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Add-on perceptual learning on refractive amblyopia in children

International Journal of Ophthalmology(English edition) 2024年第10期17卷 1850-1856页

作者： Heng-Chiao Huang wan-Hua Cho Po-Chiung Fang Pei-Wen Lin Yi-hao Chen Hsiu-Mei Huang Department of Ophthalmology Chang Gung Memorial HospitalChiayi 613TaiwanChina Department of Ophthalmology Chi-Mei Medical CenterTainan 710TaiwanChina Department of Ophthalmology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung City 833TaiwanChina School of Medicine Chang Gung UniversityTaoyuan City 333TaiwanChina

AIM:To evaluate the visual outcomes of standard amblyopic treatment add-on training via perceptual learning in refractive amblyopic children and to identify the risk factors for treatment ***:Retrospective charts were reviewed in children with refractive amblyopia who received standard treatment and add-on Cambridge Visual Stimulator(CAM)*** add-on CAM group that was enrolled had worn full-corrected glasses for at least 2mo before training.A control group received only the standard *** success was defined as best-corrected visual acuity(BCVA)≥20/*** age,sex,initial BCVA,refractive errors,sessions and duration of training,and final BCVA were ***:A total of 209 children(129 children in add-on CAM group and 80 children in control group)were ***-six percent of unilateral and 87%of bilateral amblyopic children achieved treatment *** children with unilateral or bilateral moderate amblyopia,the duration to reach BCVA≥20/25 was significantly shorter in add-on CAM group than in control *** initial BCVA(P<0.001)and high astigmatism(P=0.007)were risk factors for treatment failure after add-on CAM ***,sex,and types of refractive error were not associated with treatment ***:Add-on CAM training is an effective strategy for visual improvement and can shorten the treatment course when the effect of standard treatment is limited in amblyopic children.

关键词： amblyopia amblyopic children add-on Cambridge Visual Stimulator training astigmatism

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Variable Pitch Sliding Mode Control of Wind Turbine Based on Disturbance Observer

Variable Pitch Sliding Mode Control of Wind Turbine Based on...

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第30届中国控制与决策会议

作者： hao wan-jun hao shi-yuan Jia yi-shi Chen xin-jing Cao song-qing Qiao yan-hui Li zhe College of Electronic and Information Engineering Suzhou University of Science and Technology Department of Electrical Engineering Technical University of Denmark College of Mechanical Engineering Suzhou University of Science and Technology

Due to the randomness of the wind speed, the time variability of the wind turbine’s parameters, the nonlinearity of the system and the time delay, the output power of the wind turbine is unstable. In order to improve the dynamic performance of the system in the constant power output operation area, based on the analysis of the research status of variable pitch control of wind power generation system, a sliding mode control scheme based on disturbance observer is proposed. This method not only has the robustness for sliding mode control parameters also has many advantages such as fast response. Adding the disturbance observer is effective to restrain the external disturbance of the system, ensuring the stability of the output power and the motor speed of the wind generator system under the condition of random wind speed disturbance. The results show that the variable pitch sliding mode controller based on disturbance observer has good dynamic performance and robustness to wind speed disturbance, which can effectively improve the pitch control effect of the system.

关键词： wind power generation system pitch angle control disturbance observer sliding mode control

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关于五行的讨论

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北京中医药大学学报 2009年第1期32卷 8-11页

作者：郝万山北京中医药大学基础医学院北京100029

五行是通过"仰观天文,俯察地理,中知人事"的研究方法,揭示出的自然界一年之中气的运动变化规律。五行非五材。五材是指具体的物质、材料、元素。五行是指气的5种运动方式。从物候观察,春季是气的展放运动控制或主导着自然界的生命活动,... 详细信息

