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Severe pediatric COVID‑19:a review from the clinical and immunopathophysiological perspectives

World Journal of Pediatrics 2024年第4期20卷 307-324页

作者： Yi‑Kan Sun Can Wang Pei‑Quan lin Lei Hu Jing Ye Zhi‑Gang Gao Ru lin hao‑min li Qiang Shu li‑Su Huang lin‑Hua Tan Children's Hospital Zhejiang University School of MedicineHangzhou 310052China The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310030China Surgical Intensive Care Unit Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of General Surgery Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of Cardiopulmonary and Extracorporeal life Support Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Clinical Data Center Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of Cardiac Surgery Children’s HospitalZhejiang University School of MedicineHangzhou 310052China National Clinical Research Center for Child Health Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of Infectious Diseases Children’s HospitalZhejiang University School of MedicineHangzhou 310052China

Background Coronavirus disease 2019(COVID-19)tends to have mild presentations in ***,severe and critical cases do arise in the pediatric population with debilitating systemic impacts and can be fatal at times,meriting further attention from ***,the intricate interactions between the pathogen virulence factors and host defense mechanisms are believed to play indispensable roles in severe COVID-19 pathophysiology but remain incompletely *** sources A comprehensive literature review was conducted for pertinent publications by reviewers independently using the PubMed,Embase,and Wanfang *** keywords included“COVID-19 in children”,“severe pediatric COVID-19”,and“critical illness in children with COVID-19”.Results Risks of developing severe COVID-19 in children escalate with increasing numbers of co-morbidities and an unvaccinated *** respiratory distress stress and necrotizing pneumonia are prominent pulmonary manifestations,while various forms of cardiovascular and neurological involvement may also be *** immunological processes are implicated in the host response to COVID-19 including the type I interferon and inflammasome pathways,whose dysregulation in severe and critical diseases translates into adverse clinical *** inflammatory syndrome in children(MIS-C),a potentially life-threatening immune-mediated condition chronologically associated with COVID-19 exposure,denotes another scientific and clinical conundrum that exemplifies the complexity of pediatric *** the considerable dissimilarities between the pediatric and adult immune systems,clinical trials dedicated to children are lacking and current management recommendations are largely adapted from adult *** Severe pediatric COVID-19 can affect multiple organ *** dysregulated immune pathways in severe COVID-19 shape the disease course,epitomize the vast functional diversity of the

关键词： Immunopathophysiology MIS-C Pediatric critical care Severe pediatric COVID-19

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不同模具角度下反复弯曲-压平变形工艺对AZ31镁合金板材显微组织演变和变形行为的影响

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Transactions of Nonferrous Metals Society of China 2024年第3期34卷 812-832页

作者：李旻昊卢立伟范宇田马旻吴志强周涛齐福刚张华湖南科技大学机电工程学院湘潭411201 湖南科技大学难加工材料高效精密加工湖南省重点实验室湘潭411201 湖南科技大学材料科学与工程学院湘潭411201 重庆理工大学材料科学与工程学院重庆400054 湘潭大学材料科学与工程学院湘潭411105 烟台大学精准材料高等研究院烟台264005

采用不同角度模具的反复弯曲-压平变形工艺制备AZ31镁合金板材。通过FEM、OM、EBSD和硬度计研究AZ31镁合金在反复弯曲-压平变形过程中的显微组织演变和变形行为。结果表明,150°/150°模具在所有三组实验中都表现出最佳性能。随着道次... 详细信息

采用不同角度模具的反复弯曲-压平变形工艺制备AZ31镁合金板材。通过FEM、OM、EBSD和硬度计研究AZ31镁合金在反复弯曲-压平变形过程中的显微组织演变和变形行为。结果表明,150°/150°模具在所有三组实验中都表现出最佳性能。随着道次的增加,合金的等效应变由于剪切和弯曲作用而显著提高。经过4道次后,合金的平均晶粒尺寸显著细化至1.7μm,基面织构被弱化,这是非基面滑移、动态再结晶和孪生引起的;尤其是锥面滑移有利于引发动态再结晶和孪生。合金的硬度值达到HV 77,这是滑移、孪生和动态再结晶竞争产生的显微组织和织构综合作用的结果。

关键词： AZ31镁合金板材显微组织演变变形行为反复弯曲-压平工艺模具角度

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An intelligent control method based on artificial neural network for numerical flight simulation of the basic finner projectile with pitching maneuver

