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Impact of carbimazole combined with vitamin E on testicular injury induced by experimental hyperthyroidism in adult albino rats:oxidative/inflammatory/apoptotic pathways

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Asian Journal of Andrology 2024年第4期26卷 396-401页

作者： Ramadan S Hussein moustafa m Eyada Rashad m mostafa Samah m Elaidy Shereen H Elsayed hany m Saad Department of Dermatology College of Medicine Prince Sattam Bin Abdulaziz UniversityAl-Kharj 16242Saudi Arabia Department of Dermatology Andrology and STDsAssiut Police HospitalAssiut 71525Egypt Department of Dermatology Venereology and AndrologyFaculty of MedicineSuez Canal UniversityIsmailia 41522Egypt Department of Andrology and Sexology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Department of Clinical Pharmacology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Department of Rehabilitation Sciences Faculty of Health and Rehabilitation SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh 12271Saudi Arabia.

Thyroid hormones play essential roles in spermatogenesis,but their effects on infertile males remain poorly *** study aimed to evaluate the impact of combining carbimazole(CBZ)with vitamin E(VE)on testicular injury induced by experimental hyperthyroidism in adult albino rats,focusing on oxidative,inflammatory,and apoptotic *** this experimental study,64 adult male albino Wistar rats were divided into eight groups:Group I(control-untreated),Group II(CBZ-control),Group III(VE-control),Group IV(CBZ+VE-control),Group V(levothyroxine-induced testicular injury),Group VI(levothyroxine+CBZ-treated),Group VII(levothyroxine+VE-treated),and Group VIII(levothyroxine+CBZ+VE-treated).The study was conducted in the Faculty of medicine,Suez Canal University(Ismailia,Egypt).After cervical decapitation,both testes and epididymis were examined histopathologically and *** differences were observed among groups concerning malondialdehyde(mDA),glutathione(GSH),superoxide dismutase(SOD),and catalase(CAT;all Pmerase chain reaction analysis showed significant differences in tumor necrosis factor-α(TNF-α),interleukin-10(IL-10),Bcl-2-associated X protein(BAX),B-cell lymphoma 2 protein(Bcl2),p53,Caspase-3,Caspase-8,Caspase-9,and nuclear factor-kappa B(NF-κB)mRNA levels(all Pminiferous tubules and ***,the Group VIII showed improved spermatogenesis and a decrease in testicular side *** addition of VE to the treatment of hyperthyroid rats with CBZ reduced testicular side effects and seminiferous tubular affection when potentially improving *** research is needed to elucidate the underlying mechanisms fully.

关键词： antithyroid drugs testicular injury thyroid gland vitamin E

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mass Increase with Strong and Gravitational Potentials, and mass Defect with Electromagnetic Potential

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Journal of High Energy Physics, Gravitation and Cosmology 2024年第3期10卷 1079-1094页

作者： hany Ali Hussein Electronic & Communication Shoubra College University of Banha Banha Egypt

The proposal is “mass increases due to strong and gravitational potentials, while it decreases due to Electromagnetic potential”. This proposal explains the big difference in mass between hadrons (protons, neutrons, & mesons) and their components (quarks), mass difference between nucleus and its individual components (protons and neutrons), massless of gamma photons, abnormal masses of mesons and bosons, and the excess in galaxy masses (dark matter). Also, this proposal shows the exact relation between mass and energy: Strong Potential=−3.04mc2| Electric Potential |=−5.57×10−3mc2Gravitational Potential=−1.22×10−7mc2where m represents the excess in mass due to strong potential, or gravitational potential and represents the decrease in mass due to electromagnetic potential. Released energy here equals potential energy and doesn’t equal decrease in mass using the formula E = mc2. Released energy is transferred to heat, photons, kinetic energy… Finally, proposal will try to describe the relation between photon energy and mass of its components using the general equation of kinetic energy: Photon Energy=1/2mc2m is the sum of the individual masses of its components, while the total mass of photon is zero.

