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Suppression of mature TAU isoforms prevents Alzheimer's disease-like amyloid-beta oligomer-induced spine loss in rodent neurons

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Neural Regeneration Research 2024年第8期19卷 1655-1657页

作者： Sarah Buchholz hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany

Introduction:TAU isoforms as disease mediators:The microtubule-associated protein TAU is predominantly present in the axons of neurons under physiological *** Alzheimer’s disease(AD)and related tauopathies,TAU also mislocalizes("TAU missorting")to the soma and the dendrites,where it eventually forms aggregates,the so-called neurofibrillary tangles(for review see Zimmer-Bensch and Zempel,2021;Zempel,2023).

关键词： Alzheimer Zimmer tau

Synthetic demand data generation for individual electricity consumers:Inpainting

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Energy and AI 2024年第1期15卷 36-43页

作者： Dascha Dobrovolskij hans-Georg Stark Universität Bremen Bibliothekstraβe 528359 BremenGermany Technische Hochschule Aschaffenburg Würzburger Straβe4563743 AschaffenburgGermany

In this contribution we deal with the problem of producing“reasonable”data,when considering recorded energy consumption data,which are at certain sections incomplete and/or *** task is important,when energy providers employ prediction models for expected energy consumption,which are based on past recorded consumption data,which then of course should be reliable and *** a related contribution Yilmaz(2022),GAN-based methods for producing such“artificial data”have been *** this contribution,we describe an alternative and complementary method based on signal inpainting,which has been successfully applied to audio processing Lieb and Stark(2018).After giving a short overview of the theory of proximity-based convex optimization,we describe and adapt an iterative inpainting scheme to our *** usefulness of this approach is demonstrated by analyzing real-world-data provided by a German energy supplier.

关键词： Time series Missing data points Time-frequency analysis Convex optimization Douglas-Rachford-algorithm Gabor transform

Sensory neurons: unveiling the symphony of wound healing

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3158-3160页

作者： Dongsheng Jiang hans-Gunther Machens Yuval Rinkevich Precision Research Center for Refractory Diseases Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Trauma Medical Center Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Plastic and Hand Surgery Klinikum rechts der IsarSchool of MedicineTechnical University of MunichMunichGermany Institute of Regenerative Biology and Medicine Helmholtz Center MunichMunichGermany

In a recent paper published in Nature,Lu et *** a pivotal role of Nav1.8+nociceptor-released neuropeptide calcitonin generelated peptide(CGRP)in modulating the activities of myeloid cells during skin and muscle injury... 详细信息

关键词： healing wound al.

Amino acid and mineral digestibility,bone ash,and plasma inositol is increased by including microbial phytase in diets for growing pigs

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Journal of Animal Science and Biotechnology 2024年第2期15卷 699-712页

作者： Liz Vanessa Lagos Mike Richard Bedford hans Henrik Stein Division of Nutritional Sciences University of IllinoisUrbanaIL 61801USA AB Vista Marlborough SN84ANUK

Background The effect of microbial phytase on amino acid and energy digestibility is not consistent in pigs,which may be related to the phytase dosage or the adaptation length to the ***,an experiment was conducted to test the hypotheses that increasing dietary phytase after an 18-day adaptation period:1)increases nutrient and energy digestibility;2)increases plasma P,plasma inositol,and bone ash of young pigs;and 3)demonstrates that maximum phytate degradation requires more phytase than maximum P *** Data indicated that increasing inclusion of phytase[0,250,500,1,000,2,000,and 4,000 phytase units(FTU)/kg feed]in corn-soybean meal-based diets increased apparent ileal digestibility(AID)of Trp(quadratic;P<0.05),and of Lys and Thr(linear;P<0.05),and tended to increase AID of Met(linear;P<0.10).Increasing dietary phytase also increased AID and apparent total tract digestibility(ATTD)of Ca and P(quadratic;P<0.05)and increased ATTD of K and Na(linear;P<0.05),but phytase did not influence the ATTD of Mg or gross *** of plasma P and bone ash increased(quadratic;P<0.05),and plasma inositol also increased(linear;P<0.05)with increasing inclusion of *** concentrations of inositol phosphate(IP)6 and IP5(quadratic;P<0.05),reduced IP4 and IP3(linear;P<0.05),but increased inositol concentrations(linear;P<0.05)were observed in ileal digesta as dietary phytase *** ATTD of P was maximized if at least 1,200 FTU/kg were used,whereas more than 4,000 FTU/kg were needed to maximize inositol *** Increasing dietary levels of phytase after an 18-day adaptation period increased phytate and IP ester degradation and inositol release in the small ***,increasing dietary phytase resulted in improved digestibility of Ca,P,K,Na,and the first 4 limiting amino acids,and in increased concentrations of bone ash and plasma P and *** a corn-soybean meal diet,maximum inositol release requires appr

