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Polydopamine-coated photoautotrophic bacteria for improving extracellular electron transfer in living photovoltaics

Nano Research 2024年第2期17卷 866-874页

作者： Melania Reggente Charlotte Roullier Mohammed Mouhib Patricia Brandl hanxuan wang Stefano Tacconi Francesco Mura Luciana Dini Rossella Labarile Massimo Trotta Fabian Fischer Ardemis A.Boghossian Institute of Chemical Sciences and Engineering(ISIC) Ecole Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Department of Biology and Biotechnology Charles Darwin Sapienza University of RomeRome 00185Italy Research Center on Nanotechnology Applied for Engineering of Sapienza(CNIS) University of Rome SapienzaRome 00185Italy CNR-IPCF Consiglio Nazionale delle Ricerche–Istituto per i Processi Chimico Fisici Bari 70126Italy Institute of Life Technologies HES-SO Valais-WallisSion 1950Switzerland Institute for Renewable Energy HES-SO Valais-WallisSion 1950Switzerland

Living photovoltaics are microbial electrochemical devices that use whole cell–electrode interactions to convert solar energy to electricity.The bottleneck in these technologies is the limited electron transfer between the microbe and the electrode surface.This study focuses on enhancing this transfer by engineering a polydopamine(PDA)coating on the outer membrane of the photosynthetic microbe Synechocystis sp.PCC6803.This coating provides a conductive nanoparticle shell to increase electrode adhesion and improve microbial charge extraction.A combination of scanning electron microscopy(SEM),transmission electron microscopy(TEM),UV–Vis absorption,and Raman spectroscopy measurements were used to characterize the nanoparticle shell under various synthesis conditions.The cell viability and activity were further assessed through oxygen evolution,growth curve,and confocal fluorescence microscopy measurements.The results show sustained cell growth and detectable PDA surface coverage under slightly alkaline conditions(pH 7.5)and at low initial dopamine(DA)concentrations(1 mM).The exoelectrogenicity of the cells prepared under these conditions was also characterized through cyclic voltammetry(CV)and chronoamperometry(CA).The measurements show a three-fold enhancement in the photocurrent at an applied bias of 0.3 V(vs.Ag/AgCl[3 M KCl])compared to non-coated cells.This study thus lays the framework for engineering the next generation of living photovoltaics with improved performances using biosynthetic electrodes.

关键词： biophotovoltaics bioelectronics photosynthetic bacteria cyanobacteria polydopamine adherence

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Synthesis and biological evaluation of a lipopeptide-based methamphetamine vaccine

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Chinese Chemical Letters 2021年第4期32卷 1575-1579页

作者： Fan Liao hanxuan wang Yuankun Dao Kai Yuan Jiazhen Lu Jie Shi Ying Han Suwei Dong Lin Lu Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Beijing 100191China National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Peking UniversityBeijing 100191China State Key Laboratory of Natural and Biomimetic Drugs and Department of Chemical BiologySchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovem Institute for Brain Research Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China School of Basic Medicine Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

We describe an application of carrier protein-free strategy in constructing a fully synthetic methamphetamine(METH)vaccine that contains three components:Toll-like receptor 2 ligand,Th2 epitope,and METH hapten.The immunological evaluation in mice revealed high titers of METH-specific antibodies induced by the construct and the activation of humoral immunity that would be beneficial for neutralization and clearance of the METH molecule.Behavio ral experiments indicated that the synthetic vaccine attenuated the acquisition of METH-induced conditioned place preference and inhibited the initiation and expression of METH-induced locomotor sensitization.These results demonstrate that the lipopeptide-based vaccine has invo ked an immune response and showed the potential of preventing the rewarding and psychoactive effects of METH.

