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Urinary metabolic profiles during Helicobacter pylori eradication in chronic gastritis

World Journal of Clinical Cases 2024年第5期12卷 951-965页

作者： Wen-Ting An Yu-xia hao Hong-xia Li Xing-Kang Wu Department of Pharmacy Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Department of Gastroenterology Shanxi Provincial People's HospitalTaiyuan 030012Shanxi ProvinceChina Department of Oncology Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan 030006Shanxi ProvinceChina

BACKGROUND Helicobacter pylori(H.pylori)infection is a major risk factor for chronic gastritis,affecting approximately half of the global population.H.pylori eradication is a popular treatment method for H.pylori-positive chronic gastritis,but its mecha-nism remains unclear.Urinary metabolomics has been used to elucidate the mechanisms of gastric disease treatment.However,no clinical study has been conducted on urinary metabolomics of chronic gastritis.AIM To elucidate the urinary metabolic profiles during H.pylori eradication in patients with chronic gastritis.METHODS We applied LC–MS-based metabolomics and network pharmacology to in-vestigate the relationships between urinary metabolites and H.pylori-positive chronic gastritis via a clinical follow-up study.RESULTS Our study revealed the different urinary metabolic profiles of H.pylori-positive chronic gastritis before and after H.pylori eradication.The metabolites regulated by H.pylori eradication therapy include cis-aconitic acid,isocitric acid,citric acid,L-tyrosine,L-phenylalanine,L-tryptophan,and hippuric acid,which were involved in four metabolic pathways:(1)Phenylalanine metabolism;(2)phenylalanine,tyrosine,and tryptophan biosynthesis;(3)citrate cycle;and(4)glyoxylate and dicarboxylate metabolism.Integrated metabolomics and network pharmacology revealed that MPO,COMT,TPO,TH,EPX,CMA1,DDC,TPH1,and LPO were the key proteins involved in the biological progress of H.pylori eradication in chronic gastritis.CONCLUSION Our research provides a new perspective for exploring the significance of urinary metabolites in evaluating the treatment and prognosis of H.pylori-positive chronic gastritis patients.

关键词： LC-MS metabolomics chronic gastritis Helicobacter pylori urinary metabolites

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Modeling Near-Field Impulsive Waves Generated by Deformable Landslide Using the HBP Model Based on the SPH Method

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Journal of Ocean University of China 2024年第2期23卷 328-344页

作者： WANG Wei WEI Weicheng CHAI Bo xia hao WANG Yang DU Juan LIU Jizhixian School of Environmental Studies China University of GeosciencesWuhan 430078China Hubei Key Laboratory of Yangtze Catchment Environmental Aquatic Science Wuhan 430078China Faculty of Engineering China University of GeosciencesWuhan 430074China Research Center for Geohazards Monitoring and Warning in Three Gorges Reservoir Wanzhou 404000China

Landslide-generated impulsive waves(LGWs)in reservoir areas can seriously threaten waterway safety as well as hu-man life and properties around the two side slopes.The risk reduction and mitigation of such a hazard require the accurate prediction of near-field wave characteristics,such as wave amplitude and run-up.However,near-field LGW involves complicated fluid-solid interactions.Furthermore,the wave characteristics are closely related to various aspects,including the geometry and physical features of the slide,river,and body of water.However,the empirical or analytical methods used for rough estimation cannot derive accurate results,especially for deformable landslides,due to their significant geometry changes during the sliding process.In this study,the near-field waves generated by deformable landslides were simulated by smoothed particle hydrodynamics(SPH)based on multi-phase flow.The deformable landslides were generalized as a kind of viscous flow by adopting the Herschel-Bulkley-Papanastasiou(HBP)-based nonNewtonian rheology model.The HBP model is capable of producing deformable landslide dynamics even though the high-speed sliding process is involved.In this study,an idealized experiment case originating from Lituya LGW and a practical case of Gongjiafang LGW were reproduced for verification and demonstration.The simulation results of both cases show satisfactory consistency with the experiment/investigation data in terms of landslide movement and near-field impulsive wave characteristics,thus indicating the applicability and accuracy of the proposed method.Finally,the effects of the HBP model’s rheological parameters on the landslide dynamics and near-field wave characteristics are discussed,providing a parameter calibration method along with sug-gestions for further applications.