关键词： Bone ash Inositol Nutrient digestibility Phytase Phytate degradation Pigs

***:A Julia package for micromagnetic and atomistic simulations with GPU support

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Chinese Physics B 2024年第10期33卷 70-79页

作者： Weiwei Wang Boyao Lyu Lingyao Kong hans Fangohr Haifeng Du Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China Anhui Province Key Laboratory of Low-Energy Quantum Materials and Devices High Magnetic Field LaboratoryHFIPSChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230031China School of Physics and Optoelectronic Engineering Anhui UniversityHefei 230601China University of Southampton Southampton SO171BJUnited Kingdom

*** is an open-source Julia package for micromagnetic and atomistic *** the features of the Julia programming language,*** supports CPU and various GPU platforms,including NVIDIA,AMD,Intel,and Apple ***,*** supports Monte Carlo simulations for atomistic models and implements the nudged-elastic-band method for energy barrier *** built-in support for double and single precision modes and a design allowing easy extensibility to add new features,*** provides a versatile toolset for researchers in micromagnetics and atomistic simulations.

关键词： micromagnetic simulations atomistic simulations graphics processing units

Empowerment in chronic wound care——exploring the scope for patient contribution

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Frontiers of Nursing 2024年第1期11卷 1-16页

作者： Benedikt Hackert Ewa Klara Stürmer ulrich Weger Department of Psychology and Psychotherapy University of Witten/HerdeckeAlfred-Herrhausen-Straße 5058448 WittenGermany Department for Vascular Medicine University Heart and Vascular Center HamburgUniversity Medical Center Hamburg-EppendorfMartinistreet 5220246 HamburgGermany

Objective:In this study,we investigated the concept of empowerment in chronic wound care and propose to facilitate patient control by making use of degrees of freedom(DOF):that is,shaping of everyday wound care tasks initiated by patients and based on their wishes,mostly in terms of patients executing treatment steps,requesting or directing health care professionals to under take changes,or modifications of internal ***:As a first step,we conducted a systematic literature search,followed by an inductive form of qualitative content analysis,which resulted in the identification of 5 dimensions as main elements of empowerment:education and shared decision making,adherence to self-care behaviors,responsibility and control,general call for empowerment,and ***,the latter are noticeably absent in the *** investigate patients'freedom in shaping the wound care process,we conducted a second literature ***:A number of possibilities for patients to influence the wound care process could be identified,but experimental or clinical evidence about their effects is missing,their variety is limited,and they are only inadequately ***:However,DOF should be an indispensable aspect of genuine empowerment,since they allow patients to occupy the role of the agent in the treatment process and give rise to the subjective experience of feeling ***,in the third part,we develop a research proposal on how to investigate and include DOF in the clinical practice of wound ***,limitations about implementations are discussed(e.g.,patients being reluctant to overcome their passive role,resulting in frustration for health care professionals).

关键词： adherence chronic wounds control degrees of freedom empowerment shared decision making

Enzymatic C1 reduction using hydrogen in cofactor regeneration

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Frontiers of Chemical Science and Engineering 2024年第7期18卷 33-40页

作者： Ruishuang Sun Chenqi Cao Qingyun Wang Hui Cao ulrich Schwaneberg Yu Ji Luo Liu Haijun Xu Beijing Bioprocess Key Laboratory Beijing University of Chemical TechnologyBeijing 100029China Institute of Biotechnology Rheinisch-Westfälische Technische Hochschale(RWTH)AachenAachen 52074Germany

