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Dcalycinumines A-E,Alkaloids with Cytotoxic Activities of Nasopharyngeal Carcinoma Cells from Daphniphyllum calycinum

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Chinese Journal of Chemistry 2024年第1期42卷 35-42页

作者： Qing Tang Xiao-Yong Dai Qiang Lin Zhi-Peng Ling Yi-Kun hao Tian-Xi Zhu Ji-Hui Zhang Yi-Bo Hou Yao-Lan Li Lai-Qiang Huang jing-hao Wang Guo-Cai Wang Yu-Bo Zhang Guangdong Clinical Translational Centerfor Targeted Drug Department of PharmacologySchoolof MedicineJinan University GuangzhouGuangdong 510632China Institute of Traditional Chinese Medicine&Natural Products Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchCollegeof PharmacyJinan UniversityGuangzhouGuangdong511443China Institute of Biopharmaceutical and Health Engineering Shenzhen Key Laboratory of Gene and Antibody TherapyState Key Laboratory of Chemical OncogenomicsShenzhen International Graduate SchoolTsinghua UniversityShenzhenGuangdong 518055China The Guangzhou Key Laboratoryof Basic and Translational Research on Chronic Disease Department of PharmacyThe First Affiliated HospitalJinan UniversityGuangzhouGuangdong 510630China

Fivenovel Daphniphyllum alkaloids,named dcalycinumines A-E(1-4,6),andeight previously described Daphniphyllum alkaloids(5,7-13)were isolated from Daphniphyllum *** 1 is the first Daphniphyllum alkaloid possessing a highly rearranged 6/6/6/7/5/6 hexacyclic architecture with a unique 3-methyl-1-azabicyclo[4,4,0]decane ring *** 2 represents a rare diamino Daphniphyllum alkaloid with an unprecedented 6/5/5/6/6/5 carbon skeleton featuring a unique 1-aza-6-azaspiro[4,5]decane unit,whereas 3 also represents a rare diamino Daphniphyllum alkaloid as a possible precursor of *** 4 is the second example of c-22-nor yuzurimine-type *** structures and absolute configurations were elucidated by HRESIMS,NMR spectroscopic analyses,EcD calculations,and single-crystal X-ray ***,compound 1 showed remarkable antitumor activities,which could inhibit the proliferation,migration and invasion of nasopharyngeal carcinoma cells,and promoted nasopharyngeal carcinoma cells apoptosis.

关键词： Daphniphyllum calycinum Natural products Daphniphyllum alkaloid Structural elucidation Biological activity Apoptosis Nasopharyngealcarcinoma

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Inetetamab combined with tegafur as second-line treatment for human epidermal growth factor receptor-2-positive gastric cancer: A case report

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World Journal of Clinical Cases 2024年第4期12卷 820-827页

作者： jing-hao Zhou Qi-Jun Yi Ming-Yan Li Yan Xu Qi Dong Cong-Ying Wang Hai-Yan Liu Department of Oncology The Second Affiliated Hospital of Shandong First Medical UniversityTai’an 271000Shandong ProvinceChina

BACKGROUND Human epidermal growth factor receptor-2(HER-2)plays a vital role in tumor cell proliferation and ***,the prognosis of HER2-positive gastric cancer is ***,a novel anti-HER2 targeting drug independently developed in China,exhibits more potent antibody-dependent cell-mediated cytotoxicity than trastuzumab,which is administered as the first-line treatment for HER2-positive gastric cancer in combination with *** this case,the efficacy and safety of inetetamab combined with tegafur was investigated as a second-line treatment for HER2-positive gastric *** SUMMARY A 52-year-old male patient with HER2-positive gastric cancer presented with abdominal distension,poor appetite,and fatigue two years after receiving six cycles of oxaliplatin combined with tegafur as first-line treatment after surgery,followed by tegafur monotherapy for six *** patient was diagnosed with postoperative recurrence of gastric *** received 17 cycles of a combination of inetetamab,an innovative domestically developed anti-HER2 monoclonal antibody,and tegafur chemotherapy as the second-line treatment(inetetamab 200 mg on day 1,every 3 wk combined with tegafur twice daily on days 1–14,every 3 wk).Evaluation of the efficacy of the second-line treatment revealed that the patient achieved a stable condition and progression-free survival of 17 *** tolerated the treatment well without exhibiting any grade 3-4 adverse *** Inetetamab combined with chemotherapy for the treatment of metastatic HER2-positive gastric cancer demonstrates significant survival benefits and acceptable safety.

