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Ammonia pyrolysis oxidation excited by nanosecond pulsed discharge:Global/fluid models hybrid solution

Journal of Energy Chemistry 2025年第1期100卷 385-396页

作者： Mingming Zhang hanyu wu Qi Chen Jiaxin Yang Bonan Liu School of Mechanical Electronic and Control Engineering Beijing Jiaotong University China University of Petroleum

The kinetic characteristics of plasma-assisted oxidative pyrolysis of ammonia are studied by using the global/fluid models hybrid solution ***,the stable products of plasma-assisted oxidative pyrolysis of ammonia are *** results show that the consumption of NH3/O2and the production of N2/H2change linearly with the increase of voltage,which indicates the decoupling of nonequilibrium molecular excitation and oxidative pyrolysis of ammonia at low ***,the detailed reaction kinetics mechanism of ammonia oxidative pyrolysis stimulated by a nanosecond pulse voltage at low pressure and room temperature is *** on the reaction path analysis,the simplified mechanism is *** detailed and simplified mechanism simulation results are compared with experimental data to verify the accuracy of the simplified ***,based on the simplified mechanism,the fluid model of ammonia oxidative pyrolysis stimulated by the nanosecond pulse plasma is established to study the pre-sheath/sheath behavior and the resultant consumption and formation of key *** results show that the generation,development,and propagation of the pre-sheath have a great influence on the formation and consumption of *** consumption of NH3by the cathode pre-sheath is greater than that by the anode pre-sheath,but the opposite is true for OH and O（1S）.However,within the sheath,almost all reactions do not ***,by changing the parameters of nanosecond pulse power supply voltage,it is found that the electron number density,electron current density,and applied peak voltages are not the direct reasons for the structural changes of the sheath and ***,the discharge interval has little effect on the sheath structure and gas mixture *** research results of this paper not only help to understand the kinetic promotion of non-equilibrium excitation in the process of oxidative pyrolysis but also help to explore th

关键词： Nanosecond pulsed discharge Ammonia Oxidative pyrolysis Fluid model Global model

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Serum metabolic profile and metabolome genome‑wide association study in chicken

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Journal of Animal Science and Biotechnology 2023年第5期14卷 1926-1940页

作者： Jing Tian Xiaoning Zhu hanyu wu Yuzhe Wang Xiaoxiang Hu State Key Laboratory of Agrobiotechnology College of Biological SciencesChina Agricultural UniversityBeijing 100193China National Research Facility for Phenotypic and Genotypic Analysis of Model Animals(Beijing) China Agricultural UniversityBeijing 100193China

Background Chickens provide globally important livestock *** the genetic and molecular mechanisms underpinning chicken economic traits is crucial for improving their selective *** by a combination of genetic and environmental factors,metabolites are the ultimate expression of physiological processes and can provide key insights into livestock economic ***,the serum metabolite profile and genetic archi-tecture of the metabolome in chickens have not been well *** Here,comprehensive metabolome detection was performed using non-targeted LC–MS/MS on serum from a chicken advanced intercross line(AIL).In total,7,191 metabolites were used to construct a chicken serum metabo-lomics dataset and to comprehensively characterize the serum metabolism of the chicken AIL ***-tory loci affecting metabolites were identified in a metabolome genome-wide association study(mGWAS).There were 10,061 significant SNPs associated with 253 metabolites that were widely distributed across the entire chicken *** functional genes affect metabolite synthesis,metabolism,and *** highlight the key roles of TDH and AASS in amino acids,and ABCB1 and CD36 in *** We constructed a chicken serum metabolite dataset containing 7,191 metabolites to provide a refer-ence for future chicken metabolome characterization ***,we used mGWAS to analyze the genetic basis of chicken metabolic traits and metabolites and to improve chicken breeding.

关键词： Chicken Metabolic traits mGWAS Serum

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Prevention and treatment of gerbil hepatitis E using the programmable CRISPR-Cas13d system

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Genes & Diseases 2024年第4期11卷 94-97页

作者： Chengcheng Zhao Chong Lia Sa Li hanyu wu Pengyao Ren Tianlong Liu Xiaoxiang Hu Ran Zhang State Key Laboratory of Animal Biotech Breeding College of Biological SciencesChina Agricultural UniversityBeijing 100193China Laboratory of Veterinary Pathology and Nanopathology College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China

In recent years,the global incidence of hepatitis E virus(HEV)has been rising,leading to increased morbidity and mortality associated with ***13,a CRISPR effector,shows promise as an antiviral agent against singlestranded RNA ***13d,a type VI-D effector,exhibits higher efficiency in suppressing RNA viruses compared to other type VI ***,its in vivo activity against RNA viruses in mammals remains unknown.

