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Chinese Medical Journal 2024年第4期137卷 484-486页

作者： Jian Wu Qi Zhang Xu Jia Yingting Zhu Zhidong Li Shu Tu Ling Zhao Yifan Du Wei Liu Jiaoyan Ren Liangzhi Xu hanxiang yu Fagao Luo Wenru Su Ningli Wang Yehong Zhuo State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceSun Yat-sen UniversityGuangzhouGuangdong 510060China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Sciences Key LaboratoryBeijing 100730China School of Food Sciences and Engineering South China University of TechnologyGuangzhouGuangdong 510641China Guangzhou Huazhen Biosciences GuangzhouGuangdong 510920China

To the Editor:Normal-tension glaucoma(NTG)is a progressive optic neuropathy characterized by irreversible blindness with statistically normal intraocular pressure(IOP)(≤21 mmHg),^([1,2])which makes early-stage diagnosis in the clinical practice difficult.Pathophysiological pathways underlying NTG include vascular dysregulation,toxic metabolite accumulation,and elevated translaminar cribrosa pressure difference(TLCPD).^([3])Although various small animal models have provided evidence of different pathophysiological mechanisms,the complicated clinical phenotype cannot be fully imitated by secondary disease models,and the gap between rodents and humans weakens their translational potential.Thus,the pathological changes associated with NTG remain unclear.

关键词： elevated glaucoma diagnosis

电网的分散负荷安全域及其应用(二):线路静态失稳的边界-本质-形态及负荷安全域的稳定裕度

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中国电机工程学报 2024年第5期44卷 1737-1749,I0006页

作者：竺炜肖魏罗贤超于瀚翔郑超长沙理工大学电气与信息工程学院湖南省长沙市410114 中国电力科学研究院有限公司北京市海淀区100192

交流线路承载的静态稳定边界问题一直悬而未决。负荷安全域可约束线路压差、维持多级电网电压安全水平,但稳定裕度未知。传统静态功角稳定与电压稳定的概念、机理及分析方法都不相同。研究发现,针对线路两种静态稳定可形成统一的概念、... 详细信息

交流线路承载的静态稳定边界问题一直悬而未决。负荷安全域可约束线路压差、维持多级电网电压安全水平,但稳定裕度未知。传统静态功角稳定与电压稳定的概念、机理及分析方法都不相同。研究发现,针对线路两种静态稳定可形成统一的概念、机理,而全网静态稳定的充要条件是每条支路都满足静态稳定。基于线路的复变量状态方程,得到末端的复功率-电压(即P_(j)-Q_(j)-U_(j))、复功率-功角(即P_(j)-Q_(j)-θ_(ij))的独立方程;通过可解条件分析、偏导证明,得到唯一的P_(j)-Q_(j)稳定边界及其特征,证明两种失稳的同质性;通过解析几何分析,推导U_(j)和θ_(ij)的稳定边界及其特征,得到符合实际情况的失稳形态解释。基于P_(j)-Q_(j)稳定边界,提出线路负荷安全域的稳定裕度指标以及电压安全水平的修正方法。理论验证基于首端参考系线路模型分析的可行性,提出电网上下级拓扑的稳定域匹配方法。最后,基于状态可观性判据、方程独立性以及平衡点生成原理,分析线路功-角特性的局限性。算例表明,所提的稳定边界、稳定域匹配方法都与PSASP程序收敛性结果吻合。在新能源大量接入导致线路潮流波动性大的背景下,该研究更具理论价值及现实意义。

关键词：线路静态稳定稳定边界失稳形态线路负荷安全域稳定裕度

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机场集聚效应研究述评

综合运输 2024年第3期46卷 97-102页

作者：于瀚翔杨省贵高阳刘冰洋中国民用航空飞行学院机场学院四川广汉618307 成都市软创智业研究会四川成都610023 中国民用航空飞行学院飞行技术学院四川广汉618307