五行是通过"仰观天文,俯察地理,中知人事"的研究方法,揭示出的自然界一年之中气的运动变化规律。五行非五材。五材是指具体的物质、材料、元素。五行是指气的5种运动方式。从物候观察,春季是气的展放运动控制或主导着自然界的生命活动,便名以"木"气;夏季是气的上升运动控制或主导着生命活动,便名以"火"气;秋季是气的内收运动控制或主导着生命活动,便名以"金"气;冬季是气的潜降运动控制或主导着生命活动,便名以"水"气;而长夏是气的平稳运动控制或主导着生命活动,便名以"土"气。五行之间,以季节为序,相资生、相养助,叫五行相生;五行之间,以季节相间为序相制约、相抑制,叫五行相克。有相生则不会导致某行的不足,有相克则不会造成某行的太过,从而保证了一年之中气机变化的稳态。经过几十亿年的氤氲衍化,化育了生命世界,所有的生命都被打上了五行的烙印。《内经》把五行和阴阳并列起来,都看成是化育生命的本源。五行学说是古代人类研究大自然气的运动和变化规律的学说,是研究生命起源、生命运动规律的古代自然科学学说。

关键词：五行五材相生相克

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Extracellular vesicles from human urine-derived stem cells delay aging through the transfer of PLAU and TIMP1

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1166-1186页

作者： Shanshan Rao Zehui He Zun wang hao Yin Xiongke Hu Yijuan Tan Tengfei wan hao Zhu Yi Luo Xin wang Hongming Li Zhenxing wang Xinyue Hu Chungu Hong Yiyi wang Mingjie Luo Wei Du Yuxuan Qian Siyuan Tang Hui Xie Chunyuan Chen Department of Orthopedics Movement System Injury and Repair Research CenterXiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Angmedicine Changsha 410008China Xiangya School of Nursing Central South UniversityChangsha 410013China Department of Pediatric Orthopedics Hunan Children’s HospitalUniversity of South ChinaChangsha 410007China Department of Respiratory Medicine Xiangya HospitalCentral South UniversityChangsha 410008China School of Nursing Xinjiang Medical UniversityUrumqiXinjiang 830000China Department of Rehabilitation Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China

Aging increases the risks of various diseases and the vulnerability to *** senescence is a hallmark of aging that contributes greatly to aging and aging-related *** study demonstrates that extracellular vesicles from human urine-derived stem cells(USC-EVs)efficiently inhibit cellular senescence in vitro and in *** intravenous injection of USC-EVs improves cognitive function,increases physical fitness and bone quality,and alleviates aging-related structural changes in different organs of senescence-accelerated mice and natural aging *** anti-aging effects of USC-EVs are not obviously affected by the USC donors’ages,genders,or health *** analysis reveals that USC-EVs are enriched with plasminogen activator urokinase(PLAU)and tissue inhibitor of metalloproteinases 1(TIMP1).These two proteins contribute importantly to the anti-senescent effects of USC-EVs associated with the inhibition of matrix metalloproteinases,cyclin-dependent kinase inhibitor 2A(P16INK4a),and cyclin-dependent kinase inhibitor 1A(P21cip1).These findings suggest a great potential of autologous USC-EVs as a promising anti-aging agent by transferring PLAU and TIMP1 proteins.

关键词： Extracellular vesicles Urine-derived stem cells Cellular senescence Anti-aging PLAU TIMP1 Senescence-accelerated mice Natural aging mice

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β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture

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Bone Research 2024年第2期12卷 302-313页

作者： Jie Huang Tong Wu Yi-Rong Jiang Xuan-Qi Zheng Huan wang hao Liu Hong wang Hui-Jie Leng Dong-Wei Fan wan-Qiong Yuan Chun-Li Song Department of Orthopedics Peking University Third Hospital100191 BeijingChina Beijing Key Laboratory of Spinal Disease 100191 BeijingChina Engineering Research Center of Bone and Joint Precision Medicine 100191 BeijingChina

The autonomic nervous system plays a crucial role in regulating bone metabolism,with sympathetic activation stimulating bone resorption and inhibiting bone *** found that fractures lead to increased sympathetic tone,enhanced osteoclast resorption,decreased osteoblast formation,and thus hastened systemic bone loss in ovariectomized(OVX)***,the combined administration of parathyroid hormone(PTH)and theβ-receptor blocker propranolol dramatically promoted systemic bone formation and osteoporotic fracture healing in OVX *** effect of this treatment is superior to that of treatment with PTH or propranolol *** vitro,the sympathetic neurotransmitter norepinephrine(NE)suppressed PTH-induced osteoblast differentiation and mineralization,which was rescued by ***,NE decreased the PTH-induced expression of Runx2 but enhanced the expression of Rankl and the effect of PTH-stimulated osteoblasts on osteoclastic differentiation,whereas these effects were reversed by ***,PTH increased the expression of the circadian clock gene Bmal1,which was inhibited by NE-βAR ***1 knockdown blocked the rescue effect of propranolol on the NE-induced decrease in PTHstimulated osteoblast *** together,these results suggest that propranolol enhances the anabolic effect of PTH in preventing systemic bone loss following osteoporotic fracture by blocking the negative effects of sympathetic signaling on PTH anabolism.

