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Microsystems & Nanoengineering 2022年第3期8卷 129-140页

作者： Xuanqi Chen hao wan Rui Guo Xinpeng wang Yang wang Caicai Jiao Kang Sun Liang Hu School of Biological Science and Medical Engineering Being Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijing 100191China Biosensor National Special Laboratory Key Laboratory for Bipmedical Engineering of Ministry of EducationDepartment of Biomedical EngineeringZhejiang UniversityHangzhou 310027China Department of Biomedical Engineering School of MedicineTsinghua UniversityBeijing China

Integrated electrochemical sensing plaforms in wearable devices have great prospects in biomedical applications.However,traditional electrochemical platforms are generally fabricated on airtight printed circuit boards,which lack sufficient flexibility,air permeability,and conformability.Liquid metals at room temperature with excellent mobility and electrical conductivity show high promise in flexible electronics.This paper presents a miniaturized liquid metal-based flexible electrochemical detection system on fabric,which is intrinsically flexible,air-permeable,and conformable to the body.Taking advantage of the excellent fluidity and electrical connectivity of liquid metal,a double-layer circuit is fabricated that significantly miniaturizes the size of the whole system.The linear response,time stability,and repeatability of this system are verifed by resistance,stability,image characterization,and potassium ferricyanide tests.Finall,glucose in sweat can be detected at the millimolar level using this sensing system,which demonstrates its great potential for wearable and portable detection in biomedical fields,such as health monitoring and point-of-care testing.

关键词： wear electrochemical system

Analysis of key microbial community during the start-up of anaerobic ammonium oxidation process with paddy soil as inoculated sludge

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Journal of Environmental Sciences 2018年第2期30卷 317-327页

作者： Xianglong Xu Guohua Liu Yuanyuan wang Yuankai Zhang hao wan Lu Qi Hongchen wang School of Environment & Natural Resources Renmin University of China

A sequencing batch reactor（SBR）-anaerobic ammonium oxidation（anammox） system was started up with the paddy soil as inoculated sludge. The key microbial community structure in the system along with the enrichment time was investigated by using molecular biology methods（e.g., high-throughput 16 S r RNA gene sequencing and quantitative PCR）. Meanwhile,the influent and effluent water quality was continuously monitored during the whole start-up stage. The results showed that the microbial diversity decreased as the operation time initially and increased afterwards, and the microbial niches in the system were redistributed. The anammox bacterial community structure in the SBR-anammox system shifted during the enrichment, the most dominant anammox bacteria were Candidatus Jettenia. The maximum biomass of anammox bacteria achieved 1.68 × 10~9 copies/g dry sludge during the enrichment period, and the highest removal rate of TN achieved around 75%.

关键词： Anammox Paddy soil Community structure High-throughput sequencing qPCR

Single-atom catalysts for electrochemical energy storage and conversion

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Journal of Energy Chemistry 2021年第12期30卷 170-194,I0004页

作者： Wei Ma hao wan Lili Zhang Jin You Zheng Zhen Zhou Engineering Research Center of Advanced Functional Material Manufacturing of Ministry of Education School of Chemical EngineeringZhengzhou UniversityZhengzhou 450001HenanChina

The expedited consumption of fossil fuels has triggered broad interest in the fabrication of novel catalysts for electrochemical energy storage and conversion. Especially, single-atom catalysts(SACs) have attracted more attention owing to their high specific surface areas and abundant active centers. This review summarizes recent synthetic strategies to fabricate SACs with different metal loadings on various supports, and the structural influence of supports on metal loading. Then, the functions of SACs are illustrated on electronic structure and electrocatalysis;the isolated SACs with an unsaturated coordination environment generally accelerate the electrocatalytic process and promote the selectivity. The applications of SACs to some typical electrocatalytic reactions are also introduced in detail, as well as to electrochemical energy storage and conversion systems. Finally, the challenges and the perspectives of SACs are discussed for future exploration.

关键词： Single-atom catalysts Energy storage and conversion Electrocatalysis Batteries Fuel cells

Covalently grafting first-generation PAMAM dendrimers onto MXenes with self-adsorbed AuNPs for use as a functional nanoplatform for highly sensitive electrochemical biosensing of cTnT

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Microsystems & Nanoengineering 2022年第2期8卷 119-133页

作者： Xin Liu Yong Qiu Deming Jiang Fengheng Li Ying Gan Yuxuan Zhu Yuxiang Pan hao wan Ping wang Zhejiang University 310027 HangzhouChina Cancer Centre Zhejiang University310058 HangzhouZhejiangChina State Key Laboratory of Transducer Technology Chinese Academy of Sciences200050 ShanghaiChina Binjiang Institute of Zhejiang University 310053 HangzhouChina. School of Biomedical Engineering Tianjin Medical University300070 TianjinChina Research Center of Smart Sensing ZhejiangLab310027 HangzhouChina

