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偏头痛与女性发生心血管疾病的危险

美国医学会杂志（中文版） 2007年第6期26卷 331-338页

作者： Tobias Kurth J. Michael Gaziano Nancy R. Cook Giancarlo Logroscino hans-christoph diener Julie E. Buring 陈夏欢（译）冯雪茹（译）刘梅林（校） Divisions of Preventive Medicine Divisions of Preventive Aging Department of Medicine Brigham and Women＇s Hospital Harvard Medical School Department of Epidemiology Harvard School of Pubhc Health Massachusetts Veterans Epidemiology Research and Information Center Boston VA Heahhcare System Department of Ambulatory Care and Prevention Harvard Medical School Department of Neurology University of Duisburg- Essen Essen Germany 不详

背景：有先兆偏头痛与心血管疾病危险因素以及伴随偏头痛特殊生理学改变而产生的促血栓物质相关，可增加血管事件的危险。虽然有先兆偏头痛与缺血性卒中的危险增加相关，但是其与心血管疾病，特别是冠脉事件的相关性仍不清楚。目的：评... 详细信息

背景：有先兆偏头痛与心血管疾病危险因素以及伴随偏头痛特殊生理学改变而产生的促血栓物质相关，可增加血管事件的危险。虽然有先兆偏头痛与缺血性卒中的危险增加相关，但是其与心血管疾病，特别是冠脉事件的相关性仍不清楚。目的：评价有和无先兆的偏头痛与所有特定心血管疾病发生危险的相关性。设计、地点及参试者：于27840位美国女性中进行前瞻性队列研究。参试者年龄≥45岁，均参加了女性健康研究（Women’s Health Study，WHS）。入选时（1992～1995年）无心血管疾病和心绞痛，有偏头痛和先兆症状自我报告资料以及血脂测量数据。随访至2004年3月31日。主要观测指标：主要观测指标为重要心血管疾病复合终点事件（首次非致死性缺血性卒中、非致死性心肌梗死以及缺血性心血管疾病所致死亡），其他指标为首次缺血性卒中、心肌梗死、冠状动脉血运重建、心绞痛和缺血性心血管疾病所致死亡。结果：基线时，5125名女性（18．4％）报告有偏头痛病史，其中3610名有活动性偏头痛（1年内发生偏头痛），1434名（39．7％）有先兆症状。在平均10年的随访期间，580例发生重要心血管事件。经多变量校正后，与无先兆偏头痛女性相比，报告有先兆活动性偏头痛的女性发生重要心血管疾病的风险比为2．15（95％CI，1．58～2．92；P〈0．001），缺血性卒中的风险比为1．91（95％CI，1．17～3．10；P=0．01），心肌梗死的风险比为2．08（95％CI，1．30～1．31；P：0．002），冠状动脉血运重建的风险比为1．74（95％CI，1．23～2．46；P=0．02）．心绞痛的风险比为1．71（95％CI，1．16～2．53；P=0．007），缺血性心血管疾病所致死亡的风险比为2．33（95％CI，1．21～4．51；P=0．01）。校正年龄后，每10000名女性每年有18例新发重要心血管事件可归因于有先兆偏头痛。报告无先兆活动性偏头痛的女性心血管病或心绞痛的危险并无增加。结论：在本大规模前瞻性女性队列中，有先兆活动性偏头痛与女性发生重要心血管疾病、心肌梗死、缺血性卒中、缺血性心血管疾病所致死亡以及冠状动脉血运重建和心绞痛危险增加相关，无先兆活动性偏头痛与心血管疾病的危险增加无关。

关键词：心血管疾病危险因素无先兆偏头痛女性冠状动脉血运重建致死性心肌梗死前瞻性队列研究缺血性卒中先兆症状

Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development

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Genomics, Proteomics & Bioinformatics 2018年第3期16卷 162-171页

作者： Andreas Keller Tobias Fehlmann Nicole Ludwig Mustafa Kahraman Thomas Laufer Christina Backes Claus Vogelmeier Caroline diener Frank Biertz Christian Herr Rudolf A. Jorres hans-Peter Lenhof Eckart Meese Robert Bals Clinical Bioinformatics Saarland University 66123 Saarbriieken Germany Department of Human Genetics Saarland University Hospital 66421 Homburg Germany Hummingbird Diagnostics GmbH 69120 Heidelberg Germany Department of Internal Medicine Division for Pulmonary Diseases Philipps University of Marburg 35043 Marburg Germany Institute for Biostatistics Hannover Medical School 30625 Hanover Germany Department of Internal Medicine V- Pulmonology AlIergology Intensive Care Medicine Saarland University Hospital 66421 Homburg Germany Institute and Outpatient Clinic for Occupational Social and Environmental Medicine Comprehensive Pneumology Center Munich (CPC-M) Ludwig-Maximilians-University Munich Member of the German Center for Lung Research ( DZL) 80539 Munich Germany Bioinformatics Saarland University 66123 Saarbrucken Germany Center for Bioinformatics Saarland University 66123 Saarbrucken Germany

