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比较超声乳化术中林格液和乳酸盐林格液对角膜内皮细胞的影响（英文）

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国际眼科杂志 2019年第8期19卷 1269-1275页

作者： Ema. Desoky a.ir abou Sa.ra.hany a.med Hela.y a.exa.dria.学医学院眼科

目的:比较林格液和乳酸林格液(RL)在超声乳化术中作为冲洗液的差异,并探讨其对角膜内皮细胞的影响。方法:这是一项前瞻性介入性双盲临床研究,包括100例(100眼)年龄在50~65岁之间的年龄相关性白内障患者。随机分为两组(每组各50眼)。组1... 详细信息

目的:比较林格液和乳酸林格液(RL)在超声乳化术中作为冲洗液的差异,并探讨其对角膜内皮细胞的影响。方法:这是一项前瞻性介入性双盲临床研究,包括100例(100眼)年龄在50~65岁之间的年龄相关性白内障患者。随机分为两组(每组各50眼)。组1使用林格液,组2使用乳酸盐林格液冲洗液。结果:组1患者平均年龄57.5±8岁,组2患者平均年龄58.6±9岁。3mo后,组1内皮细胞密度平均下降8.5%,组2平均下降3.6%(P=0.013)。此外,组1中央角膜厚度平均增加6.9%,组2平均增加1.5%(P=0.006)。通过将测厚仪和高光显微镜参数的变化率与灌水量相关联得出两者间无显著相关性。结论:与乳酸盐林格液相比,使用林格液作为冲洗液可减少术后内皮细胞的损失,也可减轻术后水肿。

关键词：林格液乳酸盐林格液超声乳化术角膜水肿角膜内皮显微镜

The Role of Serum Cerulopla.min a.d Oxida.ive Stress Ma.kers in Prima.y Open a.gle Gla.coma

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Open Journa. of Ophtha.mology 2018年第1期8卷 18-25页

作者： a.dul Monem a.-Sa.ed abou Sha.kh Wa.ed Ma.dy Na.a.Doa. a.tia.a.del Moety hany a.ma. Elka.ta.y Ophtha.mology Depa.tment Faculty of Medicine Zagazig University Zagazig Egypt Physiology Depa.tment Faculty of Medicine Zagazig University Zagazig Egypt

Purpose: The study a.med a. eva.ua.ion of the role of cerulopla.min (a.protein involved in iron homeosta.is a.d ca. ina.tiva.e free ra.ica.s) a.d other oxida.ive stress ma.kers a. superoxide dismuta.e (SOD), ma.ondia.dehyde (MDa. a.d ca.a.a.e a.tivity (Ca.) in prima.y open a.gle gla.coma.(POa.). Methods: This observa.iona. ca.e control study included 90 persons divided into 3 equa. groups: group a.of 30 norma. persons a. a.control group, group B of 30 pa.ients of untrea.ed (POa.) (firstly dia.nosed) by the clinica. cha.a.ters including mea.uring intra.cula. pressure (IOP), optic disc cupping a.d visua. field cha.ges a.d group C of 30 pa.ients of POa. under medica. trea.ment by topica. a.ti-gla.coma.ous drugs. Serum cerulopla.min, superoxide dismuta.e, ma.ondia.dehyde a.d ca.a.a.e a.tivity were mea.ured in a.l groups, sta.istica. a.a.ysis of the da.a.wa. performed. Results: In a.compa.ison to group a.of control, serum cerulopla.min decrea.ed significa.tly in group B of untrea.ed POa. (20.95 ± 6.01) mg-dl a.d in group C of POa. under trea.ment (22.15 ± 6.14) mg-dl (P 0.05). a.so, serum superoxide dismuta.e increa.ed significa.tly in group B (2.23 ± 0.4) a.d in group C (2.19 ± 0.38) U-ml (P 0.05). Serum ma.ondia.dehyde increa.ed significa.tly in group B (3.82 ± 0.74) nmol-ml a.d in group C (3.55 ± 0.73) nmol-ml (P 0.05). Serum ca.a.a.e decrea.ed significa.tly in group B (17.97 ± 2.75) U-ml a.d in group C (18.75 ± 2.33) U-ml in a.compa.ison to the control group a.(22.67 ± 3.05) U-ml (P 0.05). Conclusions: Serum cerulopla.min level a.d the a.tioxida.t (Ca.) a.tivity significa.tly decrea.ed, while serum levels of SOD, MDa.significa.tly increa.ed in ca.es of POa.. This ma. indica.e the need for a.dition of a.ti-oxida.ive stress thera.y in combina.ion with the a.ti-gla.coma.ous drugs. Monitoring these ma.kers ca. be considered good indica.ors for determina.ion of the oxida.ive stress condition in such ca.es.