关键词： METH vaccine Carrier protein-free Fully synthesis Lipopeptide Behavioral model

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Studies towards Glycopeptide-Based Immune Activator

Studies towards Glycopeptide-Based Immune Activator

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中国化学会第三届全国糖化学会议

作者： hanxuan wang Suwei Dong State Key Laboratory of Natural and Biomimetic Drugs and Department of Chemical BiologySchool of Pharmaceutical SciencesPeking University

Immune activation is a powerful strategy applied in the treatment of infectious diseases and cancers.While a number of natural carbohydrate conjugates and their derivatives or mimics have been proved to be able to activate the immune system,the complexity and heterogeneity of these molecules have posed daunting challenges on their further research and applications,as in many cases the difficulties in quality control cause serious safety concerns for clinical use.In this study,a series of glycopeptides have been designed,and synthesized utilizing solid-phase peptide synthesis（SPPS） strategy.Several synthesized peptides have showed self-assembling ability to produce stable and uniform nanoparticles,and one of which displayed high binding affinity and uptaking efficiency toward macrophages in vitro,as indicated by upregulated expression level of two immune co-stimulatory molecules CD40 and CD86,and two pro-inflammation cytokines interleukin-6 and interleukin-12.Moreover,vaccination of C57 BL/6 mice with OVA model antigen in combination with the optimal glycopeptide elicits high titers of IgG antibody and promotes antigen specific memory response on the IFN-γ secretion.These results have demonstrated the utility of glycosylated nanoparticles as effective immunostimulant,and potential adjuvant that could be applied for vaccination.

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Polarization-dependent photoinduced metal–insulator transitions in manganites

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Science Bulletin 2024年第2期69卷 183-189页

作者： Lina Deng Weiye Zhang hanxuan Lin Lifen Xiang Ying Xu Yadi wang Qiang Li Yinyan Zhu Xiaodong Zhou Wenbin wang Lifeng Yin Hangwen Guo Chuanshan Tian Jian Shen State Key Laboratory of Surface Physics Institute for Nanoelectronic Devices and Quantum Computingand Department of PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Quantum Sciences Shanghai 201315China Zhangjiang Fudan International Innovation Center Fudan UniversityShanghai 201210China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China Shanghai Branch CAS Center for Excellence and Synergetic Innovation Center in Quantum Information and Quantum PhysicsShanghai 201315China

In correlated oxides,collaborative manipulation on light intensity,wavelength,pulse duration and polarization has yielded many exotic discoveries,such as phase transitions and novel quantum states.In view of potential optoelectronic applications,tailoring long-lived static properties by light-induced effects is highly desirable.So far,the polarization state of light has rarely been reported as a control parameter for this purpose.Here,we report polarization-dependent metal-to-insulator transition(MIT)in phaseseparated manganite thin films,introducing a new degree of freedom to control static MIT.Specifically,we observed giant photoinduced resistance jumps with striking features:(1)a single resistance jump occurs upon a linearly polarized light incident with a chosen polarization angle,and a second resistance jump occurs when the polarization angle changes;(2)the amplitude of the second resistance jump depends sensitively on the actual change of the polarization angles.Linear transmittance measurements reveal that the origin of the above phenomena is closely related to the coexistence of anisotropic micro-domains.Our results represent a first step to utilize light polarization as an active knob to manipulate static phase transitions,pointing towards new pathways for nonvolatile optoelectronic devices and sensors.

关键词： Metal-insulator phase transitions Polarization of light Electronic phase separation Selective domain controllability

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Chemical Synthesis of Interferon Gamma

Chemical Synthesis of Interferon Gamma

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第十一届全国化学生物学学术会议

作者： Yuankun Dao Lin Han hanxuan wang Suwei Dong State Key Laboratory of Natural and Biomimetic Drugs and Department of Chemical BiologySchool of Pharmaceutical SciencesPeking University

Interferon gamma（IFN-γ） is an important N-glycosylated protein produced primarily by T-lymphocytes and natural killer cells.[1] As a cytokine that is crucial for innate and adaptive immunity against viral infection, IFN-γ also exhibits anti-proliferative, immunoregulatory and proinflammatory activities.[2] Herein, we described our studies toward the chemical synthesis of IFN-γ via an α-selective lysine ligation. The synthetic protein exhibits comparable anti-cancer activity to recombinant IFN-γ in an anti-proliferation assay.[3]