Carbon dioxide fixation presents a potential solution for mitigating the greenhouse gas *** carbon dioxide fixation,C1 compound reduction requires a high energy *** calculations suggest that the energy source for cofactor regeneration plays a vital role in the effective enzymatic C1 *** utilizes renewable hydrogen to achieve the regeneration and supply cofactor nicotinamide adenine dinucleotide(NADH),providing a driving force for the reduction reaction to reduce the thermodynamic barrier of the reaction cascade,and making the forward reduction pathway thermodynamically *** on the regeneration of cofactor NADH by hydrogenase,and coupled with formaldehyde dehydrogenase and formolase,a favorable thermodynamic mode of the C1 reduction pathway for reducing formate to dihydroxyacetone(DHA)was designed and *** resulted in accumulation of 373.19μmol·L^(-1) DHA after 2 h,and conversion reaching 7.47%.These results indicate that enzymatic utilization of hydrogen as the electron donor to regenerate NADH is of great significance to the sustainable and green development of bio-manufacturing because of its high economic efficiency,no by-products,and environment-friendly ***,formolase efficiently and selectively fixed the intermediate formaldehyde(FALD)to DHA,thermodynamically pulled formate to efficiently reduce to DHA,and finally stored the low-grade renewable energy into chemical energy with high energy density.

关键词： [NiFe]-hydrogenase SH formolase NADH regeneration C1 compound reduction thermodynamic calculation

A simulation study on spatial and time resolution for a cost-effective positron emission particle tracking system

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Particuology 2024年第5期88卷 312-322页

作者： Josephine Oppotsch Matthias Steinke Miriam Fritsch Fritz-Herbert Heinsius Thomas Held Nikoline Hilse Viktor Scherer ulrich Wiedner Ruhr-Universität Bochum Institut für Experimentalphysik I44801 BochumGermany Ruhr-Universität Bochum Lehrstuhl für Energieanlagen und Energieprozesstechnik44801 BochumGermany

This work is the second part of a simulation study investigating the processing of densely packed and moving granular assemblies by positron emission particle tracking (PEPT).Since medical positron emission tomography (PET) scanners commonly used for PEPT are very expensive,a PET-like detector system based on cost-effective organic plastic scintillator bars is being developed and tested for its *** this context,the spatial resolution of a resting positron source,a source moving on a freely designed model path,and a particle motion given by a discrete element method (DEM) simulation is studied using Monte Carlo simulations and the software toolkit *** not only extended the simulation and reconstruction to a moving source but also significantly improved the spatial resolution compared to previous work by adding oversampling and iteration to the reconstruction ***,in the case of a source following a trajectory developed from DEM simulations,a very good resolution of about 1 mm in all three directions and an average 3D deviation between simulated and reconstructed events of 2.3 mm could be ***,the resolution for realistic particle motion within the generic grate system (which is the test rig for further experimental studies) is well below the smallest particle *** simulation of the dependence of the reconstruction accuracy on tracer particle location revealed a nearly constant efficiency within the entire detector system,which demonstrates that boundary effects can be neglected.

关键词： Positron emission particle tracking Monte Carlo method Time-of-flight Plastic scintillators Silicon photomultipliers(SiPMs)

Conception of a new 4-quadrant hydrogen compressed air energy storage power plant with an integrated electrolyzer

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Energy Reviews 2024年第3期3卷 92-101页

作者： hans-Peter Beck Ann-Kathrin Klaas Christoph Klaas Research Center Energy Storage Technologies Clausthal University of TechnologyAm Stollen 19A38640GoslarGermany Institute of Electrical Power Engineering and Energy Systems Clausthal University of TechnologyLeibnizstraße 2838678Clausthal-ZellerfeldGermany

A hydrogen compressed air energy storage power plant with an integrated electrolyzer is ideal for large-scale,long-term energy storage because of the emission-free operation and the possibility to offer multiple ancillary services on the German energy *** paper defines analyzes such a storage concept and conducts an extensive comparison with four additional storage concepts based on various *** results show that the combination of storing compressed air and hydrogen offers a higher efficiency than storing only hydrogen and lower specific investment costs than storing only compressed *** result is confirmed with analysis of the optimal sizing of each power plant component for simultaneous participation on multiple energy markets with a linear optimization dispatch *** hydrogen compressed air energy storage(HCAES)power plant can utilize more revenue possibilities than a hydrogen energy storage because of the higher round-trip efficiency and the combination of the air compressor and the integrated electrolyzer during charging *** integration of the electrolyzer,however,offers a couple of challenges itself because of the highly flexible operation mode.A new concept for the controllable 24-pulse diode-thyristor rectifier of the electrolyzer is presented,that uses mostly common components while offering little to no grid harmonics and a long *** flexible integrated electrolyzer allows for the 4-quadrant operation of the storage power plant.

关键词： Long-term energy storage Hydrogen energy storage Compressed air energy storage Mixed-integer linear programming Electrolyzer 24-Pulse thyristor rectifier