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Communications in Theoretical Physics 2024年第1期76卷 76-81页

作者： Cheng Xu Zhen-hao Yang Xiao-Mei kuang Rui-Hong Yue Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou225009China

The scalar-free black hole could be unstable against the scalar field perturbation when it is coupled to a Gauss–Bonnet(GB)invariant in a special form.It is known that the tachyonic instability in this scenario is triggered by the sufficiently strong GB coupling.In this paper,we focus on the time domain analysis of massive scalar field perturbation around the Schwarzschild de-Sitter black hole in Einstein-scalar–Gauss–Bonnet gravity.By analyzing the scalar field propagation,we find that the scalar field will finally grow when the GB coupling is large enough.This could lead to the instability of the background black hole.Furthermore,we demonstrate how the mass of the scalar field and the GB coupling strength affect the onset of tachyonic instability.

关键词： black hole perturbation scalar-Einstein-Gauss-Bonnet gravity time domain evolution me

Estimation-free spatial-domain image reconstruction of structured illumination microscopy

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 45-58页

作者： Xiaoyan Li Shijie Tu Yile Sun Yubing Han Xiang hao Cuifang kuang Xu Liu State Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and Engineering Zhejiang University Hangzhou 310027P.R.China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311200 P.R.China Collaborative Innovation Center of Extreme Optics Shanxi University TaiyuanShanxi 030006P.R.China A dvanced Biomedical Imaging Facility-Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology WuhanHubei 430074P.R.China

Structured illumination microscopy(SIM)achieves super-resolution(SR)by modulating the high-frequency information of the sample into the passband of the optical system and subsequent image reconstruction.The traditional Wiener-filtering-based reconstruction algorithm operates in the Fourier domain,it requires prior knowledge of the sinusoidal illumination patterns which makes the time-consuming procedure of parameter estimation to raw datasets necessary,besides,the parameter estimation is sensitive to noise or aberration-induced pattern distortion which leads to reconstruction artifacts.Here,we propose a spatial-domain image reconstruction method that does not require parameter estimation but calculates patterns from raw datasets,and a reconstructed image can be obtained just by calculating the spatial covariance of differential calculated patterns and differential filtered datasets(the notch filtering operation is performed to the raw datasets for attenuating and compensating the optical transfer function(OTF)).Experiments on reconstructing raw datasets including nonbiological,biological,and simulated samples demonstrate that our method has SR capability,high reconstruction speed,and high robustness to aberration and noise.

关键词： Structured illumination microscopy image reconstruction spatial domain digital micromirror device(DMD)

TRIM21-dependent ultrasmall chiral gold nanoparticles for preventing microglia senescence against Alzheimer's disease

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Science China Chemistry 2024年第4期67卷 1360-1372页

作者： Meiru Lu Changlong hao Liguang Xu Feng Yu Jiwei Jiang Yanli Wang Jun Xu Hua kuang Chuanlai Xu Maozhong Sun International Joint Research Laboratory for Biointerface and Biodetection State Key Laboratory of Food Science and ResourcesSchool of Food Science and TechnologyJiangnan UniversityWuxi 214122China Institute of Life Sciences Jiangsu UniversityZhenjiang 212013China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China National Clinical Research Center for Neurological Diseases Beijing 100070China

Tripartite motif 21(TRIM21)is an E3 ubiquitin ligase that shows great promise for protein degradation through ubiquitination.Here,ultrasmall chiral gold nanoparticles(D-or L-NPs)modified by D-or L-glutathione ligands were fabricated.After conjugated with an NLR family pyrin domain-containing protein 3(NLRP3)antibody(D-NP-a NLRP3 or L-NP-a NLRP3),DNP-a NLRP3 showed effective delivery efficiency of the antibody into microglia and prevented Aβ-mediated microglia senescence,and p16^(ink4a),a marker of senescence,in the microglia was reduced by 90.3%±7.8% while L-NP-a NLRP3 decreased by 48.01%±3.1%.Mechanistic investigations revealed that the D-NP-a NLRP3((1.5±0.3)×10^(7)M^(-1))exhibited sixteen-fold larger binding affinity to transmembrane glycoprotein SLC3A2 than L-type((9.5±2.7)×10^(5)M^(-1)),which led to a high efficiency of antibody delivery and TRIM21-dependent NLRP3 degradation.Notably,the blood-brain barrier(BBB)-crossing ability of chiral NP-a NLRP3 as well as NLRP3 degradation was demonstrated in vivo.The APP/PS1 Alzheimer's disease(AD)model mice experiments exhibited a reduction of 89.7%±6.8% for the NLRP3 protein and 84.2±7.5% for p16^(ink4a)following the intravenous administration of D-NP-a NLRP3 once a week for 60 days.Furthermore,the levels of the AD markers Aβ and phosphorylatedTau in the brains were reduced by 86.2%±8.2% and 81.6%±9.1%;these were 2.1-fold and 1.9-fold higher than those treated with L-NP-a NLRP3,respectively.The studies provide a method to rescue AD-like pathologies and prevent senescence.

