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Improved oxygen electrocatalysis at Fe N4 and Co N4 sites via construction of axial coordination

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Chinese Chemical Letters 2025年第2期36卷 482-487页

作者： Ze Zhang Lei Yang Jin-Ru Liu hao hu Jian-Li Mi Chao Su Bei-Bei Xiao Zhi-Min Ao School of Energy and Power Engineering Jiangsu University of Science and Technology Institute for Computation in Molecular and Materials Science School of Chemistry and Chemical Engineering Nanjing University of Science and Technology Institute for Advanced Materials School of Materials Science and Engineering Jiangsu University Advanced Interdisciplinary Institute of Environment and Ecology Beijing Normal University

The quest for efficient and durable catalysts using abundant resources has garnered significant interest in the field of bifunctional oxygen *** this contribution,we have designed a FeN4or CoN4embedded graphene-based bilayer as active layer and TMC3or TMN3doped graphene as supporting layer,named as FeN4/TMC3or FeN4/TMN3and CoN4/TMC3or CoN4/TMN3,wherein TM strands for transition *** on density functional theory calculations,our results demonstrate that the interaction formed between dual metal atoms in the bilayer interspace leads to the coordination environment altered from flat four-coordination to spatial five-coordination,further stabilizing the bilayer structure and impairing its affinity toward the O-containing *** to thermodynamic analysis,the bilayers of CoN4/CoN3,FeN4/FeC3,FeN4/CoC3,FeN4/NiC3,FeN4/ZnC3,FeN4/FeN3,FeN4/CrN3and FeN4/ZnN3are attractively promising for bifunctional oxygen electrocatalysis due to the small overpotential differenceΔη between oxygen reduction and oxygen evolution that are less than 1 *** functional theory calculations combined with machine learning analysis directly identify the key role played by the interbinding formed between bilayers,that boosts catalytic activity,which establishes a predictable framework for a fast screen for graphene-based bilayer vertical *** work opens up a new path for designing the efficient electrocatalysts via modification of coordination environment.

关键词： Density functional theory Machine learning Oxygen electrocatalysis Thermodynamic analysis

Lipid levels and insulin resistance markers in patients with colorectal cancer:Propensity score matching analysis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 130-142页

作者： Ren-hao hu Dong-Yi Yan Ke-hui Zhang Di Zhang Xi-Mao Cui Xiao-hua Jiang Shun Zhang Department of Gastrointestinal Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China School of Medicine Tongji UniversityShanghai 200092China Department of Emergency Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

BACKGROUND Colorectal cancer(CRC)is a prevalent malignant neoplasm characterized by subtle early *** To investigate the correlation among serum lipid profiles,the triglyceride-glucose(TyG)index,and the atherosclerotic index(AI)in patients with ***,it explored the clinical diagnostic utility of combining serum lipids with cancer antigens in the context of *** A retrospective analysis encompassed 277 patients with CRC and 1034 healthy *** Following propensity score matching,patients with CRC exhibited significantly reduced levels of serum triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol(LDL-C),as well as a diminished TyG ***,they displayed elevated AI levels compared to their healthy *** in advanced stages exhibited lower serum levels of TG,TC,and LDL-C compared to those in early *** with positive lymph node metastasis demonstrated reduced levels of TG,LDL-C,and the TyG *** operating characteristic analysis revealed that the combination of the TyG index,carcinoembryonic antigen,and carbohydrate antigen 19-9 yielded the highest positive prediction rate for CRC at 75.3%.CONCLUSION Preoperative serum lipid profiles exhibit a robust association with patients with *** concurrent assessment of multiple serum lipids and cancer antigens effectively enhances the diagnostic accuracy for CRC.