关键词： Inetetamab Gastric cancer Human epidermal growth factor receptor-2 protein Tegafur Case report

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文言小说二体之辨发覆——兼谈桐城派小说观

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明清小说研究 2024年第2期 183-204页

作者：郝敬安徽大学文学院

由于虚构性叙事的不断成熟与受众优势,中国古代小说创作在唐宋以后分为两支:一支为严守汉唐小说说理性质的传统小说;一支以魏晋杂传、唐传奇为切入点,形成以虚构性叙事为主要特征的通俗小说。明清以后,通俗小说渐成大势,传统小说日趋衰... 详细信息

由于虚构性叙事的不断成熟与受众优势,中国古代小说创作在唐宋以后分为两支:一支为严守汉唐小说说理性质的传统小说;一支以魏晋杂传、唐传奇为切入点,形成以虚构性叙事为主要特征的通俗小说。明清以后,通俗小说渐成大势,传统小说日趋衰落。蒲松龄《聊斋志异》吸收传奇之虚构性叙事技巧以创新传统小说,传统小说宗旨愈发背离与泛化,而纪的《阅微草堂笔记》严守旧法,力图回归,遂有二体之辨。桐城派古文创作崇尚雅洁,故肯定史传叙事及纪实的传统小说叙事,否定虚构性小说叙事。同时,桐城派以古文改造传统小说和叙事小说,在这两个领域产生了如许奉恩《里乘》、林经翻译欧美小说作品等代表成果。

关键词：二体之辨小说观叙事虚构

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Effects of long-term blood pressure variability on renal function in community population

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Chronic Diseases and Translational Medicine 2024年第2期10卷 149-152页

作者： Zhao Feng Zhiquan jing Zeya Li Gang Wang Shanshan Wu Dan Li jing hao Chunlei Yang Jiashu Song Xianzhong Gu Rongchong Huang Department of medical service Yongshun Community Health Service CenterYongshun TownBeijingChina Department of Cardiology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Cardiology Weihai Municipal HospitalWeihaiShandongChina National Clinical Research Center for Digestive Diseases Beijing Friendship HospitalCapital Medical UniversityBeijingChina

High blood pressure is a significant contributor to premature mortality,resulting in nearly 10 million deaths and over 200 million disabilities worldwide.1 In recent years,hypertension treatment has shifted focus not only to average blood pressure but also to blood pressure variability(BPV),categorized into very short-term,short-term,and long-term BPV based on the time period of occurrence.2,3 Long-term BPV has emerged as clinically significant,with studies demonstrating its superiority in predicting long-term cardiovascular events,stroke,and mortality compared to short-term *** its association with pre-renal function decline,reducing blood pressure fluctuations is imperative.

关键词： mortality cardiovascular function

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山区双车道公路货车移动遮断小客车跟驰风险预测模型

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吉林大学学报（工学版） 2024年第5期54卷 1323-1331页

作者：戢晓峰徐迎豪普永明郝京京覃文文昆明理工大学交通工程学院昆明650504 云南省现代物流工程研究中心昆明650604

选取典型山区双车道公路弯道和直道为研究对象,基于无人机航拍视频提取的交通轨迹数据,通过轻度提升机算法构建了货车移动遮断下小客车跟驰风险预测模型,采用支持向量机、随机森林验证了模型有效性,分析了模型关键特征参数风险作用机制... 详细信息

选取典型山区双车道公路弯道和直道为研究对象,基于无人机航拍视频提取的交通轨迹数据,通过轻度提升机算法构建了货车移动遮断下小客车跟驰风险预测模型,采用支持向量机、随机森林验证了模型有效性,分析了模型关键特征参数风险作用机制。实验结果表明:基于轻度提升机算法的风险预测模型准确率达96.9%,具有优越性,速度差、跟驰间距是模型关键特征参数,直道上单因子重要度更大;相比弯道,直道路段危险驾驶行为突出,大幅横向偏移等不稳定跟驰特征明显;由模型解释器结果可知,当速度差小于0.5 m/s、跟驰间距大于40 m时,是较为安全的跟驰状态。