关键词： chiral gold nanoparticles amyloid-β NLRP3 TRIM21 senescence Alzheimer's disease

RDH12-associated retinal degeneration caused by a homozygous pathogenic variant of 146C>T and literature review

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 311-316页

作者： Jin Li Yi-Qun Hu Hong-Bo Cheng Ting Wang Long-hao kuang Tao Huang Xiao-He Yan Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChina

AIM:To describe the clinical,electrophysiological,and genetic features of an unusual case with an RDH12 homozygous pathogenic variant and reviewed the characteristics of the patients reported with the same variant.METHODS:The patient underwent a complete ophthalmologic examination including best-corrected visual acuity,anterior segment and dilated fundus,visual field,spectral-domain optical coherence tomography(OCT)and electroretinogram(ERG).The retinal disease panel genes were sequenced through chip capture high-throughput sequencing and Sanger sequencing was used to confirm the result.Then we reviewed the characteristics of the patients reported with the same variant.RESULTS:A 30-year male presented with severe early retinal degeneration who complained night blindness,decreased visual acuity,vitreous floaters and amaurosis fugax.The best corrected vision was 0.04 OD and 0.12 OS,respectively.The fundus photo and OCT showed bilateral macular atrophy but larger areas of macular atrophy in the left eye.Autofluorescence shows bilateral symmetrical hypo-autofluorescence.ERG revealed that the amplitudes of a-and b-wave were severely decreased.Multifocal ERG showed decreased amplitudes in the local macular area.A homozygous missense variant c.146C>T(chr14:68191267)was found.The clinical characteristics of a total of 13 patients reported with the same pathologic variant varied.CONCLUSION:An unusual patient with a homozygous pathogenic variant in the c.146C>T of RDH12 which causes late-onset and asymmetric retinal degeneration are reported.The clinical manifestations of the patient with multimodal retinal imaging and functional examinations have enriched our understanding of this disease.

关键词： RDH12 gene inherited retinal degeneration homozygous pathogenic variant clinical feature multi-mode imaging

Ginsenoside Rg5 enhances the radiosensitivity of lung adenocarcinoma via reducing HSP90-CDC37 interaction and promoting client protein degradation

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Journal of Pharmaceutical Analysis 2023年第11期13卷 1296-1308页

作者： Hansong Bai Jiahua Lyu Xinyu Nie hao kuang Long Liang Hongyuan Jia Shijie Zhou Churong Li Tao Li Sichuan Cancer Hospital Institute Sichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu610041China School of Medicine University of Electronic Science and Technology of ChinaChengdu610054China School of Clinical Medicine Southwest Medical UniversityLuzhouSichuan646000China State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy West China HospitalSichuan UniversityChengdu610041China