2D MXene-Ti3C2Tx has demonstrated promising application prospects in various fields;however,it fails to function properly in biosensor setups due to restacking and anodic oxidation problems.To expand beyond these existing limitations,an effective strategy to for modifying the MXene by covalently grafting first-generation poly(amidoamine)dendrimers onto an MXene in situ(MXene@PAMAM)was reported herein.When used as a conjugated template,the MXene not only preserved the high conductivity but also conferred a specific 2D architecture and large specific surface areas for anchoring PAMAM.The PAMAM,an efficient spacer and stabilizer,simultaneously suppressed the substantial restacking and oxidation of the MXene,which endowed this hybrid with improved electrochemical performance compared to that of the bare MXene in terms of favorable conductivity and stability under anodic potential.Moreover,the massive amino terminals of PAMAM offer abundant active sites for adsorbing Au nanoparticles(AuNPs).The resulting 3D hierarchical nanoarchitecture,AuNPs/MXene@PAMAM,had advanced structural merits that led to its superior electrochemical performance in biosensing.As a proof of concept,this MXene@PAMAM-based nanobiosensing platform was applied to develop an immunosensor for detecting human cardiac troponin T(cTnT).A fast,sensitive,and highly selective response toward the target in the presence of a[Fe(CN)6]^(3-/4-)redox marker was realized,ensuring a wide detection of 0.1-1000 ng/mL with an LOD of 0.069 ng/mL.The sensor's signal only decreased by 4.38%after 3 weeks,demonstrating that it exhibited satisfactory stability and better results than previously reported MXene-based biosensors.This work has potential applicability in the bioanalysis of cTnT and other biomarkers and paves a new path for fabricating high-performance MXenes for biomedical applications and electrochemical engineering.

关键词： electrochemical anodic properly

Radical–Radical Cross-Coupling Assisted N–S Bond Formation Using Alternating Current Protocol

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CCS Chemistry 2022年第8期4卷 2674-2685页

作者： Yong Yuan Jun-Chao Qi Dao-Xin wang Ziyue Chen hao wan Jing-Yun Zhu Hong Yi Abhishek Dutta Chowdhury Aiwen Lei National Research Center for Carbohydrate Synthesis Jiangxi Normal UniversityNanchang 330022 College of Chemistry and Molecular Sciences Institute for Advanced Studies(IAS)Engineering Research Center of Organosilicon Compounds&Materials(Ministry of Education)Wuhan UniversityWuhanHubei 430072 Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials College of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhouGansu 730070

Alternating current(AC)electrolysis is a promising,yet challenging,and under-developed protocol in organic synthesis.To achieve as high an atomefficiency as possible and avoid the use of external oxidant,electrochemistry has become a standard organic synthesis tool.Herein,an AC-basedprotocol is a superior option than its counterpart,direct current(DC),especially for those reactions that cannot be accomplished by DC.

关键词： alternating current electrolysis anilines thiols cross-coupling reaction N–S bond formation

THE STUDY ON NOVEL MICROELECTRODE ARRAY CHIPS FOR THE DETECTION OF HEAVY METALS IN WATER POLLUTION

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Journal of Innovative Optical Health Sciences 2012年第1期5卷 11-17页

作者： HUI-XIN Zhao WEI CAI DA HA hao wan PING wanG Biosensor National Special Laboratory Key Laboratory for Biomedical Engineering of Education Ministry Department of Biomedical Engineering Zhejiang University Hangzhou 310027P.R.China

Qualitative and quantitative analysis of trace heavy metals in aqueous environment are rapidly assuming significance along with the rapid development of industry.In this paper,gold microelectrode array(MEA)plated with mercury film was used for simultaneous voltammetric detection of zinc,cadmium,lead and copper ions in water.The electrochemical behavior and the actual surface area of the MEA were investigated by cyclic voltammetry in K_(3)[Fe(CN)_(6)].Electrochemical impedance spectrum(EIS)was utilized to examine the deposition of mercury on the electrode surface.Based on anodic stripping voltammetry,mercury filmAu MEA was applied to the detection of heavy metals in artificial analyte,where good calibrate linearity was obtained for cadmium,lead and copper ions,but with zinc exhibiting poor linearity.

