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Anti-oxidant and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica

Asian Pacific Journal of Tropical Medicine 2013年第4期6卷 311-314页

作者： Mohan CG Deepak M viswanatha GL Savinay G hanumantharaju v Rajendra CE Praveen D Halemani Department of Pharmacognosy Government College of PharmacyBangalore-560027 Department of Phytochemistry Natural Remedies PvtLtd.Bangalore-560 100 Department of Pharmacology PES College of PharmacyBangalore-560050 Deparment of Pharmaceutics Government College of PharmacyBangalore-560027 Drug Testing Laboratory Drugs Control DepartmentPalace roadBangalore-560001 Department of Pharmaceutics Government College of PharmacyBangalore-560 027

Objective:To evaluate the anti-oxidani and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica in in vitro ***:In vitro DPPH radical scavenging activity and lipoxygenase（LOX） inhibition assays were used to evaluate the anti-oxidant and anti-inflammatory activities *** extract（MEMI）,successive water extract （SWMI） and ethyl acetate fraction（EMEMI）,n-butanol fraction（BMEMI） and water soluble fraction （WMEMI） of methanolic extract were evaluated along with respective reference standards. Results:In in ritro DPPH radical scavenging activity,the MEMI,EMEMI and BMEMI have offered significant antioxidant activity with IC50 values of 13.***.3.55 and 14.19μig/mL *** acid,a reference standard showed significant antioxidant activity with IC? value of 1.88 and found to be more potent compared to all the extracts and *** m vitro LOX inhibition assay,the MEMI,EMEMI and BMEMI have showed significant inhibition of LOX enzyme activity with IC50 values of 96.***.63.21 and 107.44μg/mL ***,reference drug Indometlhacin also offered significant inhibtion against LOX enzyme activity with IC50 of ***,MEMI was found to more potent than SWMI and among the fractions EMEMI was found to possess more potent antioxidant and anti-inflammatory ***:These findings suggest that the MEMI and *** possess potent anti-oxidani and anti-inflammatory activities in in vitro conditions.

关键词： Mangifera indica Lipoxygenase DPPH assay Antioxidants Anti-inflammatory

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