机场是重要的公共基础设施。机场集聚效应是指机场通过其自身优势促使要素、产业和各类经济活动向某一空间集中,实现经济效益的现象。对机场集聚效应研究对象、原因以及测度方法的相关研究成果进行了梳理总结。发现:机场集聚效应研究角... 详细信息

机场是重要的公共基础设施。机场集聚效应是指机场通过其自身优势促使要素、产业和各类经济活动向某一空间集中,实现经济效益的现象。对机场集聚效应研究对象、原因以及测度方法的相关研究成果进行了梳理总结。发现:机场集聚效应研究角度多样,研究方法各异;研究对象以运输机场为主,缺少对通用机场的研究,而且以定量研究成果为主,缺少定性分析成果。

关键词：民航运输机场集聚效应文献述评

PD-1信号通路在硫酸脑苷脂介导的抗哮喘气道炎症中的作用

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武汉大学学报（医学版） 2024年第1期45卷 1-7页

作者：倪海阳钟洁莹甘劭丁林琪斌黄毅丁续红余红缨聂汉祥武汉大学人民医院呼吸与危重症医学科湖北武汉430060

目的:观察程序性死亡受体1(PD-1)信号通路在硫酸脑苷脂介导的抗哮喘气道炎症的作用。方法:WTBALB/c小鼠随机分入正常对照组、哮喘对照组、硫酸脑苷脂治疗哮喘组、抗PD-1 mAb治疗哮喘组和硫酸脑苷脂+抗PD-1 mAb治疗哮喘组,每组5只。四组... 详细信息

目的:观察程序性死亡受体1(PD-1)信号通路在硫酸脑苷脂介导的抗哮喘气道炎症的作用。方法:WTBALB/c小鼠随机分入正常对照组、哮喘对照组、硫酸脑苷脂治疗哮喘组、抗PD-1 mAb治疗哮喘组和硫酸脑苷脂+抗PD-1 mAb治疗哮喘组,每组5只。四组哮喘小鼠采用鸡卵清蛋白(OVA)和PBS致敏和激发,其余各组在相应时间用等量PBS替代;硫酸脑苷脂治疗哮喘组和硫酸脑苷脂+抗PD-1 mAb治疗哮喘组在激发前1 h腹腔注射硫酸脑苷(20μg/只),其余各组在相应时间用等量PBS替代;抗PD-1 mAb治疗哮喘组和硫酸脑苷脂+抗PD-1mAb治疗哮喘组于硫酸脑苷脂干预前24 h腹腔注射抗PD-1单克隆抗体(500μg/只),其余各组在相应时间用等量PBS替代。采用流式细胞术检测肺PD-1+T细胞数量;HE和PAS染色检测肺组织学和支气管杯状细胞数量;瑞氏-姬姆萨染色检测支气管肺泡灌洗液(BALF)细胞总数和分类计数;ELISA法检测血清OVA特异性IgE和BALF中IL-4、IL-5和IL-13水平。结果:抗PD-1 mAb治疗哮喘组小鼠肺组织炎症细胞浸润增加;气道基底膜杯状细胞数量以及BALF中细胞总数和嗜酸粒细胞数量、血清OVA特异性IgE和BALF中IL-4、IL-5和IL-13水平均明显高于哮喘对照组(均P<0.01)。硫酸脑苷脂+抗PD-1 mAb治疗哮喘组小鼠肺组织炎症细胞浸润增高;气道基底膜杯状细胞数量以及BALF中细胞总数和嗜酸粒细胞数、血清OVA特异性IgE和BALF中IL-4、IL-5和IL-13水平明显高于硫酸脑苷脂治疗哮喘组(P<0.01或P<0.05)。硫酸脑苷脂治疗哮喘组小鼠肺PD-1+T细胞数量明显高于哮喘对照组和正常对照组(均P<0.01)。结论:硫酸脑苷脂可能通过激活PD-1信号通路抑制哮喘小鼠气道炎症。

