检索结果-南通市图书馆

同方期刊数据库

Key issues in water sealing performance of underground oil storage caverns: Advances and perspectives

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2023年第10期15卷 2787-2802页

作者： Yutao Li Bin Zhang Lei wang Yiguo Xue hanxun wang Lei Shi Zhenhua Peng Junyan Li School of Engineering and Technology China University of Geosciences(Beijing)Beijing100083China Department of Civil and Architectural Engineering and Construction Management University of CincinnatiCincinnatiOH45221USA CNOOC Petrochemical Engineering Co. Ltd.Qingdao266061China

Water sealing performance is important for underground water-sealed oil storage(UWSOS).The key issues concerning water sealing performance mainly include the permeability of fractured rock mass(FRM),water-sealed safety(WSS),water curtain performance,and prediction and control of water *** paper reviews the progress of above four key issues on water sealing ***,the permeability of an FRM is the basis of water sealing performance,and several commonly used permeability test methods and spatial variation characteristics of permeability are ***,the current water sealing criteria are compared,and the evaluation methods of WSS are ***,the design parameters and efficiency evaluation of water curtain systems(WCSs)are *** water inflow of oil storage caverns(OSCs)can reflect the water sealing effect,and the prediction methods and control measures of water inflow are also ***,the advantages and disadvantages of the current research are discussed,and the potential research directions are pointed out,such as optimization of water sealing criteria and FRM model,quantitative evaluation of WCS efficiency,accurate prediction of water inflow,and improvement of grouting technology.

关键词： Underground water-sealed oil storage (UWSOS) Water-sealed safety(WSS) Water curtain system(WCS) Water inflow Fractured rock mass permeability

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

不同洞距下内衬式高压储气库热-力特性分析

隧道与地下工程灾害防治 2024年第1期6卷 73-83页

作者：阮泉泉张文张彬王其宽王汉勋时广升青海大学土木水利学院青海西宁810016 中国地质大学(北京)工程技术学院北京100083

以安徽某深部硬石膏矿体建造大规模内衬岩洞式储气库为研究背景,采用ABAQUS有限元软件的热-力耦合分析方法,研究深埋洞室不同洞距下多循环充采气过程中关键结构层温度、变形、应力的分布及变化过程,探究不同洞距时围岩塑性区分布规律以... 详细信息

以安徽某深部硬石膏矿体建造大规模内衬岩洞式储气库为研究背景,采用ABAQUS有限元软件的热-力耦合分析方法,研究深埋洞室不同洞距下多循环充采气过程中关键结构层温度、变形、应力的分布及变化过程,探究不同洞距时围岩塑性区分布规律以及地表变形变化过程。结果表明:增大洞距对主要结构层的温度基本没有影响;洞距小于2倍洞径时,改变洞距对关键结构层的应力和变形、地表位移、混凝土衬砌的拉应力分布和大小以及围岩塑性区的分布有较为明显的影响,储气库间的相互作用较为显著;当洞距增大到2倍洞径后,储气库间的相互作用已经不再明显,此时增大洞距对储气库的稳定性没有明显的增强效果。

关键词：内衬岩洞深部硬石膏矿储气库热-力耦合洞室间距

同方期刊数据库

Emerging role of graphene oxide as sorbent for pesticides adsorption:Experimental observations analyzed by molecular modeling

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2021年第4期63卷 192-202页

作者： hanxun wang Baichun Hu Zisen Gao Fengjiao Zhang Jian wang Key Laboratory of Structure-Based Drug Design&Discovery Ministry of EducationShenyang Pharmaceutical UniversityShenyang110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang110016China