Ginsenoside Rg5 is a rare ginsenoside showing promising tumor-suppressive effects.This study aimed to explore its radio-sensitizing effects and the underlying mechanisms.Human lung adenocarcinoma cell lines A549 and Calu-3 were used for in vitro and in vivo analysis.Bioinformatic molecular docking prediction and following validation by surface plasmon resonance(SPR)technology,cellular thermal shift assay(CETSA),and isothermal titration calorimetry(ITC)were conducted to explore the binding between ginsenoside Rg5 and 90 kD heat shock protein alpha(HSP90a).The effects of ginsenoside Rg5 on HSP90-cell division cycle 37(CDC37)interaction,the client protein stability,and the downstream regulations were further explored.Results showed that ginsenoside Rg5 could induce cell-cycle arrest at the G1 phase and enhance irradiationinduced cell apoptosis.It could bind to HSP90a with a high affinity,but the affinity was drastically decreased by HSP90a Y61A mutation.Co-immunoprecipitation(Co-IP)and ITC assays confirmed that ginsenoside Rg5 disrupts the HSP90-CDC37 interaction in a dose-dependent manner.It reduced irradiation-induced upregulation of the HSP90-CDC37 client proteins,including SRC,CDK4,RAF1,and ULK1 in A549 cell-derived xenograft(CDX)tumors.Ginsenoside Rg5 or MRT67307(an IKKε/TBK1 inhibitor)pretreatment suppressed irradiation-induced elevation of the LC3-II/b ratio and restored irradiation-induced downregulation of p62 expression.In A549 CDX tumors,ginsenoside Rg5 treatment suppressed LC3 expression and enhanced irradiation-induced DNA damage.In conclusion,ginsenoside Rg5 may be a potential radiosensitizer for lung adenocarcinoma.It interacts with HSP90a and reduces the binding between HSP90 and CDC37,thereby increasing the ubiquitin-mediated proteasomal degradation of the HSP90-CDC37 client proteins.

关键词： Ginsenoside Rg5 Lung adenocarcinoma Radiotherapy HSP90 CDC37

Nonexistence of quantum black and white hole horizons in an improved dynamic approach

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Wen-Cong Gan Xiao-Mei kuang Zhen-hao Yang Yun-Gui Gong An-Zhong Wang Bin Wang College of Physics and Communication Electronics Jiangxi Normal University GCAP-CASPER Physics Department Baylor University Institute for Theoretical Physics & Cosmology Zhejiang University of Technology United Center for Gravitational Wave Physics (UCGWP) Zhejiang University of Technology Center for Gravitation and Cosmology College of Physical Science and Technology Yangzhou University Department of Physics School of Physical Science and Technology Ningbo University School of Aeronautics and Astronautics Shanghai Jiao Tong University

In this paper, we study the quantum geometric effects near the locations where classical black hole horizons used to appear in Einstein’s classical theory, within the framework of an improved dynamic approach, in which the internal region of a black hole is modeled by the Kantowski-Sachs (KS) spacetime and the two polymerization parameters are functions of the phase space variables. Our detailed analysis shows that the effects are so strong that black and white hole horizons of the effective quantum theory do not exist at all and instead are replaced by transition surfaces, across which the metric coefficients and their inverses are smooth and remain finite, as are the corresponding curvatures, including the Kretschmann scalar. These surfaces always separate trapped regions from anti-trapped regions. The number of such surfaces is infinite, so the corresponding KS spacetimes become geodesically complete, and no black and white hole-like structures exist in this scheme.

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Cholesterol metabolism and tumor radiotherapy

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Journal of Nutritional Oncology 2023年第3期8卷 121-128页

作者： hao kuang Jia-Hua Lyu Tao Li School of Medicine University of Electronic Science and Technology of ChinaChengdu 610054SichuanChina Department of Radiotherapy Sichuan Cancer Hospital&InstituteSichuan Cancer CenterAffiliate Cancer Hospital of University of Electronic Science and Technology of ChinaChengdu 610041SichuanChina

Cholesterol is a lipid that is an essential component of the membrane structure in mammals.Cholesterol homeostasis regulates vital activities of individual cells and governs the overall function of the mammalian body.Cholesterol is mainly obtained through the biosynthesis of endogenous cholesterol and the intake of exogenous cholesterol.Cholesterol metabolism in tumor cells is abnormally active,and cholesterol and its metabolites(precursors and derivatives)play important roles in cancer proliferation,survival,invasion,metastasis,and the resistance to radiation.Preclinical studies have indicated that blocking cholesterol synthesis and uptake can reduce tumor progression and improve the response to anticancer treatment.Therapeutic strategies that target cholesterol synthesis,reduce plasma cholesterol levels,and prevent cholesterol esterification represent promising ways to improve the clinical outcome of cancer patients.

