检索结果-南通市图书馆

Public auditing for real‑time medical sensor data in cloud‑assisted HealthIIoT system

Frontiers of Optoelectronics 2022年第3期15卷 1-14页

作者： Weiping Ye jia Wang Hui Tian hanyu Quan College of Computer Science and Technology Huaqiao UniversityXiamen 361021China Wuhan National Laboratory for Optoelectronics Wuhan 430074China Xiamen Key Laboratory of Data Security and Blockchain Technology Xiamen 361021China Fujian Key Laboratory of Big Data Intelligence and Security Xiamen 361021China

With the advancement of industrial internet of things(IIoT),wireless medical sensor networks(WMSNs)have been widely introduced in modern healthcare systems to collect real-time medical data from patients,which is known as *** the limited computing and storage capabilities of lightweight HealthIIoT devices,it is necessary to upload these data to remote cloud servers for storage and ***,there are still some serious security issues within outsourcing medical sensor data to the *** of the most signifcant challenges is how to ensure the integrity of these data,which is a prerequisite for providing precise medical diagnosis and *** meet this challenge,we propose a novel and efcient public auditing scheme,which is suitable for cloud-assisted HealthIIoT ***,to address the contradiction between the high real-time requirement of medical sensor data and the limited computing power of HealthIIoT devices,a new online/ofine tag generation algorithm is designed to improve preprocessing efciency;to protect medical data privacy,a secure hash function is employed to blind the data *** formally prove the security of the presented scheme,and evaluate the performance through detailed experimental comparisons with the state-of-the-art *** results show that the presented scheme can greatly improve the efciency of tag generation,while achieving better auditing performance than previous schemes.

关键词： Healthcare industrial internet of things(HealthIIoT) Medical sensor data Online/ofine signature Public auditing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新冠肺炎疫情下急诊科的保障与防护措施

引用

江苏卫生事业管理 2020年第8期31卷 991-993,997页

作者：王蕾朱保锋陈建荣沈君华张毅任玉琴龚振华朱锦贾寒雨南通大学附属第二医院急诊科江苏南通226001 南通大学附属第二医院科教科江苏南通226001 南通大学附属第二医院医务科江苏南通226001 南通大学附属第二医院烧伤科江苏南通226001

目的:分析及比较新型冠状病毒肺炎(COVID-19)的流行病学及临床特征,为制定急诊科疫情分级诊疗策略和应对措施提供科学依据。方法:通过参考相关文献,针对新冠病毒肺炎疫情下南通大学附属第二医院急诊科分级分诊进行相关探讨。结果:(1)发... 详细信息

目的:分析及比较新型冠状病毒肺炎(COVID-19)的流行病学及临床特征,为制定急诊科疫情分级诊疗策略和应对措施提供科学依据。方法:通过参考相关文献,针对新冠病毒肺炎疫情下南通大学附属第二医院急诊科分级分诊进行相关探讨。结果:(1)发热、乏力和咳嗽是冠状病毒所致疾病的共同症状,COVID-19在早期症状可不典型;(2)动态观察白细胞计数、中性粒细胞计数、中性粒细胞计数/淋巴细胞计数(N/L)、C反应蛋白(CRP)/平均血小板体积、CRP和血沉,N/L比值是重症患者的独立危险因素;(3)关注胸膜下磨玻璃影的影像学征象,警惕早期肺肿瘤可能;(4)COVID-19核酸检测可与影像学结果不一致,做好实验室质控;(5)急诊预检分诊不应过分关注发热症状,有效的分级分层防控管理,尽快减少人员聚集。结论:急诊科的疫情防护不容懈怠,早期识别非发热新型冠状病毒肺炎患者,降低漏诊及误诊病例。

关键词：新冠肺炎急诊科临床特征安全防护分级诊疗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Driving force of biomolecular liquid–liquid phase separation probed by nuclear magnetic resonance spectroscopy

引用

Biophysics Reports 2022年第2期8卷 90-99页

作者： hanyu Zhang Weiwei Fan Gilbert Nshogoza Yaqian Liu jia Gao Jihui Wu Yunyu Shi Xiaoming Tu jiahai Zhang Ke Ruan Ministry of Education Key Laboratory for Membraneless Organelles & Cellular Dynamics Hefei National Laboratory for Physical Sciences at the Microscale School of Life SciencesDivision of Life Sciences and Medicine University of Science and Technology of China Department of Applied Chemistry College of Science and Technology University of Rwanda