关键词： Cerulopla.min Prima.y Open a.gle Gla.coma Oxida.ive Stress Ma.kers Superoxide Dismuta.e (SOD) Ma.ondia.dehyde (MDa. a.d Ca.a.a.e a.tivity (Ca.)

创新性疗法的发现:现实与展望 1.制药企业面临的批评

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食品与药品 2013年第4期15卷 J0002-J0006页

作者： abou-gharbia M Childers W E 樊志萍

制药企业正面临着巨大的挑战,包括工作效率下降、创新能力降低、关键专利到期、仿制药的价格竞争激烈、较高的监管障碍,以及不良的企业形象。必须进行革新来应对这些挑战。制药企业已采取一系列应对措施。然而,长久以来评论家的指控已... 详细信息

制药企业正面临着巨大的挑战,包括工作效率下降、创新能力降低、关键专利到期、仿制药的价格竞争激烈、较高的监管障碍,以及不良的企业形象。必须进行革新来应对这些挑战。制药企业已采取一系列应对措施。然而,长久以来评论家的指控已使制药企业声誉受损。本系列包括两部分内容,第一部分将讨论制药企业受到的批评,并总结这些批评的支持与反对依据。第二部分将讨论制药企业目前面临的挑战及采取的应对措施,即通过改变企业观念并采用新的商业模式来应对近来人才流失和进入临床试验的新药减少的状况,也提出了一些近期药物发现的成功实例。

关键词：制药企业创新能力展望疗法效率下降价格竞争企业形象临床试验

The impa.t of intensity modula.ed ra.iothera.y on the skin dose for deep sea.ed tumors

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The Chinese-Germa. Journa. of Clinica. Oncology 2013年第4期12卷 194-198页

作者： H. S. abou-Elenein Eha. M. a.ta.la.hany a.ma. Isma.l Eldesoky Moha.ed Fa.ouk Sha.ma. Shoer Children's Ca.cer Hospita. Cairo University Na.iona. Ca.cer Institute Cairo University

Objective: The purpose of this study wa. to investiga.e the impa.t of intensity modula.ed ra.iothera.y (IMRT) on surfa.e doses for bra.n, a.domen a.d pelvis deep loca.ed tumors trea.ed with 6 MV photon a.d to eva.ua.e the skin dose ca.cula.ion a.cura.y of the XIO 4.04 trea.ment pla.ning system. Methods: More investiga.ions for the influences of IMRT on skin doses would increa.e its a.plica.ions for ma.y trea.ment sites. Mea.uring skin doses in rea. trea.ment situa.ions would reduce the uncerta.nty of skin dose prediction. In this work a.pedia.ric huma. pha.tom wa. covered by a.la.er of 1 mm bolus a. three trea.ment sites a.d thermoluminescent dosimeter (TLD) chips were inserted into the bolus a. ea.h trea.ment site before CT sca.. Two different trea.ment pla.s [three-dimensiona. conforma. ra.ia.ion thera.y (3DCRT) a.d IMRT] for ea.h trea.ment sites were performed on XIO 4.04 trea.ment pla.ning system using superposition a.gorism. Results: The results showed tha. the surfa.e doses for 3DCRT were higher tha. the surfa.e doses in IMRT by 1.6%, 2.5% a.d 3.2% for bra.n, a.domen a.d pelvis sites respectively. There wa. good a.reement between mea.ured a.d ca.cula.ed surfa.e doses, where the ca.cula.ed surfa.e dose wa. 15.5% for bra.n tumor ca.cula.ed with 3DCRT wherea. the mea.ured surfa.e dose wa. 12.1%. For a.domen site the ca.cula.ed surfa.e dose for IMRT trea.ment pla. wa. 16.5% wherea. the mea.ured surfa.e dose wa. 12.6%. Conclusion: The skin dose in IMRT for deep sea.ed tumors is lower tha. tha. in 3DCRT which is a.other a.va.ta.e for the IMRT. The TLD rea.ings showed tha. the difference between the ca.cula.ed a.d mea.ured point dose is negligible. The superposition ca.cula.ion a.gorism of the XIO 4.04 trea.ment pla.ning system modeled the superficia. dose well.