关键词：哮喘气道炎症硫酸脑苷脂程序性死亡受体1

A Method Based on Knowledge Distillation for Fish School Stress State Recognition in Intensive Aquaculture

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Computer Modeling in Engineering & Sciences 2022年第6期131卷 1315-1335页

作者： Siyuan Mei Yingyi Chen hanxiang Qin Huihui yu Daoliang Li Boyang Sun Ling Yang Yeqi Liu College of Information and Electrical Engineering China Agricultural UniversityBeijing100083China National Innovation Center for Digital Fishery China Agricultural UniversityBeijing100083China School of Information Science and Technology Beijing Forestry UniversityBeijing100083China

Fish behavior analysis for recognizing stress is very important for fish welfare and production management in aquaculture.Recent advances have been made in fish behavior analysis based on deep learning.However,most existing methods with top performance rely on considerable memory and computational resources,which is impractical in the real-world scenario.In order to overcome the limitations of these methods,a new method based on knowledge distillation is proposed to identify the stress states of fish schools.The knowledge distillation architecture transfers additional inter-class information via a mixed relative loss function,and it forces a lightweight network(GhostNet)to mimic the soft probabilities output of a well-trained fish stress state recognition network(ResNeXt101).The fish school stress state recognition model’s accuracy is improved from 94.17%to 98.12%benefiting from the method.The proposed model has about 5.18 M parameters and requires 0.15 G FLOPs(floating-point operations)to process an image of size 224×224.Furthermore,fish behavior images are collected in a land-based factory,and a dataset is constructed and extended through flip,rotation,and color jitter augmentation techniques.The proposed method is also compared with other state-of-the-art methods.The experimental results show that the proposed model is more suitable for deployment on resource-constrained devices or real-time applications,and it is conducive for real-time monitoring of fish behavior.

关键词： Fish behavior deep learning knowledge distillation aquaculture

抗CD20单克隆抗体对哮喘小鼠气道炎症的影响

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武汉大学学报（医学版） 2024年第6期45卷 651-656页

作者：贺基龙章宗悦左小淑林琪斌倪海阳丁续红黄毅余红缨聂汉祥武汉大学人民医院呼吸与危重症医学科湖北武汉430060

目的:观察抗CD20单克隆抗体(简称抗CD20单抗)对哮喘小鼠气道炎症的影响。方法:将15只6~8周龄的BALB/c雌性小鼠随机分成正常对照组、哮喘对照组和抗CD20单抗治疗组,每组5只。哮喘对照组和抗CD20单抗治疗组以屋尘螨(HDM)致敏和激发,正常... 详细信息

目的:观察抗CD20单克隆抗体(简称抗CD20单抗)对哮喘小鼠气道炎症的影响。方法:将15只6~8周龄的BALB/c雌性小鼠随机分成正常对照组、哮喘对照组和抗CD20单抗治疗组,每组5只。哮喘对照组和抗CD20单抗治疗组以屋尘螨(HDM)致敏和激发,正常对照组以等量PBS代替,其中抗CD20单抗治疗组在第1次激发前2 d给予抗CD20单抗经鼻滴入联合腹腔注射,正常对照组和哮喘对照组给予等量同型对照抗体代替。苏木精-伊红(HE)染色和糖原(PAS)染色观察肺部炎症和气道杯状细胞增生;瑞氏-吉姆萨染色检测支气管肺泡灌洗液(BALF)细胞总数和分类计数;酶联免疫吸附试验检测血清HDM特异性IgE及BALF中IL-4、IL-5、IL-13、IFN-γ和IL-10水平;流式细胞术检测肺CD19+B细胞数量。结果:与哮喘对照组比较,抗CD20单抗治疗组哮喘小鼠肺组织炎性细胞浸润减少,气道基底膜杯状细胞数量以及BALF中细胞总数、嗜酸粒细胞、巨噬细胞和淋巴细胞数量明显减少(P0.05);BALF中IL-10水平明显增高(P<0.01)。同时,抗CD20单抗治疗组哮喘小鼠肺CD19+B细胞数量明显减少(P<0.01)。结论:经鼻滴入联合腹腔注射抗CD20单抗可以减轻哮喘小鼠气道炎症,可能与其去除肺B细胞导致气道IL-10水平增高有关。

