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A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)

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Military Medical Research 2020年第1期7卷 1-22页

作者： Ying-Hui Jin lin Cai Zhen-Shun cheng Hong cheng Tong Deng Yi-Pin Fan cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui li Yi-Rong li Ke liang li-Kai lin li-Sha Luo Jing Ma lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang yan Zhao Ming-Juan Zhao hao Zi Xian-Tao Zeng Yong-yan Wang Xing-Huan Wang 无 Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Hospital Management Wuhan UniversityWuhan 430071China Department of Respiratory Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Pharmacy Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Evidence-Based Medicine and Knowledge Translation Henan UniversityKaifeng 475000China China Academy of Chinese Medical Sciences Beijing 100700China China Center for Evidence Based Traditional Chinese Medicine(CCEBTCM) Beijing 100700China Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Clinical Laboratory Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Infectious Diseases Zhongnan Hospital of Wuhan UniversityWuhan 430071China Division of Medical Affairs Zhongnan Hospital of Wuhan UniversityWuhan 430071China Division of Nursing Affairs Zhongnan Hospital of Wuhan UniversityWuhan 430071China Office of Nosocomial Infection Control Zhongnan Hospital of Wuhan UniversityWuhan 430071China Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Health Research Methods Evidenceand ImpactMcMaster UniversityHamiltonON L8S 4L8Canada Department of Traditional Chinese Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Global Health Institute Wuhan UniversityWuhan 430072China the Zhongnan Hospital of Wuhan University Novel Coronavirus Management and Research Team Evidence-Based Medicine Chapter of China International Exchange and Promotive Association for Medical and Health Care(CPAM)

In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named "2019 novel coronavirus(2019-nCoV)" by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV.

关键词： 2019 novel coronavirus 2019-nCoV Respiratory disease Pneumonia Infectious diseases Rapid advice guideline Clinical practice guideline Evidence-based medicine

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Study on influences of TiN capping layer on time-dependent dielectric breakdown characteristic of ultra-thin EOT high-k metal gate NMOSFET with kMC TDDB simulations

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Chinese Physics B 2016年第8期25卷 347-351页

作者：徐昊杨红罗维春徐烨峰王艳蓉唐波王文武祁路伟李俊峰闫江朱慧珑赵超陈大鹏叶甜春 Key Laboratory of Microelectronics Devices & Integrated Technology Institute of Micro ElectronicsChinese Academy of Sciences

The thickness effect of the TiN capping layer on the time dependent dielectric breakdown（TDDB） characteristic of ultra-thin EOT high-k metal gate NMOSFET is investigated in this *** on experimental results,it is found that the device with a thicker TiN layer has a more promising reliability characteristic than that with a thinner TiN *** the charge pumping measurement and secondary ion mass spectroscopy（SIMS） analysis,it is indicated that the sample with the thicker TiN layer introduces more Cl passivation at the IL/Si interface and exhibits a lower interface trap *** addition,the influences of interface and bulk trap density ratio Nit/Not are studied by TDDB simulations through combining percolation theory and the kinetic Monte Carlo（kMC） *** lifetime reduction and weibull slope lowering are explained by interface trap effects for TiN capping layers with different thicknesses.

关键词： high-k metal gate TiN capping layer TDDB interface trap density

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金属与半导体Ge欧姆接触制备、性质及其机理分析

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物理学报 2013年第16期62卷 344-348页

作者：严光明李成汤梦饶黄诗浩王尘卢卫芳黄巍赖虹凯陈松岩厦门大学物理学系半导体光子学研究中心厦门361005

金属与Ge材料接触时界面处存在着强烈的费米钉扎效应,尤其与n型Ge形成的欧姆接触的比接触电阻率高,是制约Si基Ge器件性能的关键因素之一.本文对比了分别采用金属Al和Ni与Si衬底上外延生长的p型Ge和n型Ge材料的接触特性.发现在相同的较... 详细信息

金属与Ge材料接触时界面处存在着强烈的费米钉扎效应,尤其与n型Ge形成的欧姆接触的比接触电阻率高,是制约Si基Ge器件性能的关键因素之一.本文对比了分别采用金属Al和Ni与Si衬底上外延生长的p型Ge和n型Ge材料的接触特性.发现在相同的较高掺杂条件下,NiGe与n型Ge可形成良好的欧姆接触,其比接触电阻率较Al接触降低了一个数量级,掺P浓度为2×1019cm-3时达到1.43×10-5·***与p型Ge接触和Al接触的比接触电阻率相当,掺B浓度为4.2×1018cm-3时达到1.68×10-5·***与n型Ge接触和Al电极相比较,在形成NiGe过程中,P杂质在界面处的偏析是其接触电阻率降低的主要原因.采用NiGe作为Ge的接触电极在目前是合适的选择.