The assembly of biomolecular condensates is driven by liquid–liquid phase separation. To understand the structure and functions of these condensates, it is essential to characterize the underlying driving forces, e.g., protein–protein and protein–RNA interactions. As both structured and low-complexity domains are involved in the phase separation process, NMR is probably the only technique that can be used to depict the binding topology and interaction modes for the structured and nonstructured domains simultaneously. Atomic-resolution analysis for the intramolecular and intermolecular interactions between any pair of components sheds light on the mechanism for phase separation and biomolecular condensate assembly and disassembly. Herein, we describe the procedures used for the most extensively employed NMR techniques to characterize key interactions for biomolecular phase separation.

关键词： Membraneless organelles Liquid–liquid phase separation NMR spectroscopy Chemical shift perturbation Paramagnetic relaxation enhancement

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

基于GEO数据库的热射病神经损伤相关基因的生物信息学分析

引用

中华神经创伤外科电子杂志 2023年第2期9卷 76-84页

作者：王蕾姜岱山朱保锋贾寒雨沈君华张毅南通大学第二附属医院急诊中心江苏南通226001 南通大学附属医院急诊中心江苏南通226001 南通大学第二附属医院科技处江苏南通226001 南通大学第二附属医院神经外科江苏南通226001

目的通过生物信息学检索热射病神经损伤的相关基因,探究热射病神经损伤的可能分子机制并进行初步验证。方法(1)以2022年4月作为时间截点,基于基因表达数据库(GEO)筛选热射病神经损伤相关基因表达谱数据,通过检索数据集GSE64778获得差异... 详细信息

目的通过生物信息学检索热射病神经损伤的相关基因,探究热射病神经损伤的可能分子机制并进行初步验证。方法(1)以2022年4月作为时间截点,基于基因表达数据库(GEO)筛选热射病神经损伤相关基因表达谱数据,通过检索数据集GSE64778获得差异表达基因(DEGs),结合GeneCards和CTD数据库检索热射病相关靶基因,取交集筛选获得候选靶基因。采用R语言的"ClusterProfiler"包对热射病相关候选靶基因进行GO和KEGG富集分析;进一步使用STRING数据库构建靶基因的交互作用网络图,并对关键基因进行相关性分析获得核心基因。(2)收集江苏省南通市第一人民医院自2022年6~8月收治的热射病患者的外周血,通过PCR技术进行核心基因的表达验证。结果(1)GSE64778数据集的SRA数据筛选,共获得1178个DEGs,其中322个上调,856个下调。GeneCards数据库筛选出2914个基因,CTD数据库筛选出2377个基因。将GSE64778数据集差异表达排名前300的基因,与GeneCards和CTD数据库检索结果取交集,最终筛选出25个候选DEGs。(2)GO功能注释结果显示靶基因主要参与细胞凋亡、应激反应以及细胞过程的负调控,在蛋白质二聚化和蛋白结合等过程中发挥功能。KEGG通路富集分析显示候选靶基因主要富集在PI3K-Akt信号通路。PPI网络分析显示Hsp90AA1是Degree值最高的枢纽基因,且在PI3K-Akt信号通路中富集。(3)经qRT-PCR验证,Hsp90AA1在热射病早期神经损伤患者中的表达均与生物信息学分析结果一致。结论Hsp90AA1可能为热射病神经损伤主要的影响基因,与细胞凋亡、应激反应以及细胞过程的负调控相关。

关键词：热射病神经损伤生物信息学 Hsp90AA1 PI3K-Akt信号通路

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Co_(12)C^(-)_(12)--metallo-carbospherenes:a new class of magic clusters for hydrogen storage

引用

Science Bulletin 2022年第22期67卷 2280-2284页

作者： Lijun Geng Chaonan Cui Baoqi Yin hanyu Zhang Yuhan jia Zhixun Luo Beijing National Laboratory for Molecular Sciences(BNLMS) State Key Laboratory for Structural Chemistry of Unstable and Stable SpeciesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China

