Hepatocellular carcinoma Cardiovascular disease deaths Fine-Gray model Risk factor Nomograph Predict

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基于分数阶时域Talbot效应的宽带射频信号实时频谱分析

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光子学报 2024年第4期53卷 139-145页

作者：杨波赵雷杨淑娜池灏中国矿业大学信息与控制工程学院徐州221116 杭州电子科技大学通信工程学院杭州310018

提出一种基于分数阶时域Talbot效应的宽带射频信号实时频谱分析方案。该方案基于采样和色散结构,实现射频信号频率到光脉冲时间间隔的映射。通过预先经过一个满足分数阶时域Talbot距离的色散元件,光脉冲在采样之前的重复频率发生倍增。... 详细信息

提出一种基于分数阶时域Talbot效应的宽带射频信号实时频谱分析方案。该方案基于采样和色散结构,实现射频信号频率到光脉冲时间间隔的映射。通过预先经过一个满足分数阶时域Talbot距离的色散元件,光脉冲在采样之前的重复频率发生倍增。利用分数阶时域Talbot效应,可以显著提升系统的频率测量带宽。实验结果表明,利用9阶分数阶时域Talbot效应,实现29.7 GHz带宽内单音和双音射频信号的实时频谱分析。数值仿真结果进一步验证了该方案能够有效分析频率快速变化的宽带射频信号。该方案结构简单、带宽大、可实时处理,有望应用于电子对抗、宽带雷达、认知无线电等场景。

关键词：频谱分析光子辅助射频频谱分析实时傅里叶变换 Talbot效应分数阶时域Talbot效应

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基于代理训练集的属性推理攻击防御方法

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计算机学报 2024年第4期47卷 907-923页

作者：董恺蒋驰昊李想凌振杨明东南大学计算机科学与工程学院南京211189

本文首次提出针对属性推理攻击的有效防御方法.属性推理攻击可以揭示出用于训练公开模型的原始私有数据集中的隐私属性信息.现有研究已经针对不同的机器学习算法提出了多种属性推理攻击.这些攻击很难防御,一方面原因是训练有素的模型总... 详细信息

本文首次提出针对属性推理攻击的有效防御方法.属性推理攻击可以揭示出用于训练公开模型的原始私有数据集中的隐私属性信息.现有研究已经针对不同的机器学习算法提出了多种属性推理攻击.这些攻击很难防御,一方面原因是训练有素的模型总是会记住训练数据集中的显性和隐性全局属性,另一方面原因在于模型提供者无法事先知道哪些属性将受到攻击从而难以有针对性地进行防御.为了解决这个问题,本文提出了一种通用的隐私保护模型训练方法,名为PPMT(Privacy Preserving Model Training).它以迭代的方式工作.在每次迭代中,PPMT构建一个代理数据集,并在该数据集而不是私有数据集上训练模型.虽然每次迭代会同时导致隐私性的提升和功能性的降低,但隐私性的提升呈快速指数级,而功能性的降低则是缓慢线性的.经过多次迭代,PPMT在模型功能性的约束下最大化全局属性的隐私性,并生成最终的模型.本文选择了两种代表性的机器学习算法和三个典型的数据集来进行实验评估PPMT所训练出模型的功能性、隐私性和鲁棒性.结果显示,使用PPMT训练出的模型,在全局属性上会以不同速度朝不同方向改变,在功能性上的平均损失为1.28%,在超参数α保密的情况下被可能攻击倒推的成功率仅有22%~33%.这说明,PPMT不仅能保护私有数据集的全局属性隐私性,而且能保证模型有足够的功能性,以及面对可能攻击的鲁棒性.

关键词：人工智能安全属性推理攻击全局属性隐私隐私增强代理数据集

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共同体(community)是如何构成的?——基于三种政治现象学的研究

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武汉理工大学学报（社会科学版） 2024年第2期37卷 135-146页

作者：郝长墀武汉大学哲学学院武汉430072

文章主要讨论了胡塞尔、海德格尔和萨特对于共同体是如何构成的这个问题提供的三种现象学的路径。胡塞尔对于现实的德国和欧洲共同体的理解与他现象学中关于Einfühlung(同感或移情)作为共同体形成的方式之间具有某种张力,但是在胡塞尔... 详细信息

