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吉林中部地区小绥河组变质粉砂岩碎屑锆石u-Pb年代学研究及其地质意义

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山东科技大学学报（自然科学版） 2019年第6期38卷 11-22页

作者：韩作振钟文建宋志刚韩超 hans-PETER Schertl 任祥高丽华山东科技大学地球科学与工程学院山东青岛266590 海洋矿产资源实验室青岛海洋科学与技术试点国家实验室山东青岛266071 波鸿鲁尔大学地质矿产地球物理研究所德国北莱茵-威斯特法伦州波鸿44780

对吉林省中部地区小绥河组变质粉砂岩进行了LA-ICP-MS碎屑锆石u-Pb年代学、地球化学及锆石Hf同位素的研究,探讨了变质粉砂岩的形成时代、物源及构造背景。通过u-Pb定年分析,获得小绥河组变质粉砂岩碎屑锆石3组u-Pb年龄:459~474Ma、441~4... 详细信息

对吉林省中部地区小绥河组变质粉砂岩进行了LA-ICP-MS碎屑锆石u-Pb年代学、地球化学及锆石Hf同位素的研究,探讨了变质粉砂岩的形成时代、物源及构造背景。通过u-Pb定年分析,获得小绥河组变质粉砂岩碎屑锆石3组u-Pb年龄:459~474Ma、441~446Ma和417~426Ma,其形成时代应为晚志留世-早泥盆世。通过全岩地球化学和锆石Hf同位素分析,认为小绥河组变质粉砂岩原岩物源主要来自于兴蒙造山带东段中奥陶世至早泥盆世的火成岩。小绥河组变质粉砂岩可能形成于弧陆碰撞的造山环境。

关键词：吉林小绥河组变质粉砂岩碎屑锆石u-Pb 年代学

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AT+SC切石英晶体谐振器热滞的自动测量方法和结果

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宇航计测技术 1984年第S1期 28-36页

作者： hans-Joachim Forster Siemens 赵洪举

本文的目的是要说明传统的HC—27/u玻璃壳封装的精密石英晶体谐振器温度补偿的极限。为了对限制补偿精度的谐振器的热滞（返回）进行测量,建立了计算机控制的滞后测量台,该测量台曾用来测量由3个德国厂家制造的多种晶体。与AT切晶体相比... 详细信息

本文的目的是要说明传统的HC—27/u玻璃壳封装的精密石英晶体谐振器温度补偿的极限。为了对限制补偿精度的谐振器的热滞（返回）进行测量,建立了计算机控制的滞后测量台,该测量台曾用来测量由3个德国厂家制造的多种晶体。与AT切晶体相比较,SC切晶体没有显示出实际优点。用数字温度补偿石英晶体振荡器可获得的频率稳定度,单仅晶体谐振器的热滞一项,就限制在△f/f=±1×10-7左右。如果把用做补偿的温度传感器的不精确度和数字化的分辨误差加在一起,则对于连续生产而废品率不高的情况可以把可达到的频率稳定度假定为△f/f=±2×10-7。这个数值实际上与工作温度范围无关。

关键词：石英晶体谐振器晶体电流 AT+SC 石英晶体振荡器晶体振荡器热滞温度补偿温度校正转折点温度参考温度计算机控制电脑控制数字补偿 SC

Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4^(-/-) mouse model

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World Journal of Hepatology 2016年第8期8卷 401-410页

作者： Florian P Reiter Ralf Wimmer Lena Wottke Renate Artmann Jutta M Nagel Manuel O Carranza Doris Mayr Christian Rust Peter Fickert Michael Trauner Alexander L Gerbes Simon Hohenester Gerald u Denk Department of Medicine Ⅱ Liver Center Munich University of Munich Institute of Pathology University of Munich Department of Medicine Ⅰ Krankenhaus Barmherzige Brüder Research unit for Experimental and Molecular Hepatology Division of Gastroenterology and Hepatology Department of Internal Medicine hans Popper Laboratory of Molecular Hepatology Division of Gastroenterology and Hepatology Department of Internal Medicine Ⅲ Medical University of Vienna Transplant Center Munich of the university of Munich

