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Open Journal of Medical Psychology 2012年第3期1卷 44-50页

作者： Monica S. Bachmann hansjorg znoj Jeannette Brodbeck Department of Clinical Psychology and Psychotherapy Institute of Psychology University of Berne Berne Switzerland

Objectives: This study aimed at identifying distinct quitting trajectories over 29 days after an unassisted smoking ces- sation attempt by ecological momentary assessment (EMA). In order to validate these trajectories we tested if they predict smoking frequency up to six months later. Methods: EMA via mobile phones was used to collect real time data on smoking (yes/no) after an unassisted quit attempt over 29 days. Smoking frequency one, three and six months after the quit attempt was assessed with online questionnaires. Latent class growth modeling was used to analyze the data of 230 self-quitters. Results: Four different quitting trajectories emerged: quitter (43.9%), late quitter (11.3%), returner (17%) and persistent smoker (27.8%). The quitting trajectories predicted smoking frequency one, three and six months after the quit attempt (all p < 0.001). Conclusions: Outcome after a smoking cessation attempt is better described by four distinct trajectories instead of a binary variable for abstinence or relapse. In line with the relapse model by Marlatt and Gordon, late quitter may have learned how to cope with lapses during one month after the quitting attempt. This group would have been allocated to the relapse group in traditional outcome studies.

关键词： Smoking Cessation Lapse Relapse Process Ecological Momentary Assessment Self-Quitter

Epigenetic modulations rendering cell-to-cell variability and phenotypic metastability

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Journal of Genetics and Genomics 2016年第8期43卷 503-511页

作者： Shawal Spencer Agustina Gugliotta Natascha Godecke hansjorg Hauser Dagmar Wirth Model Systems for Infection and Immunity Helmholtz Centre for Infection ResearchBraunschweig 38124Germany Experimental Hematology Hannover Medical SchoolHannover 30625Germany cell culture laboratory faculty of biochemistry and biological sciencesnational university of the littoralSanta Fe 3000Argentina

Tumor cells display phenotypic plasticity and heterogeneity due to genetic and epigenetic variations which limit the predictability of therapeutic interventions. Chromatin modifications can arise stochas- tically but can also be a consequence of environmental influences such as the microenvironment of cancer cells. A better understanding of the impact and dynamics of epigenetic modulation at defined chromosomal sites is required to get access to the underlying mechanisms. We investigated the epige- netic modulations leading to cell-to-cell heterogeneity in a tumor cell line model. To this end, we analyzed expression variance in 80 genetically uniform cell populations having a single-copy reporter randomly integrated in the genorne. Single-cell analysis showed high intraclonal heterogeneity. Epige- netic characterization revealed that expression heterogeneity was accompanied by differential histone marks whereas contribution of DNA methylation could be excluded. Strikingly, some clones revealed a highly dynamic, stochastically altered chromatin state of the transgene cassette which was accompanied with a metastable expression pattern. In contrast, other clones represented a robust chromatin state of the transgene cassette with a stable expression pattern. Together, these results elucidate locus-specific epigenetic modulation in gene expression that contributes to phenotypic heterogeneity of cells and might account for cellular plasticity.

关键词： lntraclonal heterogeneityEpigenetic regulationDNA methylationDifferential histone marksMetastable expression

Use of pCONUS HPC for the treatment of unruptured wide- necked bifurcation aneurysms: early clinical experience using single antiplatelet therapy

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Stroke & Vascular Neurology 2021年第1期6卷 57-64页

作者： Marta Aguilar Perez Victoria Hellstern Carmen Serna Candel Christina Wendl hansjorg Bazner Oliver Gansladt Hans Henkes Neuroradiologische Klinik NeurozentrumKlinikum StuttgartStuttgartGermany Institut fur Rontgendiagnostik Zentrum fur NeuroradiologieFakultat für Medizin der Universitat RegensburgRegensburgGermany Neurologische Klinik NeurozentrumKlinikum StuttgartStuttgartGermany Neurochirurgische NeurozentrumKlinikum StuttgartStuttgartGermany Medizinische Fakultat Universitat Duisburg-EssenEssenGermany