文章主要讨论了胡塞尔、海德格尔和萨特对于共同体是如何构成的这个问题提供的三种现象学的路径。胡塞尔对于现实的德国和欧洲共同体的理解与他现象学中关于Einfühlung(同感或移情)作为共同体形成的方式之间具有某种张力,但是在胡塞尔的理论中我们发现,Einfühlung究竟是“同感”还是“移情”,这个区分成了理解真正的人类共同体的关键。海德格尔认为,移情应该建立在共在的基础之上,他把共在作为此在的内在本质部分,强调的是非本真和本真共同体的关系。萨特认为,海德格尔的共在不应该是理论的前提,而是需要进行仔细分析的对象。在萨特看来,人与人之间的根本关系是冲突,不可能存在真正的Einfühlung。文章最后以“同感”(不是“移情”)为核心概念,讨论了community与communion之间的内在本质联系,指出真正人类共同体的可能路径。

关键词：共同体同感移情共在冲突

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进水方式对OAO蔬菜潜流湿地净化效果的影响

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中国给水排水 2024年第1期40卷 104-109页

作者：巢波张皓驰陈太飞李先宁东南大学能源与环境学院江苏南京210096

为提高好氧/厌氧/好氧(OAO)蔬菜潜流湿地对总氮的去除效果,同时维持其对有机物的高去除率,在野外条件下采用人工模拟的当地村落无序排放污水,分析不同进水方式(首端进水、三点进水和两点进水)对湿地去除污染物效果的影响。结果表明,相... 详细信息

为提高好氧/厌氧/好氧(OAO)蔬菜潜流湿地对总氮的去除效果,同时维持其对有机物的高去除率,在野外条件下采用人工模拟的当地村落无序排放污水,分析不同进水方式(首端进水、三点进水和两点进水)对湿地去除污染物效果的影响。结果表明,相较于首端进水,三点进水方式下湿地对总氮的去除效果有所提高,但对COD和总磷去除率的提升效果不显著,最佳脱氮进水流量比为1∶2∶1,脱氮效果提升13.56%,氨氮、硝态氮和总氮去除率分别达到75.11%、95.07%和79.86%,相应出水平均浓度分别为0.65、0.53和1.32 mg/L。采用两点进水方式时,湿地脱氮除磷效率及COD去除率均高于三点进水和首端进水,最佳脱氮进水流量比为1∶3,氨氮、硝态氮和总氮去除率分别为82.10%、97.71%和85.59%,相应出水平均浓度分别为0.92、0.09和0.93 mg/L。

关键词： OAO蔬菜潜流湿地村落无序排放污水脱氮三点进水两点进水

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Improved Pittsburgh Sleep Quality Index scores on first postoperative night achieved by propofol anesthesia in patients undergoing ambulatory gynecologic surgery

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World Journal of Clinical Cases 2022年第21期10卷 7256-7264页

作者： chi-hao Hu Wen-Ying Chou Department of Anesthesia National Cheng Kung University HospitalTainan 704Taiwan Institute of Clinical Pharmacy and Pharmaceutical Science National Cheng Kung UniversityTainan 704Taiwan

BACKGROUND Sleep disturbance on the first postoperative night commonly develops for patients after day surgeries. The choice of either total intravenous anesthesia by propofol or total inhalation anesthesia with sevoflurane has become an issue for preventing sleep *** To compare sleep quality on the first postoperative night for female patients after total intravenous anesthesia by propofol and total inhalation anesthesia with *** We enrolled 61 American Society of Anesthesia(ASA) class Ⅰ-Ⅱ outpatients who underwent minor gynecologic surgeries by either propofol or sevoflurane anesthesia. Sleep quality of the very night was assessed by the Pittsburgh Sleep Quality Index(PSQI) on the next day, and PSQI scores were compared by the Wilcoxon signed-rank test and paired t-test pre-operatively and *** For the propofol group, the mean postoperative global PSQI score(3.3 ± 1.3) was lower than the mean preoperative global PSQI score(4.9 ± 2.3)(P < 0.001);for the sevoflurane group, the mean postoperative global PSQI score(6.5 ± 2.8) was higher than the mean preoperative global PSQI score(5.5 ± 3.2)(P = 0.02). Eighty percent of patients receiving propofol anesthesia subjectively reported improved sleep quality, but only 17% of patients receiving sevoflurane anesthesia reported improved sleep *** Sleep quality assessed by the PSQI is better improved in ASA class Ⅰ-Ⅱ female patients receiving propofol anesthesia other than sevoflurane anesthesia for undergoing minor gynecologic surgeries.

