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The radial organization of neuronal primary cilia is acutely disrupted by seizure and ischemic brain injury

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Frontiers in Biology 2017年第2期12卷 124-138页

作者： Gregory W. Kirschen hanxiao liu Tracy Lang Xuelin Liang Shaoyu Ge Qiaojie Xiong Medical Scientist Training Program (MSTP) Stony Brook University Stony Brook NY 11794 USA Molecular & Cellular Pharmacology Program Stony Brook University Stony Brook NY 11794 USA Department of Neurobiology & Behavior Stony Brook University Stony Brook NY 11794 USA Simons Summer Research Program (SSRP)

BACKGROUND： Neuronal primary cilia are sensory organelles that are critically involved in the proper growth, development, and function of the central nervous system （CNS）. Recent work also suggests that they signal in the context of CNS injury, and that abnormal ciliary signaling may be implicated in neurological diseases. METHODS： We quantified the distribution of neuronal primary cilia alignment throughout the normal adult mouse brain by immunohistochemical staining for the primary cilia marker adenylyl cyclase Ⅲ （ACⅢ） and measuring the angles of primary cilia with respect to global and local coordinate planes. We then introduced two different models of acute brain insult--temporal lobe seizure and cerebral ischemia, and re-examined neuronal primary cilia distribution, as well as ciliary lengths and the proportion of neurons harboring cilia. RESULTS： Under basal conditions, cortical cilia align themselves radially with respect to the cortical surface, while cilia in the dentate gyms align themselves radially with respect to the granule cell layer. Cilia of neurons in the striatum and thalamus, by contrast, exhibit a wide distribution of ciliary arrangements. In both cases of acute brain insult, primary cilia alignment was significantly disrupted in a region-specific manner, with areas affected by the insult preferentially disrupted. Further, the two models promoted differential effects on ciliary lengths, while only the ischemia model decreased the proportion of ciliated cells. CONCLUSIONS： These findings provide evidence for the regional anatomical organization of neuronal primary cilia in the adult brain and suggest that various brain insults may disrupt this organization.

关键词： cerebral cortex dentate gyrus temporal lobe seizure cerebral ischemia

Burden of non-communicable diseases in China and its provinces, 1990–2021: Results from the Global Burden of Disease Study 2021

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中华医学杂志(英文版) 2024年第19期137卷 2325-2333页

作者： liu hanxiao Yin Peng Qi Jinlei Zhou Maigeng Department of Epidemiology School of Public Health Cheeloo College of Medicine Shandong University Jinan Shandong China National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China

Background: Non-communicable diseases (NCDs) are the primary causes of disability and death. The aim of this study is to analyze the disease burden of NCDs in China from 1990 to ***: This study used data on NCDs in China and its provinces from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021. The study analyzed the disease burden of NCDs in 2021 and its changes from 1990 to 2021 using indicators including deaths and disability-adjusted life years (DALYs).Results: Between 1990 and 2021, the NCD burden in China exhibited an upward trend. In 2021, China had 10.6 (95% uncertainty interval [UI]: 9.0–12.2) million deaths and 349.3 (95% UI: 301.5–401.2) million DALYs due to NCDs, accounting for 91.0% (95% UI: 90.4–91.7%) of all deaths and 86.7% (95% UI: 86.0–87.4%) of all DALYs. NCDs caused a lower disease burden in females than in males. Cardiovascular diseases and neoplasms were the main NCD level 2 causes of deaths and DALYs, resulting in 5.1 (95% UI: 4.3–5.9) and 2.8 (95% UI: 2.3–3.4) million deaths and 100.2 (95% UI: 84.6–116.6) million and 71.2 (95% UI: 59.3–85.2) million DALYs in 2021, respectively. Chronic respiratory diseases were the third leading cause of NCD deaths, while musculoskeletal disorders were the third leading cause of NCD DALYs. Qinghai, Xizang, and Heilongjiang had the highest age-standardized mortality rates and age-standardized DALY rates (per 100,000) for NCDs, while Hong Kong Special Administration Region (SAR), Macao SAR, and Shanghai recorded the lowest age-standardized mortality rates and age-standardized DALY ***: NCDs caused a high disease burden in China and exhibited heterogeneity across sexes and provinces. China needs to focus on addressing key NCDs and implement intervention measures tailored to the disease distribution characteristics to reduce the NCD burden.