Chronic obstructive pulmonary disease （COPD） significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease are compared to controls. Longitudinal cohort studies such as the COPD-centered German COPD and SYstemic consequences-COmorbidities NETwork （COSYCONET） study provide the patient and biomaterial base for discovering predictive molecular markers. We asked whether microRNA （miRNA） profiles in blood collected from COPD patients prior to a tumor diagnosis could support an early diagnosis of tumor development independent of the tumor type. From 2741 participants of COSYCONET diagnosed with COPD, we selected 534 individuals including 33 patients who developed cancer during the follow-up period of 54 months and 501 patients who did not develop cancer, but had similar age, gender and smoking history. Genome-wide miRNA profiles were generated and evaluated using machine learning techniques. For patients developing cancer we identified nine miRNAs with significantly decreased abundance （two-tailed unpaired t-test adjusted for multiple testing P 〈 0.05）, including members of the miR-320 family. The identified miRNAs regulate different cancer-related pathways including the MAPK pathway （P - 2.3 × 10 -5）. We also observed the impact of confounding factors on the generated miRNA profiles, underlining the value of our matched analysis. For selected miRNAs, qRT-PCR analysis was applied to validate the results. In conclusion, we identified several miRNAs in blood of COPD patients, which could serve as candidates for biomarkers to help identify COPD patients at risk of developing cancer.

关键词： microRNA Cancer COPD Lung Biomarker COSYCONET

A case of methicillin-resistant Staphylococcus aureus infection following bile duct stenting

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World Journal of Gastroenterology 2005年第9期11卷 1396-1398页

作者： Markus K diener Alexis Ulrich Theresia Weber Moritz N Wente Markus W Büchler Helmut Friess Department of General Surgery

AIM: To present a case of methicillin-resistant Staphylococcus aureus (MRSA) infection following bile duct stenting in a patient with malignant biliary ***: A 78-year-old male patient was admitted to a community hospital with progredient painless jaundice lasting over two weeks, weight loss and sweating at *** a stent should be implanted pre-operatively in jaundiced patients or whether these patients should directly undergo surgical resection, was ***: ERC and a biopsy from the papilla of Vater revealed an adenocarcinoma. In addition, a 7-Ch plastic stent was placed into the common bile duct. Persistent abdominal pain, increasing jaundice, weakness and indigestion led to the transfer of the patient to our hospital.A pylorus-preserving pancreatoduodenectomy wasperformed. Intraoperatively, bile leaked out of the transected choledochus andthe stent was found to be dislocated in the duodenum. A smear of the bile revealed an infection with MRSA, leading to post-operative isolation of the ***:As biliary stents can cause severe infection of the bile, the need for pre-operative placement of biliary stents should be carefully evaluated in each individual case.

关键词： Methicillin-resistant Staphylococcus aureus Bile Infection Stent Biliary obstruction Malignancy Surgery

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一个数学上有争议的例子：非标准分析

数学译林 1990年第3期9卷 235-246页

作者： diener,F 苏虹

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车轮材料的评定

国外铁道车辆 1996年第2期33卷 39-44页

作者： diener 方学贞

根据UIC812-3规定,可用断裂力学计算出R7优质钢车轮的极限韧性值。然后再按ASTM E399标准进行断裂韧性测试。只有经过反复系列试验才能测试出断裂韧性值作为标准值采用。

关键词：车轮材料断裂韧性铁路车辆

外国品牌的货币和非货币促销活动对瑞士顾客购买意向的有效性

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外国品牌的货币和非货币促销活动对瑞士顾客购买意向的有效性

作者： Lara Noemi diener 华东师范大学

学位级别：硕士

促销活动在公司的整体营销战略中发挥着关键作用,例如增强品牌知名度、刺激消费者需求、推动销售和吸引新客户。通过提供折扣、优惠券、免费礼品和其他促销活动,公司可以激励消费者进行购买,他们原本可能不会购买的产品或服务。这对那... 详细信息

促销活动在公司的整体营销战略中发挥着关键作用,例如增强品牌知名度、刺激消费者需求、推动销售和吸引新客户。通过提供折扣、优惠券、免费礼品和其他促销活动,公司可以激励消费者进行购买,他们原本可能不会购买的产品或服务。这对那些尚未决定是否购买产品或服务的消费者来说更为明显。一个精心设计的促销活动可以大力的推动他们进行购买,增加销售的可能性并且同时提高高公司的收入。此外,促销活动还可以帮助建立客户的忠诚度,这可以为公司带来长期的利益。通过向现有客户提供独家促销活动,公司可以激励客户重复购买并培养品牌忠诚度。这最终会给公司创造客户的终身价值以及带来可持续的收入来源。对于寻求最大化营销投资回报率的公司来说,了解不同类型的促销活动以及他们对购买意向的影响至关重要。过调查研究确定对其目标受众最有效的促销活动,公司可以制定规划有针对性的营销策略,帮助提高购买意向,增加收入。这项研究分析了不同类型的促销活动(付费和免费)和不同价值(高和低)如何影响消费者的购买意向。将感知风险当作一个介体来分析感知风险,刚具体的来讲财务和业绩是如何潜在的影响不同的自变量和因变量之间的关系。此项研究是想瑞士人口发放调查问卷完成的。结果显示,促销活动确实对购买意向产生了积极的影响,且增加促销活动的价值会增加对消费者对该活动的吸引力。然而,对财务和业绩风险的感知并没有随着促销价值的增加而增加,这表明瑞士消费者的风险规避能力比之前研究过的其他国家的消费者要低。研究还发现,瑞士消费者在做出购买决定时高度重视产品的价值和质量,这表明企业应该注重展示其产品的价值,以建立客户忠诚度并提高购买意向。总的来说,这项研究为寻求制定有效策略来提高瑞士消费者购买意向的外国公司提供了有用的见解。通过了解瑞士人的需求和偏好,公司可以量身定制其营销推广和定价策略,以更好地满足这个独特市场的需求。这些研究结果也有助于不断增长的关于促销及其对消费者行为影响的研究。