关键词： Colorectal cancer Serum lipids Triglyceride-glucose index Atherosclerotic index Diagnostic marker

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新型二维声子晶体带隙特性及调控方法研究

大连理工大学学报 2025年第1期65卷 48-55页

作者：胡启国胡皓魏晨胡豁然重庆交通大学机电与车辆工程学院重庆400074 国网重庆市电力公司信息通信分公司重庆401120

为拓宽声子晶体弹性波带隙,提出一种关于基体双侧对称的声子晶体结构模型.采用有限元法计算了该声子晶体的能带结构和本征模态,基于局域共振机理深入分析了其带隙的形成机理,通过改变几何参数及施加等轴预拉伸应变的方法对该声子晶体的... 详细信息

为拓宽声子晶体弹性波带隙,提出一种关于基体双侧对称的声子晶体结构模型.采用有限元法计算了该声子晶体的能带结构和本征模态,基于局域共振机理深入分析了其带隙的形成机理,通过改变几何参数及施加等轴预拉伸应变的方法对该声子晶体的带隙进行被动调控与主动调控.仿真结果表明:所提声子晶体结构基体中的长波行波与振子的谐振相互耦合作用产生一条局域共振带隙,通过优化几何参数可以获得起始频率更低的宽频带隙,对结构施加等轴预拉伸应变可以有效拓宽带隙且带隙宽度随着预拉伸应变的增大而变宽.研究结果为声子晶体的带隙主动调控提供了方案,为结构减振降噪提供了新思路.

关键词：声子晶体带隙特性带隙调控预拉伸应变

考虑绿证-阶梯碳双向交互与碳捕集的综合能源系统低碳经济调度

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电力自动化设备 2025年第2期45卷 69-77页

作者：郝丹宁胡志坚谈竹奎李天格王扬胡号邓卓武汉大学电气与自动化学院湖北武汉430072 贵州电网有限责任公司电力科学研究院贵州贵阳550005

完善绿证市场与碳市场的互动机制有利于提升综合能源系统的低碳经济运行水平。为此,提出一种考虑绿证-阶梯碳双向交互与碳捕集的综合能源系统低碳经济调度策略。引入绿证交易机制与阶梯式碳交易机制,通过挖掘绿证所蕴含的低碳属性价值,... 详细信息

完善绿证市场与碳市场的互动机制有利于提升综合能源系统的低碳经济运行水平。为此,提出一种考虑绿证-阶梯碳双向交互与碳捕集的综合能源系统低碳经济调度策略。引入绿证交易机制与阶梯式碳交易机制,通过挖掘绿证所蕴含的低碳属性价值,构建绿证-阶梯碳双向交互模型,以绿证获得量和碳排放权交易量为交互媒介联动绿证市场与碳市场;建立含储液罐的碳捕集电厂综合灵活运行模型,以扩大风电的上网空间;以系统综合运行成本最小为优化目标,设置多个运行场景对所提调度策略的有效性进行对比验证。算例结果表明,所提策略能够改善系统的用能结构,有效提高系统的风电消纳能力与低碳经济效益。

关键词：绿证交易阶梯式碳交易碳捕集电厂综合能源系统低碳经济调度

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多路径监测下的气体泄漏源识别定位方法研究

安全与环境学报 2025年第2期25卷 674-684页

作者：孟戈胡浩武汉工程大学土木工程与建筑学院武汉430074 中国科学院武汉岩土力学研究所岩土力学与工程国家重点实验室武汉430071

危险气体泄漏极易引起严重的安全事故。开路式激光探测仪可以实现多条路径下的泄漏浓度监测,但无法实现对泄漏源进行精确定位。另外,有效的监测数据样本受外界环境、有效监测距离及泄漏源强度影响。因此,以露天的油气联合站场天然气泄... 详细信息

危险气体泄漏极易引起严重的安全事故。开路式激光探测仪可以实现多条路径下的泄漏浓度监测,但无法实现对泄漏源进行精确定位。另外,有效的监测数据样本受外界环境、有效监测距离及泄漏源强度影响。因此,以露天的油气联合站场天然气泄漏为对象开展气体泄漏监测及反演定位研究。首先,采用高精度三维超声风速仪对站场进行气象监测并绘制风场羽流轮廓。接着,根据不同风场羽流数据,建立不同风场下的设备泄漏场概率。选取两个典型的泄漏源,并控制不同的泄漏流量。利用基于激光色散光谱技术的开路式激光甲烷探测仪在站场区域进行合理布设。通过建立的蒙特卡洛-贝叶斯反演定位模型对路径上气体泄漏体积分数数据进行处理,得到泄漏源的位置及量化泄漏强度。结果表明,基于泄漏场风险概率分布的监测布设方案在高、中、低不同体积分数下均能有效响应并且在2 m监测范围的监测数据样本更有参考性。在有效的监测数据样本基础上,计算出的泄漏源定位误差结果在2 m以内并且泄漏源强在相关置信区间内。通过对监测及定位结果进行分析,验证了本模型及方法的合理性,可解决多路径体积分数监测下“线”到“点”的定位问题,更好满足油气联合站场泄漏事故的监测和应急响应要求。