关键词： Non-communicable diseases Disease burden Deaths Disability-adjusted life years Cardiovascular disease Neoplasms Chronic respiratory disease Musculoskeletal disorders

Comparative population genomics dissects the genetic basis of seven domestication traits in jujube

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Horticulture Research 2020年第1期7卷 1769-1782页

作者： Mingxin Guo Zhongren Zhang Yanwei Cheng Sunan Li Peiyin Shao Qiang Yu Junjie Wang Gan Xu Xiaotian Zhang Jiajia liu Linlin Hou hanxiao liu Xusheng Zhao College of Life Sciences Luoyang Normal UniversityLuoyang 471934China Jujube Research Center Luoyang Normal UniversityLuoyang 471934China Novogene Bioinformatics Institute Beijing 100083China

Jujube(Ziziphus jujuba Mill.)is an important perennial fruit tree with a range of interesting horticultural *** was domesticated from wild jujube(Ziziphus acidojujuba),but the genomic variation dynamics and genetic changes underlying its horticultural traits during domestication are poorly ***,we report a comprehensive genome variation map based on the resequencing of 350 accessions,including wild,semi-wild and cultivated jujube plants,at a>15×*** the combination of a genome-wide association study(GWAS)and selective sweep analysis,we identified several candidate genes potentially involved in regulating seven domestication traits in *** fruit shape and kernel shape,we integrated the GWAS approach with transcriptome profiling data,expression analysis and the transgenic validation of a candidate gene to identify a causal gene,ZjFS3,which encodes an ethyleneresponsive transcription ***,we identified a candidate gene for bearing-shoot length and the number of leaves per bearing shoot and two candidate genes for the seed-setting rate using *** the selective sweep analysis,we also discovered several putative genes for the presence of prickles on bearing shoots and the postharvest shelf life of fleshy *** study outlines the genetic basis of jujube domestication and evolution and provides a rich genomic resource for mining other horticulturally important genes in jujube.

关键词： jujube traits mining

基于Q-Learning算法的毫微微小区功率控制算法

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电子与信息学报 2019年第11期41卷 2557-2564页

作者：李云唐英刘涵霄重庆邮电大学移动通信技术重庆市重点实验室

该文研究macro-femto异构蜂窝网络中移动用户的功率控制问题,首先建立了以最小接收信号信干噪比为约束条件,最大化毫微微小区的总能效为目标的优化模型;然后提出了基于Q-Learning算法的毫微微小区集中式功率控制(PCQL)算法,该算法基于... 详细信息

该文研究macro-femto异构蜂窝网络中移动用户的功率控制问题,首先建立了以最小接收信号信干噪比为约束条件,最大化毫微微小区的总能效为目标的优化模型;然后提出了基于Q-Learning算法的毫微微小区集中式功率控制(PCQL)算法,该算法基于强化学习,能在没有准确信道状态信息的情况下,实现对小区内所有用户终端的发射功率统一调整。仿真结果表明该算法能实现对用户终端的功率有效控制,提升系统能效。

关键词：集中式功率控制 Q-Learning算法能效优化

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双碳背景下电除尘器的节能减碳分析

发电技术 2023年第5期44卷 738-744页

作者：刘含笑浙江菲达环保科技股份有限公司浙江省诸暨市311800

双碳背景下节能提效是燃煤电厂减碳的第一优选,通过对超低排放改造前后干式电除尘器、湿式电除尘器、辅助设备及除尘技术路线进行能效参数分析评测,挖掘其节能减碳空间。超低排放改造前,300 MW级、600 MW级、1000 MW级机组配套干式电除... 详细信息

双碳背景下节能提效是燃煤电厂减碳的第一优选,通过对超低排放改造前后干式电除尘器、湿式电除尘器、辅助设备及除尘技术路线进行能效参数分析评测,挖掘其节能减碳空间。超低排放改造前,300 MW级、600 MW级、1000 MW级机组配套干式电除尘器的高压电耗对应的CO_(2)年排放量分别约为6000、9000、14000t,且电除尘性能越好,对应的能耗及CO_(2)排放量越高;超低排放改造后,1000 MW级机组配套电除尘器的高压供电电耗对应的CO_(2)年排放量约为18000 t,较超低排放改造前增加了约20%,但通过节能优化可减排约60%。300 MW级、600MW级、1000MW级机组配套湿式电除尘器的高压供电电耗对应的CO_(2)年排放量分别约为2000、2500、3400 t;630 MW机组低温省煤器可年减排CO_(2)约19000t,280t/h炉相变凝聚器可年减排CO_(2)约8000t。与湿式电除尘技术路线相比,660MW机组以低低温电除尘技术为核心的烟气协同治理技术路线可年减排CO_(2)约3000t。研究结果可为后续燃煤电厂碳减排提供参考。

关键词：燃煤电厂超低排放电耗 CO_(2)减排碳达峰碳中和

工业烟气CO_(2)的排放特征、测试及捕集技术研究

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发电技术 2024年第1期45卷 62-68页

作者：刘含笑罗水源刘小伟浙江菲达环保科技股份有限公司浙江省诸暨市311800 华北电力大学能源动力与机械工程学院北京市昌平区102206 浙江省环保集团生态环保研究院有限公司浙江省杭州市310030 煤燃烧国家重点实验室(华中科技大学) 湖北省武汉市430074

CO_(2)是主要的温室气体,减排CO_(2)应对气候变化已成为国际共识,工业烟气是重要的人为CO_(2)排放源。对工业烟气CO_(2)的排放特征、主要测试及治理技术进行了系统的分析和研究:电力、钢铁、水泥等工业行业排放烟气中CO_(2)浓度分别在9.... 详细信息