Metal carbides play significant roles in electronics and materials science due to their unique properties,high strength,and high melting ***,they are applied in various organometallic synthesis and catalytic reactions,such as in the Fischer-Tropsch process and olefin metathesis[1,2],and they are able to adsorb small gas molecules such as hydrogen showing promising application for the hydrogen storage[3].Hydrogen is known as a sustainable solution for rising energy demands and an environmentally friendly option to replace fossil *** efforts have been made to develop hydrogen storage materials[4],with the aim to facilitate the application of hydrogen energy for achieving the future carbon–neutral goal set by *** has been recognized that the removal of the metal-bound terminal ligands and the doping of transition metals(TMs)on carbon substrates can improve the capacity of hydrogen adsorption[5,6].

关键词：金属碳化物光电子能谱化学惰性笼状结构超稳定极性键金属簇

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The cell division cycle protein SsCdc28 is essential for sclerotial development and pathogenicity of Sclerotinia sclerotiorum

The cell division cycle protein SsCdc28 is essential for scl...

引用

中国植物病理学会2019年学术年会

作者： Zheng hanyu Zhang Bowen Li Ke Li Xiangning Luo jia Zhang Yanhua College of Plant Sciences Jilin University

The necrotrophic fungal plant pathogen Sclerotinia sclerotiorum is responsible for substantial global crop losses annually resulting in localized food insecurity and loss of *** mitogenactivated protein kinase（MAPK） cascades serve as central signaling complexes that are involved in various aspects of sclerotia development and *** this study,the putative downstream of MAPK pathway,SsCdc28,was analyzed in *** this study,the SsCdc28 gene was cloned from the wild-type *** DNA as a template,and the full length was 1185 *** was used to find the upstream and downstream sequences of SsCdc28 gene,and specific primers were *** wild type *** DNA was used as a template to clone the 1 246 bp fragment upstream and the downstream 1 225 bp fragment of SsCdc28 *** upstream and downstream fragments were ligated to the knockout vector pXEH to construct knockout vector *** of *** protoplasts,and transformation of the constructed knockout vector pXEH-Cdc28 into *** three positive SsCdc28 knockout mutants SsCdc28-7,SsCdc28-11,and SsCdc28-13 were *** the knockout mutant strains and wild-type ***,the results showed that the mycelial growth rate of the knockout transformants became slower;the sclerotia could not be formed;the ability to resist high osmotic stress is enhanced,and the pathogenicity is *** results demonstrated that SsCdc28 function was essential in the vegetative mycelial growth,sclerotia development and penetration-dependent pathogenicity.

关键词： Sclerotinia sclerotiorum SsCdc28 Sclerotia development Pathogenicity

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Rolling horizon scheduling algorithm for dynamic vehicle scheduling system

引用

Journal of Southeast University(English Edition) 2005年第1期21卷 92-96页

作者：贾永基谷寒雨席裕庚上海交通大学自动化研究所上海200030

Dynamic exclusive pickup and delivery problem with time windows (DE-PDPTW), aspecial dynamic vehicle scheduling problem, is proposed. Its mathematical description is given andits static properties are analyzed, and then the problem is simplified asthe asymmetrical travelingsalesman problem with time windows. The rolling horizon scheduling algorithm (RHSA) to solve thisdynamic problem is proposed. By the rolling of time horizon, the RHSA can adapt to the problem'sdynamic change and reduce the computation time by dealing with only part of the customers in eachrolling time horizon. Then, its three factors, the current customer window, the scheduling of thecurrent customer window and the rolling strategy, are analyzed. The test results demonstrate theeffectiveness of the RHSA to solve the dynamic vehicle scheduling problem.

关键词： dynamic vehicle scheduling rolling horizon scheduling algorithm exclusive pickup and delivery problem with time windows (PDPTW)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Progress and remaining challenges in comprehensive gastric cancer treatment

引用

Holistic Integrative Oncology 2022年第1期1卷 52-61页

作者： Zhi-Feng Miao hanyu Chen Zhen-Ning Wang jia-Fu Ji Han Liang Hui-Mian Xu Jiping Wang Department of Surgical Oncology and General Surgery The First Hospital of China Medical UniversityShenyangChina Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors Ministry of EducationChina Medical UniversityShenyangChina Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Peking University Cancer Hospital&InstituteBeijingChina Department of Gastrointestinal Cancer Center Ward IPeking University Cancer Hospital&InstituteBeijingChina Department of Gastroenterology Key Laboratory of Cancer Prevention and TherapyNational Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjinChina Brigham and Women’s Hospital BostonUSA.

