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Impact of carbimazole combined with vitamin e on testicular injury induced by experimental hyperthyroidism in adult albino rats:oxidative/inflammatory/apoptotic pathways

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Asian Journal of Andrology 2024年第4期26卷 396-401页

作者： Ramadan s Hussein moustafa m eyada Rashad m mostafa samah m elaidy shereen H elsayed hany m saad Department of Dermatology College of Medicine Prince Sattam Bin Abdulaziz UniversityAl-Kharj 16242Saudi Arabia Department of Dermatology Andrology and STDsAssiut Police HospitalAssiut 71525Egypt Department of Dermatology Venereology and AndrologyFaculty of MedicineSuez Canal UniversityIsmailia 41522Egypt Department of Andrology and sexology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Department of Clinical Pharmacology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Department of Rehabilitation sciences Faculty of Health and Rehabilitation SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh 12271Saudi Arabia.

Thyroid hormones play essential roles in spermatogenesis,but their effects on infertile males remain poorly *** study aimed to evaluate the impact of combining carbimazole(CBZ)with vitamin e(Ve)on testicular injury induced by experimental hyperthyroidism in adult albino rats,focusing on oxidative,inflammatory,and apoptotic *** this experimental study,64 adult male albino Wistar rats were divided into eight groups:Group I(control-untreated),Group II(CBZ-control),Group III(Ve-control),Group IV(CBZ+Ve-control),Group V(levothyroxine-induced testicular injury),Group VI(levothyroxine+CBZ-treated),Group VII(levothyroxine+Ve-treated),and Group VIII(levothyroxine+CBZ+Ve-treated).The study was conducted in the Faculty of medicine,suez Canal University(Ismailia,egypt).After cervical decapitation,both testes and epididymis were examined histopathologically and *** differences were observed among groups concerning malondialdehyde(mDA),glutathione(GsH),superoxide dismutase(sOD),and catalase(CAT;all Pmerase chain reaction analysis showed significant differences in tumor necrosis factor-α(TNF-α),interleukin-10(IL-10),Bcl-2-associated X protein(BAX),B-cell lymphoma 2 protein(Bcl2),p53,Caspase-3,Caspase-8,Caspase-9,and nuclear factor-kappa B(NF-κB)mRNA levels(all Perthyroid group treated with CBZ alone(Group VI)exhibited testicular side effects,affecting seminiferous tubules and ***,the Group VIII showed improved spermatogenesis and a decrease in testicular side *** addition of Ve to the treatment of hyperthyroid rats with CBZ reduced testicular side effects and seminiferous tubular affection when potentially improving *** research is needed to elucidate the underlying mechanisms fully.

关键词： antithyroid drugs testicular injury thyroid gland vitamin e

Communication-less management strategy for electric Vehicle Charging in Droop-controlled Islanded microgrids

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Journal of modern Power systems and Clean energy 2024年第4期12卷 1227-1238页

作者： Abdullah Azhar Al-Obaidi mohammed Zaki el-sharafy hany e.Z.Farag saifullah shafiq Ali Al-Awami Independent electricity system Operator(IesO) MississaugaCanada Department of electrical engineering and Computer science York UniversityTorontoCanada University of Queensland StLucia QLD 4067Australia Department of electrical engineering King Fahd University of Petroleum&MineralsDhahranSaudi Arabia

Adopting high penetration levels of electric vehicles(eVs)necessitates the implementation of appropriate charging management systems to mitigate their negative impacts on pow-er distribution ***,most of the proposed ev charging management techniques rely on the availability of high-bandwidth communication *** techniques are far from realization due to①the lack of utility-grade communica-tion systems in many cases such as secondary(low-voltage)pow-er distribution systems to which eVs are connected,rural ar-eas,remote communities,and islands,and②existing fears and concerns about the data privacy of eV users and cyber-physical *** these cases,appropriate local control schemes are needed to ensure the adequate management of eV charging without violating the grid operation ***,this paper introduces a new communication-less management strategy for eV charging in droop-controlled islanded *** proposed strategy is autonomous,as it is based on the measurement of system frequency and local bus *** proposed strategy implements a social charging fairness policy during periods when the microgrid distributed genera-tors(DGs)are in short supply by allocating more system capaci-ty to the eVs with less charging in the ***,a novel communication-less eV load shedding scheme is incorpo-rated into the management strategy to provide relief to the mi-crogrid during events of severe undervoltage or underfrequency occurrences due to factors such as high loading or DG *** simulations demonstrate the superiority of the pro-posed strategy over the state-of-the-art controllers in modulat-ing the eV charging demand to counteract microgrid instability.