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Defence Technology（防务技术） 2024年第2期32卷 663-674页

作者： Yiming liang Guangning li min Xu Junmin Zhao Feng hao Hongbo Shi Northwestern Polytechnical University School of Astronautics Xi’an 710072China China North Industries Group Corporation No 203 Research Institute Xi’an 710065China

In this paper,an intelligent control method applying on numerical virtual flight is *** proposed algorithm is verified and evaluated by combining with the case of the basic finner projectile model and shows a good application ***,a numerical virtual flight simulation model based on overlapping dynamic mesh technology is *** order to verify the accuracy of the dynamic grid technology and the calculation of unsteady flow,a numerical simulation of the basic finner projectile without control is carried *** simulation results are in good agreement with the experiment data which shows that the algorithm used in this paper can also be used in the design and evaluation of the intelligent controller in the numerical virtual flight ***,combined with the real-time control requirements of aerodynamic,attitude and displacement parameters of the projectile during the flight process,the numerical simulations of the basic finner projectile’s pitch channel are carried out under the traditional PID(Proportional-Integral-Derivative)control strategy and the intelligent PID control strategy *** intelligent PID controller based on BP(Back Propagation)neural network can realize online learning and self-optimization of control parameters according to the acquired real-time flight *** with the traditional PID controller,the concerned control variable overshoot,rise time,transition time and steady state error and other performance indicators have been greatly improved,and the higher the learning efficiency or the inertia coefficient,the faster the system,the larger the overshoot,and the smaller the stability *** intelligent control method applying on numerical virtual flight is capable of solving the complicated unsteady motion and flow with the intelligent PID control strategy and has a strong promotion to engineering application.

关键词： Numerical virtual flight Intelligent control BP neural network PID Moving chimera grid

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Large-disturbance Stability Analysis of Power Systems with Synchronous Generator and Converter-interfaced Generation

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 997-1002页

作者： Lei Chen Yong min liangshuai hao Guangzheng Xing Yalou li Shiyun Xu Department of Electrical Engineering Tsinghua UniversityBeijing 100084China China Electric Power Research Institute Beijing 100192China

This letter studies large-disturbance stability of the power system with a synchronous generator(SG)and a converter-interfaced generation(CIG)connected to infinite *** power system is multi-timescale and first *** is shown that the boundary of region of attraction(ROA)of the simplified model is composed of stable manifolds of unstable equilibrium point(UEP)or semi-singular point(SSP),named anchor points,and singular surface *** type of anchor point determines the dominant instability pattern of the power *** the anchor point is UEP or SSP,the dominant instability pattern is the instability of rotor angle of SG or the instability of phase-locked loop and outer control loop(OCL)of CIG,*** of dominant instability pattern can be analyzed with the relative position relationship between UEP and *** effect of OCL is *** the OCL is activated,the ROA becomes smaller and the system is more prone to instability of *** is necessary to consider the OCL when studying the large-disturbance stability of the power system.

关键词： Converter-interfaced generation large-disturbance stability outer control loop phase-locked loop synchronous generator voltage source converter

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TULAM:trajectory-user linking via attention mechanism

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Science China(Information Sciences) 2024年第1期67卷 51-68页

作者： hao li Shuyu CAO Yaqing CHEN min ZHANG Dengguo FENG Trusted Computing and Information Assurance Laboratory Institute of SoftwareChinese Academy of Sciences University of Chinese Academy of Sciences

Recently,the application of location-based services(LBS) has become a prevalent means to provide convenience in customers’ everyday ***,because massive volumes of location information are collected by LBS applications,users may suffer from serious privacy *** studies have shown that the identities of users can be inferred from historical anonymous trajectories,which is formulated as the trajectory-user linking(TUL) *** some recurrent neural network(RNN)-based models have been proposed to capture implicit movement patterns among trajectories to improve TUL performance,they cannot learn the sequential and contextual semantics within any individual trajectory completely,leaving the advantages of RNNs *** therefore propose an RNN model with an attention mechanism called TULAM to improve the accuracy of the TUL *** learns sequential relationships within individual trajectories via RNN and captures contextual semantics from trajectories via a multi-head attention ***,we propose a novel location encoding method called approximate one-hot to solve the corpus shortage problem of trajectory *** were conducted on real datasets from the Gowalla and Foursquare LBS *** experimental results indicate that TULAM is a practical solution that achieves significant improvements over existing methods with satisfactory model complexity and convergence.