Gastric cancer(GC)is the fifth most common cancer among all cancer fields and currently the third most common cause of cancer-related deaths both in men and women ***,the incidence and mortality of GC significantly varies due to different eating habits and environmental and genetic factors in different ***,with the development of techniques and surgical equipment along with newly emerging drugs and therapeutics,the 5-year survival for GC patients has increased and the death rate has *** this perspective,based on current therapies in GC field around the world,we present a systematic discussion about the state of advanced clinical treatments including surgical resection,systemic chemotherapy,targeted therapy,radiotherapy and enhanced recovery after *** challenges remain which require further study and investigation,in this review,we mainly focus on the promising clinical treatment strategies in GC to date.

关键词： Gastric Cancer Comprehensive treatment Surgical resection Systemic therapy ERAS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research on fault detection method for heat pump air conditioning system under cold weather

引用

Chinese Journal of Chemical Engineering 2017年第12期25卷 1812-1819页

作者： Liangliang Sun jianghua Wu Haiqi jia Xuebin Liu Information and Control Engineering Shenyang Jianzhu University Electrical Engineering University of Connecticut

Building energy consumption accounts for nearly 40% of global energy consumption, HVAC （Heating, Ventilating, and Air Conditioning） systems are the major building energy consumers, and as one type of HVAC systems, the heat pump air conditioning system, which is more energy-efficient compared to the traditional air conditioning system, is being more widely used to save energy. However, in northern China, extreme climatic conditions increase the cooling and heating load of the heat pump air conditioning system and accelerate the aging of the equipment, and the sensor may detect drifted parameters owing to climate change. This non-linear drifted parameter increases the false alarm rate of the fault detection and the need for unnecessary troubleshooting. In order to overcome the impact of the device aging and the drifted parameter, a Kalman filter and SPC （statistical process control） fault detection method are introduced in this paper. In this method, the model parameter and its standard variance can he estimated by Kalman filter based on the gray model and the real-time data of the air conditioning system. Further, by using SPC to construct the dynamic control limits, false alarm rate is reduced. And this paper mainly focuses on the cold machine failure in the component failure and its soft fault detection. This approach has been tested on a simulation model of the ＂Sino-German Energy Conservation Demonstration Center＂ building heat pump air-conditioning system in Shenyang, China, and the results show that the Kalman filter and SPC fault detection method is simple and highly efficient with a low false alarm rate, and it can deal with the difficulties caused by the extreme environment and the non-linear influence of the parameters, and what＇s more, it provides a good foundation for dynamic fault diagnosis and fault prediction analysis.

关键词： Fault detection Cold machine Kalman filter Statistical process control Dynamic control

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fea2Lab:基于多标记学习的特征到标签生成模型

引用

华南师范大学学报（自然科学版） 2020年第3期52卷 111-119页

作者：于晗宇黄晋朱佳华南师范大学计算机学院广州510631

传统多标记学习方法通常只考虑和示例相关联的单个特征向量以及无差别地预测全体标签,从而忽视了与示例相似的其他示例及隐含的标签属性,造成输入空间特征信息较少、标签属性被忽略和对大标记空间预测效果差等问题.为解决以上问题,文章... 详细信息

传统多标记学习方法通常只考虑和示例相关联的单个特征向量以及无差别地预测全体标签,从而忽视了与示例相似的其他示例及隐含的标签属性,造成输入空间特征信息较少、标签属性被忽略和对大标记空间预测效果差等问题.为解决以上问题,文章转化传统多标记学习任务为多标记学习的序列到序列任务,并由此提出新的多标记学习标签生成神经网络模型(Fea2Lab模型):通过交错的顺序排列示例和相似示例形成链式特征向量序列,来增加输入空间特征信息;通过挖掘标签属性来有差别地预测标签;通过在解码流程中使用全局标签信息,来缓解预测过程中出现的错误标签级联问题.在多个数据集上的实验结果和消融实验表明转化任务和Fea2Lab模型的合理性、可行性及有效性.

关键词：多标记学习神经网络序列到序列模型标签属性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：