关键词：哮喘抗CD20单克隆抗体气道炎症 B细胞白细胞介素-10

静脉注射利多卡因后差异蛋白质的蛋白质组学分析

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宁夏医科大学学报 2024年第6期46卷 571-576页

作者：李翔张永海杨凡张玉杨万吉高冉文岳马少玲马汉祥宁夏医科大学第一临床医学院银川750004 宁夏医科大学总医院麻醉与围术期医学科宁夏医科大学第一临床医学院银川750004

目的利用蛋白质组学技术定量分析静脉注射利多卡因(IVL)前后血清中差异蛋白质的表达。方法选取健康志愿者5例,IVL 1.5 mg·kg^(-1)后再以3 mg·(kg·h)^(-1)持续泵注30 min。IVL前和IVL后1 h各采集静脉血5 mL,通过串联质谱标记及高效液... 详细信息

目的利用蛋白质组学技术定量分析静脉注射利多卡因(IVL)前后血清中差异蛋白质的表达。方法选取健康志愿者5例,IVL 1.5 mg·kg^(-1)后再以3 mg·(kg·h)^(-1)持续泵注30 min。IVL前和IVL后1 h各采集静脉血5 mL,通过串联质谱标记及高效液相色谱分离技术鉴定IVL后差异表达蛋白,并采用京都基因和基因组百科全书(KEGG)和基因本体论(GO)数据库分析鉴定差异蛋白的生物学信息。结果检测到IVL前后的血清中差异蛋白共15种,其中上调蛋白6种、下调蛋白9种。GO分析发现,大部分差异蛋白参与了细胞进程;亚细胞结构定位发现多数差异蛋白定位于细胞外区域及细胞质;功能富集分析发现多数蛋白参与炎性反应调节、B细胞的活化调控和蛋白质加工。上调蛋白组KEGG通路富集到p53信号通路。通过对上调组和下调组差异蛋白分析,发现差异蛋白依托泊苷诱导的2.4号蛋白(EI24)参与p53信号通路且调控钙离子浓度。结论IVL可能通过调控依托泊苷诱导的EI24和上池蛋白(SBSN)抑制肿瘤细胞的发生与发展;EI24可能通过调控细胞内钙离子浓度参与IVL产生的镇静作用。

关键词：差异蛋白基因本体论富集分析串联质谱标签利多卡因

Dielectric Properties and Lattice Distortion in Rhombohedral Phase Region and Phase Coexistence Region of PZT Ceramics

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Communications in Theoretical Physics 2005年第5期43卷 855-860页

作者： ZHANGDuan-Ming ZHONGZhi-Cheng hanxiang-yun YANWen-Sheng SUNHong-Zhang YANGFeng-Xia ZHENGKe-yu WEINian LIZhi-Huai DepartmentofPhysics HuazhongUniversityofScienceandTechnologyWuhan430074China／／FacultyofPhysicsandElectronicTechnologyHubeiUniversityWuhan430062China DepartmentofPhysics HuazhongUniversityofScienceandTechnologyWuhan430074China／／DepartmentofPhysicsXiangfanCollegeXiangfan441053China

In this paper, the relation between the dielectric properties and the lattice distortion in the phase coexistence region is discussed using a phase statistical distribution model, and in the rhombohedral phase region the two connection equations on the dielectric properties and the lattice distortion are established. Particularly, the relation between the dielectric properties and the lattice distortion is investigated in the phase coexistence region of PZT ceramics, and the fitting value of the volume fraction of the tetragonal phase VT to composition x in the equation is determined. Further,the fitting results are well consistent with the related experimental data. It involves more profound physical process than relation between the dielectric properties and composition x.