CO_(2)是主要的温室气体,减排CO_(2)应对气候变化已成为国际共识,工业烟气是重要的人为CO_(2)排放源。对工业烟气CO_(2)的排放特征、主要测试及治理技术进行了系统的分析和研究:电力、钢铁、水泥等工业行业排放烟气中CO_(2)浓度分别在9.7%~15%、2%~28%、11%~29%;CO_(2)测试技术主要有非分散红外吸收法、气相色谱法、光谱法、化学吸收法等,其中,非分散红外吸收法在国内外应用最为成熟,是目前主流的固定源CO_(2)测试技术;CO_(2)捕集技术主要有吸收法、吸附法、膜分离法、深冷法等,其中,化学吸收法广泛用于低浓度CO_(2)烟气(体积浓度≤30%)捕集。研究结果可为后续工业大幅降碳提供借鉴。

关键词：工业烟气 CO_(2)排放捕集技术测试方法

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袋式除尘器脱Hg特性研究

发电技术 2023年第2期44卷 193-200页

作者：刘含笑郭高飞浙江菲达环保科技股份有限公司浙江省诸暨市311800

袋式除尘器是重要的工业烟尘治理设备。通过机理分析、数据调研和工程实测相结合的手段,对袋式除尘器的脱Hg性能进行了系统研究。结果表明:袋式除尘器在高效除尘的同时会脱除绝大部分颗粒Hg,脱除效率在95%~100%;由于入口气态Hg浓度及飞... 详细信息

袋式除尘器是重要的工业烟尘治理设备。通过机理分析、数据调研和工程实测相结合的手段,对袋式除尘器的脱Hg性能进行了系统研究。结果表明:袋式除尘器在高效除尘的同时会脱除绝大部分颗粒Hg,脱除效率在95%~100%;由于入口气态Hg浓度及飞灰未燃尽碳的含量等不同,袋式除尘器对气态Hg的脱除效率差异较大,但部分测试数据也达到90%以上。工程实测某15 MW循环流化床(circulating fluidized bed,CFB)锅炉配套袋式除尘器,其对气态Hg、颗粒Hg和总Hg的脱除效率分别为82.14%、99.88%和98.44%,系统Hg平衡系数为91.38%。研究结果可为工业烟气后续Hg排放控制提供一定参考。

关键词：燃煤电厂袋式除尘器脱Hg 排放控制脱除效率

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凝聚器二维单扰流柱流场中颗粒凝并模拟

动力工程学报 2015年第4期35卷 292-297页

作者：刘含笑姚宇平郦建国浙江菲达环保科技股份有限公司浙江诸暨311800

选取二维单扰流柱为研究对象,通过CFD软件和拉格朗日方法,引入2d-LES模型模拟湍流场,采用离散相模型(DPM)计算颗粒的运动轨迹;利用欧拉方法,采用颗粒群平衡模型(PBM),通过用户自定义函数(UDF)功能分别导入湍流凝并核函数和分段核函数来... 详细信息

选取二维单扰流柱为研究对象,通过CFD软件和拉格朗日方法,引入2d-LES模型模拟湍流场,采用离散相模型(DPM)计算颗粒的运动轨迹;利用欧拉方法,采用颗粒群平衡模型(PBM),通过用户自定义函数(UDF)功能分别导入湍流凝并核函数和分段核函数来进行计算,得出颗粒凝并规律.结果表明:扰流柱具有很好的产涡效果,可使不同粒径颗粒良好掺混;颗粒的湍流凝并效果显著,且湍流强度、湍动能与湍流凝并效果呈正相关.

关键词： PM2.5 凝聚器颗粒群平衡模型湍流数值模拟

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湍流场中颗粒破碎的数值模拟

环境工程学报 2015年第8期9卷 3937-3943页

作者：刘含笑姚宇平郦建国浙江菲达环保科技股份有限公司诸暨311800

在保证较好凝并的前提下最大限度地抑制颗粒破碎是湍流凝并技术的研究关键,通过CFD软件,选二维单扰流柱为研究对象,采用颗粒群平衡模型(PBM),通过UDF功能,分别将破碎核函数定义为常数、Laakkonen Breakage Kernels模型、分段函数,模拟... 详细信息

在保证较好凝并的前提下最大限度地抑制颗粒破碎是湍流凝并技术的研究关键,通过CFD软件,选二维单扰流柱为研究对象,采用颗粒群平衡模型(PBM),通过UDF功能,分别将破碎核函数定义为常数、Laakkonen Breakage Kernels模型、分段函数,模拟湍流场中颗粒的破碎规律,旨在摸索一种适用于工程应用的颗粒湍流破碎模型和计算方法,为相关实验研究和工程设计提供参考。

关键词： PM2.5 颗粒破碎数值模拟颗粒群平衡方程湍流