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现代预防医学 2024年第4期51卷 607-612页

作者：乔栩胡玉麒范云喆叶婷婷马春兰蔡长伟杨淑娟 Jan D.reinhardt 杨波四川大学-香港理工大学灾后重建与管理学院四川大学华西公共卫生学院/华西第四医院中国铁路成都局集团有限公司社会保险管理部成都大学附属医院武汉大学空间全生命周期健康国际研究中心南京医科大学第一附属医院江苏省医院康复研究中心瑞士截瘫研究中心卢塞恩大学健康科学与医学系

目的探究职业人群肥胖与非酒精性脂肪肝的关联，以及高尿酸血症在关联路径中的中介作用，为职业人群非酒精性脂肪肝的预防与干预策略提供参考。方法采用多阶段整群抽样，基于西南职业人群队列，通过问卷调查获取调查对象社会人口学指... 详细信息

目的探究职业人群肥胖与非酒精性脂肪肝的关联，以及高尿酸血症在关联路径中的中介作用，为职业人群非酒精性脂肪肝的预防与干预策略提供参考。方法采用多阶段整群抽样，基于西南职业人群队列，通过问卷调查获取调查对象社会人口学指标、生活方式等信息，并获取其体检信息。通过Spearman秩相关系数和logistic回归分析肥胖与非酒精性脂肪肝之间的相关关系。通过中介效应模型探讨高尿酸血症在肥胖与非酒精性脂肪肝关联中的中介效应。结果共纳入15 029例研究对象，其中新发非酒精性脂肪肝患者1 190人。Logistic回归结果显示，调整年龄、性别等协变量后，肥胖会增加非酒精性脂肪肝发生的风险(OR=3.37, 95%CI:2.78～4.09),且年龄<45岁人群(OR=3.93, 95%CI:3.12～4.94)和女性亚组(OR=3.65, 95%CI:1.98～6.71)中肥胖对非酒精性脂肪肝发生风险的影响更大。中介分析发现，高尿酸血症在肥胖与非酒精性脂肪肝之间的中介效应占比为11.72%,亚组分析中，女性亚组高尿酸血症中介效应占比更高(23.81%)。结论肥胖与非酒精性脂肪肝的发生密切相关，在年轻人和女性群体影响更大，并会通过高尿酸血症影响非酒精性脂肪肝。加强肥胖和高尿酸血症的预防教育，倡导健康的生活方式或可减少肥胖与高尿酸血症导致的非酒精性脂肪肝。

关键词：肥胖高尿酸血症非酒精性脂肪肝

The core-merging giant impact in Earth's accretion history and its implications

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Acta Geochimica 2022年第4期41卷 553-567页

作者： You Zhou Yun Liu Christian reinhardt Hongping Deng International Research Center for Planetary Sciences College of Earth SciencesChengdu University of TechnologyChengdu610059China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang550081China CAS Center for Excellence in Comparative Planetology HefeiChina Center for Theoretical Astrophysics and Cosmology Institute for Computational ScienceUniversity of ZurichWinterthurerstrasse 1908057ZurichSwitzerland Department of Applied Mathematics and Theoretical Physics Centre for Mathematical SciencesUniversity of CambridgeWilberforce RoadCambridgeCB30WAUK

The Earth’s accretion process is accompanied by a large number of *** is widely accepted that collisions dominate the Earth’s late accretion *** all these collisions,there is a special type of collision called Core-merging giant impact(CMGI),in which much or most the impactor’s core merges directly with the protoEarth’s *** core-merging scenario plays an important role in the Earth’s accretion process and deeply affects the formation of the Earth’s core and ***,because CMGI is a small probability event,it has not been fully *** we use the SPH method to comprehensively study all possible CMGIs in the Earth’s accretion *** find that CMGI only occurs in the initial conditions with small impact angle,small impact velocity and big *** further discuss the implications of *** are confident that CMGI inevitably causes the chemical disequilibrium of the Earth’s core and *** CMGI process also brings many light elements into the Earth’s *** particular,if the Moon-forming giant impact is a CMGI,then CMGI can also explain the abnormal content of HSEs in the Earth’s current mantle.