AIM: To study the interleukin-1(IL-1) pathway as a therapeutic target for liver fibrosis in vitro and in vivo using the ATP-binding cassette transporter b4^(-/-)(Abcb4^(-/-)) mouse ***: Female and male Abcb4^(-/-) mice from 6 to 13 mo of age were analysed for the degree of cholestasis(liver serum tests), extent of liver fibrosis(hydroxyproline content and Sirius red staining) and tissue-specific activation of signalling pathways such as the IL-1 pathway [quantitative polymerase chain reaction(q PCR)]. For in vivo experiments, murine hepatic stellate cells(HSCs) were isolated via pronasecollagenase perfusion followed by density gradient centrifugation using female mice. Murine HSCs were stimulated with up to 1 ng/m L IL-1β with or without 2.5 μg/m L Anakinra, an IL-1 receptor antagonist, respectively. The proliferation of murine HSCs was assessed via the Brd u assay. The toxicity of Anakinra was evaluated via the fluorescein diacetate hydrolysis(FDH) assay. In vivo 8-wk-old Abcb4^(-/-) mice with an already fully established hepatic phenotype were treated with Anakinra(1 mg/kg body-weight daily intraperitoneally) or vehicle and liver injury and liver fibrosis were evaluated via serum tests, q PCR, hydroxyproline content and Sirius red staining. RESuLTS: Liver fibrosis was less pronounced in males than in female Abcb4^(-/-) animals as defined by a lower hydroxyproline content(274 ± 64 μg/g vs 436 ± 80 μg/g liver, respectively; n = 13-15; P u-test) and lower m RNA expression of the profibrogenic tissue inhibitor of metalloproteinase-1(TIMP)(1 ± 0.41 vs 0.66 ± 0.33 fold, respectively; n = 13-15; P u-test). Reduced liver fibrosis was associated with significantly lower levels of F4/80 m RNA expression(1 ± 0.28 vs 0.71 ± 0.41 fold, respectively; n = 12-15; P u-test) and significantly lower IL-1β m RNA expression levels(1 ± 0.38 vs 0.44 ± 0.26 fold, respectively; n = 13-15; P u-te

关键词： Cholestasis Primary sclerosing cholangitis The ATP-binding cassette transporter b4 Liver fibrosis Interleukin-1

Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation

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National Science Review 2021年第2期8卷 14-16页

作者： Feng-Liang Liu Kaixin Wu Jiaoyang Sun Zilei Duan Xiongzhi Quan Junqi Kuang Shilong Chu Wei Pang Han Gao Ling Xu Ying-Chang Li Hai-Lin Zhang Xue-Hui ang Rong-Hua Luo Xiao-Li Feng hans R.Sch?ler Xinwen Chen Duanqing Pei Guangming Wu Yong-Tang Zheng Jiekai Chen Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of Sciences Center for Cell Fate and Lineage (CCLA) Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) CAS Key Laboratory of Regenerative Biology Guangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of Sciences Department of Developmental Biology School of Basic Medical SciencesSouthern Medical University Central Laboratory The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People's Hospital university of the Chinese Academy of Sciences Joint School of Life Science Guangzhou Medical University Kunming National High-level Biosafety Research Center for Non-human Primates Center for Biosafety Mega-ScienceKunming Institute of Zoology Chinese Academic of Sciences Department of Cell and Developmental Biology Max Planck Institute for Molecular Biomedicine Medical Faculty University of Münster

Although monkeys and pigs can be infected with SARS-Co V-2, they generally have a long growth cycle and a large size that is difficult to handle in large quantities. However, the readily available rats and mice are not susceptible to SARSCo V-2 because of differences in ACE2(angiotensin-converting enzyme 2), the receptor mediating cell entry of SARSCo V-2 [1]. Thus, the key to establishing a mouse model of COVID-19 is to make the mice express human ACE2 protein, and therefore become SARS-Co V-2 *** reported COVID-19 mouse models using a random insertion transgene approach [2,3] or adenoviral approach to express h ACE2 [4], lack the tissue-specificity of h ACE2 expression and might not replicate COVID-19 precisely, limiting their applications in certain studies.

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对在不同社会中的犯罪和未成年人违法犯罪行为的研究——异同两方面的分析

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青少年犯罪研究 2003年第2期 67-79,46页

作者： PaulCFriday 任昕 ElmarWeitekamp hans-JuergenKerner TerranceTaylor. 北卡罗莱纳大学夏洛蒂分校，美国加利福尼亚州立大学萨加门托分校，美国 K.u.Leuven勒芬天主教大学比利时杜宾根大学，德国乔治亚州立大学

Front-end readout electronics system of ProtoDuNE-SP LAr TPC

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Radiation Detection Technology and Methods 2019年第3期3卷 192-201页

作者： hans-Gerd Berns Hucheng Chen Alessio D’Andragora Jack Fried Daniel Gastler S.Gao Eric Hazen Wenbin Hou Shaorui Li Feng Liu Veljko Radeka Maura Spanu Emerson Vernon Elizabeth Worcester Matthew Worcester Krithika Yethiraj Bo Yu Junbin Zhang Physics Department Brookhaven National LaboratoryUptonNY 11973USA Instrumentation Division Brookhaven National LaboratoryUptonNY 11973USA Crocker Nuclear Laboratory University of California DavisDavisCA 95616USA Department of Physics Boston UniversityBostonMA 02215USA Department of Engineering Physics Tsinghua UniversityBeijing 10084China

