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The role of axon guidance molecules in the pathogenesis of epilepsy

Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： Zheng Liu Chunhua Pan hao huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

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A survey of operating system support for persistent memory

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Frontiers of Computer Science 2021年第4期15卷 29-48页

作者： Miao CAI hao huang Department of Computer Science and Technology Nanjing UniversityNanjing 210023China

Emerging persistent memory technologies,like PCM and 3D XPoint,offer numerous advantages,such as higher density,larger capacity,and better energy efficiency,compared with the ***,they also have some drawbacks,e.g.,slower access speed,limited write endurance,and unbalanced read/write *** memory technologies provide both great opportunities and challenges for operating *** a result,a large number of solutions have been *** the increasing number and complexity of problems and approaches,we believe this is the right moment to investigate and analyze these works *** this end,we perform a comprehensive and in-depth study on operating system support for persistent memory within three ***,we present an overview of how to build the operating system on persistent memory from three perspectives:system abstraction,crash consistency,and system ***,we classify the existing research works into three categories:storage stack,memory manager,and OS-bypassing *** each category,we summarize the major research topics and discuss these topics ***,we present the challenges and opportunities in each topic,describe the contributions and limitations of proposed approaches,and compare these solutions in different ***,we also envision the future operating system based on this study.

关键词： persistent memory operating system survey

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Multi-group pin power reconstruction method based on colorset form functions

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Nuclear Science and Techniques 2009年第1期20卷 60-64页

作者： huang hao School of Nuclear Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China

A multi-group pin power reconstruction method that fully exploits nodal information obtained from global coarse mesh solution has been *** expands the intra-nodal flux distributions into nonseparable semi-analytic basis functions,and a colorset based form function generating method is proposed,which can accurately model the spectral interaction occurring at assembly *** demonstrate its accuracy and applicability to realistic problems, the new method is tested against two benchmark problems,including a mixed-oxide fuel *** results show that the new method is comparable in accuracy to fine-mesh methods.

关键词：群组管理 LWR 二维多群辐射输运过程原子核

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Computational study of laser fragmentation in liquid:Phase explosion,inverse Leidenfrost effect at the nanoscale,and evaporation in a nanobubble

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Science China(Physics,Mechanics & Astronomy) 2022年第7期65卷 99-114页

作者： hao huang Leonid V.Zhigilei School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China Department of Materials Science and Engineering University of VirginiaCharlottesville 22904-4745USA

Laser fragmentation in liquid is an effective and environment-friendly processing technique capable of yielding colloidal nanoparticles and atomic clusters with a narrow size distribution. The advancement of this technique can be facilitated by an improved understanding of processes that control the sizes, shapes, and structures of the produced nanoparticles. In this work, the dependence of the fragmentation mechanisms on the energy density deposited by the laser pulse is investigated in atomistic simulations performed for 20 nm Au nanoparticles irradiated in water by 10 ps laser pulses. The simulations reveal that the decrease in the absorbed laser energy leads to sequential transitions from the regime of “strong” phase explosion, when all products of an explosive phase decomposition of the irradiated nanoparticle are promptly injected into the water surrounding a nanobubble formed around the nanoparticle, to two distinct regimes of nanoparticle fragmentation leading to the formation of a large central nanoparticle surrounded by smaller satellite fragments. First, in the regime of “mild” phase explosion, the central nanoparticle is produced by the reflection of some of the hot metal droplets generated by the explosive decomposition of the nanoparticle from the boundary of the nanobubble. This reflection is attributed to the inverse Leidenfrost effect acting at the nanoscale. The reflected droplets converge in the center of the nanobubble and coalesce into a single droplet that solidifies shortly after the collapse of the nanobubble. Further decrease in the absorbed laser energy brings the irradiation conditions below the threshold for the phase explosion and results in the formation of a core-satellite structure of the fragmentation products through an interplay of the intense evaporation from the surface of the irradiated nanoparticle, evolution of the nanobubble, and condensation of the metal vapor into clusters and small satellite nanoparticles. The computationa

关键词： laser fragmentation in liquid molecular dynamics simulations phase explosion inverse Leidenfrost effect nanobubble nanoparticles

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Bidding strategy for wind generation considering conventional generation and transmission constraints

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Journal of Modern Power Systems and Clean Energy 2015年第1期3卷 51-62页

作者： hao huang Fangxing LI Customized Energy Solutions PhiladelphiaPA 19102USA University of Tennessee KnoxvilleTN 37996USA

Under the environmental crisis of global warming,more efforts are put in application of low carbon energy,especially low-carbon *** of wind generation is one potential solution to provide lowcarbon electricity *** paper researches operation of wind generation in a de-regulated power *** develops bidding models under two schemes for variable wind generation to analyze the competition among generation companies(GENCOs)considering transmission *** proposed method employs the supply function equilibrium(SFE)for modeling the bidding strategy of *** bidding process is solved as a bi-level optimization *** the upper level,the profit of an individual GENCO is maximized;while in the lower level,the market clearing process of the independent system operator(ISO)is modeled to minimize the production *** intelligent search based on genetic algorithm and Monte Carlo simulation(MCS)is applied to obtain the *** PJM five-bus system and the IEEE 118-bus system are used for numerical *** results show when wind GENCOs play as strategic bidders to set the price,they can make significant profit uplifts as opposed to playing as a price taker,because the profit gain will outweigh the cost to cover wind uncertainty and reliability ***,this may result in an increase in total production cost and the profit of other units,which means consumers need to pay ***,it is necessary to update the existing market architecture and structure considering these pros and cons in order to maintain a healthy competitive market.