关键词： Propofol Ambulatory gynecologic surgery Pittsburgh Sleep Quality Index American Society of Anesthesia

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Rheological and mechanical properties of aluminosilicious cementitious materials as refractory castable binders

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Journal of Iron and Steel Research International 2022年第7期29卷 1145-1151页

作者： Zhong-feng Xia Chang-hao Chen Wen-hao chi Zhou-fu Wang hao Liu Yan Ma Xi-tang Wang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

Metakaolin(MK)is an important refractory raw material,which has been used as a cementitious *** order to improve the bonding strength of MK,the composite cementitious materials were prepared by MK mixed with hydrat-able alumina(HA)and microsilica(MS),*** silane coupling agent(SCA)was introduced as a modifying *** rheological properties of MK-based composite cementitious slurries were *** mechanical properties of corundum castables bonded with the composite cementitious materials and calcium aluminate cement(CAC)were comparatively *** results show that SCA improves the rheological properties of MK-based composite cementitious *** slurry of MK–MS mixture flows in a plastic manner,while the slurry of MK–HA mixture presents pseudoplastic *** addition of SCA reduces the yield stress value of the MK–HA *** bonding strength of castables bonded with MK-based composite cementitious materials is lower than that of CAC bonding *** room temperature strength of MK–MS composite bonding castable remains the highest after being treated either at 1100 or 1550°C,and its high temperature modulus of rupture is higher than that of CAC bonding castables with microsilica added.

关键词： Metakaolin Hydratable alumina Microsilica Silane coupling agent Corundum castable Calcium aluminate cement

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Glass-forming ability, microhardness, corrosion resistance, and dealloying treatment of ***40Ndx alloy ribbons

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International Journal of Minerals,Metallurgy and Materials 2017年第6期24卷 708-717页

作者： hao-yi chi Zhen-gui Yuan Yan Wang Min Zuo De-gang Zhao hao-ran Geng Shandong Provincial Key Laboratory of Preparation and Measurement of Building Materials School of Materials Science and Engineering University of Jinan Jinan 250022 China

The influence of Nd addition on the glass-forming ability (GFA), microhardness, and corrosion resistance of Mg60−xCu40Ndx(x = 5, 10, 15, 20, and 25, at%) alloys were investigated by differential scanning calorimetry, Vickers-type hardness tests, and electrochemical methods. The results suggest that the GFA and microhardness of the amorphous alloys increase until the Nd content reaches 20at%. The corrosion potential and corrosion current density obtained from the Tafel curves indicate that the Mg35Cu40Nd25ternary alloy exhibits the best corrosion resistance among the investigated alloys. Notably, nanoporous copper (NPC) was synthesized through a single-step dealloying of Mg60−xCu40Ndx(x = 5, 10, 15, 20, and 25) ternary alloys in 0.04 mol·L−1H2SO4solution under free corrosion conditions. The influence of dealloying process parameters, such as dealloying time and temperature, on the microstructure of the ribbons was also studied using the surface diffusivity theory. The formation mechanism of dealloyed samples with a multilayered structure was also discussed. © 2017, University of Science and Technology Beijing and Springer-Verlag Berlin Heidelberg.

关键词： Corrosion Corrosion resistance Differential scanning calorimetry Glass Microhardness Neodymium alloys Ternary alloys

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Terahertz metadevices for silicon plasmonics

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chip 2022年第4期1卷 37-65页

作者： Yuan Liang hao Yu Hong Wang hao chi Zhang Tie Jun Cui Southern University of Science and Technology(SUSTech) and the Engineer-ing Research Center of Integrated Circuits for Next-Generation Communica-tionsMinistry of EducationSouthern University of Science and TechnologyShenzhen 518055China Department of Materials Science and Engineering&Shenzhen Engineering Research Center for Novel Electronic Information Ma-terials and Devices Southern University of Science and TechnologyShenzhenChina State Key Laboratory of Millimeter Waves and Institute of Electromag-netic Space Southeast UniversityNanjing 210096China

Metamaterial devices(metadevices)have been developed in progress aiming to generate extraordinary performance over traditional de-vices in the(sub-)terahertz(THz)domain,and their planar integra-tion with complementary-metal-oxide-semiconductor(CMOS)cir-cuits pave a new way to build miniature silicon plasmonics that over-comes existing challenges in chip-to-chip *** an effort towards low-power,crosstalk-tolerance,and high-speed data link for future exascale data centers,this article reviews the recent progress on two metamaterials,namely,the spoof surface plasmon polaritons(SPPs),and the split-ring resonator(SRR),as well as their imple-mentations in silicon,focusing primarily on their fundamental the-ories,design methods,and implementations for future THz *** to their respective dispersion characteristic at THz,these two metadevices are highly expected to play an important role in miniature integrated circuits and systems toward compact size,dense integration,and outstanding performance.A design example of a fully integrated sub-THz CMOS silicon plasmonic system integrating these two metadevices is provided to demonstrate a dual-channel crosstalk-tolerance and energy-efficient on-off keying(OOK)communication *** directions and potential applications for THz metade-vices are discussed.

关键词： CMOS I/O transceiver Channel crosstalk Metamaterial Metawaveguide Spoof surface plasmon polaritons Split-ring resonator Terahertz Transmission line Interconnect

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