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基于FRAM的有限空间作业安全职责半定量分析

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中国安全科学学报 2023年第5期33卷 88-95页

作者：王涵宇谭钦文西南科技大学环境与资源学院四川绵阳621010 西南科技大学非煤矿山安全技术四川省高等学校重点实验室四川绵阳621010

为解决作业相关人员安全职责边界模糊以及履责过程中多岗位、多环节安全职责交互关系不清晰的问题,引入功能共振分析方法(FRAM),构建有限空间作业安全职责系统半定量分析模型,展现多岗位间安全职责交互和协同配合关系,通过定量化系统功... 详细信息

为解决作业相关人员安全职责边界模糊以及履责过程中多岗位、多环节安全职责交互关系不清晰的问题,引入功能共振分析方法(FRAM),构建有限空间作业安全职责系统半定量分析模型,展现多岗位间安全职责交互和协同配合关系,通过定量化系统功能单元的上下游耦合变异性,理清系统各功能要素间耦合作用影响机制。结果表明:基于FRAM的有限空间作业6方人员安全职责全局系统变异性数值为1.99×1010,下游功能单元F5(作业人员)和F6(应急救援人员)的输入可变性影响数值分别为171.5和250,受上游功能单元的耦合变异影响较大,易产生不良事故后果,结合有限空间作业8类关键影响因素分析功能共振结果,针对2个上游功能单元和6条失效链路提出加强作业安全投入等有效屏障措施。

关键词：功能共振分析方法(FRAM) 有限空间作业安全职责半定量分析耦合变异性

Umbilical cord-derived mesenchymal stem cells regulate thymic epithelial cell development and function in Foxn 1^-/- mice

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Cellular & Molecular Immunology 2014年第3期11卷 275-284页

作者： Guangyang Liu Lihua wang Tianxiang Pang Delin Zhu Yi Xu hanyu wang Xiuli Cong Yongjun Liu Key Laboratory of Systems Bioengineering School of Chemical Engineering and Technology Tianjin University Tianjin China AIliancells Institute of Stem Cells and Translational Regenerative Medicine Tianjin China The State Key Laboratory of Experimental Hematology Institute of Hematology and Hospital of Blood Diseases Graduate School of Chinese Academy of Medical Sciences and Peking Union of Medical College Tianjin China University of Florida Department of Medicine Gainesville FL USA GL and LW are cofirst authors and contributed equally to this study

Thymic microenvironments are essential for the maturation of thymocytes, which can be anatomically compartmentalized into cortical and medullar regions. The absence of the gene encoding the transcription factor forkhead box nl （Foxnl） causes epithelial differentiation to stall in the precursor stage, resulting in the formation of an abnormal thymus. In this study, we used human umbilical cord-derived mesenchymal stem cells （UC-MSCs） to treat Foxn1^-/- mice, and then analyzed the maturation and distribution of thymic epithelial cells in the Foxn1^-/- thymic rudiment and the thymopoiesis of this newly developed rudiment. Our data showed a well-organized cortex-medulla architecture and an obvious improvement in the maturation of thymic epithelial ceils along with the appearance of UEA-1^＋MHCIIhi thymic epithelial cells in the rudiment. We further demonstrated improved thymopoiesis and the enhanced export of mature T cells with increased numbers of regulatory T cells into the peripheral blood. Furthermore, we observed that MSCs can engraft into thymic tissue and express many cytokines or proteins, particularly keratinocyte growth factor （KGF） and CD248, which are essential for thymic development. Collectively, our data identified a new mechanism for MSCs, which may provide a proper microenvironment for the reconstitution and functional maturation of the thymus in Foxn1^-/- mice. Additionally, we elicited additional insights into the therapeutic efficacy of MSCs in several autoimmune diseases.