关键词： Giant impact Core-merging process Disequilibrium of the Earth’s core and mantle

Starving out brain tumors: a reprogrammed lysine catabolism serves as a novel target for glioblastoma treatment

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5136-5138页

作者： Désirée Gül Oliver H.Krämer Christoph reinhardt Molecular and Cellular Oncology Department of Otorhinolaryngology Head and Neck SurgeryUniversity Medical CenterJohannes Gutenberg-University Mainz55131MainzGermany Department of Toxicology University Medical CenterJohannes Gutenberg-University Mainz55131 MainzGermany Center for Thrombosis and Hemostasis(CTH) University Medical CenterJohannes Gutenberg-University MainzLangenbeckstrasse 155131 MainzGermany German Center for Cardiovascular Research(DZHK) Partner Site Rhine-MainUniversity Medical CenterJohannes Gutenberg-University Mainz55131 MainzGermany

In their recent study published in Nature,Yuan and colleagues enlighten the role of histone lysine crotonylation(Kcr)in brain tumor *** report a novel lysine-dependent mechanism through which glioblastoma stem cells m... 详细信息

关键词： glioblastoma interferon treatment

Early warning and disaster management:the importance of geographic information(Part B)

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International Journal of Digital Earth 2010年第3期3卷 313-315页

作者： Guest Editors Milan Konecny Wolfgang reinhardt Laboratory on Geoinformatics and Cartography Institute of Geography Faculty of Science Masaryk UniversityKotlarska 261137 BRNOCzech Republic AGIS Geoinformatics Lab Institute of Applied Computer Science(INF4)University of the BundeswehrMu¨nchenGermany

This special issue is part of a double special issue(Part A was published in the previous issue of this journal)dealing with the role of Geographic Information(GI)for Early Warning(EW)and Disaster Management(DM).In the editorial of Part A we gave an introduction to the topic focussing on initiatives from the EU and China and we have highlighted the importance of Digital Earth for EWand *** have also reflected on the outcome of some events organized by the guest editors which were important for the topic and for this special issue.

关键词： journal disaster Early

An exotic Cretaceous kimberlite linked to metasomatized lithospheric mantle beneath the southwestern margin of the S?o Francisco Craton,Brazil

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Geoscience Frontiers 2022年第1期13卷 182-203页

作者： Luísa D.V.Carvalho Tiago Jalowitzki Ricardo Scholz Guilherme O.Gonçalves Marcelo Peres Rocha Rogério Silvestre Pereira Cristiano Lana Marco Paulo de Castro Gláucia Queiroga reinhardt A.Fuck Universidade Federal de Ouro Preto(UFOP) Escola de MinasDepartamento de GeologiaCampus Morro do Cruzeiro35400-000 Ouro PretoMGBrazil Universidade de Brasília(UnB) Instituto de GeociênciasCampus Universitário Darcy Ribeiro70910-900 BrasíliaDFBrazil Independent Geologist Consultant

We present major and trace element compositions of mineral concentrates comprising garnet xenocrysts,ilmenite,phlogopite,spinel,zircon,and uncommon minerals(titanite,calzirtite,anatase,baddeleyite and pyrochlore)of a newly discovered Late Cretaceous kimberlite(U-Pb zircon age 90.0±1.3 Ma;2σ)named Osvaldo Franca 1,located in the Alto Paranaíba Igneous Province(APIP),southeastern *** grains are lherzolitic(Lherz-1,Lherz-2 and Lherz-3),harzburgitic(Harz-3)and wehrlitic(Wehr-2).The pyrope xenocrysts cover a wide mantle column in the subcratonic lithosphere(66–143 km;20–43 kbar)at relatively low temperatures(811–875°C).The shallowest part of this mantle is represented by Lherz-1 pyropes(20–32 kbar),which have low-Cr(Cr_(2)O_(3)=1.74–6.89 wt.%)and fractionated middle to heavy rare earth elements(MREE-HREE)*** deepest samples are represented by Lherz-2,Lherz-3,Harz-3,and Wehr-2 pyropes(36–43 kbar).They contain high-Cr contents(Cr_(2)O_(3)=7.36–11.19 wt.%)and are characterized by sinusoidal(Lherz-2 and Wehr-2)and spoon-like(Lherz-3 and Harz-3)REE *** to their REE and trace elements,pyrope xenocrysts have enriched nature(e.g.,Ce and Yb ***_(2)O_(3)),indicating that the cratonic lithosphere has been affected by a silicate melt with subalkaline/tholeiite composition due to their low Zr,Ti and Y *** minerals with typical kimberlitic signatures,such as ilmenite and zircon,the exotic compositions of phlogopite and ulvöspinel suggest an enriched component in the magma *** formation of rare mineral phases with strong enrichment of light-REE(LREE)and high field strength elements(HFSE)is attributed to the late-stage kimberlitic *** propose a tectonic model where a thermal anomaly,represented by the low-velocity seismic anomaly observed in P-wave seismic tomography images,supplied heat to activate the alkaline magmatism from a metasomatized cratonic mantle source during the late-stages of Gondwana fragmentation and conse