关键词：菱形相共存绝缘性点阵畸变 PZT陶瓷压电性质

Optimization of aviation adjuvants based on wettability analysis for insecticide application on maize using UAV

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International Journal of Agricultural and Biological Engineering 2021年第5期14卷 11-18页

作者： yu Zang Zhiyan Zhou Ying Zang Xiwen Luo Juan Liao Rui Ming Cancan Song Le Zi Rui Jiang hanxiang Xiao College of Engineering South China Agricultural University/Guangdong Engineering Research Center for Agricultural Aviation Application(ERCAAA)Guangzhou 510642China National Center for International Collaboration Research on Precision Agricultural Aviation Pesticides Spraying Technology(NPAAC) Guangzhou 510642China Key Laboratory of Key Technology on Agricultural Machine and Equipment(South China Agricultural University) Ministry of EducationGuangzhou 510642China Institute of Plant Protection Guangdong Academy of Agricultural SciencesGuangzhou 510640China

Adjuvants can increase the control efficacy of diseases and insect pests by changing the physico-chemical properties of pesticides.Most of the aviation spray adjuvants are versions of ground adjuvants.Maize insecticide sprays with unmanned aerial vehicles(UAV),have problems such as relatively low droplet deposition rate and poor wettability.Hence,wettability research and optimization tests for aviation spray adjuvants are needed.The present study screened 12 spray adjuvants using physico-chemical property experiments.The adjuvants were applied to improve the droplet deposition and control efficacy in maize borers controlling by UAV.The selected spray adjuvants were Po2(a hyperbranched polymer adjuvant)and VO3(a vegetable oil adjuvant).Results showed that,(1)When Po2 was added in water-dispersible granules(WGs)at volume rate of 12 L/hm2,the dynamic surface tension(DST)of WGs was decreased by 37.41%,and the maize leaves were covered by droplets 100%,the droplet deposition was increased by 104%and maize borer control was increased by 46%;(2)VO3 decreased the surface tension of ultra-low-volume(ULV)formulation by 12.02%and the maize leaves were covered by droplets 100%.The effect of VO3 on improving the droplet deposition and control efficacy at 12 L/hm2 with ULV was not significant.Thus,the addition of aviation spray adjuvant to improve the wettability of WGs significantly improved the droplet deposition and control efficacy but it had no significant effect on the ULV formulation.

关键词： unmanned aerial vehicles spray adjuvants wettability maize insecticide application

风机叶片气动脉冲除冰结构脱冰计算模型及试验验证

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电工技术学报 2023年第13期38卷 3630-3639页

作者：于周舒立春胡琴蒋兴良李汉湘输配电装备及系统安全与新技术国家重点实验室(重庆大学) 重庆400044

随着低碳型电力系统建设的发展,风力发电系统的发展速度进一步提升。山地风能资源丰富,然而建设于此的风力发电机在冬季极易覆冰。为减少覆冰造成的风机出力损失,保证风电场电力调度稳定,对风力发电机应用防/除冰技术十分重要。该文提... 详细信息

随着低碳型电力系统建设的发展,风力发电系统的发展速度进一步提升。山地风能资源丰富,然而建设于此的风力发电机在冬季极易覆冰。为减少覆冰造成的风机出力损失,保证风电场电力调度稳定,对风力发电机应用防/除冰技术十分重要。该文提出一种适用于风机叶片的气动脉冲除冰结构,并基于此结构建立相关脱冰计算模型。为了验证该结构的除冰效果和脱冰计算模型的准确性,在人工气候试验室开展了不同温度和冰层厚度下的覆冰与除冰试验。结果表明:随着冰层厚度的增加和覆冰温度的降低,平均除冰气压呈现增加趋势,脱冰面积比出现减小趋势;经验证,该文建立的脱冰计算模型可信度高,基于该模型可知,适当提高变形层的弹性模量和厚度可以增加脱冰面积比。

关键词：风力发电机覆冰脱冰计算模型气动脉冲除冰