关键词： keratinocyte growth factor mesenchymal stem cells thymus development regulatory T cells

Adsorption behavior of CO_(2) in magnesite micro-pores at high temperature and pressure

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Geoscience Frontiers 2021年第2期12卷 991-999页

作者： Longxing Yang Lei Liu Hong Liu Li Yi Xiaoyu Gu Haibo Liu hanyu wang United Laboratory of High-Pressure Physics and Earthquake Science Key Laboratory of Earthquake PredictionInstitute of Earthquake ForecastingCEABeijing100036China

The fluid inclusions in mantle rocks and melt indicated that a large amount of CO_(2)fluid exists in the deep earth,which is of great significance for understanding the deep carbon cycle and the composition of ***,it was also suggested that carbonate minerals were likely to be the main host of mantle *** the same time,the distribution and behavior of carbon in the mantle still remain a *** this paper,the adsorption behavior and occurrence characteristics of supercritical CO_(2)in magnesite(MgCO3)pores were studied by the Grand Canonical Monte Carlo method(GCMC)under the different conditions of CO_(2)pressures(0–100 MPa),temperatures(350–1500 K)and the pore sizes(7.5–30Å).The simulated results showed that the adsorption of CO_(2)in magnesite was a physical adsorption,which was mainly controlled by the intermolecular *** gas adsorption became more stable when the adsorption site shifted from the high energy site to the low energy site with increasing pressure(P)and decreasing temperature(T)and pore *** the same time,the variations of excess adsorption amounts of CO_(2)in the pores of magnesite(Nexcess)under the different conditions were quantitatively *** was found that the Nexcess decreased with increasing T,but increased with increasing P and pore *** results favor understanding the CO_(2)migration,seismic precursor observations,and heat transfer process in the deep earth.

关键词： CO_(2) Magnesite Adsorption Nexcess GCMC Carbon cycle

Unveiling non-radiative center control in CsPbBr_(3) nanocrystals:A comprehensive comparative analysis of hot injection and ligandassisted reprecipitation approaches

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Nano Research 2024年第5期17卷 4525-4534页

作者： Daocheng Hong Yuchen Zhang Shuhan Pan hanyu Liu Wei Mao Wanli Zhang Yuhui Ye Zhihong Wei Xuxing Lu Xiaoyong wang Zhenda Lu Yuxi Tian Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province Yancheng Institute of TechnologyYancheng 224051China Laboratory of Mesoscopic Chemistry of MOE School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China College of Engineering and Applied Sciences Nanjing UniversityNanjing 210023China National Laboratory of Solid State Microstructures School of PhysicsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China School of Electronic Electrical Engineering and PhysicsFujian University of TechnologyFuzhou 350118China

Metal-halide perovskite nanocrystals(NCs)have gained significant attention in the field of optoelectronic and photonic devices due to their promising *** their exceptional optical properties,the impact of different synthetic strategies on the fundamental nature of NCs,such as nonradiative recombination centers,remains poorly *** this study,we investigated the photophysical properties of CsPbBr_(3) NCs synthesized using two distinct methods,hot injection and ligand-assisted reprecipitation,at the individual particle *** observed different blinking behaviors under specific photoexcitation power densities and proposed,through intensity-lifetime analysis and Monte-Carlo simulations,that these different synthetic strategies can fabricate NCs with similar crystal structures but distinct surface quenchers with varying energy levels,which significantly affected the photo-induced blinking-down and blinking-up behaviors in individual *** findings indicate a practical and feasible approach for controlling defect engineering in perovskite NCs,with significant implications for their use in optoelectronic and other technological applications.

关键词： metal-halide perovskite nanocrystals photophysical properties nonradiative recombination centers hot injection method ligand-assisted reprecipitation

基于纳米活性结构的不互溶W-Cu体系直接合金化及其热力学机制

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金属学报 2023年第5期59卷 679-692页

作者：王寒玉李彩赵璨曾涛王祖敏黄远天津大学材料科学与工程学院天津300354

利用纳米多孔活性结构诱导和促进W和Cu直接合金化,主要包括3步骤:首先,通过两步阳极氧化和还原退火在W表面制备纳米多孔结构;然后,在纳米多孔W上电沉积Cu层;最后,在近Cu熔点温度(980℃)下退火,得到W/Cu层状复合材料/连接件。W/Cu界面的... 详细信息