关键词： mortality hepatitis treatment

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Identification of highly efficacious PROTACs targeting BRD4 against acute myeloid leukemia:Design,synthesis,and biological evaluations

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Chinese Chemical Letters 2023年第6期34卷 426-431页

作者： Aiping Chen Yue Zhong Yunxiao Liu Zhancheng Xie hanyu wu Wei Shi Wenlong Huang Renxiang Tan Hai Qian College of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China Center of Drug Discovery State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease China Pharmaceutical UniversityNanjing 210009China

The abnormal activation of BRD4 accelerates the progression of acute myeloid leukemia(AML),developing more precise therapeutics to intervene BRD4 promise to be an excellent opportunity to avoid current limitations of chemotherapy in ***,a range of small-molecule PROTACs with the privileged 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one scaffold were rationally designed,which harbored different carbon or ethylenedioxy chains to degrade BRD4 mediated by the E3 ubiquitin ligase *** them,the most potential B24 exhibited remarkable BRD4 degradation and excellent anti-proliferative activities in MV4-11 cells,with values of DC_(50)and IC_(50)for 0.75 nmol/L and 0.4 nmol/L,respectively,which were better than the BRD4 inhibitor(+)-***,this compound could time-dependently degrade the target protein in the BRD4-,CRBN-,and proteasome-dependent ***,B24 dramatically decreased the level of proto-oncogene c-Myc,and induced cell apoptosis by arresting the cell cycle in G0/G1 phase,down-regulating Bcl-2 and up-regulating Bax to amplify apoptotic *** proof-of-concept study also highlighted the feasibility of BRD4-based PROTACs as a more powerful strategy against AML.

关键词： Acute myeloid leukemia BRD4 PROTACs Protein degradation Apoptosis

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Experimental study of current loss of a single-hole post-hole convolute on the QG I generator

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Plasma Science and Technology 2020年第1期22卷 104-110页

作者： hanyu wu Zhengzhong ZENG Mengtong QIU Peitian CONG Jinhai ZHANG Xinjun ZHANG Ning GUO State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Northwest Institute of Nuclear TechnologyXi’an 710024People’s Republic of China

The post-hole convolute(PHC),which is used to transport and combine the pulse power flux,is a key component in huge pulsed power *** loss at the PHC is a challenging problem for *** explore a method of reducing the current loss,a single-hole PHC was designed for experiments on the current loss on the Qiang Guang I *** experimental results showed that the current loss at the single-hole PHC is related to the distance/between the vicinity of the cathode hole and the surface of the downstream side of the ***,a single-hole PHC with a blob cathode hole transmitted current more effectively than the PHC with a circle cathode *** relative current loss at the single-hole PHC with the cathode coaled w ith gold foil was about 30%-50% of that with the cathode coated with nickel and titanium *** gap closing speed was also obtained from the current waveforms in the *** speed was 5.74-14.52 cmμs 1 which was different from the classical plasma expansion velocity of 3 cmμs 1.

关键词： plasma post-hole convolute magnetic insulation current loss

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Transcription-wide impact by RESCUE-induced off-target single-nucleotide variants in mammalian cells

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Journal of Molecular Cell Biology 2023年第2期15卷 17-28页

作者： Guo Li Xiaoning Zhu Yihan Wang Hongru Ma Yuzhe Wang hanyu wu Xiangyang Li Yiling Wang Jianen Gao Xuexin Chen Xingxu Huang Yuan Yao Xiaoxiang Hu College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310027China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311200China State Key Laboratory of Agrobiotechnology College of Biological SciencesChina Agricultural UniversityBeĳing 100193China National Research Institute for Family Planning Beĳing 100081China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Institute of Insect Sciences College of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310058China Zhejiang Lab Hangzhou 311121China

RNA base editing is a promising tool in precise molecular therapy. Currently, there are two widely used RNA base editors, REPAIRand RESCUE. REPAIR only facilitates A-to-I conversions, while RESCUE performs both A-to-I and C-to-U conversions. Thus, RESCUEcan generate twice the number of mutations compared to REPAIR. However, transcription-wide impact due to RESCUE-induced offtarget single-nucleotide variants (SNVs) is not fully appreciated. Therefore, to determine the off-target effects of RESCUE-mediatedediting, we employed transcription-wide sequencing on cells edited by RESCUE. The SNVs showed different off-target effects onmRNA, circRNA, lncRNA, and miRNA expression patterns and their interacting networks. Our results illustrate the transcriptionwide impact of RESCUE-induced off-target SNVs and highlight the need for careful characterization of the off-target impact by thisediting platform.