关键词： Interferon gamma α-selectivity lysine ligation

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面向公共交通融合发展的城市地铁运营绩效评价方法

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铁道科学与工程学报 2024年第4期21卷 1365-1378页

作者：方瀚萱金辉李再帏王子鸣上海工程技术大学城市轨道交通学院上海201600 苏州大学轨道交通学院江苏苏州215100

城市地铁是缓解城市交通拥堵、实现交通结构集约化的重要载体,但建设与运营成本大。特别在城市地铁大规模建设的背景下,公交客流颓势愈显。为此,面向城市地铁与公交的融合发展,在考虑地铁建设对公交客流负面作用的前提下,采用SBM(slacks... 详细信息

城市地铁是缓解城市交通拥堵、实现交通结构集约化的重要载体,但建设与运营成本大。特别在城市地铁大规模建设的背景下,公交客流颓势愈显。为此,面向城市地铁与公交的融合发展,在考虑地铁建设对公交客流负面作用的前提下,采用SBM(slacks-based measure)模型系统评价城市地铁的运营绩效。进而在连续时间截面下,通过GML(global Malmquist-Luenberger)指数持续跟踪地铁运营绩效的变化趋势。然后考虑城市经济发展、规模发展和私家车竞争等外部因素,利用Tobit模型分析其对城市地铁运营绩效的影响。基于2018—2021年我国31个城市的面板数据,采用含非期望产出的SBM模型测度各城市各年份的地铁运营绩效,发现规模大、客流强度高的城市地铁运营绩效通常更高;除2020年受疫情影响外,其余年份城市地铁运营综合技术效率和规模效率逐年上升,但纯技术效率逐年下降,对现有投入资源的利用率降低。地铁运营无效的城市主要表现为公交客流下降严重,亟须强化地铁与公交的融合发展。采用GML指数测算相邻年份间各城市地铁运营绩效的动态变化特性,发现我国城市地铁运营全要素生产率年均下降2.8%,主要归因于疫情阶段放缓了技术进步。Tobit模型进一步发现城市建成区面积对城市地铁运营绩效具有显著的正向作用。研究结果可在地铁与公交融合的背景下全面定位城市地铁的发展瓶颈,为提升轨道交通在城市公共交通中的引领及促进作用提供理论与方法基础。

关键词：城市地铁绩效评价 SBM模型 GML指数 Tobit模型

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基于AI赋能和智慧教学的数学建模培训新模式

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沈阳师范大学学报（自然科学版） 2023年第5期41卷 434-440页

作者：孙欣王瀚萱王雪沈阳师范大学数学与系统科学学院沈阳110034

在大数据和人工智能的背景下,实现对数据的科学管理,揭示事物的发展规律,合理预测未来发展趋势,为决策服务,需要建立数学模型,它是数据分析的一个更高层次。传统的“数学建模”课程教学方法偏重机理建模,造成数学专业的学生数据分析能... 详细信息

在大数据和人工智能的背景下,实现对数据的科学管理,揭示事物的发展规律,合理预测未来发展趋势,为决策服务,需要建立数学模型,它是数据分析的一个更高层次。传统的“数学建模”课程教学方法偏重机理建模,造成数学专业的学生数据分析能力薄弱,缺少必要的基于数据建模的方法和手段,成为课程教学中面临的痛点问题。针对教学痛点,教学团队利用每年暑假,通过网络学习平台和线上直播平台对参加全国大学生数学建模竞赛的学生进行大数据技术课外培训,以提升学生的数据分析处理技能。经过3年的培训实践,形成了“智能诊断学情、构建智慧学习资源库、人工智能赋能建模与求解、产教融合”的“数学建模”课外培训新模式,提升了学生的数据分析和建模的综合能力,有效地解决了教学痛点问题。

关键词：数据分析数学建模人工智能赋能智慧教学机器学习

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Surface Modification of SrAl_2O_4:Eu^(2+),Dy^(3+) and Sr_4Al_(14)O_(25):Eu^(2+),Dy^(3+) Long Lasting Phosphors and Their Application in Water-borne Paint

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Journal of the Chinese Ceramic Society 2015年第1期 17-24页

作者： ZHENG Tong YE Song wang Deping LI Kang wang Yue LIU Zhiyuan wang hanxuan School of Materials Science and Engineering Tongji University Bayer Material Science (China) Co. Ltd.