关键词： information security data security and privacy trajectory-user linking deep learning recurrent neural network attention mechanism

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A Novel Divide and Conquer Solution for Long-term Video Salient Object Detection

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Machine Intelligence Research 2024年第4期21卷 684-703页

作者： Yun-Xiao li Cheng-li-Zhao Chen Shuai li Ai-min hao Hong Qin State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing 100191China College of Computer Science and Technology China University of Petroleum(East China)Qingdao 266580China Department of Computer Science Stony Brook UniversityNew York 11794USA

Recently,a new research trend in our video salient object detection(VSOD)research community has focused on enhancing the detection results via model self-fine-tuning using sparsely mined high-quality keyframes from the given *** such a learning scheme is generally effective,it has a critical limitation,i.e.,the model learned on sparse frames only possesses weak generalization *** situation could become worse on“long”videos since they tend to have intensive scene ***,in such videos,the keyframe information from a longer time span is less relevant to the previous,which could also cause learning conflict and deteriorate the model ***,the learning scheme is usually incapable of handling complex pattern *** solve this problem,we propose a divide-and-conquer framework,which can convert a complex problem domain into multiple simple ***,we devise a novel background consistency analysis(BCA)which effectively divides the mined frames into disjoint *** for each group,we assign an individual deep model on it to capture its key attribute during the fine-tuning *** the testing phase,we design a model-matching strategy,which could dynamically select the best-matched model from those fine-tuned ones to handle the given testing *** experiments show that our method can adapt severe background appearance variation coupling with object movement and obtain robust saliency detection compared with the previous scheme and the state-of-the-art methods.

关键词： Video salient object detection background consistency analysis weakly supervised learning long-term information background shift.

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Synergistic precipitant powered self-assembly of papain for cross-linked enzyme crystals preparation

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Particuology 2024年第2期85卷 102-112页

作者： Qi hao Pan Guo Honghai Wang min Su Chunli li Yuqi Hu Weiyi Su School of Chemical Engineering and Technology Hebei University of TechnologyTianjin300130China National-Local Joint Engineering Laboratory for Energy Conservation of Chemical Process Integration and Resources Utilization Tianjin300130China

In this study,we prepared cross-linked enzyme crystals(CLECs)of papain to further broaden the application of the enzyme with high activity in extreme ***,papain crystals were successfully obtained based on the micro-batch,batch,and expanded batch crystallization ***,ammonium sulfate and polyethylene glycol 6000(PEG6000)were synergistically used as the precipitants,while L-cysteine was applied to enhance the activity of ***,the interaction between L-cysteine and papain was modeled by molecular docking *** was found that L-cysteine could form a hydrogen bond with aspartic acid residue(Asp)at site 158,and the electrostatic attraction with lysine residue(Lys)at site 156 was also quite *** the enzyme crystals were cross-linked by glutaraldehyde at optimized *** papain CLECs were identified by various methods,and it was found that the thermal stability and enzymatic activity both increased compared to the raw *** importantly,it could be applied at more rigorous conditions,for example,pH of 4.

关键词： Papain Cross-linked enzyme crystals L-cysteine Molecular docking Crystallization

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Effects of soil metal(loid)s pollution on microbial activities and environmental risks in an abandoned chemical smelting site

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Journal of Environmental Sciences 2024年第9期143卷 60-70页

作者： hao li Jun Yao Jianli liu Ning min Geoffrey Sunahara Dongyang Men Robert Duran School of Water Resources and Environment Research Center of Environmental Science and EngineeringChina University of Geosciences(Beijing)Beijing 100083China Department of Natural Resource Sciences McGill University21111Lakeshore DriveSte-Anne-de-BellevueQuebecH9X 3V9Canada Equipe Environnement et Microbiologie MELODY groupUniversitéde Pau et des Pays de l’AdourE2S-UPPAIPREM UMR CNRS 5254BP 115564013 Pau CedexFrance