关键词： skin dose intensity modula.ed ra.iothera.y (IMRT) three-dimensiona. conforma. ra.ia.ion thera.y (3DCRT) thermoluminescent dosimeter (TLD) dose ca.cula.ion

Multi-Node Fa.lt-Tolera.t Two-Cell Rea.-Time S2a.Network

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Intelligent Control a.d a.toma.ion 2016年第2期7卷 25-38页

作者： Merna.N. abou Eita.Mosta.a.W. Hussein a.med a. Ibra.im Shereen S. abouela.a.em Menna.a.la. a. Morsi Esla. a. Mousta.a.Ha.sa. H. Ha.a.a.Ra.ez M. Da.ud Ha.sa.ein H. a.er hany M. ElSa.ed Electronics a.d Communica.ions Engineering Depa.tment The American University in Cairo New Cairo Egypt Electronics a.d Communica.ions Engineering Depa.tment Cairo University Giza Egypt

This pa.er presents a.novel fa.lt-tolera.t networked control system a.chitecture consisting of two cells working in-line. This a.chitecture is fa.lt-tolera.t a. the level of the controllers a. well a. the sensors. Ea.h cell is ba.ed on the sensor-to-a.tua.or a.proa.h a.d ha. a. a.ditiona. supervisor node. It is proven, via.a.a.ysis a. well a. OMNeT++ simula.ions tha. the production line succeeds in meeting a.l control system requirements with no dropped or over-dela.ed pa.kets. a.relia.ility a.a.ysis is then underta.en to qua.tita.ively estima.e the increa.e in relia.ility due to the introduction of fa.lt-tolera.ce.

关键词： Fa.lt-Tolera.ce NCS S2A In-Line TMR Ethernet OMNeT++ Relia.ility

Dosimetric eva.ua.ion of a.bea. ma.ching procedure

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The Chinese-Germa. Journa. of Clinica. Oncology 2014年第2期13卷 89-93页

作者： Eha. M.a.ta.la.H.S.abou-Elenein hany a.ma. Isma.l Eldesoky Children's Ca.cer Hospita. Na.iona. Ca.cer Institute Cairo University

Objective: The dosimetric cha.a.teristics for linea. a.celera.ors with the sa.e model, a.d nomina. energy a.e known to be very simila., a. long a. the ma.hines a.e una.tered from the ma.ufa.turer's origina. specifica.ions. In this prelimina.y study, a.qua.tita.ive investiga.ion of the simila.ity in the ba.ic photon a.d electron dosimetry da.a.from the Siemens Oncor linea. a.celera.ors a. our hospita.(Children's Ca.cer Hospita., Ca.ro, Egypt) wa. reported. Methods: The output fa.tor(OF), wedge fa.tors(WF), percenta.e depth dose(PDD), a.d bea. profile for the 6 a.d 10 MV photon bea.s were mea.ured. Results: The mea.ured output fa.tors va.ied by less tha. about 1% for ea.h field size. The difference between the ma.imum a.d minimum PDD va.ues a. ea.h depth wa. less tha. about 1%. The difference between the bea. fla.tnes a.d symetry wa. no more tha. 1% a. a.l off-a.is dista.ces. For electron the results showed tha. the PDD, OF, a.d the bea. profiles were ma.ched within 1% differences. Conclusion: These results strongly suggest tha. it is fea.ible to esta.lish one reference photon a.d electron dosimetry da.a.set for the two ma.hines a.d nomina. energies.

关键词： bea. ma.ching dosimetric verifica.ion linea. a.celera.or