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Cationic antimicrobial peptide： LL-37 and its role in periodontitis

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Frontiers in Biology 2017年第2期12卷 116-123页

作者： hansa jain Department of Pedodontics Harsarn Dass Dental College India

BACKGROUND： Periodomitis i.e. inflammation of the periodontium is a multifactorial disease. Antimicrobial peptides （AMPs） which demonstrate a broad-spectrum of activity against varied number of bacteria, fungi, viruses, and parasites, and cancerous cells have been linked to periodontitis. The AMPs even possess the caliber of immunomodulation, and are significantly responsive to innate immuno-stimulation and infections. LL-37 plays a salubrious role by preventing and in treatment of chronic forms of periodontitis. OBJECTIVE： In the present work we will review the role of antimicrobial peptide LL-37 in periodontitis. METHODS： A systematic search was carried out from the beginning till August, 2016 using the Pubmed search engine. The keywords included ＂LL-37,＂＂periodontitis,＂＂Papillon-Lefevre syndrome,＂＂Morbus Kostmann,＂＂Haim-Munk syndrome＂ along with use of Boolean operator ＂and.＂ RESULTS： The search resulted in identifying 67 articles which included articles linking LL-37 with periodontitis, articles on Papillon-Lefevre syndrome, Morbus Kostmann, Haim-Munk syndrome, LL-37 and periodontitis and articles on pathogenicity of periodontitis. CONCLUSION： The literature search concluded that LL-37 plays a pivotal role in preventing and treatment of severe form of periodontitis.

关键词： LL-37 antimicrobial peptides cathelicidin periodontitis

Antibacterial effect of bestatin during periodontitis

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Frontiers in Biology 2016年第5期11卷 387-390页

作者： hansa jain Department of Pedodontics Harsarn Dass Dental College India

Periodontitis is a polymicrobial disease inciting inflammatory destruction of the tooth-supporting tissues, i.e., periodontium. The initiation of this infectious disease is ascribed to the formation of subgingival biofilms. These biofilms cause stimulation of myriad of chronic inflammatory reactions by the affected tissue. The Gram-negative anaerobe Porphyromonas gingivalis is commonly found as part of the microbiota of subgingival biofilms, and is involved in the occurrence of the disease. P. gingivalis possesses numerous virulence factors supporting its survival, regulating its communication with other species in the biofilm, degrading host tissues. Fusobacterium nucleatum is pivotal for formation of biofilm and promotes growth and invasion properties ofP. gingivalis. Bestatin is an aminopeptide inhibitor, produced by actinomycetes. It possesses antibacterial properties against P. gingivalis and F. nucleatum. The following review focuses on action of bestatin on the mentioned bacteria.

关键词： bestatin Porphyromonas gingivalis Fusobacterium nucleatum periodontitis biofilm

Preservation Artifacts and Loss Pattern of Arsenic: A Case Study from Highly Contaminated Location in Central-East India

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Journal of Environmental Protection 2011年第9期2卷 1211-1217页

作者： Piyush Kant Pandey hansa Zankyani Madhurima Pandey 不详

Arsenic is the focus of public attention because of its wider prevalence and toxicity. Proper sampling is important in characterizing toxic water contaminants in the groundwater. The present paper studies aspects of sampling, preservation artifacts, analytical issues etc. in a natural arsenic contaminated groundwater. The samples were collected from arsenic contaminated groundwater at three locations of village Kaudikasa in Rajnandgaon (Chhattisgarh). The standard method of sampling and preservation of arsenic was examined. The permitted sample holding time in this state is 180 days which has been found to be unrealistic on examination. The communication also compares the loss pattern of arsenic in unpreserved samples with samples preserved and kept at 4?C. It was found that about As losses during hold- ing after preservation were about 0% in one day, 35% in seven day, 70% in fifteen day, and 65% in thirty days time. Hence, the present recommended method of preservation leads to huge under reporting of As in natural samples. If the pattern of losses observed at the present location exists at other locations then the actual As levels could be much higher than the reported ones.

关键词： Arsenic Groundwater Contamination Preservation Loss Pattern Chhattisgarh

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恩里克·费米在罗马，1931—1932

国际物理教育通讯 2002年第30期 5-6,4页

作者： hansa.Bethe 张Min路不详华中科技大学