Abandoned chemical smelting sites containing toxic substances can seriously threaten and pose a risk to the surrounding ecological *** samples were collected from different depths(0 to 13 m)and analyzed for metal(loid)s content and fractionation,as well as microbial *** potential ecological risk indices for the different soil depths(ordered from high to low)were:1 m(D-1)>surface(S-0)>5 m(D-5)>13 m(D-13)>9 m(D-9),ranging between 1840.65-13,089.62,and representing extremely high environmental risks,of which Cd(and probably not arsenic)contributed to the highest environmental risk.A modified combined pollution risk index(MCR)combining total content and mobile proportion of metal(loid)s,and relative toxicities,was used to evaluate the degree of contamination and potential environmental *** the near-surface samples(S-0 and D-1 layers),the MCR considered that As,Cd,Pb,Sb,and Zn achieved high and alarming degrees of contamination,whereas Fe,Mn,and Ti were negligible or low to moderate pollution *** microcalorimetry and enzymatic activity measurements of contaminated soil samples were used to assess the microbial metabolic activity *** analysis elucidated the relationship between metal(loid)s exchangeable fraction or content and microbial activity characteristics(plic activity in the D-1 layer was low presumably due to heavy metal *** activity indicators and microcalorimetric growth rate(k)measurements were considered sensitive indicators to reflect the soil microbial activities in abandoned chemical smelting sites.

关键词： Abandoned chemical smelting sites Microbial activities Modified combined pollution risk Microcalorimetry Enzymatic activities

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Tiered clustering-based management architecture in mega-satellite networks

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Science China(Information Sciences) 2024年第5期67卷 215-227页

作者： Qi hao Di ZHOU min SHENG Yan SHI Jiandong li State Key Laboratory of Integrated Service Networks Xidian University

Hybrid orbital networking and the proliferation of satellites raise explosive management complexity in mega-satellite networks(MSNs) and prompt the management architecture to the hierarchy. In this regard, we propose a tiered clustering-based management architecture(TCMA) to realize the high-efficient and low-cost management performance. Specifically, based on the constrained satellite coverage, we derive an expression of the mapping relationship between the required control overhead of the controller interaction,the average path length of the proposed TCMA, and the corresponding number of management tiers and cluster size. The expression can determine the optimal number of tiers of the TCMA by minimizing the required flow table size between controllers, while ensuring high transmission efficiency. We then exhibit the elasticity of the hierarchical TCMA by adding the peer connections at the second-highest management tier to reduce maximum redundant paths. Simulation results verify the effectiveness of the proposed TCMA and illustrate that a 3-tier TCMA is sufficient for thousands of satellites.

关键词： mega-satellite networks hierarchical architecture average hop tiered structure clustering

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Genome-wide association study of grain micronutrient concentrations in bread wheat

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Journal of Integrative Agriculture 2024年第5期23卷 1468-1480页

作者： Yongchao hao Fanmei Kong lili Wang Yu Zhao Mengyao li Naixiu Che Shuang li min Wang ming hao Xiaocun Zhang Yan Zhao State Key Laboratory of Crop Biology/College of Agronomy Shandong Agricultural UniversityTai'an 271018China College of Resources and Environment Shandong Agricultural UniversityTai'an 271018China Jining liangshan Ecological Environment Affairs Center Jining 272100China College of Forestry Shandong Agricultural UniversityTai'an 271018China

Bread wheat(Triticum aestivum)is a staple food crop *** genetic dissection of important nutrient traits is essential for the biofortification of wheat to meet the nutritional needs of the world's growing ***,45,298 single-nucleotide polymorphisms(SNPs)from 55K chip arrays were used to genotype a panel of 768 wheat cultivars,and a total of 154 quantitative trait loci(QTLs)were detected for eight traits under three environments by genome-wide association study(GWAS).Three QTLs(qMn-3B.1,qFe-3B.4,and qSe-3B.1/qFe-3B.6)detected repeatedly under different environments or traits were subjected to subsequent analyses based on linkage disequilibrium decay and the P-values of significant *** SNPs in the three QTL regions formed six haplotypes for qMn-3B.1,three haplotypes for qFe-3B.4,and three haplotypes for qSe-3B.1/*** analysis revealed significant differences among *** results indicated that the concentrations of several nutrient elements have been modified during the domestication of landraces to modern *** on the QTL regions,we identified 15 high-confidence genes,eight of which were stably expressed in different tissues and/or developmental ***3B02G046100 in qMn-3B.1 and TraesCS3B02G199500 in qSe-3B.1/qFe-3B.6 were both inferred to interact with metal ions according to the Gene Ontology(GO)***3B02G199000,which belongs to qSe-3B.1/qFe-3B.6,was determined to be a member of the WRKY gene ***,this study provides several reliable QTLs that may significantly affect the concentrations of nutrient elements in wheat grain,and this information will facilitate the breeding of wheat cultivars with improved grain properties.

关键词： bread wheat nutritional element GWAS domestication haplotype

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