关键词： deformable landslide impulsive waves near-field SPH nonNewtonian fluids

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Genome-wide analysis of Panonychus citrimicro RNAs witha focus on potential insecticidal activity of 4 micro RNAs toeggs and nymphs

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Insect Science 2024年第2期31卷 354-370页

作者： Chuan-Zhen Li Yu-Hang Liu Deng Pan Meng-hao xia Qiang Zhang Yu-Chuang Li Guo-Rui Yuan Jin-Jun Wang Wei Dou Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionAcademy of Agricultural SciencesSouthwestUniversityChongqingChina Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Academy of Agricultural SciencesSouthwest UniversityChongqingChina

Panonychus citriMcGregor(Acari:Tetranychidae),a destructive citrus pest,causes considerable annual economic losses due to its short lifespan and rapid resistancedevelopment.MicroRNA(miRNA)-induced RNA interference is a promising approachfor pest control because of endogenous regulation of pest growth and development.Tosearch for miRNAs with potential insecticidal activity inP.citri,genome-wide analysis ofmiRNAs at different developmental stages was conducted,resulting in the identificationof 136 miRNAs,including 73 known and 63 novel miRNAs.A total of 17 isomiRNAsand 12 duplicated miRNAs were characterized.MiR-1 and miR-252-5p were identified asreference miRNAs forP.citriandTetranychus urticae.Based on differential expressionanalysis,treatments with miR-let-7a and miR-315 mimics and the miR-let-7a antagomirsignificantly reduced the egg hatch rate and resulted in abnormal egg development.Over-expression or downregulation of miR-34-5p and miR-305-5p through feeding significantlydecreased the adult eclosion rate and caused molting defects.The 4 miRNAs,miR-let-7a,miR-315,miR-34-5p,and miR-305-5p,had important regulatory functions and insectici-dal properties in egg hatching and adult eclosion.In general,these data advance our un-derstanding of miRNAs in mite biology,which can assist future studies on insect-specificmiRNA-based green pest control technology.

关键词： growth and development microRNAs Panonychus citri referencemiRNAs regulation small RNA libraries

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Tungsten chalcogenides as anodes for potassium-ion batteries

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Tungsten 2024年第2期6卷 278-292页

作者： Yu-Han Wu Wei-hao xia Yun-Zhuo Liu Peng-Fei Wang Yu-Hang Zhang Jin-Ru Huang Yang Xu De-Ping Li Li-Jie Ci School of Environmental and Chemical Engineering Shenyang University of TechnologyShenyang 110870China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China State Key Laboratory of Advanced Welding and Joining School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Department of Chemistry University College LondonLondon WC1H 0AJUnited Kingdom

Potassium-ion batteries(PIBs)by virtue of their strong cost competitiveness and similar electrochemical properties to lithiumion batteries have been deemed to be a promising electrochemical energy storage technology.To promote the application in the commercial market,developing electrode materials with high specifi c capacities,superior cycling stability,and reliable safety is of great importance.Anode materials as an important component of PIBs play a decisive role,among which twodimensional transition metal chalcogenides(2D TMCs)have attracted wide attention owing to their unique material and electrochemical properties.In the 2D TMCs’family,molybdenum chalcogenides as fl agship are the most studied materials and demonstrated the potential as anodes.With the deepening of research on 2D TMCs,another shining member that possesses similar properties to molybdenum chalcogenides,tungsten chalcogenides(WS_(2),WSe_(2),and WTe_(2)),has aroused tremendous attention.Despite many inspiring results,various challenges remain to be further addressed;meanwhile,some results are still unclear and disputed.Herein,this review fi rst introduces their material properties and electrochemical storage mechanisms.Then,we systematically overview the research progress and put forward promoting improvement strategies.Finally,challenges and opportunities that would be future research directions are discussed.

关键词： Electrochemical energy storage Potassium-ion batteries Anodes Tungsten chalcogenides

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Fibroblast growth factor 5 overexpression ameliorated lipopolysaccharide-induced apoptosis of hepatocytes through regulation of the phosphoinositide-3-kinase/protein kinase B pathway

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Chinese Medical Journal 2022年第23期135卷 2859-2868页

作者： Shengyu Cui Yuhua Li Xutao Zhang Bing Wu Ming Li Jixian Gao Lin Xu hao xia Department of Cardiology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Cardiovascular Research Institute Wuhan UniversityWuhanHubei 430060China Hubei Key Laboratory of Cardiology WuhanHubei 430060China Intensive Care Unit Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430019China Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei 430060China