关键词：安全工程油气联合站场泄漏监测开路式激光探测仪反演定位

New perspectives on DNA methylation modifications in ocular diseases

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 340-350页

作者： Fei-Fei Zong Da-Dong Jia Guang-Kun huang Meng Pan hao hu Shi-Yi Song Liang Xiao Ru-Weng Wang Liang Liang The First College of Clinical Medical Science China Three Gorges UniversityDepartment of PathologyYichang Central People’s HospitalYichang 443003Hubei ProvinceChina The Second People’s Hospital of China Three Gorges University the Second People’s Hospital of YichangYichang 443000Hubei ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Shaanxi University of Chinese Medicine Basic Medical CollegeXianyang 712046Shaanxi ProvinceChina

The methylation of DNA is a prevalent epigenetic modification that plays a crucial role in the pathological progression of ocular *** methylation can regulate gene expression,thereby affecting cell function and signal *** diseases are a kind of complex diseases,and their pathogenesis involves many factors such as genetic,environmental and individual *** addition,inflammation,oxidative stress and lipid metabolism,which abnormal DNA methylation is closely related to,are also considered to be major factors in eye *** current understanding of DNA methylation in eye diseases is becoming more complex and *** addition to the simple suppression of gene expression by hypermethylation,factors such as hypomethylation or demethylation,DNA methylation in non-promoter regions,interactions with other epigenetic modifications,and dynamic changes in DNA methylation must also be ***,although some genes are at abnormal methylation levels,their expression is not significantly changed,which indirectly reflects the complexity of gene *** review aims to summarize and compare some relevant studies,and provide with new ideas and methods for the prevention and treatment of different eye diseases,such as glaucoma,retinoblastoma,and diabetic retinopathy.

关键词： DNA methylation modification epigenetic glaucoma retinoblastoma diabetic retinopathy methylase inhibitors

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港口岸电系统部署规划技术与运营方法综述

电力系统自动化 2025年第3期49卷 42-59页

作者：戴磊王玉冰郭思清胡昊方斯顿海洋工程全国重点实验室(上海交通大学) 上海市200240 重庆大学电气工程学院重庆市400074

岸电系统通过关闭停靠船舶发电设备来降低港口区域的排放,是港口能源-交通融合的中枢装备,其运行和规划对未来港口综合能源系统实现“碳中和”目标具有重要作用。为厘清当前研究现状并指出制约岸电系统发展的瓶颈问题,从岸电系统的环境... 详细信息

岸电系统通过关闭停靠船舶发电设备来降低港口区域的排放,是港口能源-交通融合的中枢装备,其运行和规划对未来港口综合能源系统实现“碳中和”目标具有重要作用。为厘清当前研究现状并指出制约岸电系统发展的瓶颈问题,从岸电系统的环境效益评估、岸电系统的技术标准及其部署方案、岸电系统政策规划及运营策略3个方面对港口岸电系统进行综述。分析表明,岸电系统在港口绿色发展中起关键作用,但目前岸电系统的安装率与使用率呈现较大矛盾。针对岸电系统的未来发展,提出岸电全生命周期规划、岸电系统能源-交通融合管理、岸电系统多方主体运行管理3项未来发展重点。

关键词：岸电系统港口碳减排能源-交通融合环境效益可再生能源

抗阻运动诱导骨骼肌释放鸢尾素并改善2型糖尿病大鼠骨髓内皮祖细胞功能

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中国病理生理杂志 2025年第1期41卷 19-27页

作者：寇猛胡好张勇陈亚东安徽工程大学体育学院安徽芜湖241000 合肥师范学院体育科学学院安徽合肥230061

目的:观察抗阻运动对2型糖尿病大鼠模型内皮祖细胞功能的影响并探讨肌因子鸢尾素在其间的作用机制。方法:40只6周龄健康雄性SD大鼠,取10只作为对照组,其余用高脂高糖饲料喂养联合链脲佐菌素腹腔注射进行糖尿病造模后随机分为模型组和模... 详细信息