关键词： blocker metabolism inhibited

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Constraints on smoothness parameter and dark energy using observational H(z) data

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Research in Astronomy and Astrophysics 2011年第2期11卷 125-136页

作者： hao-Ran Yu1,Tian Lan1,hao-Yi wan2,Tong-Jie Zhang1,3 and Bao-Quan wang4 1 Department of Astronomy,Beijing Normal University,Beijing 100875,China 2 Business Office,Beijing Planetarium,Beijing 100044,China 3 Center for High Energy Physics,Peking University,Beijing 100871,China 4 Department of Physics,Dezhou University,Dezhou 253023,China Department of Astronomy Beijing Normal University Business Office Beijing Planetarium

With large-scale homogeneity,the universe is locally inhomogeneous,clustering into stars,galaxies and larger *** property is described by the smoothness parameter α which is defined as the proportion of matter in the form of intergalactic *** we consider the inhomogeneities over a small scale,there should be modifications of the cosmological distances compared to a homogenous *** and Roeder developed a second-order ordinary differential equation（D-R equation） that describes the angular diameter distance-redshift relation for inhomogeneous cosmological ***,we may obtain the D-R equation for observational H（z） data（OHD）.The density-parameter ΩM,the state of dark energy ω,and the smoothness-parameter α are constrained by a set of OHD in a spatially flat XCDM universe as well as a spatially flat XCDM *** using a χ2 minimization method,we get α = 0.81＋0.19-0.20 and ΩM = 0.32＋0.12-0.06 at the 1σ confidence *** we assume a Gaussian prior of ΩM = 0.26 ± 0.1,we get α = 0.93＋0.07-0.19 and ΩM = 0.31＋*** the XCDM model,α is constrained to α≥ 0.80 but ω is weakly constrained around-1,where ω describes the equation of state of the dark energy（pX = ωρX）.We conclude that OHD constrains the smoothness parameter more effectively than the data of SNe Ia and compact radio sources.

关键词： cosmology -- dark energy -- cosmological parameters

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球体图像视觉伺服投影距离的非线性观测

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华南理工大学学报（自然科学版） 2018年第3期46卷 16-22页

作者：叶国强李伟光万好华南理工大学机械与汽车工程学院广东广州510640

球体图像视觉伺服由于不变视觉特征的设计可获得良好的运动解耦特性,但球体特征雅可比矩阵的计算依赖于若干未知三维参数,即被观测目标点的三维投影距离.针对球体图像视觉伺服特征雅可比矩阵未知三维参数的在线估计问题,文中提出了一种... 详细信息

球体图像视觉伺服由于不变视觉特征的设计可获得良好的运动解耦特性,但球体特征雅可比矩阵的计算依赖于若干未知三维参数,即被观测目标点的三维投影距离.针对球体图像视觉伺服特征雅可比矩阵未知三维参数的在线估计问题,文中提出了一种结合线性时变系统持续激励引理的投影距离非线性观测算法.首先结合统一投影模型对球体特征运动学进行分析,然后根据持续激励引理设计系统状态的在线更新法则,在已知摄像机运动及目标图像特征的情况下实现对未知三维投影距离的在线观测,并对观测器稳定性进行了分析.试验结果表明,该算法可有效实现对三维投影距离的在线估计,与基于深度观测的间接估计方法相比具有更优的估计精度及观测动态特性,能有效地提高球体图像视觉伺服控制的动态收敛特性.