关键词：金属与Ge接触性质 NiGe 比接触电阻率

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo Yong-Heng Zhao Gang Zhao li-Cai Deng Xiao-wei liu Yi-Peng Jing Gang Wang hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping li Zhong-Rui Bai Yue Wu yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen li Chen xue-Lei Chen Xiao-yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-wei Fan Lei Feng Jian-Ning Fu Peng Gao xue-Fei Gong Bo-Zhong Gu yan-Xin Guo Zhan-Wen Han Bo-liang He Jin-liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua Jiang Xiang Jiang Zhi-Bo Jiang Ge Jin Xiao Kong xu Kong Ya-Juan Lei Ai-Hua li Chang-Hua li Guang-wei li Hai-Ning li Jian li Qi li Shuang li Sha-Sha li Xin-Nan li yan li Yin-Bi li Ye-Ping li Yuan liang Chien-cheng lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong tang Qing-Sheng Tao Yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-ling Wang Jian-Ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-Qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng wei Ming-Zhi wei Hong Wu Ke-Fei Wu xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing ling-Zhe xu Xin-Qi xu yan xu Tai-Sheng yan De-Hua yang Hai-Feng yang Hui-Qin yang Ming yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan wei-Min Yuan Chao Zhai En-Peng Zhang Hua-wei Zhang Jian-Nan Zhang li-Pin Zhang wei Zhang Yong Zhang yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou xu Zhou Jie Zhu Yong-Tian Zhu Si-cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment

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Science China(Physics,Mechanics & Astronomy) 2017年第7期60卷 53-59页

作者： li Wang Qian Yue KeJun Kang JianPing cheng YuanJing li TszKing Henry Wong ShinTed lin JianPing Chang JingHan Chen Qinghao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong li He QingJu He Jinwei Hu HanXiong Huang TengRui Huang liPing Jia hao Jiang HauBin li Hong li JianMin li Jin li Jun li Xia li xueQian li YuLan li FongKay lin ShuKui liu hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian tang weiYou tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu Yucheng Wu haoyang Xing Yin xu Tao xue liTao yang Songwei yang Nan Yi Chunxu Yu HaiJun Yu weiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu weiBin Zhu ZhongHua Zhu Key Laboratory of Particle and Radiation Imaging (Ministry of Education) and Department of Engineering Physics Tsinghua University Institute of Physics Academia Sinica School of Physical Science and Technology Sichuan University NUCTECH Company YaLong River Hydropower Development Company Department of Nuclear Physics China Institute of Atomic Energy School of Physics Nankai University Department of Physics Banaras Hindu University

We report the first results on 76Ge neutrinoless double beta decay from stage one of the China dark-matter experiment （CDEX）. A p-type point-contact high-purity germanium detector with a mass of 994g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304kgd has been analyzed over a wide spectral band from 500keV to 3MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039MeV energy range. The half-life of76Ge neutrinoless double beta decay derived based on this result is 70v2〉6.4× 1022 yr （90%C.L.）. An upper limit on the effective Majorana-neutrino mass of 5.0eV has been achieved.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector 76Ge isotope

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Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China

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Biomedical and Environmental Sciences 2020年第12期33卷 893-905页