关键词： mass Defect Dark matter Photon Gamma Photon Strong Potential Gravitational Potential Electromagnetic Potential Quarks mesons Bosons Deuterium Proton Neutron

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In silico identification of antiviral compounds for the treatment of chikungunya virus infection:qsar modelling and md simulation analysis

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medicine in Novel Technology and Devices 2024年第2期22卷 102-114页

作者： Hayder m Abdulhamza muthanna S.Farhan Sara.S Hassan hany Aqeel Al-Hussainy Amjad Ibrahim Oriabi Department of Pharmacy Kut University CollegeAlkutWasit52001Iraq Department of Pharmaceutical Chemistry College of PharmacyUniversity of BaghdadBaghdadIraq Al-manara College for medical Sciences Department of PharmacyIraq Department of Pharmacy Hilla University CollegeBabylonIraq Dr hany Akeel Institute Iraqi Medical Research CenterBaghdad10001Iraq

Chikungunya virus(CHIKV),transmitted by arthropods,has gained global recognition for its impact on public *** has expanded globally,including Africa,Asia,and the Indian subcontinent,and has a helicase protein in its genome that is crucial for its ***,the study targeted the helicase protein of CHIKV with 745 antiviral compounds using an mL-based QSAR model and molecular *** binders(5279172,78161839,6474310,and 5330286)were selected for mD simulation based on the control(Silvestrol).All compounds had the highest binding scores,with 78161839 showing the most consistent RmSD and the least conformational variation,indicating high *** also showed the lowest binding free energy(ΔG¼31.31 kcal/mol),indicating energetically favourable *** and FEL also depicted the stable complex confirmation of the protein and 78161839 complex during the 100 ns ***,this study aimed to identify helicase function antiviral binders that could be experimentally tested for treating CHIKV.

关键词： Chikungunya virus machine learning based QSAR molecular dynamic solution Helicase

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Planning Target Volume margin in Linac-Based Stereotactic Radiosurgery for Brain metastases

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Journal of Cancer Therapy 2024年第7期15卷 265-272页

作者： hany S. Attallah Radwa m. Hamed Khaled m. EL-Shahat Aliaa mahmoud mahmoud Abdallah Ibraheem Haggag Emad moustafa Adel Yassin Department of Radiation Oncology International Medical Center (IMC) Cairo Egypt Department of Radiation Oncology Armed Forces Medical Collogue (AFCM) Cairo Egypt Department of medical Physics Al Azhar University Cairo Egypt Department of medical Physics International Medical Center (IMC) Cairo Egypt Department of medical Physics Department of Clinical Oncology Faculty of Medicine Zagazig University Zagazig Egypt

Background: The treatment of brain metastases with radiotherapy has shifted to the use of Stereotactic Radio-surgery (SRS). The technical issue of expanding the treatment volume around the Gross Tumor Volume (GTV) is a current debate. Radiotherapy centers use variable GTV-PTV margins, ranging from one to 2 mm. material and methods: We performed a dosimetric comparison in plans of twenty patients using three margins: PTV zero, PTV1, and PTV2. We also developed imaginary Peel volumes. These volumes are described as follows: Peel1 = PTV1 − GTV, Peel2 = PTV2 − GTV. Results: Our results showed that the mean PTV volume differed significantly across the different margins (p = 0.000). The V12 of the brain significantly varied as a function of PTV margin (p = 0.000). The target coverage and plan quality indices were not significantly different. The Peel volume dosimetric analysis showed that the mean dose was significantly higher in the nearby normal brain tissue: Peel1 (p = 0.022) and Peel 2 (p = 0.013). Conclusion: According to our dosimetric analysis, expanding the GTV into a PTV by 1 mm margin is more convenient than 2 mm.

关键词： SRS Brain metastases PTV

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体外培养弓形虫裂殖子

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中国兽医科学 2024年第4期54卷 566-567页

作者： Jin-Lei Wang Ting-Ting Li Nian-Zhang Zhang meng Wang Li-Xiu Sun Zhi-Wei Zhang Bao-Quan Fu hany m Elsheikha Xing-Quan Zhu

弓形虫病是由弓形虫(Toxoplasma gondii)引起的一种重要的人兽共患寄生虫病,对全球公共卫生体系和畜牧业发展造成巨大威胁。据估计,全球大约有三分之一的人口感染了弓形虫。孕妇在怀孕初期首次感染弓形虫,可能会导致胎儿发育异常、流产... 详细信息

弓形虫病是由弓形虫(Toxoplasma gondii)引起的一种重要的人兽共患寄生虫病,对全球公共卫生体系和畜牧业发展造成巨大威胁。据估计,全球大约有三分之一的人口感染了弓形虫。孕妇在怀孕初期首次感染弓形虫,可能会导致胎儿发育异常、流产、畸形或死胎,每年约有超过五万起流产与此相关。因此,弓形虫是孕期必检病原之一。另外,弓形虫引起的动物流产问题也非常严重,绵羊的流产率介于11%~25%,猪的流产率介于5%~15%,每年由此而造成的经济损失超3亿元。