关键词： Charging battery management communication-less control droop control electric vehicle islanded microgrid

In silico identification of antiviral compounds for the treatment of chikungunya virus infection:qsar modelling and md simulation analysis

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medicine in Novel Technology and Devices 2024年第2期22卷 102-114页

作者： Hayder m Abdulhamza muthanna s.Farhan sara.s Hassan hany Aqeel Al-Hussainy Amjad Ibrahim Oriabi Department of Pharmacy Kut University CollegeAlkutWasit52001Iraq Department of Pharmaceutical Chemistry College of PharmacyUniversity of BaghdadBaghdadIraq Al-manara College for medical sciences Department of PharmacyIraq Department of Pharmacy Hilla University CollegeBabylonIraq Dr hany Akeel Institute Iraqi Medical Research CenterBaghdad10001Iraq

Chikungunya virus(CHIKV),transmitted by arthropods,has gained global recognition for its impact on public *** has expanded globally,including Africa,Asia,and the Indian subcontinent,and has a helicase protein in its genome that is crucial for its ***,the study targeted the helicase protein of CHIKV with 745 antiviral compounds using an mL-based QsAR model and molecular *** binders(5279172,78161839,6474310,and 5330286)were selected for mD simulation based on the control(silvestrol).All compounds had the highest binding scores,with 78161839 showing the most consistent RmsD and the least conformational variation,indicating high *** also showed the lowest binding free energy(ΔG¼31.31 kcal/mol),indicating energetically favourable *** and FeL also depicted the stable complex confirmation of the protein and 78161839 complex during the 100 ns ***,this study aimed to identify helicase function antiviral binders that could be experimentally tested for treating CHIKV.

关键词： Chikungunya virus machine learning based QsAR molecular dynamic solution Helicase

mass Increase with strong and Gravitational Potentials, and mass Defect with electromagnetic Potential

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Journal of High energy Physics, Gravitation and Cosmology 2024年第3期10卷 1079-1094页

作者： hany Ali Hussein electronic & Communication Shoubra College University of Banha Banha Egypt

The proposal is “mass increases due to strong and gravitational potentials, while it decreases due to electromagnetic potential”. This proposal explains the big difference in mass between hadrons (protons, neutrons, & mesons) and their components (quarks), mass difference between nucleus and its individual components (protons and neutrons), massless of gamma photons, abnormal masses of mesons and bosons, and the excess in galaxy masses (dark matter). Also, this proposal shows the exact relation between mass and energy: strong Potential=−3.04mc2| electric Potential |=−5.57×10−3mc2Gravitational Potential=−1.22×10−7mc2where m represents the excess in mass due to strong potential, or gravitational potential and represents the decrease in mass due to electromagnetic potential. Released energy here equals potential energy and doesn’t equal decrease in mass using the formula e = mc2. Released energy is transferred to heat, photons, kinetic energy… Finally, proposal will try to describe the relation between photon energy and mass of its components using the general equation of kinetic energy: Photon energy=1/2mc2m is the sum of the individual masses of its components, while the total mass of photon is zero.

关键词： mass Defect Dark matter Photon Gamma Photon strong Potential Gravitational Potential electromagnetic Potential Quarks mesons Bosons Deuterium Proton Neutron

Knowledge‐based deep learning system for classifying Alzheimer's disease for multi‐task learning

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CAAI Transactions on Intelligence Technology 2024年第4期9卷 805-820页

作者： Amol Dattatray Dhaygude Gaurav Kumar Ameta Ihtiram Raza Khan Pavitar Parkash singh Renato R.maaliw III Natrayan Lakshmaiya mohammad shabaz muhammad Attique Khan hany s.Hussein Hammam Alshazly Department of Data science University of WashingtonSeattleWashingtonUSA Department of Computer science&engineering Parul Institute of TechnologyParul UniversityVadodaraGujaratIndia Department of Computer science Jamia HamdardDelhiIndia Department of management Lovely Professional UniversityPhagwaraIndia 5 College of engineering Southern Luzon State UniversityLucbanQuezonPhilippines Department of mechanical engineering Saveetha School of EngineeringSIMATSChennaiTamil NaduIndia model Institute of engineering and Technology JammuJ&KIndia Department of Computer science HITEC UniversityTaxilaPakistan Department of Computer science and mathematics Lebanese American UniversityBeirutLebanon electrical engineering Department College of EngineeringKing Khalid UniversityAbhaSaudi Arabia electrical engineering Department Aswan UniversityAswanEgypt Faculty of Computers and Information South Valley UniversityQenaEgypt

Deep learning has recently become a viable approach for classifying Alzheimer's disease(AD)in medical ***,existing models struggle to efficiently extract features from medical images and may squander additional information resources for illness *** address these issues,a deep three‐dimensional convolutional neural network incorporating multi‐task learning and attention mechanisms is *** upgraded primary C3D network is utilised to create rougher low‐level feature *** introduces a new convolution block that focuses on the structural aspects of the magnetORCID:ic resonance imaging image and another block that extracts attention weights unique to certain pixel positions in the feature map and multiplies them with the feature map ***,several fully connected layers are used to achieve multi‐task learning,generating three outputs,including the primary classification *** other two outputs employ backpropagation during training to improve the primary classification *** findings show that the authors’proposed method outperforms current approaches for classifying AD,achieving enhanced classification accuracy and other in-dicators on the Alzheimer's disease Neuroimaging Initiative *** authors demonstrate promise for future disease classification studies.