Background:Sepsis is a systemic inflammatory syndrome induced by several infectious agents.Multiple organs are affected by sepsis,including the liver,which plays an important role in metabolism and immune homeostasis.Fibroblast growth factors(FGFs)participate in several biological processes,although the role of FGF5 in sepsis is unclear.Methods:In this study,lipopolysaccharide(LPS)was administrated to mice to establish a sepsis-induced liver injury.A similar in vitro study was conducted using L-02 hepatocytes.Western blot and immunohistochemistry staining were performed to evaluate the FGF5 expression level in liver tissues and cells.Inflammatory cell infiltrations,cleaved-caspase-3 expressions,reactive oxygen species and levels of inflammatory cytokines were detected by immunofluorescence,dihydroethidium staining,and reverse transcription quantitative polymerase chain reaction analysis,respectively.Flow cytometry was used to detect the apoptosis level of cells.In addition,ribonucleic acid(RNA)-sequencing was applied to explore the possible mechanism by which FGF5 exerted effects.Results:LPS administration caused FGF5 down-regulation in the mouse liver as well as in L-02 hepatocytes.Additionally,with FGF5 overexpression,liver injury and the level of hepatocyte apoptosis were ameliorated.Further,RNA sequencing performed in hepatocytes revealed the phosphoinositide-3-kinase/protein kinase B(PI3K/AKT)pathway as a possible pathway regulated by FGF5.This was supported using an inhibitor of the PI3K/AKT pathway,which abrogated the protective effect of FGF5 in LPSinduced hepatocyte injury.Conclusion:The anti-apoptotic effect of FGF5 on hepatocytes suffering from LPS has been demonstrated and was dependent on the activation of the PI3K/AKT signaling pathway.

关键词： Apoptosis FGF5 Hepatocyte Liver PI3K/AKT Sepsis

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肌动蛋白成核因子Spire的研究进展

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生理学报 2024年第2期76卷 341-345页

作者：庞涛张丽霞白安娜杨文郝利霞内蒙古医科大学附属医院康复科呼和浩特010030

肌动蛋白成核因子主要分为3类:Arp2/3复合体、Spire和Formin蛋白。其中Spire通过稳定的纵向四聚体成核组装微丝,将肌动蛋白结合到微丝生长端。早在1999年Wellington等人就发现Spire是肌动蛋白的成核剂,然而多年来的研究大多数着眼于Arp... 详细信息

肌动蛋白成核因子主要分为3类:Arp2/3复合体、Spire和Formin蛋白。其中Spire通过稳定的纵向四聚体成核组装微丝,将肌动蛋白结合到微丝生长端。早在1999年Wellington等人就发现Spire是肌动蛋白的成核剂,然而多年来的研究大多数着眼于Arp2/3、Formin蛋白,作为肌动蛋白成核因子的一员,关于Spire的相关研究相对较少。有研究显示,Spire蛋白通过合成肌动蛋白参与到囊泡运输过程。近几年还有研究发现,Spire在神经发育方面也有着重要作用。本文希望通过对Spire的结构、表达、功能以及与疾病的关联等方面的研究进行梳理,以便找到未来针对Spire研究富有意义的可能方向。

关键词：肌动蛋白成核因子 Spire-2 神经元

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基于编码视频的动态手势数据优化与识别

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北京邮电大学学报 2024年第2期47卷 90-96页

作者：谢晓燕曹盘宇夏浩陈雨馨西安邮电大学计算机学院西安710121

编码视频数据流中的运动矢量和残差等语法元素可用于替代光流进行运动表示,但其固有的像素噪声和特征稀疏性会影响精细动作的识别精度。对此,在对编码视频语法元素进行数据优化的基础上,设计了一个高精度、低复杂度的动态手势识别框架... 详细信息

编码视频数据流中的运动矢量和残差等语法元素可用于替代光流进行运动表示,但其固有的像素噪声和特征稀疏性会影响精细动作的识别精度。对此,在对编码视频语法元素进行数据优化的基础上,设计了一个高精度、低复杂度的动态手势识别框架。首先,提出了关键P帧选择方法,通过选择信息量更高的编码帧解决了特征稀疏性问题;其次,提出了联合残差特征表示方法,利用残差得到精细的手势轮廓图,去除了运动矢量中手部以外的像素噪声;最后,设计了一种轻量而高效的动态手势识别模型,利用优化后的运动矢量和残差获得了类似于光流的计算效果。在viva,sheffield klnect gesture,NvGesture和EgoGesture等数据集上对所提方法进行了验证,实验结果显示,所提方法中仅使用RGB数据模式可达到的识别精度分别为82.94%、99.72%、81.12%和90.48%,降低了89%的存储开销,并且以4.7倍的运行速度获得了与先进方法相近的结果。