利用纳米多孔活性结构诱导和促进W和Cu直接合金化,主要包括3步骤:首先,通过两步阳极氧化和还原退火在W表面制备纳米多孔结构;然后,在纳米多孔W上电沉积Cu层;最后,在近Cu熔点温度(980℃)下退火,得到W/Cu层状复合材料/连接件。W/Cu界面的表征结果表明,2种金属间的扩散距离约为27 nm,W和Cu之间成功实现直接合金化。同时,针对此前建立的不互溶金属直接合金化热力学模型存在的问题,改进了表面能和压力能的计算方法,解决了表面原子层数选用导致表面能结果具有随意性的问题和热力学计算中的单位尺度问题,实现了基于纳米活性结构的不互溶W-Cu直接合金化的热力学计算。热力学计算结果表明,W表面纳米多孔化之后W-Cu体系的表面能大幅提升,可以作为W和Cu直接合金化的热力学驱动力。分析认为,除具有高表面能的晶面增多之外,纳米结构形状也是W表面纳米化后表面能提高的主要原因之一。

关键词：不互溶W-Cu体系纳米多孔结构直接合金化热力学模型表面能

代谢综合征组成部分与膝关节骨性关节炎的因果关系:孟德尔随机化研究

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中国循证医学杂志 2023年第11期23卷 1241-1246页

作者：王惠达张智王晗宇马兴西安交通大学第一附属医院骨科西安710061

目的采用孟德尔随机化分析方法,探讨代谢综合征组成部分与膝关节骨性关节炎的因果关联。方法对全基因关联研究数据库(GWAS)进行数据挖掘,暴露因素为代谢综合征组成部分(腰围水平、甘油三酯水平、高密度脂蛋白胆固醇水平、高血压和2型糖... 详细信息

目的采用孟德尔随机化分析方法,探讨代谢综合征组成部分与膝关节骨性关节炎的因果关联。方法对全基因关联研究数据库(GWAS)进行数据挖掘,暴露因素为代谢综合征组成部分(腰围水平、甘油三酯水平、高密度脂蛋白胆固醇水平、高血压和2型糖尿病),结局因素为膝关节骨性关节炎。采用逆方差加权法(IVW)、MR-Egger法、Simple Mode法、加权中位数法和Weighted Mode法等回归模型进行孟德尔随机化分析。结果IVW结果显示,腰围水平与膝关节骨性关节炎呈正性相关关系[OR=3.088,95%CI(2.574,3.704),P0.05)。ME-Egger截距测试结果不存在多效性(P>0.05),表明孟德尔随机化在本研究中为因果推断的有效方法。结论中心性肥胖及低高密度脂蛋白胆固醇血症是膝关节骨性关节炎的独立危险因素,但甘油三酯水平、高血压和2型糖尿病与膝关节骨性关节炎的因果关系尚不确定。

关键词：孟德尔随机化膝关节骨性关节炎代谢综合征

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基于变论域模糊控制的高旋弹姿态控制算法

北京理工大学学报 2022年第6期42卷 634-640页

作者：申强万初朋高潇王晗瑜北京理工大学机电学院北京100081

针对高速旋转弹姿态控制系统存在的模型不确定、非线性、强耦合等问题,提出了基于变论域模糊控制的参数自适应姿态控制算法.在建立姿态控制模型并通过前置反馈补偿方法对俯仰偏航通道进行解耦的基础上,利用变论域模糊控制器对姿态闭环... 详细信息

针对高速旋转弹姿态控制系统存在的模型不确定、非线性、强耦合等问题,提出了基于变论域模糊控制的参数自适应姿态控制算法.在建立姿态控制模型并通过前置反馈补偿方法对俯仰偏航通道进行解耦的基础上,利用变论域模糊控制器对姿态闭环反馈控制系统参数进行在线自适应整定.仿真结果表明:变论域模糊控制器能有效改善闭环反馈控制系统的动态响应特性,减小弹体参数时变对控制器性能的影响,提高其适应性.