Background In recent years,a growing number of stents and stent-like devices have become available to facilitate the treatment of challenging aneurysms.However,the need for dual antiplatelet therapy can limit their use,especially in ruptured aneurysms.The hydrophilic polymer coating(pHPC,phenox)is a novel glycan-based multilayer polymer that reduces platelet adhesion.This study aims to report our initial experience using the pCONUS HPC device for the treatment of unruptured wide-necked bifurcation aneurysms(WNBA)using acetylsalicylic acid(ASA)as single antiplatelet therapy(SAPT).Methods We retrospectively identified all patients who were treated with the pCONUS HPC for unruptured WNBA in a multi-staged procedure using ASA as SAPT.Records were made of periprocedural complications,clinical outcome and angiographic and clinical follow-up.Results We identified 15 patients with 15 WNBA.The average age was 69 years old(range,41-76).Seven aneurysms were located in the middle cerebral artery,five in the anterior communicating artery,two at the basilar tip and one in the posterior communicating artery.Immediate post-treatment angiography showed five aneurysms with modified Raymond-Roy classification(mRRC)grade Ⅰ and four aneurysms with mRRC grade Ⅱ.There were no haemorrhagic complications.Four patients developed thrombus formation during the second treatment session,all of them completely resolving after administration of glycoprotein Ⅱb/Ⅲa antagonists.Angiographic follow-up data were available for 10 patients and showed adequate occlusion(mRRC Ⅰ or Ⅱ)in eight aneurysms(80%).In-stent stenosis was observed in one patient whereas two patients showed de novo stenosis in one of the efferent branches.Conclusions This early experience on the use of the pCONUS HPC device suggests that it can be useful for treating unruptured WNBA under ASA as SAPT.Further investigation with a randomised treatment registry and larger cohort is needed.

关键词： treatment bifurcation HPC

Effective intrahepatic CD8＋ T-cell immune responses are induced by low but not high numbers of antigen-expressing hepatocytes

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Cellular & Molecular Immunology 2016年第6期13卷 805-815页

作者： Aaron Ochel Marcin Cebula Mathias Riehn Upneet Hillebrand Christoph Lipps Reinhold Schirmbeck hansjorg Hauser Dagmar Wirth Model Systems for Infection and Immunity Helmholtz Centre for Infection Research Inhoffenstr. 7 38124 Braunschweig Germany Clinic for Internal Medicine I University Hospital UIm Albert-Einstein-Allee 23 89081 UIm Germany Experimental Hematology Medical School Hannover Carl-Neuberg-Str. 1 D-30625 Hannover Germany Current address Institute for Immunology Justus-Liebig University Giessen BFS Schubertstr. 81 35390 Giessen Germany

Liver infections with hepatotropic viruses, such as hepatitis B virus and hepatitis C virus are accompanied by viral persistence and immune failure. CD8＋ T cells are crucial mediators of the intrahepatic antiviral immune response. Chronic infections of the liver and other organs correlate with T-cell exhaustion. It was previously suggested that high antigen load could result in T-cell exhaustion. We aimed at elucidating the impact of different intrahepatic antigen loads on the quality of CD8＋ T-cell-mediated immunity by employing an infection-free transgenic mouse model expressing ovalbumin （Ova） as the target antigen. Adoptive transfer of OT-I cells induced a transient intrahepatic immune response toward both high and low Ova levels. However, antigen clearance was achieved only in mice expressing low antigen levels. In contrast, T cells exposed to high antigen levels underwent exhaustion and became depleted, causing antigen persistence. Moreover, when functional T cells were exposed to high intrahepatic antigen levels, a complete transition toward exhaustion was observed. Thus, this study shows that the antigen expression level in the liver correlates inversely with T-cell immunity in vivo and governs the efficiency of immune responses upon antigen presentation.

关键词： antigen load chronicity immune modulation T-cell exhaustion

中国经济的高速增长──不具转型危机的转型?

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当代财经 2001年第5期 7-14页

作者： hansjorg Herr Jan Priewe 德国柏林财经学院柏林德国柏林应用科学学院

高投资需求是中国经济增长的主要动力。国有企业可能因三种因素而触发转型危机：现有亏损和坏账的真实数据比目前的统计数据恐怕要高；如果继续拖延国有企业重组，如果保持、甚至软化预算约束，如果债务升级，那么长期债务积累的危险将... 详细信息

高投资需求是中国经济增长的主要动力。国有企业可能因三种因素而触发转型危机：现有亏损和坏账的真实数据比目前的统计数据恐怕要高；如果继续拖延国有企业重组，如果保持、甚至软化预算约束，如果债务升级，那么长期债务积累的危险将会增加；如果货币、财政和工业政策出现急转弯，对国有企业实行硬预算约束，而造成大批企业倒闭、失业急剧上升、投资减少及金融体系重大冲击。要避免转型危机，就必须把渐进转型所“创造”的时间果断用于推动重组。财政扩张对需求会有短期影响，抵抗通货紧缩，而不造成通货膨胀压力，但对未来能否保持持续增长在很大程度上取决于消费者和投资者的行为。

关键词：中国经济增长投资需求转型危机国有企业重组财政扩张政策

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以氢气为气相色谱的载气

实验与分析 2008年第5期 40-41页

作者： hansjorg Kajer Science Support

气相色谱流动相-载气在色谱方法的优化过程中通常很少被人关注，事实上，通过使用不同的气体往往可以优化分离效果。氢气发生器使氢气作为气相色谱系统的载气非常方便，克服了其他载气体需要购买气瓶的缺点。