关键词： classification deep learning

Planning Target Volume margin in Linac-Based stereotactic Radiosurgery for Brain metastases

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Journal of Cancer Therapy 2024年第7期15卷 265-272页

作者： hany s. Attallah Radwa m. Hamed Khaled m. eL-shahat Aliaa mahmoud mahmoud Abdallah Ibraheem Haggag emad moustafa Adel Yassin Department of Radiation Oncology International Medical Center (IMC) Cairo Egypt Department of Radiation Oncology Armed Forces Medical Collogue (AFCM) Cairo Egypt Department of medical Physics Al Azhar University Cairo Egypt Department of medical Physics International Medical Center (IMC) Cairo Egypt Department of medical Physics Department of Clinical Oncology Faculty of Medicine Zagazig University Zagazig Egypt

Background: The treatment of brain metastases with radiotherapy has shifted to the use of stereotactic Radio-surgery (sRs). The technical issue of expanding the treatment volume around the Gross Tumor Volume (GTV) is a current debate. Radiotherapy centers use variable GTV-PTV margins, ranging from one to 2 mm. material and methods: We performed a dosimetric comparison in plans of twenty patients using three margins: PTV zero, PTV1, and PTV2. We also developed imaginary Peel volumes. These volumes are described as follows: Peel1 = PTV1 − GTV, Peel2 = PTV2 − GTV. Results: Our results showed that the mean PTV volume differed significantly across the different margins (p = 0.000). The V12 of the brain significantly varied as a function of PTV margin (p = 0.000). The target coverage and plan quality indices were not significantly different. The Peel volume dosimetric analysis showed that the mean dose was significantly higher in the nearby normal brain tissue: Peel1 (p = 0.022) and Peel 2 (p = 0.013). Conclusion: According to our dosimetric analysis, expanding the GTV into a PTV by 1 mm margin is more convenient than 2 mm.

关键词： sRs Brain metastases PTV

Gram-negative bacterial diversity and evidence of international clones of multidrug-resistant strains in zoo animals

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Integrative Zoology 2024年第3期19卷 417-423页

作者： João Pedro Rueda FURLAN micaela santana RAmOs Fábio Parra seLLeRA Irys hany Lima GONZALeZ Patrícia Locosque RAmOs eliana Guedes sTeHLING Department of Clinical Analyses Toxicology and Food ScienceSchool of Pharmaceutical Sciences of Ribeirão PretoUniversity of São PauloRibeirão PretoBrazil Department of Internal medicine School of Veterinary Medicine and Animal ScienceUniversity of São PauloSão PauloBrazil school of Veterinary medicine Metropolitan University of SantosSantosBrazil Coordination of Wild Fauna Secretary of EnvironmentInfrastructure and LogisticsSão PauloBrazil

Antimicrobial resistance(AmR)is a growing phenomenon that poses a major public health challenge worldwide(Dhingra et al.2020;Antimicrobial Resistance Collaborators 2022).The selective pressure exerted in clinical settings has contributed to the longlasting successful dissemination of multidrug-resistant(mDR)Gram-negative bacteria in these environments(Chia et al.2020).

关键词： multidrug clinical

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辐射式电加热器中电加热芯的优化布置研究

工业加热 2024年第9期53卷 33-38页

作者：韩磊金宇超郭屹博黄浩胡自成 hany s-el-mesery 江苏东方瑞吉能源装备有限公司江苏镇江212132 江苏大学能源与动力工程学院江苏镇江212013

为降低辐射式电加热器的电加热芯表面温度以延长电加热器寿命,本文设计了四种电加热芯布置方式,采用Fluent模拟研究了电加热芯布置方式对其电加热器内部温度场和表面温度的影响规律。结果表明:在满足物料出口温度要求条件下,各方案电加... 详细信息

为降低辐射式电加热器的电加热芯表面温度以延长电加热器寿命,本文设计了四种电加热芯布置方式,采用Fluent模拟研究了电加热芯布置方式对其电加热器内部温度场和表面温度的影响规律。结果表明:在满足物料出口温度要求条件下,各方案电加热芯与氮气区域温度差分别为:方案一约为190℃,方案二约为210℃,方案三约为200℃,方案四约为180℃,方案四温度差相比其余方案降低10~30℃,温度场更加稳定;各方案电加热芯平均温度:方案一约为910℃;方案二约为950℃;方案三约为905℃;方案四约为860℃,电加热芯温度相比其他布置形式降低40~90℃。

关键词：辐射式电加热器电加热芯布置方式表面温度 Fluent 温度场

Heterocyclic synthesis Using Nitrilimines： Part 16. synthesis of some New Pyrazole and spiropyrazoline Derivatives

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Chinese Journal of Chemistry 2011年第4期29卷 751-756页

作者： Dalloul, hany m Department of Chemistry Faculty of Applied Science Alaqsa University of Gaza P. O. Box 4051 Gaza 76888 Palestine

1,3-Dipolar cycloaddition of the nitrilimines with the 2-propylidene-3-coumaranone afforded the corresponding pyrazole derivatives. similar reactions of nitrilimines with 3-ethylidene-1-indanone furnished spiropyrazol... 详细信息

关键词： heterocycles cycloaddition nitrilimine pyrazole spiropyrazoline