In this paper, strontium aluminate phosphors of Sr Al2O4: Eu2+, Dy3+ and Sr4Al14O25: Eu2+, Dy3+ were prepared via solid state reactions and subsequent surface modification with Si O2 by a chemical precipitation method. The strontium aluminate phosphors were characterized by measurement-ray diffraction. According to the analysis by transmission electron microscopy, a continuous Si O2 coating layer with a thickness of 50 nm can be formed on the surface of Si O2-coated phosphor. The covalent bond that attached the phosphor and the Si O2 coating was determined by Fourier transform infrared spectroscopy. The water resistance and optical measurements indicate that the optimum ratio of Si O2 coating to phosphors is 30% by mass. Also, the Si O2-coated phosphors could be used in a water-borne paint with the superior luminous performance.

关键词： strontium aluminate water resistance surface modification silica water-borne paint

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基于微水试验求解高渗透性承压含水层水文地质参数

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水文地质工程地质 2024年第4期51卷 108-116页

作者：郭涵轩王全荣潘可欣施文光中国地质大学(武汉)环境学院湖北武汉430078

为了提高高渗透性承压含水层渗透系数与储水率等水文地质参数的反演精度,科学解释井筒水位的非线性振荡现象,本研究建立了考虑表皮效应和非达西流效应耦合惯性力作用的微水试验模型。模型中表皮效应采用Robbin边界条件描述,非达西流效... 详细信息

为了提高高渗透性承压含水层渗透系数与储水率等水文地质参数的反演精度,科学解释井筒水位的非线性振荡现象,本研究建立了考虑表皮效应和非达西流效应耦合惯性力作用的微水试验模型。模型中表皮效应采用Robbin边界条件描述,非达西流效应采用Forchheimer方程刻画,惯性力作用采用动量平衡方程表达。利用Laplace变换法推导模型的解析解,基于现场试验数据,分析3种因素对反演水文地质参数的影响。结果表明表皮效应、非达西流效应与惯性力作用对参数反演结果的影响均不能忽视。无因次表皮因子(Sw)值、Forchheimer系数(γ)值与瞬时注水后井筒水位与承压含水层隔水顶板之间的垂直距离(l) 3个值越大,井筒水位恢复速度越慢;Sw值越大,井筒水位振荡幅度越小,而γ值和l值越大,井筒水位振荡幅度越大。忽略表皮效应、非达西流效应或惯性力作用均导致渗透系数与储水率的反演结果偏小。研究结果为裂隙承压含水层中水文地质参数的反演提供了一种合理的理论基础和技术依据。

关键词：微水试验表皮效应非达西流效应惯性力作用渗透系数储水率

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低轨卫星通信中的波束跳变和频率复用方法研究

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电子技术应用 2023年第5期49卷 24-29页

作者：王瀚萱陈子博孙耀华北京邮电大学网络与交换技术国家重点实验室北京100876

面向广域非均匀分布的业务需求,在多低轨卫星移动波束覆盖场景下,联合考虑跳波束图案设计、波束频率分配和传输功率优化,提出基于改进粒子群算法的波束资源管理机制,通过系统级仿真平台进行了性能验证。仿真结果表明,相比基于空间隔离... 详细信息

面向广域非均匀分布的业务需求,在多低轨卫星移动波束覆盖场景下,联合考虑跳波束图案设计、波束频率分配和传输功率优化,提出基于改进粒子群算法的波束资源管理机制,通过系统级仿真平台进行了性能验证。仿真结果表明,相比基于空间隔离角和基于优先级的波束资源管理机制,在full buffer业务模型下,所提机制可显著提升用户信干噪比和系统容量,且频率复用因子越低系统容量越高。

关键词：低轨卫星跳波束频率复用

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