关键词：交通运输安全工程跟驰风险预测轻度提升机算法货车移动遮断山区双车道公路

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Multimodal imaging diagnosis and analysis of prognostic factors in patients with adult-onset Coats disease

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1469-1476页

作者： Wei Zhou Hui Zhou Yuan-Yuan Liu Meng-Xuan Li Xiao-Han Wu Jiao Liang jing hao Sheng-Nan Liu Chun-Jie Jin Department of Ophthalmology Tianjin Medical University General HospitalTianjin 300052China Department of Ophthalmology Shanxi Yuncheng Tongde HospitalYuncheng 044000Shanxi ProvinceChina Department of Information Tianjin Medical University General HospitalTianjin 300052China

AIM:To describe the multimodal imaging features,treatment,and outcomes of patients diagnosed with adultonset Coats ***:This retrospective study included patients first diagnosed with Coats disease at≥18 years of age between September 2017 and September *** patients received anti-vascular endothelial growth factor(VEGF)therapy(conbercept,0.5 mg)as the initial treatment,which was combined with laser photocoagulation as *** the patients underwent best corrected visual acuity(BCVA)and intraocular pressure examinations,fundus color photography,spontaneous fluorescence tests,fundus fluorescein angiography,optical coherence tomography(OCT),OCT angiography,and other *** alterations and multimodal image findings in the affected eyes following treatment were compared and the prognostic factors were ***:The study included 15 patients who were aged 24-72(57.33±12.61)y at *** hypertension was the most common associated systemic condition,occurring in 13(86.7%)*** BCVA ranged from 2.0 to 5.0(4.0±1.1),which showed improvement following treatment(4.2±1.0).Multimodal imaging revealed retinal telangiectasis in 13 patients(86.7%),patchy hemorrhage in 5 patients(33.3%),and stage 2B disease(Shield’s staging criteria)in 11 patients(73.3%).OCT revealed that the baseline central macular thickness(CMT)ranged from 129 to 964μm(473.0±230.1μm),with 13 patients(86.7%)exhibiting a baseline CMT exceeding 250μ***,8 patients(53.3%)presented with an epiretinal membrane at baseline or during ***-reflective scars were observed on OCT in five patients(33.3%)with poor visual *** deteriorated in one patient who did not receive *** vision was stable in three patients who received laser treatment,whereas improvement was observed in one of two patients who received anti-VEGF therapy *** addition,8 of 9 patients(88.9%)who received laser treatment and conbercept exhibited sta

关键词： adult-onset Coats disease multimodal imaging anti-vascular endothelial growth factor conbercept

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长江经济带跨界污染协同治理动力机制分析——基于扎根理论

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生态经济 2024年第4期40卷 175-184页

作者：陈芳郝婧安徽大学经济学院安徽合肥230601 安徽大学创新发展战略研究院安徽合肥230601

传统的“政府单核”思维和单一的属地治理模式已无法有效回应跨界污染问题,以“多元共治、区域合作、协调对话”为主要方式的协同治理更加符合当下的治理需求。立足于长江经济带,通过对跨界污染事件报道的扎根分析,构建了协同治理动力... 详细信息

传统的“政府单核”思维和单一的属地治理模式已无法有效回应跨界污染问题,以“多元共治、区域合作、协调对话”为主要方式的协同治理更加符合当下的治理需求。立足于长江经济带,通过对跨界污染事件报道的扎根分析,构建了协同治理动力机制模型,提炼出外源驱动、内生驱动、多元共治、赋能建设、思想引导和流程优化六个主导要素,进一步归纳为驱动力、能动力和执行力三维动力,分别作用于协同意愿、协同结构和协同过程三个阶段。利用模型对跨界污染事件进行回溯分析后发现,当前长江经济带跨界污染协同治理总体上存在驱动力失衡、能动力不足和执行力有限的问题,应结合具体实际有的放矢地予以强化。

关键词：协同治理动力机制跨界污染扎根理论长江经济带

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Adaptive ultra-hypofractionated whole-pelvic radiotherapy in high-risk and very high-risk prostate cancer on 1.5-Tesla MR-Linac:Estimated delivered dose and early toxicity results

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Chronic Diseases and Translational Medicine 2024年第1期10卷 51-61页