关键词： Low carbon Electricity market Game theory Generator bidding Intermittency Locational marginal pricing

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Hardware-in-the-loop simulation technology of wide-band radar targets based on scattering center model

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Chinese Journal of Aeronautics 2015年第5期28卷 1476-1484页

作者： huang hao Pan Minghai Lu Zhijun Key Laboratory of Radar Imaging and Microwave Photonics Ministry of Education Nanjing University of Aeronautics and Astronautics Shanghai Key Laboratory of Space Intelligent Control Technology

Hardware-in-the-loop （HWIL） simulation technology can verify and evaluate the radar by simulating the radio frequency environment in an anechoic chamber. The HWIL simulation technology of wide-band radar targets can accurately generate wide-band radar target echo which stands for the radar target scattering characteristics and pulse modulation of radar transmitting signal. This paper analyzes the wide-band radar target scattering properties first. Since the responses of target are composed of many separate scattering centers, the target scattering characteristic is restructured by scattering centers model. Based on the scattering centers model of wide-band radar target, the wide-band radar target echo modeling and the simulation method are discussed. The wide-band radar target echo is reconstructed in real-time by convoluting the transmitting signal to the target scattering parameters. Using the digital radio frequency memory （DRFM） system, the HWIL simulation of wide-band radar target echo with high accuracy can be actualized. A typical wide-band radar target simulation is taken to demonstrate the preferable simulation effect of the reconstruction method of wide-band radar target echo. Finally, the radar target time-domain echo and high-resolution range profile （HRRP） are given. The results show that the HWIL simulation gives a high-resolution range distribution of wide-band radar target scattering centers.

关键词： Digital radio frequencymemory Error analysis Hardware-in-the-loop simu-lation Radar targets Scattering parameters

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科学绿化视角下高等学校生态校园景观环境分析

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城市建筑 2025年第1期22卷 224-227页

作者：庞希玲黄浩华设设计集团股份有限公司南京工业大学建筑学院

基于科学绿化视角,分析了生态校园建设中高等学校校园景观环境存在的问题,对生态校园的景观环境营造方法进行了探索,提出了“共生、共享、共育”的校园生态规划方法,创新了“森林校园、湿地校园、海绵校园”的生态校园设计策略,赋能生... 详细信息

基于科学绿化视角,分析了生态校园建设中高等学校校园景观环境存在的问题,对生态校园的景观环境营造方法进行了探索,提出了“共生、共享、共育”的校园生态规划方法,创新了“森林校园、湿地校园、海绵校园”的生态校园设计策略,赋能生态校园景观环境设计方法创新与新路径和新探索模式。

关键词：科学绿化生态校园校园景观环境生态建设

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Discriminative tonal feature extraction method in mandarin speech recognition

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The Journal of China Universities of Posts and Telecommunications 2007年第4期14卷 126-130页

作者： huang hao ZHU Jie Department of Electronic Engineering Shanghai Jiao Tong UniversityShanghai 200240 China

To utilize the supra-segmental nature of Mandarin tones, this article proposes a feature extraction method for hidden markov model （HMM） based tone modeling. The method uses linear transforms to project Fo（fundamental frequency） features of neighboring syllables as compensations, and adds them to the original Fo features of the current syUable. The transforms are discriminatively trained by using an objective function termed as ＂minimum tone error＂, which is a smooth approximation of tone recognition accuracy. Experiments show that the new tonal features achieve 3.82% tone recognition rate improvement, compared with the baseline, using maximum likelihood trained HMM on the normal F0 features. Further experiments show that discriminative HMM training on the new features is 8.78% better than the baseline.

关键词： discriminative training tone recognition feature extraction Mandarin speech recognition

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Automatic context induction for tone model integration in mandarin speech recognition

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The Journal of China Universities of Posts and Telecommunications 2012年第1期19卷 94-100页

作者： huang hao LI Bing-hu Department of Information Science and Engineering Xinjiang University Urumqi 830046 China Laboratory of Multi-Lingual Information Technology Xinjiang University Urumqi 830046 China

Tone model （TM） integration is an important task for mandarin speech recognition. It has been proved to be effective to use discriminatively trained scaling factors when integrating TM scores into multi-pass speech recognition. Moreover, context-dependent （CD） scaling can be applied for better interpolation between the models. One limitation of this approach is a large number of parameters will be introduced, which makes the technique prone to overtraining. In this paper, we propose to induce context-dependent model weights by using automatically derived phonetic decision trees. Question at each tree node is chosen to minimize the expected recognition error on the training data. First order approximation of the minimum phone error （MPE） objective function is used for question pruning to make tree building efficient. Experimental results on continuous mandarin speech recognition show the method is capable of inducing the most crucial phonetic contexts and obtains significant error reduction with far fewer parameters, compared with that obtained by using manually designed context-dependent scaling parameters.

关键词： TM integration MPE decision tree mandarin speech recognition context-dependent

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Trivariate B-spline solid construction by pillow operation and geometric iterative fitting

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Science China(Information Sciences) 2018年第11期61卷 232-234页

作者： Hongwei LIN hao huang Chuanfeng HU School of Mathematical Science State Key Laboratory of CAD&CG Zhejiang University

While the traditional geometric design community focuses on the design of curves and surfaces, the advent of isogeometric analysis (IGA)[1] has made the development of methods for designing trivariate B-spline solids (TBSs) imperative. In IGA, a valid TBS should have a positive Jacobian value at every point in its domain. A negative Jacobian value at any point in the domain of the TBS can render the IGA invalid.

关键词： TBS Trivariate B-spline solid construction by pillow operation and geometric iterative fitting GFD Figure

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