关键词：动态手势识别编码视频运动矢量残差数据优化

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结合特征信息聚类分区的遥感影像配准方法

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中国科学院大学学报（中英文） 2024年第1期41卷 97-106页

作者：石正一刘朔夏昊中国科学院空天信息创新研究院北京100089 中国科学院大学北京100049

针对由于地形起伏、地物类型丰富等因素导致一般配准方法无法正确拟合遥感影像局部区域的问题,提出一种基于特征信息层次聚类对影像区域快速划分实现精细拟合的方法。该方法利用差分空间尺度约束提取更高精度的SIFT的特征点,并结合Helli... 详细信息

针对由于地形起伏、地物类型丰富等因素导致一般配准方法无法正确拟合遥感影像局部区域的问题,提出一种基于特征信息层次聚类对影像区域快速划分实现精细拟合的方法。该方法利用差分空间尺度约束提取更高精度的SIFT的特征点,并结合Hellinger变换优化匹配效率,完成特征粗匹配。根据点邻域信息完成初始聚类,得到变换模型;计算匹配点对不同变换模型的符合程度构建倾向集,根据距离合并集合得到聚类中心,使用泰森多边形法生成子区域。求解每个子区域的变换模型并插值拼接,得到配准结果。使用农田、山地、沿海城镇地形的遥感影像进行实验,将SIFT+ST、FSC-SIFT、PSO-SIFT方法的配准效果与该方法进行对比,结果表明该方法的精度与目视配准效果均更优。

关键词：遥感影像配准层次聚类局部拟合子区域划分模型一致性

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数字服务贸易网络的企业创新效应

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当代财经 2024年第1期 126-139页

作者：宋跃刚郝夏珍河南师范大学商学院河南新乡453007 南开大学经济学院天津300071

中国企业面临数字服务贸易迅速发展与创新水平“一高两低”并存的现实困境,利用数字服务贸易网络突破企业创新发展困境是新发展阶段中国经济发展方式转型的重要战略支撑。将多重异质性纳入理论框架,并运用社会网络分析方法,测度中国企... 详细信息

中国企业面临数字服务贸易迅速发展与创新水平“一高两低”并存的现实困境,利用数字服务贸易网络突破企业创新发展困境是新发展阶段中国经济发展方式转型的重要战略支撑。将多重异质性纳入理论框架,并运用社会网络分析方法,测度中国企业在数字服务贸易网络中的中心性、联系强度与结构洞指标,实证检验了数字服务贸易网络嵌入对中国企业创新水平的影响。研究发现,数字服务贸易网络嵌入对企业创新水平具有显著促进作用,但其促进作用会因企业异质性存在显著差异;数字服务贸易网络嵌入通过“贸易规模效应”“成本节约效应”和“技术吸收能力效应”作用于企业创新;企业生存分析结果表明,数字服务贸易网络嵌入有助于降低企业的创新终止风险率。基于以上结论,应积极推动企业融入全球数字服务贸易网络,并合理布局企业在网络中的位置,由“被动嵌入”转向“主动利用”,推动实现创新高质量发展。

关键词：数字服务贸易网络企业创新水平生存分析模型

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高速公路边坡位置基坑支护结构设计

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建筑与装饰 2024年第6期 112-114页

作者：邱豪侠上海城建市政工程(集团)有限公司上海 200333

随着城市多系统立体交通的快速化建设,在上层交通系统建设过程中其承台基坑设计需考虑的环境因素较为复杂,边界条件较为苛刻.本文以上海某高速公路改建项目的承台基坑工程为背景,介绍通过合理的基坑支护设计方案,解决基坑开挖过程中对... 详细信息

随着城市多系统立体交通的快速化建设,在上层交通系统建设过程中其承台基坑设计需考虑的环境因素较为复杂,边界条件较为苛刻.本文以上海某高速公路改建项目的承台基坑工程为背景,介绍通过合理的基坑支护设计方案,解决基坑开挖过程中对现状通行高速公路及地面道路位移、沉降控制的难题,确保道路通行的安全.

关键词：高速公路基坑支护软土地层

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