关键词：促销活动货币与非货币购买意向感知风险财务风险绩效风险

Prospective study to evaluate the prognostic value of different nutritional assessment scores in liver surgery: NURIMAS Liver (DRKS00006340)

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 400-413页

作者： Pascal Probst Juri Fuchs Michael R.Schön Georgios Polychronidis Christos Stravodimos Arianeb Mehrabi Markus K.diener Philipp Knebel Markus W.Büchler Katrin Hoffmann Department of General Visceral and Transplantation SurgeryUniversity of HeidelbergIm Neuenheimer Feld 11069120 HeidelbergGermany Department of General and Visceral Surgery Städtisches Klinikum KarlsruheMoltkestraße 9076133 KarlsruheGermany

Background:Malnutrition is recognised as a preoperative risk factor for patients undergoing hepatic *** is important to identify malnourished patients and take preventive therapeutic action before ***,there is no evidence regarding which existing nutritional assessment score(NAS)is best suited to predict outcomes of liver ***:All patients scheduled for elective liver resection at the surgical department of the University Hospital of Heidelberg and the Municipal Hospital of Karlsruhe were screened for *** NASs were calculated before operation,and patients were categorised according to each score as being either at risk or not at risk for *** association of malnutrition according to each score and occurrence of at least one major complication was the primary endpoint,which was achieved using a multivariate logistic regression analysis including established risk factors in liver surgery as ***:The population consisted of 182 *** percentage of patients deemed malnourished by the NAS varied among the different scores,with the lowest being 2.20%(Mini Nutritional Assessment)and the highest 52.20%(Nutritional Risk Classification).Forty patients(22.0%)had a major *** of the scores were significantly associated with major ***:None of the twelve investigated NAS defined a state of malnutrition that was independently associated with postoperative *** means of measuring malnutrition in liver surgery should be investigated prospectively.

关键词： Malnutrition liver surgery hepatic resection nutritional assessment

Effects of a Two-Day Teachers’ Training Course on Activity Time in Physical Education

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Open Journal of Preventive Medicine 2014年第5期4卷 317-326页

作者： Miriam Wanner Eva Martin-diener Claudia Frick Susi Kriemler Brian W. Martin Institute of Social and Preventive Medicine University of Zurich Zurich Switzerland Physical Activity and Health Work Unit Institute of Social and Preventive Medicine University of Zurich Zurich Switzerland

Schools are a key setting for promoting physical activity in children. There is little evidence on the potential of widely implemented programs to improve the quality of physical education (PE). The aim was to assess the effects of a short training course for classroom teachers on the quality of PE, assessed as activity time during PE. A quasi-experimental study was conducted with 6 intervention (N = 86) and 13 control classes (N = 151). Schools were selected in a random procedure (26.9% participation). Participation in children was 86.2% (mean age 7.8 years, 48.9% girls). Physical activity was assessed objectively using accelerometers. Effect on time spent in sedentary, moderate, vigorous and moderate-to-vigorous (MVPA) activities, steps and counts/minute during PE were analysed using t-tests and mixed linear models. Physical activity time increased significantly in the intervention but not in the control group between baseline and follow-up (relative increase in moderate-to-vigorous physical activity of 12% in intervention group). Increases were strongest in girls and in children inactive at baseline. In the mixed linear models adjusted for clustering, the effects were significant in girls for vigorous activities, sedentary time and counts/minute, in inactive children for steps. Results indicate that a short training course for classroom teachers can have subtle positive effects on physical activity time during PE. Girls and the most inactive children at baseline profited most from the intervention.

关键词： Health Promotion Physical Activity Physical Education Teaching

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仓储——可作典范的医药批发行业方案

现代包装 2014年第9期 52-54,56页

作者： PETER diener

SSI Schafer公司为药品批发商Salus公司在斯洛文尼亚首都卢布尔雅那建成了中欧最现代的分销中心之一。除了各种库区和配货区的整体设备方案之外，这座仓库的亮点是：接入了规模最佳的自动化系统。

关键词：行业医药仓储斯洛文尼亚自动化系统设备方案 SSI 批发商