关键词： Osvaldo França 1 kimberlite Alto Paranaíba Igneous Province Metasomatized cratonic lithosphere Zircon U-Pb geochronology

Preface: Metamorphism and Orogenic Belts——Response from Micro-to Macro-Scale

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Journal of Earth Science 2019年第6期30卷 1075-1083页

作者： Xu-Ping Li Hans-Peter Schertl Jürgen reinhardt Shandong Key Laboratory of Depositional Mineralization and Sedimentary Minerals Shandong University of Science and TechnologyQingdao 266590China Ruhr-University Bochum Institute of GeologyMineralogy and GeophysicsD-44780 BochumGermany College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China Department of Earth Sciences University of the Western CapeBellville 7535South Africa

The geological toolbox for the analysis of orogenic processes has seen substantial additions over the recent *** advances have been made in the ability to simulate geological conditions and processes by computer modeling,we have a much improved knowledge of geochemical processes(trace elements and isotopes in particular),and,last but not least,the range and versatility of micro-analytical methods and instrumentation available to us has been expanded *** latter aspect has had a particular impact on metamorphic petrology as the conventional tools to determine pressure-temperaturetime paths via rock and mineral analysis combined with isotope geochronology have generally gained in precision and accuracy through a much improved *** has moved from whole-grain analysis to spot analyses on zoned single grains while analyzing trace elements and isotopes at the same *** is therefore possible to recognize complex multi-stage orogenic events in single samples or single *** profiles in minerals provide us with time-scales of metamorphic and magmatic *** and trace elements as well as isotope profiles of mineral grains give us insight into changing ambient conditions during mineral *** special issue focuses on pressure-temperature conditions and geochronology of metamorphic rocks,isotope studies of magmatic rocks,partial melting and metasomatic processes,all with a view at tectonic implications and *** of the evidence has been gained from small-scale observation and *** field work and detailed microscopic examination remain indispensable,though,as demonstrated clearly by the"expansion"of the P-T space as applicable to crustal metamorphic processes towards extreme pressures and *** a consequence,much interest has thus focused on UHP and UHT rocks and the orogenic processes that generate *** is petrological evidence for subduction to,and subsequent exhumation fr

关键词： orogeny metasomatism UHP metamorphism UHT metamorphism geochemistry geochronology

Influence of vascular endothelial growth factor and radiation on gap junctional intercellular communication in glioblastoma multiforme cell lines

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Neural Regeneration Research 2017年第11期12卷 1816-1822页

作者： reinhardt Krcek Pauline Latzer Irenaus Anton Adamietz Helmut Biihler Carsten Theiss Institute of Anatomy Department of CytologyRuhr-University BochumBochumNorth Rhine-WestphaliaGermany Department of Radiotherapy and Radio-Oncology University Medical Centre MarienhospitalRuhr-University BochumHerneNorth Rhine-WestphaliaGermany Institute for Molecular Oncology Radio-Biology and Experimental RadiotherapyUniversity Medical Centre MarienhospitalRuhr-University BochumHerneNorth Rhine-WestphaliaGermany

Glioblastoma multiforme （GBM） is a highly aggressive glial brain tumor with an unfavorable prognosis despite all current therapies including surgery, radiation and chemotherapy. One characteristic of this tumor is a strong synthesis of vascular endothelial growth factor （VEGF）, an angiogenesis factor, followed by pronounced vascularization. VEGF became a target in the treatment of GBM, for example with bevacizumab or the tyrosine kinase inhibitor axitinib, which blocks VEGF receptors. To improve patients＇ prognosis, new targets in the treatment of GBM are under investigations. The role of gap junctions in GBM remains un- known, but some experimental therapies affect these intercellular channels to treat the tumor. Gap junctions are composed of connexins to allow the transport of small molecules between adjacent cells through gap junc- tional intercellular communication （GJIC）. Based on data derived from astrocytes in former studies, which show that VEGF is able to enhance GJIC, the current study analyzed the effects of VEGF, radiation therapy and VEGF receptor blockade by axitinib on GJIC in human GBM cell lines U-87 and U-251. While VEGF is able to induce GJIC in U-251 cells but not in U-87 cells, radiation enhances GJIC in both cell lines. VEGF reocptor blockade by axitinib diminishes radiation induced effects in U-251 partially, while increases GJIC in U-87 cells. Our data indicate that VEGF and radiation are both modifying components of GJ1C in pathologic brain tumor tissue.