作者： MA yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan liU Si Hong FAN Yi Pin WU Gui Hui yanG Pu Ye BAI Jiang Feng CHEN Hong CHEN li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI liang JIN Hai hao LEI Xiao li Chun yan li Min Qing li Qun tang li Xian Yong liU Hong De liU Jin Ping liU Zhang MA Yu Ting MAO Ya MO liu Fen NA Hui WANG Jing wei SONG Fang li SUN Sheng WANG Dong Ting WANG Ming xuan WANG Xiao yan WANG Yin Zhen WANG Yu Dong WU wei WU Lan Ping XIAO yan Hua XIE Hai Jun xu Hong Ming xu Shou Fang xuE Rui Xia yanG Chun yanG Kai Jun YUAN Sheng li ZHANG Gong Qi ZHANG Jin Bo ZHANG lin Song Zhao Shu Sen Zhao Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG yan Ping WANG Yong yan 无 Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Centre for Health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Tuberculosis The Public Health Clinical Center of ChengduChengdu 610066SichuanChina Department of Infectious Disease Shaanxi Infectious Disease HospitalXi'an 610113ShaanxiChina Department of Infectious Disease Yulin Chinese Medicine HospitalYulin 719000ShaanxiChina President's Office The First Hospital of QiqiharQiqihar 161005HeilongjiangChina Department of Traditional Chinese Medicine Shangluo Central HospitalShangluo 726000ShaanxiChina Department of Traditional Chinese Medicine The People's Hospital of QitaiheQitaihe 154603HeilongjiangChina Department of Scientific Research Xianyang Central HospitalXianyang 712000ShaanxiChina Department of traditional Chinese medicine The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230012AnhuiChina Department of Infectious Disease Heping Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000ShanxiChina Department of Traditional Chinese Medicine Langfang Hospital of Chinese MedicineLangfang 065000HeibeiChina Department of Traditional Chinese Medicine Xingtai Hospital of Chinese MedicineXingtai 054001HeibeiChina Department of Traditional Chinese Medicine The People's Hospital of Guangxi Zhuang Autonomous RegionNanning 168600GuangxiChina Department of Traditional Chinese Medicine The First People'sHospital of FangchenggangFangchenggang 538001GuangxiChina Department of Traditional Chinese Medicine Mianyang Hospital of Traditional Chinese MedicineMianyang 621000SichuanChina Department of Traditional Chinese Medicine Liuzhou People's HospitalLiuzhou 545006GansuChina Department of Traditional Chinese Medici

Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains *** A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of *** Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two *** Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.

关键词： Comorbidities COVID-19 Severity Gender Age Treatment outcome

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中西太平洋金枪鱼围网自由鱼群渔场重心变动及其与南方涛动指数的关系

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南方水产科学 2020年第2期16卷 70-76页

作者：李鹏许柳雄周成王学昉唐浩刘伟上海海洋大学海洋科学学院上海201306 国家远洋渔业工程技术研究中心/农业农村部大洋渔业开发重点实验室/农业农村部大洋渔业资源环境观测实验站上海201306

文章根据2013—2017年中国中西太平洋金枪鱼围网船队捕捞日志,利用捕捞自由鱼群作业位置、作业时间和渔获量等数据信息,分析了自由鱼群渔场重心月间变化、年际变化与南方涛动指数(South Oscillation Index,SOI)的关系。结果显示,渔获量... 详细信息

文章根据2013—2017年中国中西太平洋金枪鱼围网船队捕捞日志,利用捕捞自由鱼群作业位置、作业时间和渔获量等数据信息,分析了自由鱼群渔场重心月间变化、年际变化与南方涛动指数(South Oscillation Index,SOI)的关系。结果显示,渔获量较高的海域海表温度(Sea surface temperature,SST)高于29℃;自由鱼群的渔场重心主要分布介于160°E—175°W;2013—2015年渔场重心有逐年向东偏移的趋势,但无明显的月间变化规律;SOI为正值时,中西太平洋“暖池”较正常年份向西偏移,自由鱼群渔场重心亦明显向西偏移;反之,自由鱼群渔场重心较正常年份向东偏移。相关性分析显示SOI和月间渔场重心的经度之间呈负相关(相关系数为?0.27,P<0.05),表明金枪鱼围网渔场变动和异常气候的发生存在密切联系。研究结果对于掌握中西太平洋金枪鱼围网渔场变动规律具有一定参考价值。

关键词：金枪鱼围网自由鱼群南方涛动指数渔场重心变动中西太平洋

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Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial

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Journal of Integrative Medicine 2021年第2期19卷 111-119页