关键词：人兽共患寄生虫病弓形虫流产率裂殖子畜牧业发展三分之一全球公共卫生体外培养

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multicomponent synthesis and designing of tetrasubstituted imidazole compounds catalyzed via ionic-liquid for acid steel corrosion protection:Experimental exploration and theoretical calculations

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Chinese Journal of Chemical Engineering 2023年第3期55卷 304-319页

作者： hany m.Abd El-Lateef mai m.Khalaf K.Shalabi Antar A.Abdelhamid Department of Chemistry College of ScienceKing Faisal UniversityAl-Ahsa 31982Saudi Arabia Department of Chemistry Faculty of ScienceSohag UniversitySohag 82524Egypt Chemistry Department Faculty of ScienceMansoura UniversityMansouraEgypt Chemistry Department Faculty of ScienceAlbaha UniversityAlbaha 1988Saudi Arabia

Five new tetrasubstituted imidazoles were designed with outstanding yields(83%-92%) in the occurrence of ionic liquid-based-pyridinium as a catalyst. The constructions of all synthesized derivatives were established by spectral tools and their purities were verified using thin-layer chromatography(TLC), displaying single-spot. The performance of corrosion protection of the prepared imidazole derivatives was examined theoretically and practically for acid steel corrosion. The experimental study was conducted by electrochemical(electrochemical impedance spectroscopy(EIS) and Tafel polarization(PPS)) *** findings from the used approaches concluded that the synthesized compounds were wellorganized inhibitors with an efficiency of 90.7%-98.5% at 50℃ and 0.7 mmol·L^(-1). The Tafel polarization results indicate the protective action of the additives was under mixed-monitoring. The additive adsorption on the electrode interface performed as a distinguished aspect for protection. The surface exploration on the blank and protected metal was completed by field emission scanning electron microscopy(FESEm). Computational studies by monte Carlo(mC) simulation and quantum chemical calculation(DFT)were related to practical findings. The corrosion protection adsorption mechanism was reinforced by the preferable fitted Langmuir isotherm model. All findings from the applied-inspected approaches alternately confirm each other.

关键词： Adsorption Ionic-liquid catalyst Tetrasubstituted imidazoles Corrosion Pickling acid mathematical modeling

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Heterocyclic Synthesis Using Nitrilimines： Part 16. Synthesis of Some New Pyrazole and Spiropyrazoline Derivatives

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Chinese Journal of Chemistry 2011年第4期29卷 751-756页

作者： Dalloul, hany m Department of Chemistry Faculty of Applied Science Alaqsa University of Gaza P. O. Box 4051 Gaza 76888 Palestine

1,3-Dipolar cycloaddition of the nitrilimines with the 2-propylidene-3-coumaranone afforded the corresponding pyrazole derivatives. Similar reactions of nitrilimines with 3-ethylidene-1-indanone furnished spiropyrazol... 详细信息

关键词： heterocycles cycloaddition nitrilimine pyrazole spiropyrazoline

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Significant Lifetime Enhancement in QLEDs by Reducing Interfacial Charge Accumulation via Fluorine Incorporation in the ZnO Electron Transport Layer

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Nano-micro Letters 2022年第12期14卷 432-446页

作者： Dong Seob Chung Tyler Davidson-Hall Giovanni Cotella Quan Lyu Peter Chun hany Aziz Department of Electrical and Computer Engineering Waterloo Institute for NanotechnologyUniversity of Waterloo200 University Avenue WestWaterlooON N2L 3G1Canada Ipswich Research Centre Huawei Technologies Research&Development(UK)Ltd.Phoenix House(B55)Adastral ParkIpswich IP53REUK Ottawa IC Laboratory Huawei Canada19 Allstate ParkwayMarkhamON L3R 5B4Canada

ZnO nanoparticles are widely used for the electron transport layers(ETLs)of quantum dots light emitting devices(QLEDs).In this work we show that incorporating fluorine(F)into the ZnO ETL results in significant enhancement in device electroluminescence stability,leading to LT50 at 100 cd m^(−2) of 2,370,000 h in red QLED,47X longer than the control devices.X-ray photo-electron spectroscopy,time-of-flight secondary ion mass spectroscopy,photoluminescence and electrical measurements show that the F passivates oxygen vacancies and reduces electron traps in *** photoluminescence versus bias measurements and capacitance-voltage-luminance measurements reveal that the CF4 plasma-treated ETLs lead to increased electron concentration in the QD and the QD/hole transport layer interface,subsequently decreasing hole accumulation,and hence the higher *** findings provide new insights into the critical roles that optimizing charge distribution across the layers play in influencing stability and present a novel and simple approach for extending QLED lifetimes.