目的:观察抗阻运动对2型糖尿病大鼠模型内皮祖细胞功能的影响并探讨肌因子鸢尾素在其间的作用机制。方法:40只6周龄健康雄性SD大鼠,取10只作为对照组,其余用高脂高糖饲料喂养联合链脲佐菌素腹腔注射进行糖尿病造模后随机分为模型组和模型运动组,每组15只。对照组和模型组动物于鼠笼内安静饲养,模型运动组进行12周(3次/周)尾部负重爬梯训练。末次训练后72 h,分离血浆、腓肠肌和股骨,测定各组织鸢尾素含量以及腓肠肌和股骨含纤连蛋白Ⅲ型结构域蛋白5(FNDC5)mRNA和蛋白表达量;分离培养骨髓内皮祖细胞,经外源性鸢尾素处理48 h后,利用CCK-8法、黏附实验分别检测细胞活力和黏附能力,通过裸鼠颈动脉损伤模型检测内皮修复能力,Western blot法检测磷脂酰肌醇3-激酶(PI3-K)/Akt/内皮型一氧化氮合酶(eNOS)信号通路蛋白的表达量。结果:(1)在体实验:与对照组比较,模型组血浆、腓肠肌和股骨鸢尾素含量以及腓肠肌FNDC5 mRNA和蛋白表达量降低(P0.05)。(2)细胞实验:①内皮祖细胞未经鸢尾素处理:与对照组比较,模型组内皮祖细胞活力、黏附功能以及内皮损伤修复能力降低(P<0.05),PI3-K、Akt、eNOS蛋白表达下调(P<0.05);与模型组比较,模型运动组内皮祖细胞功能改善(P<0.05),PI3-K、Akt、eNOS蛋白表达上调(P<0.05)。②内皮祖细胞经鸢尾素处理:与未经鸢尾素处理组比较,补充鸢尾素后模型组和模型运动组内皮祖细胞功能提升(P<0.05),PI3-K、Akt、eNOS蛋白表达显著增加(P<0.05)。结论:规律抗阻运动能够改善2型糖尿病大鼠内皮祖细胞功能,其机制可能与骨骼肌释放的肌因子鸢尾素调控PI3-K/Akt/eNOS信号通路有关。

关键词：抗阻运动糖尿病骨骼肌鸢尾素内皮祖细胞

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Wild-type and molten globular chorismate mutase achieve comparable catalytic rates using very different enthalpy/entropy compensations

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Science China Chemistry 2014年第1期57卷 156-164页

作者： hu hao Department of Chemistry The University of Hong Kong

The origin of the catalytic power of enzymes with a meta-stable native state,*** globular state,is an unsolved challenging issue in *** help understand the possible differences between this special class of enzymes and the typical ones,we report here computer simulations of the catalysis of both the well-folded wild-type and the molten globular mutant of chorismate *** the ab initio quantum mechanical/molecular mechanical minimum free-energy path method,we determined the height of reaction barriers that are in good agreement with experimental ***-substrate interactions were analyzed in detail to identify factors contributing to *** angular order parameters of backbone N–H bonds and side-chain methyl groups suggested site-specific,non-uniform rigidity changes of the enzymes during *** change of conformational entropy from the ground state to the transition state revealed distinctly contrasting entropy/enthalpy compensations in the dimeric wild-type enzyme and its molten globular monomeric variant.A unique catalytic strategy was suggested for enzymes that are natively molten globules:some may possess large conformational flexibility to provide strong electrostatic interactions to stabilize the transition state of the substrate and compensate for the entropy loss in the transition *** equilibrium conformational dynamics in the reactant state were analyzed to quantify their contributions to the structural transitions enzymes needed to reach the transition *** results suggest that large-scale conformational dynamics make important catalytic contributions to sampling conformational regions in favor of binding the transition state of substrate.

关键词： conformational entropy,enthalpy entropy compensation,enzyme evolution