The accumulation of pesticide residues in the environment due to their persistence and stability is causing increasing health ***,researchers have rekindled their interest in eliminating pesticides from the environment by a range of biological and chemical *** particular,graphene oxide(GO)has drawn great attention because it impressively enhances adsorption of pesticides in aqueous solutions,which provides promising environmental applications on water purification to remove pesticide ***,although multiple studies have highlighted the adsorption of environmental contaminants by GO,the underlining molecular mechanisms remain ***,we further delved into the knowledge regarding their adsorption molecular mechanism that is of both practical and theoretical *** was revealed that theπ-πstacking and van der Waals interactions accounted for the major adsorption interactions between GO and its removing pesticides through integrating both density functional theory(DFT)calculation,fully atomistic molecular dynamics(MD)simulation,and binding free energy *** findings not only bridged the theoretical gap of the adsorption mechanisms of GO,but also provided a venue for visualizing the adsorption process,which were essential for guiding its future adsorption applications.

关键词： calculation. adsorption pesticides

Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2022年第6期12卷 2905-2922页

作者： Peilu Song Fan Zhao Dahong Li Jiqiang Qu Miao Yao Yuan Su hanxun wang Miaomiao Zhou Yujie wang Yinli Gao Feng Li Dongmei Zhao Fengjiao Zhang Yu Rao Mingyu Xia Haitao Li Jian wang Maosheng Cheng Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China MOE Key Laboratory of Protein Sciences School of Pharmaceutical SciencesMOE Key Laboratory of Bioorganic Phosphorus Chemistry Chemical BiologyTsinghua UniversityBeijing 100084China MOE Key Laboratory of Protein Sciences Beijing Advanced Innovation Center for Structural BiologyTsinghua-Peking Joint Center for Life SciencesSchool of Life Sciences and School of MedicineTsinghua UniversityBeijing 100084China School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShengyang 110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Department of Cell Biology Key Laboratory of Cell BiologyMinistry of Public Healthand Key Laboratory of Medical Cell BiologyMinistry of EducationChina Medical UniversityShenyang 110001China

The p21 activated kinase 4(PAK4) is serine/threonine protein kinase that is critical for cancer *** by X-ray crystallography and structure-based optimization,we report a novel subseries of C-3-substituted 6-ethynyl-1 H-indole derivatives that display high potential and specificity towards group Ⅱ *** these inhibitors,compound 55 exhibited excellent inhibitory activity and kinase selectivity,displayed superior anti-migratory and anti-invasive properties against the lung cancer cell line A549 and the melanoma cell line *** 55 exhibited potent in vivo antitumor metastatic efficacy,with over 80% and 90% inhibition of lung metastasis in A549 or B16-BL6 lung metastasis models,*** mechanistic studies demonstrated that compound 55 mitigated TGF-β1-induced epithelial-mesenchymal transition(EMT).

关键词： Anti-cancer PAK4 inhibitor Kinase selectivity Cocrystallization Lung metastasis EMT

Photoswitchable Molecular Recognition Enabled by Dithienylethene-Mediated Structural Changes of Dynamic Covalent Hydrazone Bonds

在线全文

学校读者我要写书评

暂无评论

CCS Chemistry 2024年第2期6卷 497-506页

作者： Lifeng wang hanxun Zou Hebo Ye Yu Hai Hanwei Lu Junmiao Deng Lei You State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002 College of Chemistry and Material Science Fujian Normal UniversityFuzhou 350007 University of Chinese Academy of Sciences Beijing 100049 Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108

Light-induced recognition,assemblies,and materials are intensive areas of research due to their high spatiotemporal ***,we demonstrated photoswitchable molecular recognition via dithienylethene-triggeredreversible structural regulation of dynamic covalent hydrazone *** combining dithienylethenes and cyclic hemiacetals,the photochemical open-ring and closed-ring forms enabled turningoff and on the creation of awide range of hydrazones when ***-induced bidirectional switching between hydrazones and their cyclization structures promoted by a neighboring carboxyl group was further *** taking advantage of reversible structural changes totoggleon andoff the binding pocket,photoswitchable recognitionofmetal ionswas ***,the construction of an acylhydrazone polymer offered a facile way for light-mediated selective extraction/*** strategies and results reported here should find applications in many contexts,such asdynamicassemblies,molecular switches,and smart materials.