作者： Linrui Gao Ran Wei Shirui Qin Yuan Tian Wenlong Xia Yongwen Song Shulian Wang Hui Fang Yu Tang hao jing Yueping Liu Yuan Tang Shunan Qi Bo Chen Yexiong Li Nianzeng Xing Ningning Lu Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina GCP Center/Clinical Research Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Urology State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background: Magnetic resonance(MR)-guided ultra-hypofractionated radiotherapy with whole-pelvic irradiation(UHF-WPRT)is a novel approach to radiotherapy for patients with high-risk(HR)and very high-risk(VHR)prostate cancer(PCa).However,the inherent complexity of adaptive UHF-WPRT might inevitably result in longer on-couch *** aimed to estimate the delivered dose,study the feasibility and safety of adaptive UHF-WPRT on a 1.5-Tesla ***: Ten patients with clinical stage T3a-4N0-1M0-1c PCa,who consecutively received UHF-WPRT,were enrolled *** contours of the target and organ-at-risks on the position verification-MR(PV-MR),beam-on 3D-MR(Bn-MR),and post-MR(after radiotherapy delivery)were derived from the pre-MR data by deformable image *** physician then manually adjusted them,and dose recalculation was performed *** Prism 9(GraphPad Prism Software Inc.)was utilized for conducting statistical ***: In total,we collected 188 MR scans(50 pre-MR,50 PV-MR,44 Bn-MR,and 44 post-MR scans).With median 59 min,the mean prostate clinical target volume(CTV)-V_(100%)was 98.59%±2.74%,and the mean pelvic CTVp-V_(100%)relative percentages of all scans was 99.60%±1.18%.The median V29 Gy change in the rectal wall was−2%(−18%to 20%).With a median follow-up of 9 months,no patient had acute Common Terminology Criteria for Adverse Events(CTCAE)grade 2 or more severe genitourinary(GU)or gastrointestinal(GI)toxicities(0%).Conclusion: UHF-RT to the prostate and the whole pelvis with concomitant boost to positive nodes using an Adapt-To-Shape(ATS)workflow was technically feasible for patients with HR and VHR PCa,presenting only mild GU and GI *** estimated target dose during the beam-on phase was clinically acceptable based on the 3D-MR-based dosimetry *** trial registration Chinese Clinical Trial Registry ChiCTR2000033382.

关键词： dosimetry hypofractionation magnetic resonance imaging prostate cancer radiation dose radiotherapy

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生命科学、医学领域科技伦理治理法治化:从全球共识到中国行动

河北法律职业教育

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河北法律职业教育 2024年第5期2卷 78-84页

作者：郝静天津医科大学医学人文学院法学教研室天津医科大学卫生健康法治研究中心

中国式现代化需要的是依法向善的科技创新。中国式现代化的进程应该是法治与创新比翼齐飞、齐头并进的进程。当前,我国生命科学、医学领域创新加速,伦理法治挑战日益涌现,特别是2018年“基因编辑婴儿”事件将我国生命科学、医学领域科... 详细信息

中国式现代化需要的是依法向善的科技创新。中国式现代化的进程应该是法治与创新比翼齐飞、齐头并进的进程。当前,我国生命科学、医学领域创新加速,伦理法治挑战日益涌现,特别是2018年“基因编辑婴儿”事件将我国生命科学、医学领域科技伦理治理及其法治化问题推到了风口浪尖。紧随创新发展的步伐,积极推进我国生命科学、医学领域伦理治理法治化无疑是时代落在我们肩上的责任。面向人民生命健康,在尊重全球共识的同时还要深刻把握中国的具体情况,做到国内法治和国际法治统筹推进,方能以负责任的科技创新为人民生命健康保驾护航,进而促进我国生命科学、医学领域新质生产力的发展。

关键词：科技伦理治理法治化生命科学生命医学

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GB/T 42790-2023《丙烯酸共聚聚氯乙烯树脂》标准解读

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聚氯乙烯 2024年第5期52卷 15-24页

作者：郝晶锦西化工研究院有限公司辽宁葫芦岛125000

介绍了GB/T 42790—2023《丙烯酸共聚聚氯乙烯树脂》的制定和发布过程,从标准的制定原则、技术指标的确定和检测方法、检验规则等方面详细解读了标准内容,并总结了部分指标的验证试验过程,为相关使用方深入理解和应用该标准提供指导。

关键词：丙烯酸共聚聚氯乙烯树脂国家标准性能指标检测方法

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