关键词： Colloidal quantum dots Quantum dots light emitting device Device stability Zinc oxide nanoparticles Fluorine

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Analysis and Assessment of Wind Energy Potential of Socotra Archipelago in Yemen

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Computers, materials & Continua 2022年第1期70卷 1177-1193页

作者： murad A.Almekhlafi Fahd N.Al-Wesabi Imran Khan Nadhem Nemri Khalid mahmood hany m.hgoub Noha Negm Amin m.El-Kustaban Ammar Zahary Department of Electrical Engineering–Communication Engineering Sana’a UniversityYemen Department of Computer Science King Khalid UniversityMuhayel AseerKingdom of Saudi Arabia Faculty of Computer and IT Sana’a UniversitySana’aYemen Department of Electrical Engineering University of Engineering and TechnologyPeshawarP.O.B 814Pakistan Department of Information Systems King Khalid UniversityMayahel AseerKSA Computer Science Department King Khaled UniversityKSA&Faculty of Computers and InformationComputer Science DepartmentMenoufia UniversityEgypt Computer Science Department King Khaled UniversityKSA&Faculty of ScienceDepartment of Mathematics and Computer ScienceMenoufia UniversityEgypt Electronics Department Faculty of EngineeringUSTSana’aYemen Faculty of Computer and IT Sana’a UniversityYemen

The increasing use of fossil fuels has a significant impact on the environment and ecosystem,which increases the rate of *** the high potential of renewable energy sources inYemen and the absence of similar studies in the region,this study aims to examine the potential of wind energy in Socotra *** was done by analyzing and evaluating wind properties,determining available energy density,calculating wind energy extracted at different altitudes,and then computing the capacity factor for a number of wind turbines and determining the *** average wind speed in Socotra Island was obtained from the Civil Aviation and meteorology Authority data,only for the five-year data currently *** results showed high wind speeds from June to September(9.85-14.88 m/s)while the wind speed decreased for the rest of the *** average wind speed in the five years was 7.95 m/*** average annual wind speed,wind energy density,and annual energy density were calculated at different altitudes(10,30,and 50 m).According to the International Wind Energy Rating criteria,the region of Socotra Island falls under Category 7 and is classified as‘Superb’for most of the *** study provides useful information for developing wind energy and an efficient wind approach.

关键词： Energy potential wind characteristics Weibull distribution wind power density Socotra island

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Expression levels ofβcatenin and galectin-3 in meningioma and their effect on brain invasion and recurrence:a tissue microarray study

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Cancer Biology & medicine 2017年第3期14卷 319-326页

作者： Rehab Allah Ahmed Abdelhadi m Shebl hany Onsy Habashy Department of Pathology Mansoura UniversityFaculty of MedicineMansoura DK 35516Egypt

Objective:meningiomas are neoplasms that arise from the meninges of the central nervous system(CNS).They constitute about25.6%of CNS tumors diagnosed in *** morphological variants of meningiomas display aggressive behavior,leading to brain-invasive growth *** meningiomas are usually treated by complete surgical excision,the risk of postoperative recurrence ***,additional biomarkers for predicting aggressive behavior must be *** study aims to explore the clinical and biological relevance of the protein expression levels ofβ-catenin and galectine-3 in meningioma and to understand the pathobiology of this ***:This retrospective study was carried out on 153 cases of meningioma by using tissue microarrays and immunohistochemistry forβ-catenin and ***:Highβ-catenin expression was significantly associated with transitional and meningiotheliomatous meningiomas,low tumor grade,low recurrence rate,and low incidence of brain ***,high galectin-3 expression was associated with brain invasion,recurrence,high tumor grade,and tumor *** regression analysis indicated that among all variables included in the model,β-catenin and galactin-3 expression levels were significant predictors of tumor recurrence(Pmeningioma recurrence but not in brain *** molecules could be important potential therapeutic targets and predictors for meningiomas.

关键词： Immunohistochemistry meningioma recurrence brain invasion galectin-3 and β-catenin

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