作者： Jie Wu Shu-wei Duan Hong-tao yang Yue-yi Deng wei li Ya-ni He Zhao-hui Ni Yong-li Zhan Shan lin Zhi-yong Guo Jun Zhu Jing-ai Fang xu-sheng liu li-hua Wang Rong Wang Nian-song Wang Xiao-hong cheng li-qun He Ping Luo Shi-ren Sun Ji-feng Sun Ai-ping Yin Geng-ru Jiang Hong-yu Chen Wen-hu liu Hong-li lin Meng liang Lu Ma Ming Chen li-qun Song Jian Chen Qing Zhu Chang-ying Xing Yun li Ji-ning Gao Rong-shan li Ying li hao Zhang Ying Lu Qiao-ling Zhou Jun-zhou Fu Qiang He Guang-yan Cai Xiang-mei Chen Department of Nephrology Chinese People’s Liberation Army General HospitalChinese People’s Liberation Army Institute of NephrologyState Key Laboratory of Kidney Diseases(2011DAV00088)National Clinical Research Center for Kidney DiseasesBeijing 100853China Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300192China Department of Nephrology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Nephrology Shandong University of Traditional Chinese Medicine Affiliated HospitalJinan 250011.Shandong ProvinceChina Department of Nephrology Daping HospitalArmy Medical UniversityChongqing 400042China Department of Nephrology Renji HospitalShanghai Jiao Tong UniversityShanghai 200127China Department of Nephrology Guang’anmen HospitalChina Academy of Traditional Chinese Medical SciencesBeijing 100053China Department of Nephrology Tianjin Medical University General HospitalTianjin 300052China Department of Nephrology Changhai Hospital of ShanghaiNaval Medical UniversityShanghai 200433China Department of Nephrology West China HospitalChengdu 610083Sichuan ProvinceChina Department of Nephrology First Affiliated Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Nephrology Shanxi Medical University Second Affiliated HospitalTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Shandong Provincial HospitalJinan 250021Shandong ProvinceChina Department of Nephrology and Rheumatology Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai 200233China Department of Nephrology Shaanxi Traditional Chinese Medicine HospitalXi'an 710003Shaanxi ProvinceChina Department of Nephrology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200021China Department of Nephrology Jilin University Se

Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney ***:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan ***,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical *** glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 *** outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of ***:A total of 735 participants were *** percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg *** with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(Pline did not change statistically *** average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any ***:SYKFT decreased the proteinur

关键词： Herbal medicine,Chinese Shenyankangfu Tablet Primary glomerulonephritis Randomized controlled trial Double blind Double dummy

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由超拍电子伏特加速器产生的超高能伽马射线气泡

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Science Bulletin 2024年第4期69卷 449-457页

作者： LHAASO Collaboration Zhen Cao Chuandong Gao Cong li Ruo-Yu liu Ruizhi yang 不详 Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China University of Science and Technology of China Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 100deg2 in ultra-high energy(UHE)up to a few PeV in the direction of the star-forming region Cygnus X,implying the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola form with the photon indexΓ(E)=(2.71±0.02)+(0.11±0.02)×log10(E/10 TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive OB association(Cygnus OB2)and a microquasar(Cygnus X-3),as well as previously reported multi-TeV sources,an enhanced concentration of UHEγ-rays is observed with 2 photons at energies above 1 *** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium Star cluster

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First experimental constraints on WIMP couplings in the effective field theory framework from CDEX

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Science China(Physics,Mechanics & Astronomy) 2021年第8期64卷 15-22页

作者： Yi Wang Zhi Zeng Qian Yue liTao yang KeJun Kang YuanJing li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing cheng cheng Yi Chiang WenHan Dai Zhi Deng Changhao Fang XinPing Geng Hui Gong QiuJu Guo xuYuan Guo HongJian He li He ShengMing He Jinwei Hu TuChen Huang HanXiong Huang HaiTao Jia liPing Jia Xi Jiang HauBin li JianMin li Jin li Mingxuan li RenMingJie li Xia li YuLan li Bin liao FongKay lin ShinTed lin ShuKui liu yanDong liu Yu liu YuanYuan liu ZhongZhi liu hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian tang weiYou tang yang Tian GuangFu Wang li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu Yucheng Wu haoyang Xing Yin xu Tao xue YuLu yan Nan Yi Chunxu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu Key Laboratory of Particle and Radiation Imaging(Ministry of Education) Department of Engineering PhysicsTsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Institute of Physics Academia SinicaTaipei 11529China NUCTECH Company Beijing 100084China YaLong River Hydropower Development Company Chengdu 610051China College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875China College of Physics Sichuan UniversityChengdu 610065China School of Physics Peking UniversityBeijing 100871China Sino-French Institute of Nuclear and Technology Sun Yet-sen UniversityZhuhai 519082China Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413China Department of Physics Banaras Hindu UniversityVaranasi 221005India Department of Physics Beijing Normal UniversityBeijing 100875China School of Physics Nankai UniversityTianjin 300071China

We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region.

关键词： WIMP EFT CDEX dark matter annual modulation

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