关键词： Microelectrode array(MEA)chip heavy metals detection water pollution

Cardiomyocyte electrical-mechanical synchronized model for high-content, dose-quantitative and time-dependent drug assessment

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Microsystems & Nanoengineering 2021年第2期7卷 131-142页

作者： Jiaru Fang Xinwei Wei Hongbo Li Ning Hu Xingxing Liu Dongxin Xu Tao Zhang hao wan Ping wang Xi Xie The First Affiliated Hospital of Sun Yat-Sen University School of Electronics and Information TechnologyGuangdong Province Key Laboratory of Display Material and TechnologySun Yat-sen UniversityGuangzhou510006China Biosensor National Special Laboratory Key Laboratory of Biomedical Engineering of Ministry of EducationDepartment of Biomedical EngineeringZhejiang UniversityHangzhou310027China State Key Laboratory of Transducer Technology Chinese Academy of SciencesShanghai200050China School of Biomedical Engineering Sun Yat-sen UniversityGuangzhou510006China

Cardiovascular diseases have emerged as a significant threat to human health.However,drug development is a time-consuming and costly process,and few drugs pass the preclinical assessment of safety and efficacy.The existing patch-clamp,Ca2+imaging,and microelectrode array technologies in cardiomyocyte models for drug preclinical screening have suffered from issues of low throughput,limited long-term assessment,or inability to synchronously and correlatively analyze electrical and mechanical signals.Here,we develop a high-content,dose-quantitative and time-dependent drug assessment platform based on an electrical-mechanical synchronized(EMS)biosensing system.This microfabricated EMS can record both firing potential(FP)and mechanical beating(MB)signals from cardiomyocytes and extract a variety of characteristic parameters from these two signals(FP–MB)for further analysis.This system was applied to test typical ion channel drugs(lidocaine and isradipine),and the dynamic responses of cardiomyocytes to the tested drugs were recorded and analyzed.The high-throughput characteristics of the system can facilitate simultaneous experiments on a large number of samples.Furthermore,a database of various cardiac drugs can be established by heat map analysis for rapid and effective screening of drugs.The EMS biosensing system is highly promising as a powerful tool for the preclinical development of new medicines.

关键词： electrical consuming patch

Recent progress in functionalized layered double hydroxides and their application in efficient electrocatalytic water oxidation

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Journal of Energy Chemistry 2019年第5期28卷 93-104页

作者： Xiaolong Deng Jinzhao Huang hao wan Fashen Chen Yifan Lin Xijin Xu Renzhi Ma Takayoshi Sasaki School of Physics and Technology University of JinanJinan 250022ShandongChina National Institute for Materials Science (NIMS) Beijing Tsinghua University University of Tokyoin the National Institutefor Research in Inorganic Materials International Center for Materials Nanoarchitectonics (WPI-MANA) National Institute for Materials Science (NIMS)Namiki 1-1Tsukubalbaraki 305-0044Japan Northwestern Polytechnical University Shanghai University Konkuk University Linyi University Beijing Jiaotong University Instituteof Solid State Physics Chinese Academy of Sciences Nanyang TechnologicalUniversity in Singapore

Layered double hydroxides (LDHs), a class of anionic clays consisting of brucite-like host layers and interlayer anions, have been widely investigated in the last decade due to their promising applications in many areas such as catalysis, ion separation and adsorption. Owing to the highly tunable compositi on and uniform distribution of metal cations in the brucite-like layers, as well as the facile exchangeability of intercalated anions, LDHs can be modified and functionalized to form various nanostructures/composites through versatile processes such as anion intercalation and exfoliation, decoration of nanoparticles, selfassembly with other two-dimensional (2D) materials, and controlled growth on conductive supports (e.g., nanowire arrays, nano tubes, 3D foams). In this article, we briefly review the recent advances on both the LDH nano structures and functionalized composites toward the applications in energy conversion, especially for water oxidation.

关键词： Layered double hydroxide Energy conversion Water splitting Functionalization

Evaluating the efficacy and cardiotoxicity of EGFR-TKI AC0010 with a novel multifunctional biosensor

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微系统与纳米工程(英文) 2023年第3期9卷 259-271页

作者： Deming Jiang Xinwei Wei Yuxuan Zhu Yong Qiu Xin Liu Liubing Kong Fengheng Li Jingwen Liu Liujing Zhuang hao wan Kejing Ying Ping wang Biosensor National Special Laboratory Key Laboratory for Biomedical Engineering of Education MinistryDepartment of Biomedical EngineeringZhejiang UniversityHangzhouZhejiang 310027China Innovation Center for Smart Medical Technologies&Devices Binjiang Institute of Zhejiang UniversityZhejiang 310053China Cancer Center Zhejiang UniversityHangzhouZhejiang 310058China College of Pharmaceutical Sciences Zhejiang UniversityHangzhouZhejiang 310058China Department of Gastroenterology Zhejiang University School of Medicine Second Affiliated HospitalHangzhouZhejiang 310009China Department of Respiratory and Critical Medicine Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouChina State Key Laboratory for Sensor Technology Chinese Academy of SciencesShanghai 200050China