关键词： molecular recognition photoswitch dynamic covalent chemistry hydrazone selective extraction/release

花岗岩裂隙岩体油水两相渗流可视化试验及数值模拟研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

地学前缘 2023年第3期30卷 465-475页

作者：孙哲张彬陈大伟李玉涛王汉勋中国地质大学(北京)工程技术学院北京100083 自然资源部重大工程地质安全风险防控工程技术创新中心北京100083

地下水封油库利用“隙存水封”的原理通过地下洞室进行石油地下存储,并多建于结晶岩体中,岩体裂隙渗流特性直接影响地下油库储油安全。地下洞库水封机理可简化为围岩裂隙中的油水两相渗流问题,需同时考虑油驱水和水驱油过程。基于分形... 详细信息

地下水封油库利用“隙存水封”的原理通过地下洞室进行石油地下存储,并多建于结晶岩体中,岩体裂隙渗流特性直接影响地下油库储油安全。地下洞库水封机理可简化为围岩裂隙中的油水两相渗流问题,需同时考虑油驱水和水驱油过程。基于分形理论定量刻画了天然花岗岩裂隙面的粗糙度,通过3D打印技术制备了不同粗糙度的透明裂隙,利用研制的单裂隙多相渗流可视化试验装置开展了模型试验,并结合数值模拟对花岗岩粗糙裂隙中的油水驱替规律进行了研究。研究表明:水油流度比的差异导致花岗岩裂隙两相驱替呈现出不同效果,油驱水前缘呈活塞式整体推进,而水驱油前缘呈指进式推进;压力差或隙宽的增加更加显著地提升油驱水效果,但裂隙粗糙度的增加则对裂隙中流体的流动起到了阻碍作用,使得驱替难以进行;在考虑裂隙粗糙度和油相黏度的情况下,仅通过围岩裂隙水压力大于洞库内部油压来判别水封性能的“水封准则”存在缺陷;由于“贾敏效应”的作用,水驱油时裂隙中的油将难以被完全驱替,当油库发生油品泄漏时,难以将油品完全驱回洞库内部。研究成果可为粗糙裂隙岩体两相渗流规律及地下洞库水封机理的研究提供参考依据。

关键词：花岗岩粗糙裂隙油水驱替多相渗流装置 3D打印技术可视化试验数值模拟

大断面矩形顶管上跨施工对既有地铁隧道变形影响研究

在线全文

学校读者我要写书评

暂无评论

工程地质学报 2022年第5期30卷 1703-1712页

作者：姜之阳张彬刘硕王汉勋刘杨中国地质大学(北京)工程技术学院北京100083 自然资源部重大工程地质安全风险防控工程技术创新中心北京100083 中铁四局集团第三建设有限公司天津300163

大断面矩形顶管上跨既有地铁隧道施工过程中,由于近距离开挖出土卸荷,导致既有地铁隧道产生上浮变形,危及地铁运营安全。本文以北京市通州区畅和西路(兆善大街—潞阳大街)综合管廊矩形顶管工程为背景,采用FLAC^(3D)有限差分软件建立了... 详细信息

大断面矩形顶管上跨既有地铁隧道施工过程中,由于近距离开挖出土卸荷,导致既有地铁隧道产生上浮变形,危及地铁运营安全。本文以北京市通州区畅和西路(兆善大街—潞阳大街)综合管廊矩形顶管工程为背景,采用FLAC^(3D)有限差分软件建立了大断面矩形顶管上跨既有地铁隧道的三维数值模型,研究了双线矩形顶管上跨施工引起地铁隧道上浮的变形规律以及采用不同抗浮配重对既有地铁隧道的变形影响,并将模拟结果与现场监测数据进行对比,验证了数值模型的准确性。研究结果表明:双线顶管上跨施工引起地铁隧道的上浮变形大于单线顶管引起的上浮变形,且最大上浮变形均位于顶管隧道轴线处;施加与开挖损失土体近似重量的配重,可改变地铁隧道原有水平变形规律,导致先穿越的地铁隧道整体向始发井方向移动,后穿越的地铁隧道整体向接收井方向移动。随抗浮配重的增加,地铁隧道上浮位移减小,所受拉应力减小,且施加开挖损失土体重量50%的抗浮配重,可以将地铁上浮变形控制在1.4 mm以内;研究成果为该工程地铁隧道抗浮设计提供了参考依据。