关键词：高旋弹姿态反馈控制变论域参数自适应

Comparative Experimental Study on Heat Transfer Characteristics of Building Exterior Surface at High and Low Altitudes

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Journal of Thermal Science 2024年第3期33卷 1119-1131页

作者： JIA Yonghong GUO Shurui LI Jin GUO Lei CHENG Zhu ZHANG Yin YANG hanyu LONG Enshen Institute for Disaster Management and Reconstruction Sichuan UniversityChengdu610065China MOE Key Laboratory of Deep Earth Science and Engineering College of Architecture and EnvironmentSichuan UniversityChengdu610065China

The external surface heat transfer coefficient of building envelope is one of the important parameters necessary for building energy saving design,but the basic data in high-altitude area are ***,the authors propose a modified measurement method based on the heat balance of a model building,and use the same model building to measure its external surface heat transfer coefficient under outdoor conditions in Chengdu city,China at an altitude of 520 m and Daocheng city at an altitude of 3750 m *** results show that the total heat transfer coefficient(h_(t))of building surface in high-altitude area is reduced by 34.48%.The influence of outdoor wind speed on the convective heat transfer coefficient(h_(c))in high-altitude area is not as significant as that in low-altitude *** fitting relation between convection heat transfer coefficient and outdoor wind speed is also *** the same heating power,the average temperature rise of indoor and outdoor air at highaltitude is 41.9%higher than that at low altitude,and the average temperature rise of inner wall is 25.8%higher than that at low *** shows that high-altitude area can create a more comfortable indoor thermal environment than low-altitude area under the same energy consumption *** is not appropriate to use the heat transfer characteristics of the exterior surface of buildings in low-altitude area for building energy saving design and related heating equipment selection and system terminal matching design in high-altitude area.

关键词： altitude heat transfer characteristics convective heat transfer coefficient(h_(c)) radiative heat transfer coefficient(h_(r)) external building envelope

不同原料对酱香大曲微生物群落结构及多样性的影响

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食品科学 2022年第10期43卷 133-141页

作者：赵驰苏伟母应春郑璞王涵钰贵州大学酿酒与食品工程学院贵州贵阳550025 贵州大学贵州省发酵工程与生物制药重点实验室贵州贵阳550025

分别以青稞、紫小麦和纯小麦为原料,相同条件下加工而成的酱香大曲为样品,采用Illumina平台对微生物群落结构和多样性进行分析,并基于多元统计分析揭示了组间分离情况及标记微生物。结果表明:在门水平上,3种大曲样品中均以子囊菌门、厚... 详细信息

分别以青稞、紫小麦和纯小麦为原料,相同条件下加工而成的酱香大曲为样品,采用Illumina平台对微生物群落结构和多样性进行分析,并基于多元统计分析揭示了组间分离情况及标记微生物。结果表明:在门水平上,3种大曲样品中均以子囊菌门、厚壁菌门和放线菌门为绝对优势门。在细菌属中,小麦曲(XMQ)以克罗彭斯特菌属、枝芽孢菌属、乳杆菌属和魏斯氏菌属为主;紫麦曲(ZMQ)以克罗彭斯特菌属、枝芽孢菌属、uncultured_bacterium_f_Bacillaceae、芽孢杆菌属和火山渣芽孢杆菌属为主;青稞曲(QKQ)以乳杆菌属、魏斯氏菌属和高温放线菌属为主。在真菌属中,样品均以热子囊菌属和德巴利氏酵母属为优势属;同时,XMQ以丝衣霉属、红曲霉属、哈萨克斯坦酵母属和孢圆酵母属为主;ZMQ以红曲霉属、曲霉属和Rasamsonia为主;QKQ以哈萨克斯坦酵母属、孢圆酵母属和嗜热真菌属为主。此外,主成分分析、聚类分析和正交偏最小二乘判别分析等多元分析表明组间分离明显,线性判别分析在优势属中共获得了10种差异显著细菌属和9种差异显著真菌属,从而得到了不同原料条件下在微生物属水平上的菌群关键生物标记物。本研究为酱香大曲品质提升奠定了理论基础。

关键词：酱香大曲原料高通量测序微生物多样性多元分析线性判别分析