Purpose As a prototype of Deep underground Neutrino Experiment far detector,ProtoDuNE single-phase Liquid Argon(LAr)Time Projection Chamber(TPC)sits in H4 beam line at CERN to characterize detector *** consists of 6 full-size Anode Plane Assemblies(APAs)plus 18 Cathode Plane Assembly(CPA)modules to form two 3.6-m drift regions with a total of 15,360 readout *** achieve a good signal-to-noise ratio with this noble liquid detector(770ton LAr),cold electronics developed at BNL for extremely low temperature(77K–89K)operation is an optimal solution,which decouples the electrode and cryostat design from the readout *** With CMOS front end ASICs integrated with the TPC electrodes,the electronic noise is independent of the fiducial volume and much lower than with readout electronics at room *** addition,signal digitization and multiplexing to high-speed links inside the cryostat result in large reduction in the quantity of cables and the number of cryostat penetrations,giving the designers of both the TPC and the cryostat the freedom to choose the optimum *** and conclusions By April 2018,we have successfully instrumented 6 APAs with cold electronics,and the results of the integration test before the final installation in the cryostat look very promising.

关键词： ProtoDuNE-SP TPC APA Cold electronics Integration test Introduction

Digital world meets urban planet–new prospects for evidencebased urban studies arising from joint exploitation of big earth data,information technology and shared knowledge

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International Journal of Digital Earth 2020年第1期13卷 136-157页

作者： Thomas Esch Hubert Asamer Felix Bachofer Jakub Balhar Martin Boettcher Enguerran Boissier Pablo d’Angelo Caroline MGevaert Andreas Hirner Katerina Jupova Franz Kurz Andy Yaw Kwarteng Emmanuel Mathot Mattia Marconcini Alessandro Marin Annekatrin Metz-Marconcini Fabrizio Pacini Marc Paganini hans Permana Tomas Soukup Soner uereyen Christopher Small Vaclav Svaton Julian Nils Zeidler German Aerospace Center(DLR) German Remote Sensing Data Center(DFD)WeßlingGermany GISAT s.r.o. PragueCzech Republic Brockmann Consult GmbH GeesthachtGermany Terradue Srl RomeItaly International Institute for Geo-Information Science and Earth Observation(ICT) Universiteit TwenteEnschedeNetherlands Remote Sensing and GIS Center Sultan Qaboos UniversityMuscatOman European Space Agency(ESA) FrascatiItaly Department of Earth and Environmental Sciences Columbia UniversityLamont Doherty Earth ObservatoryNew YorkNYUSA VSB Technical university of Ostrava IT4InnovationsOstravaCzech Republic

The digital transformation taking place in all areas of life has led to a massive increase in digital data–in particular,related to the places where and the ways how we *** facilitate an exploration of the new opportunities arising from this development the urban Thematic Exploitation Platform(u-TEP)has been *** enabling instrument represents a virtual environment that combines open access to multisource data repositories with dedicated data processing,analysis and visualisation ***,it includes mechanisms for the development and sharing of technology and *** an introduction of the underlying methodical concept,this paper introduces four selected use cases that were carried out on the basis of u-TEP:two technology-driven applications implemented by users from the remote sensing and software engineering community(generation of cloud-free mosaics,processing of drone data)and two examples related to concrete use scenarios defined by planners and decision makers(data analytics related to global urbanization,monitoring of regional land-use dynamics).The experiences from u-TEP’s pre-operations phase show that the system can effectively support the derivation of new data,facts and empirical evidence that helps scientists and decision-makers to implement improved strategies for sustainable urban development.

关键词： Service platform urban human settlements earth observation decision support

流体在岩浆活动过程中对铀、钍搬运和分离的作用

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国外铀金地质 1992年第3期8卷 15-17,24页

作者： hans Keppler Peter J.Wyllie 张家富

铀、钍地球化学对了解地球中的热积累、u-Th-Pb年龄测定、矿床成因都是相当重要的,这是因为238u和232Th的放射性子元素的不平衡对岩浆生成过程中出现的某些作用产生了一些约束。通过实验,我们研究了铀、钍在人造花岗岩熔体和水流体之间... 详细信息

铀、钍地球化学对了解地球中的热积累、u-Th-Pb年龄测定、矿床成因都是相当重要的,这是因为up>238up>u和up>232up>Th的放射性子元素的不平衡对岩浆生成过程中出现的某些作用产生了一些约束。通过实验,我们研究了铀、钍在人造花岗岩熔体和水流体之间的分配。

关键词：铀矿床钍矿床岩浆作用搬运

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Magnetotail High-Speed Plasma Flows at Geomagnetically Quiet Times: Relation to the Magnetic Reconnection and Auroral Activation

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Magnetotail High-Speed Plasma Flows at Geomagnetically Quiet...