关键词： cell communication vascular endothelial growth factor irradiation vascular endothelial growth factor-receptor blockade glioma neurobiotin connexin cell culture immunohistochemistry microinjection

Two-Photon Direct Laser Writing Beyond the Diffraction Limit Using the Nanopositioning and Nanomeasuring Machine

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Nanomanufacturing and Metrology 2021年第3期4卷 149-155页

作者： Laura Mohr-Weidenfeller Annika-Verena Hacker Carsten reinhardt Eberhard Manske Microsystems Technology Group Ilmenau University of TechnologyMax-Planck-Ring 12IlmenauGermany Institute for Process Measurement and Sensor Technology Ilmenau University of TechnologyGustav-Kirchhoff-Str.1IlmenauGermany Bremen University of Applied Science Neustadtswall 30BremenGermany

Since the first realization of two-photon direct laser writing(DLW)in Maruo et al.(Opt Lett 22:132-134,1997),the manufacturing using direct laser writing techniques spread out in many laboratories all over the *** materials with different material properties open a new field for micro-and *** achievable structuring resolution using this technique is reported to be sub-100 nm(Paz et *** *** Appl.24:042004,2012),while a smallest linewidth of 25 nm could be shown in Tan et al.(Appl Phys Lett 90:071106,2007).In our approach,the combination of DLW with the nanopositioning and nanomeasuring machine NMM-1 offers an improvement of the technique from the engineering side regarding the ultra-precise positioning(Weidenfeller et *** Adv Fabr Technol Micro/Nano Opt Photon Ⅺ 10544:105440E,2018).One big benefit besides the high positioning resolution of 0.1 nm is offered by the positioning range of 25 mm×25 mm×5 mm(Jager et *** Technisches Messen 67:319-323,2000;Manske et *** Meas Sci Technol 18:520-527,2007).Thus,a trans-scale fabrication without any stitching or combination of different positioning systems is *** immense synergy between the highly precise positioning and the DLW is demonstrated by the realization of resist lines and trenches whose center-to-center distance undergoes the modified diffraction limit for two-photon *** precise positioning accuracy enables a defined distance between illuminated ***,with a comparable huge width of the trenches of 1.655|im due to a low effective numerical aperture of 0.16,a resist line of 30 nm between two written trenches could be *** the interrelationships for achieving such narrow trenches have not yet been clarified,much smaller resist lines and trench widths are possible with this approach in the near future.

关键词： Direct laser writing Nanopositioning and nanomeasuring machine Two-photon absorption Laser power controlling

UV-LED projection photolithography for high-resolution functional photonic components

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Microsystems & Nanoengineering 2021年第4期7卷 149-159页

作者： Lei Zheng Urs Zywietz Tobias Birr Martin Duderstadt Ludger Overrmeyer Bernhard Roth Carsten reinhardt Hannover Centre for Optical Technologies Leibniz University HannoverHannoverLower Saxony 30167Germany Cluster of Excellence PhoenixD(Photonics Opticsand Engineering-Innovation Across Disciplines)HannoverLower Saxony 30167Germany Laser Zentrum Hannover e.V HannoverLower Saxony 30167Germany Institute of Transport and Automation Technology Leibniz University HannoverGarbsenLower Saxony 30823Germany Bremen University of Applied Science BremenBremen 28199Germany

The advancement of micro-and nanostructuring techniques in optics is driven by the demand for continuous miniaturization and the high geometrical accuracy of photonic devices and integrated ***,UV-LED projection photolithography is demonstrated as a simple and low-cost approach for rapid generation of two-dimensional optical micro-and nanostructures with high resolution and accuracy using standard optics *** developed system enables the projection of structure patterns onto a substrate with 1000-fold *** devices,e.g.,waveguides and microring resonators,on rigid or flexible substrates with varied geometrical complexity and overall structure dimensions from the nanometer to centimeter scale were successfully *** particular,high-resolution gratings with feature sizes down to 150 nm and periods as small as 400 nm were realized for the first time by this *** made of doped laser active materials were fabricated,and their spontaneous emission was *** demonstrated superior performance of the developed approach may find wide applications in photonics,plasmonics,and optical materials science,among others.

关键词： projection resolution optics