关键词： Cancer Cholesterol metabolism Radiotherapy Radioresistance

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数字孪生赋能预制菜冷链发展的研究进展

现代食品科技 2024年第6期40卷 356-363页

作者：匡红云郝皓游世胜苏醒上海市逆向物流与供应链协同创新中心上海第二工业大学上海201209 上海第二工业大学经济与管理学院上海201209 上海艾伦物流有限公司上海201800

疫情、宅经济助推预制菜所代表的“便捷化餐饮”新消费潮流。数字技术催生新的情景应用和价值创造,推动要素、流程和组织管理的创新,赋能产业升级。该研究分析我国预制菜冷链供应链中存在的产地预冷缺乏、信息要素不流通问题,比如冷链... 详细信息

疫情、宅经济助推预制菜所代表的“便捷化餐饮”新消费潮流。数字技术催生新的情景应用和价值创造,推动要素、流程和组织管理的创新,赋能产业升级。该研究分析我国预制菜冷链供应链中存在的产地预冷缺乏、信息要素不流通问题,比如冷链配套设施不足、冷链操作不规范、最后一公里配送及销售损耗。数字孪生模型可模拟和预测预制菜在冷链过程中的质量变化,引入物联网和区块链等技术后可实现产品的运输监控和追踪溯源。该研究提出利用数字孪生技术搭建预制菜的数字化冷链追踪溯源系统,实施预制菜冷链供应链的供应链、数字链、信任链和利益链的“链条化”发展,尝试探索一条适合我国预制菜发展的数字化道路,助力预制菜与冷链供应链的数字化转型和产业发展。

关键词：预制菜冷链供应链数字孪生数字化

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Ultrafast magneto-optical dynamics in nickel(111)single crystal studied by the integration of ultrafast reflectivity and polarimetry probes

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Chinese Physics B 2024年第3期33卷 65-69页

作者：匡皓余军潇陈洁 H.E.Elsayed-Ali 李润泽 Peter M.Rentzepis School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Center for Transformative Science ShanghaiTech UniversityShanghai 201210China Center for Ultrafast Science and Technology Key Laboratory for Laser Plasmas (Ministry of Education)Collaborative Innovation Center of IFSA (CICIFSA)School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Department of Electrical and Computer Engineering Old Dominion UniversityNorfolkVirginia 23529USA Department of Electrical and Computer Engineering Texas A&M UniversityCollege StationTexas 77843USA

With the integration of ultrafast reflectivity and polarimetry probes,we observed carrier relaxation and spin dynamics induced by ultrafast laser excitation of Ni(111)single crystals.The carrier relaxation time within the linear excitation range reveals that electron-phonon coupling and dissipation of photon energy into the bulk of the crystal take tens of picoseconds.On the other hand,the observed spin dynamics indicate a longer time of about 120 ps.To further understand how the lattice degree of freedom is coupled with these dynamics may require the integration of an ultrafast diffraction probe.

关键词： ultrafast spin dynamics non-equilibrium dynamics multi-probe

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多分支特征映射的遥感图像目标检测算法

计算机科学与探索 2024年第6期18卷 1543-1555页

作者：闵锋况永刚郝琳琳彭伟明武汉工程大学计算机科学与工程学院智能机器人湖北省重点实验室武汉430205

由于遥感图像具有背景复杂、目标较小且密集、尺度连续变化大等特点,通用目标检测器难以较好地适应,导致检测效果不佳。针对以上问题,基于YOLOv5s模型,提出一种多分支特征映射的遥感图像目标检测算法。首先,利用结构重参数化技术设计一... 详细信息

由于遥感图像具有背景复杂、目标较小且密集、尺度连续变化大等特点,通用目标检测器难以较好地适应,导致检测效果不佳。针对以上问题,基于YOLOv5s模型,提出一种多分支特征映射的遥感图像目标检测算法。首先,利用结构重参数化技术设计一种结合门控通道转换的RepVGG模块,采用其串联结构替换原主干网络的C3模块,聚合全局上下文信息,增强特征表达和特征提取能力;其次,使用自适应指数加权池化方法以及逆过程重构特征融合网络的采样方式,最大化地保留特征信息,改善较小目标的检测效果;最后,引入EIoU和Focal Loss组合作为模型的损失函数,优化预测框的回归速率以及难易样本的损失权重分配,进一步提高定位精度。在DIOR和NWPU VHR-10数据集上的实验结果表明,提出算法的平均精度均值分别达到92.2%、92.5%,较YOLOv5s分别提高了3.5个百分点、5.6个百分点,达到了更好的检测效果,同时实时性也满足实际场景下的遥感图像目标检测。

关键词：遥感图像结构重参数化门控通道转换采样方式损失权重分配