关键词：大断面矩形顶管上跨地铁隧道平行双线抗浮配重卸荷作用

在线全文

学校读者我要写书评

暂无评论

某变电站人工堆积边坡稳定性分析

岩土工程技术 2023年第3期37卷 352-356页

作者：李从昀黄骁张雪张晓宸王汉勋北京电力经济技术研究院有限公司北京100055 北京市地质工程勘察院北京100048 中国地质大学(北京)工程技术学院北京100083

以北京市门头沟区某变电站场地人工堆积边坡为研究对象,基于系统的现场勘察和室内外试验结果,选择典型边坡剖面,应用极限平衡法研究了不同工况下的边坡稳定性,并提出了针对性的防治措施。结果表明:在天然工况下,该人工堆积边坡剖面1-1... 详细信息

以北京市门头沟区某变电站场地人工堆积边坡为研究对象,基于系统的现场勘察和室内外试验结果,选择典型边坡剖面,应用极限平衡法研究了不同工况下的边坡稳定性,并提出了针对性的防治措施。结果表明:在天然工况下,该人工堆积边坡剖面1-1和剖面2-2均处于欠稳定–不稳定状态;在暴雨工况下,剖面1-1和剖面2-2处均处于不稳定状态,边坡整体上处于不稳定状态。根据边坡稳定性的分析结果,结合工程实际情况,确定桩板式挡土墙为该人工堆积边坡的优化支护方案。

关键词：人工堆积边坡暴雨工况极限平衡法稳定性分析

不同开挖方法偏压大跨隧道围岩稳定性对比分析

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

工程地质学报 2018年第4期26卷 866-873页

作者：耿招张彬李伟瀚黄峰王汉勋中国地质大学(北京)工程技术学院北京100083 国土资源部深部地质钻探技术重点实验室北京100083

偏压地形对大跨隧道的围岩变形和支护结构受力有较大的负面影响,科学选择开挖方法是确保隧道施工安全的重要前提。Hoek-Brown强度准则综合考虑岩体结构面特征、岩块强度和施工扰动对岩体劣化效应的影响,能更好地反映隧道开挖过程中围岩... 详细信息

偏压地形对大跨隧道的围岩变形和支护结构受力有较大的负面影响,科学选择开挖方法是确保隧道施工安全的重要前提。Hoek-Brown强度准则综合考虑岩体结构面特征、岩块强度和施工扰动对岩体劣化效应的影响,能更好地反映隧道开挖过程中围岩的变形情况。据此,本文以贵阳市环城路七冲村二号隧道为工程依托,通过现场调查及经验查表的方法确定了Hoek-Brown强度参数,采用FLAC3D对三台阶法和双侧壁导洞法的开挖过程进行了模拟计算,结合现场围岩变形和钢拱架轴力监测数据,对两种开挖方法的围岩稳定性进行了对比分析,得出结论:相比于三台阶法,双侧壁导洞法能更有效地控制围岩塑性区发展和围岩变形,可以有效地减少偏压荷载对隧道围岩造成的不利影响,但钢拱架受力不均匀,可能对支护结构稳定产生不利影响;综合考虑施工安全和施工进度,围岩较破碎的隧道出口段和入口段应采用双侧壁导洞法施工,围岩较完整的其他区间段可采用三台阶法施工,以节省工期。

关键词：偏压大跨隧道开挖方法 Hoek-Brown准则现场监测