关键词：气相色谱系统氢气发生器载气体优化过程分离效果谱方法流动相

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中国为什么不应开放资本账户

江西财经大学学报 2003年第2期 14-16页

作者： hansjorg Herr Jan Priewe 陈少平柏林财经学院柏林科技应用大学

中国加入WTO后中国和西方的政治家、学者及商业界领袖们都在呼吁中国跨出融入世界经济大潮的最后一步。他们积极主张中国完全开放金融市场并缩小国家对经济的干预范围,从而使人民币可自由兑换外币,消除资本交易控制,即完全开放外汇市场... 详细信息

中国加入WTO后中国和西方的政治家、学者及商业界领袖们都在呼吁中国跨出融入世界经济大潮的最后一步。他们积极主张中国完全开放金融市场并缩小国家对经济的干预范围,从而使人民币可自由兑换外币,消除资本交易控制,即完全开放外汇市场。然而,我们对此却表示十分怀疑,因为不论是从经济还是政治角度来看,这种观点都非常值得商榷。在本文中,我们将首先讨论市场开放的预期经济利益,然后探究此举给宏观经济带来的一般后果,包括不同类型资本流动的作用。最后,我们会讨论“

关键词： WTO 完全开放资本帐户

Prospective observational multicenter study to define a diagnostic algorithm for biliary candidiasis

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World Journal of Gastroenterology 2014年第34期20卷 12260-12268页

作者： Philipp Lenz Franziska Eckelskemper Thomas Erichsen Tim Lankisch Alexander Dechêne Gabriele Lubritz Frank Lenze Torsten Beyna hansjorg Ullerich Andre Schmedt Dirk Domagk Department of Medicine B University of MuensterD-48149 MuensterGermany Department of Gastroenterology Hepatology and EndocrinologyHannover Medical School30625 HannoverGermany Department of Gastroenterology and Hepatology University Hospital Essen45147 EssenGermany Institute of Medical Microbiology University Hospital MuensterD-48149 MuensterGermany

AIM:To develop an algorithm to improve the diagnosis and treatment of patients with biliary candidiasis.METHODS:We performed a prospective study of 127patients who underwent endoscopic retrograde cholangiopancreatography,for various biliary disorders,at 3 tertiary referral centers in Germany from July 2011through July 2012(ClinicalTrials.gov:NCT01109550).Bile,buccal,and stool samples were collected.When indicated,endoscopic transpapillary bile duct biopsies were performed to clarify the etiology of bile duct strictures and to prove invasive fungal infections.RESULTS:Candida species were detected in 38 of the 127 bile samples(29.9%).By multivariate analysis patients’age and previous endoscopic sphincterotomy were independent risk factors for biliary candidiasis(P7 d)(P=0.089)tend to be at risk for biliary candidiasis.One patient was negative in mycological culture of bile fluid but invasive biliary candidiasis was diagnosed histologically.Of Candida subspecies detected,36.7%were azole-resistant,such as C glabrata.Eight patients received anti-mycotic therapy,based on our algorithm.Of these,3 had cancer with biliary tract involvement,2had secondary sclerosing cholangitis,1 had retroperitoneal fibrosis,and 5 had septicemia.In all patients contamination was ruled out by smears of the endoscope channel.CONCLUSION:Gastroenterologists should be aware of frequent candida colonization in patients with cholangitis and biliary disorders.Our suggested algorithm facilitates the further clinical management.

关键词： Cholangitis Biliary candidiasis Invasive fungal infection Biliary obstruction

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中国经济的高速增长

国民经济管理

国民经济管理 2001年第8期

作者： hansjorg Herr Jan Priewe

关键词：中国经济增长投资需求转型危机国有企业重组财政扩张政策

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切触几何和拓扑简史

数学译林 2006年第2期25卷 133-148页

作者： hansjorg Geiges 丁帆(译) 潘建中(校)

切触几何的起源可以追溯到1872年Sophus Lie[57]，参见[58，59]，引入切触变换（contact transformation）作为研究微分方程组的一种几何工具．这门学科与纯粹数学的其它领域有很多联系，对应用领域如力学、光学、热力学及控制理论也很... 详细信息

切触几何的起源可以追溯到1872年Sophus Lie[57]，参见[58，59]，引入切触变换（contact transformation）作为研究微分方程组的一种几何工具．这门学科与纯粹数学的其它领域有很多联系，对应用领域如力学、光学、热力学及控制理论也很重要，然而在很长一段时间里，切触几何不像它的孪生姐妹辛几何那样受到重视。

关键词：辛几何切触简史拓扑微分方程组纯粹数学控制理论热力学光学时间