关键词： transcription-wide off-target SNV RESCUE RNA

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μs前沿百kV激光触发水开关的实验研究

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强激光与粒子束 2015年第4期27卷 228-231页

作者：张信军吴撼宇西北核技术研究所强脉冲辐射环境模拟与效应国家重点实验室西安710024

开展了百kVμs前沿脉冲作用下激光触发水开关的研究。水开关采用球板电极结构,球头轴向开激光通孔,高压极为平板电极。开关自击穿电压133kV,抖动263ns。实验研究了激光击穿弧长占据间隙不同比例、不同触发能量和不同触发时刻等因素对触... 详细信息

开展了百kVμs前沿脉冲作用下激光触发水开关的研究。水开关采用球板电极结构,球头轴向开激光通孔,高压极为平板电极。开关自击穿电压133kV,抖动263ns。实验研究了激光击穿弧长占据间隙不同比例、不同触发能量和不同触发时刻等因素对触发抖动的影响。结果表明激光触发可将抖动有效减小到30ns以内。触发能量高于19mJ时触发抖动与能量大小关系不大。

关键词：激光触发水开关抖动击穿时延

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被保险人法律地位的反思与重构

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浙江大学学报（人文社会科学版） 2019年第4期49卷 217-228页

作者：吴涵昱浙江大学光华法学院

被保险人在我国学界被认定为保险合同的关系人,但该认定本身存在内在矛盾。基于保险合同分散风险、补偿损失的功能特点,保险合同中权利义务的结构分配相对于传统的民事合同有所不同:被保险人虽非订立合同的主体,但其享有保险金请求权,... 详细信息

被保险人在我国学界被认定为保险合同的关系人,但该认定本身存在内在矛盾。基于保险合同分散风险、补偿损失的功能特点,保险合同中权利义务的结构分配相对于传统的民事合同有所不同:被保险人虽非订立合同的主体,但其享有保险金请求权,是保险合同所保障的对象。而保险合同关系人的定位显然无法完全体现被保险人在保险合同中的重要性。鉴于被保险人的实际地位以及理论体系的考量,应当将被保险人定位为保险合同的实际当事人,并将其体现于我国的立法之中:在投保人解除制度中增加被保险人的介入权;在团体保险中增加被保险人的契约转换权;在中止复效制度中增加保险人催缴保险费并说明后果的义务以及被保险人申请复效的资格;在投保人造成被保险人伤亡的制度中,规定投保人与被保险人不一致时,保险人仍需承担责任的除外情形;在总原则中增加对被保险人倾斜保护的原则,使被保险人的法律地位得以充分体现。

关键词：被保险人法律地位实际当事人合同关系人

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论基因信息在保险核保中的使用及限制

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浙江大学学报（人文社会科学版） 2023年第12期53卷 87-105页

作者：吴涵昱中国计量大学法学院浙江杭州310018

我国现行规范采取完全禁止保险人使用基因信息核保的立法模式存在争议。从利益平衡的角度来看,完全禁止模式保护被保险人人格利益的基本立场值得肯定,然而该模式并未充分兼顾保险法的对价平衡原则以及保险本身的运作机理,亦不符合比例... 详细信息

我国现行规范采取完全禁止保险人使用基因信息核保的立法模式存在争议。从利益平衡的角度来看,完全禁止模式保护被保险人人格利益的基本立场值得肯定,然而该模式并未充分兼顾保险法的对价平衡原则以及保险本身的运作机理,亦不符合比例原则的要求,存在适当调整的空间。以禁止为原则允许为例外的严格限制模式是较为适宜的解困方案。这种模式既符合保险风险测算的原理,同时兼顾了对价平衡原则,并能够平衡各方利益,符合比例原则。此外,该模式亦与商业保险在我国的功能定位相契合。至于保险人使用部分基因信息核保所产生的对价失衡风险、基因歧视及弱势群体难以获得保险保障的风险、隐私与个人信息泄露的风险,可以从限定基因信息收集范围、限定险种、设定额度门槛、禁止保险人以基因检测为核保条件、细化如实告知义务、设立前置审批程序、完善基因信息收集程序等方面通过制度设计予以规制。

关键词：基因信息核保利益平衡比例原则严格限制

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合理期待原则的二维功能及本土化路径

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浙江大学学报（人文社会科学版） 2021年第6期51卷 215-233页

作者：吴涵昱中国计量大学法学院浙江杭州310018

合理期待原则作为美国保险法中保护被保险人利益的重要原则,共有两方面的功能:在抽象层面,该原则对被保险人的保护具有价值指引的功能;在具体规范层面,该原则具有对保险合同中的利益失衡进行司法矫正的功能。与我国现有规范相比,合理期... 详细信息

合理期待原则作为美国保险法中保护被保险人利益的重要原则,共有两方面的功能:在抽象层面,该原则对被保险人的保护具有价值指引的功能;在具体规范层面,该原则具有对保险合同中的利益失衡进行司法矫正的功能。与我国现有规范相比,合理期待原则的价值指引功能更加直观、系统,在保护被保险人利益方面更具有倾向性;在司法矫正功能方面,合理期待原则与我国现有规范存在重合,但其矫正范围和尺度更为灵活。在本土化路径上,首先应借鉴其价值指引功能,将合理期待原则以基本原则的形式在我国保险法理论中予以确立,并从价值层面指引立法者和司法裁判者充分考虑被保险人的合理期待及引起被保险人合理期待的相关因素,以更好地体现被保险人中心主义。其次,应当进一步借鉴其司法矫正功能,在裁判说理的过程中将合理期待原则以法理阐释的方式融入对现有条文的说理解释,以实现个案的矫正纠偏。

关键词：合理期待原则本土化价值指引司法矫正

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