Non-small cell lung cancer(NSCLC)is a leading cause of cancer mortality worldwide.Although epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs)have dramatically improved the life expectancy of patients with NSCLC,concerns about TKI-induced cardiotoxicities have increased.AC0010,a novel third-generation TKI,was developed to overcome drug resistance induced by EGFR-T790M mutation.However,the cardiotoxicity of AC0010 remains unclear.To evaluate the efficacy and cardiotoxicity of AC0010,we designed a novel multifunctional biosensor by integrating microelectrodes(MEs)and interdigital electrodes(IDEs)to comprehensively evaluate cell viability,electrophysiological activity,and morphological changes(beating of cardiomyocytes).The multifunctional biosensor can monitor AC0010-induced NSCLC inhibition and cardiotoxicity in a quantitative,label-free,noninvasive,and real-time manner.AC0010 was found to significantly inhibit NCI-H1975(EGFR-L858R/T790M mutation),while weak inhibition was found for A549(wild-type EGFR).Negligible inhibition was found in the viabilities of HFF-1(normal fibroblasts)and cardiomyocytes.With the multifunctional biosensor,we found that 10μM AC0010 significantly affected the extracellular field potential(EFP)and mechanical beating of cardiomyocytes.The amplitude of EFP continuously decreased after AC0010 treatment,while the interval decreased first and then increased.We analyzed the change in the systole time(ST)and diastole time(DT)within a beating interval and found that the DT and DT/beating interval rate decreased within 1 h after AC0010 treatment.This result probably indicated that the relaxation of cardiomyocytes was insufficient,which may further aggravate the dysfunction.Here,we found that AC0010 significantly inhibited EGFR-mutant NSCLC cells and impaired cardiomyocyte function at low concentrations(10μM).This is the first study in which the risk of AC0010-induced cardiotoxicity was evaluated.In addition,novel multifunctional biosensors can comprehensively evaluate the antitu

关键词： cardio TKI impaired

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早期生化检验对糖尿病肾病的诊断效果分析

中国实用医药 2024年第1期19卷 86-88页

作者：万昊昕南昌市第三医院 330009

目的分析早期生化检验对糖尿病肾病的诊断效果。方法选取43例糖尿病肾病患者为观察组,以同期进行常规体检的72例健康人群为对照组。两组均进行α_(1)微球蛋白(α_(1)-MG)、尿素氮(BUN)、视黄醇结合蛋白(RBP)、C反应蛋白(CRP)、胱抑素C(C... 详细信息

目的分析早期生化检验对糖尿病肾病的诊断效果。方法选取43例糖尿病肾病患者为观察组,以同期进行常规体检的72例健康人群为对照组。两组均进行α_(1)微球蛋白(α_(1)-MG)、尿素氮(BUN)、视黄醇结合蛋白(RBP)、C反应蛋白(CRP)、胱抑素C(CysC)、同型半胱氨酸(Hcy)、血清肌酐(SCr)、微量白蛋白(mAlb)等生化指标检验。对比两组生化指标检验结果,分析糖尿病肾病患者生化指标检验的阳性检出率。结果观察组CRP、CysC、α_(1)-MG、BUN、RBP、Hcy、SCr、mAlb水平分别为(11.53±2.05)mg/L、(2.11±0.49)mg/L、(35.16±8.02)mg/L、(13.62±2.15)mmol/L、(85.16±19.43)mg/L、(20.16±3.92)μmol/L、(175.62±15.23)μmol/L、(42.62±10.35)mg/L,均显著高于对照组的(8.95±1.04)mg/L、(0.96±0.12)mg/L、(10.92±3.61)mg/L、(5.21±1.02)mmol/L、(50.36±10.98)mg/L、(13.26±1.28)μmol/L、(123.61±10.25)μmol/L、(21.16±8.26)mg/L,差异有统计学意义(P<0.05)。糖尿病肾病患者CRP、CysC、α_(1)-MG、BUN、RBP、Hcy、SCr、mAlb单独检验及联合检验阳性检出率分别为62.79%、72.09%、37.21%、58.14%、44.19%、69.77%、86.05%、60.47%、97.67%。各项生化检验联合诊断糖尿病肾病患者可取得较高的阳性检出率。结论早期生化检验应用于糖尿病肾病临床诊断中可取得较高的诊断效能。

关键词：糖尿病肾病糖尿病生化检验早期诊断效果