关键词：视觉伺服特征雅可比持续激励引理非线性观测

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Al掺杂对Li(Al_yCo_(1-y))O_2材料结构的影响

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高等学校化学学报 2001年第2期22卷 175-178页

作者：郝万君陈岗史延慧吉林大学材料科学系长春130023

报道了在 80 0℃烧结制备的新型锂二次电池正极材料Li(AlyCo1-y)O2 (y =0 ,0 .11)的X射线衍射结果和由此而揭示的结构演化过程 .研究表明 ,y≤ 0 .5时 ,材料呈单相 ,0 .6≤ y≤ 0 .9时 ,材料呈两相[Li(AlyCo1-y)O2 ,γ LiAlO2 ]共存状态... 详细信息

报道了在 80 0℃烧结制备的新型锂二次电池正极材料Li(AlyCo1-y)O2 (y =0 ,0 .11)的X射线衍射结果和由此而揭示的结构演化过程 .研究表明 ,y≤ 0 .5时 ,材料呈单相 ,0 .6≤ y≤ 0 .9时 ,材料呈两相[Li(AlyCo1-y)O2 ,γ LiAlO2 ]共存状态 ,y =1时 ,材料又呈单相 ,为γ LiAlO2 相 .Li(AlyCo1-y)O2 材料中y值的上限即Al的最大固溶度在 0 .5左右 .在单相区 (y≤ 0 .5 ) ,随着Al掺杂的增多 ,Li(AlyCo1-y)O2 材料晶格结构参数发生变化 ,a轴缩短 ,c轴变长 ,c/a比基本呈线性增加 ,材料的层状属性更加明显 .

关键词：正极材料 XRD 结构锂二次电池钴酸锂铝掺杂

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完善刑事诉讼中证人出庭制度——欧洲人权法院的判例及其启示

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烟台大学学报（哲学社会科学版） 2020年第1期33卷 33-44页

作者：郝万爽北京大学法学院北京100871

欧洲人权法院相关判例对刑事诉讼中证人出庭的案件范围、出庭的作证方式以及出庭的保障措施作出了比较详尽的规定。我国2012年《刑事诉讼法》虽然规定了强制关键证人出庭制度,但实践中一直存在的关键证人出庭率低的问题依然没有得到解... 详细信息

欧洲人权法院相关判例对刑事诉讼中证人出庭的案件范围、出庭的作证方式以及出庭的保障措施作出了比较详尽的规定。我国2012年《刑事诉讼法》虽然规定了强制关键证人出庭制度,但实践中一直存在的关键证人出庭率低的问题依然没有得到解决。学者们普遍认为这是由于立法将决定关键证人出庭与否的裁量权赋予了法院。而透过欧洲人权法院的判例,发现立法真正的问题在于对质权的缺失、审前证言笔录适用情形不明确、匿名作证方式不完善及强制关键证人出庭的配套措施不足。

关键词：欧洲人权法院证人出庭

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布尔台煤矿综放工作面矿压显现规律研究

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煤炭工程 2022年第12期54卷 78-83页

作者：郝万东中国煤炭科工集团太原研究院有限公司山西太原030006

针对神东矿区特大型矿井放顶煤开采矿压监测研究不足的问题,以布尔台煤矿放顶煤工作面为背景,对该条件下的矿压显现规律进行了现场实测研究。巷道变形监测显示,辅运巷顶板位移累计下沉量为100~130mm,正帮帮鼓量150mm,副帮帮鼓量累计100m... 详细信息

针对神东矿区特大型矿井放顶煤开采矿压监测研究不足的问题,以布尔台煤矿放顶煤工作面为背景,对该条件下的矿压显现规律进行了现场实测研究。巷道变形监测显示,辅运巷顶板位移累计下沉量为100~130mm,正帮帮鼓量150mm,副帮帮鼓量累计100m,顶板离层最大为5mm,巷道变形程度可控;围岩应力结果显示,超前支承压力影响范围大于75m,须严格执行超前锚杆索支护;工作面液压支架受力监测结果显示,初次来压步距为71.3m,来压持续长度为16.9m,周期来压平均步距为14.8m,来压距离约为9m;微震监测结果显示,微震事件多聚集在机头和机尾附近,微震大能量事件聚集在侧向采空区煤柱附近,工作面推进速度越快,微震总能量越大,保持工作面匀速开采有利于工作面矿压治理。该研究结果可为高产高效放顶煤开采矿井矿压防治提供借鉴参考。

关键词：神东矿区综放工作面矿压显现微震

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