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Changes of the glutathione redox system during the weaning transition in piglets, in relation to small intestinal morphology and barrier function

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Journal of Animal Science and Biotechnology 2020年第4期11卷 993-1008页

作者： Jeroen Degroote hans Vergauwen Wei Wang Chris Van Ginneken Stefaan De Smet Joris Michiels Laboratory for Animal Nutrition and Animal Product Quality(LANUPRO) Department of Animal Sciences and Aquatic EcologyFaculty of Bioscience EngineeringGhent UniversityBlock FCampus CoupureCoupure Links 6539000 GhentBelgium Laboratory of Applied Veterinary Morphology Department of Veterinary SciencesFaculty of BiomedicalPharmaceutical and Veterinary SciencesUniversity of AntwerpUniversiteitsplein 1WilrijkBelgium.

Background: Weaning is known to result in barrier dysfunction and villus atrophy in the immediate post-weaning phase, and the magnitude of these responses is hypothesized to correlate with changes in the glutathione(GSH)redox system. Therefore, these parameters were simultaneously measured throughout the weaning phase, in piglets differing in birth weight category and weaning age, as these pre-weaning factors are important determinants for the weaning transition. Low birth weight(LBW) and normal birth weight(NBW) littermates were assigned to one of three weaning treatments;i.e. weaning at 3 weeks of age(3 w), weaning at 4 weeks of age(4 w) and removal from the sow at 3 d of age and fed a milk replacer until weaning at 3 weeks of age(3 d3 w). For each of these treatments, six LBW and six NBW piglets were euthanized at 0, 2, 5, 12 or 28 d post-weaning piglets, adding up 180 ***: Weaning increased the glutathione peroxidase activity on d 5 post-weaning in plasma, and duodenal and jejunal mucosa. Small intestinal glutathione-S-transferase activity gradually increased until d 12 post-weaning, and this was combined with a progressive rise of mucosal GSH up till d 12 post-weaning. Oxidation of the GSH redox status(GSH/GSSG eh) was only observed in the small intestinal mucosa of 3 d3 w weaned piglets at d 5 postweaning. These piglets also demonstrated increased fluorescein isothiocyanate dextran(FD4) and horseradish peroxidase fluxes in the duodenum and distal jejunum during the experiment, and specifically demonstrated increased FD4 fluxes at d 2 to d 5 post-weaning. On the other hand, profound villus atrophy was observed during the weaning transition for all weaning treatments. Finally, LBW and NBW piglets did not demonstrate notable differences in GSH redox status, small intestinal barrier function and histo-morphology throughout the ***: Although moderate changes in the GSH redox system were observed upon weaning, the GSH redox status remai

关键词： Barrier function Glutathione Oxidative stress Redox status Small intestine Weaned piglet

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Single-operator cholangioscopy for biliary complications in liver transplant recipients

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World Journal of Gastroenterology 2017年第22期23卷 4064-4071页

作者： Anna Hüsing-Kabar Hauke sebastian Heinzow Hartmut hans-Jürgen Schmidt Carina Stenger hans Ulrich Gerth Michele Pohlen Gerold Tholking Christian Wilms Iyad Kabar Department of Transplant Medicine University Hospital Muenster Department of Medicine D Division of General Internal MedicineNephrology and RheumatologyUniversity Hospital Muenster Department of Medicine A Hematology and OncologyUniversity Hospital Muenster

To evaluate cholangioscopy in addition to endoscopic retrograde cholangiopancreatography (eRCP) for management of biliary complications after liver transplantation (LT).MeTHODSTwenty-six LT recipients with duct-to-duct biliary reconstruction who underwent eRCP for suspected biliary complications between April and December 2016 at the university hospital of Muenster were consecutively enrolled in this observational study. After evaluating bile ducts using fluoroscopy, cholangioscopy using a modern digital single-operator cholangioscopy system (SpyGlass DS™) was performed during the same procedure with patients under conscious sedation. All patients received peri-interventional antibiotic prophylaxis and bile was collected during the intervention for microbial analysis and for antibiotic susceptibility ***-three biliary complications were found in a total of 22 patients, whereas four patients showed normal bile ducts. Anastomotic strictures were evident in 14 (53.8%) patients, non-anastomotic strictures in seven (26.9%), biliary cast in three (11.5%), and stones in six (23.1%). A benefit of cholangioscopy was seen in 12 (46.2%) patients. In four of them, cholangioscopy was crucial for selective guidewire placement prior to planned intervention. In six patients, biliary cast and/or stones failed to be diagnosed by eRCP and were only detectable through cholangioscopy. In one case, a bile duct ulcer due to fungal infection was diagnosed by cholangioscopy. In another case, signs of bile duct inflammation caused by acute cholangitis were evident. One patient developed post-interventional cholangitis. No further procedure-related complications occurred. Thirty-seven isolates were found in bile. Sixteen of these were gram-positive (43.2%), 12 (32.4%) were gram-negative bacteria, and Candida species accounted for 24.3% of all isolated microorganisms. Interestingly, only 48.6% of specimens were sensitive to prophylactic ***-operator c

关键词： Cholangioscopy endoscopic retrograde cholangiopancreatography Liver transplantation Biliary complications Biliary strictures

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调控铝在ITH沸石骨架中的位置以用于催化甲醇制烯烃

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Chinese Journal of Catalysis 2024年第1期56卷 114-121页

作者：范凯吴勤明刘烁孔海宇王森 eduard Kunkes Trees De Baerdemaeker Andrei-Nicolae Parvulescu Nils Bottke Toshiyuki Yokoi Dirk e.De Vos 孟祥举张维萍肖丰收浙江省应用化学重点实验室浙江大学化学系中国浙江杭州310028 浙江大学化学与生物工程学院中国浙江杭州310028 大连理工大学精细化工国家重点实验室中国辽宁大连116012 中国科学院山西煤炭化学研究所煤转化国家重点实验室中国山西太原030001 巴斯夫股份有限公司德国东京工业大学资源化学研究所日本鲁汶大学表面化学与催化中心比利时

随着低碳烯烃需求量的增加,甲醇制烯烃(MTO)成为由非石油资源制取低碳烯烃的关键技术,其中沸石由于具有可调节的酸度、有序的微孔结构和较好的择型性能而被广泛用作MTO反应催化剂.ITQ-13沸石(ITH拓扑结构)由于其独特的九元环结构在MTO... 详细信息

随着低碳烯烃需求量的增加,甲醇制烯烃(MTO)成为由非石油资源制取低碳烯烃的关键技术,其中沸石由于具有可调节的酸度、有序的微孔结构和较好的择型性能而被广泛用作MTO反应催化剂.ITQ-13沸石(ITH拓扑结构)由于其独特的九元环结构在MTO反应中表现出较好的丙烯选择性和反应寿命,引起了广泛关注.研究表明,分子筛的酸中心分布与MTO反应性能密切相关,因此,研究ITQ-13沸石中铝分布与MTO反应性能的关系,对进一步提升其MTO催化性能具有重要意义.本文分别以与ITH具有共同基本结构单元(双四元环,D4Rs)的LTA沸石(LTA-ITH)和薄水铝石(C-ITH)为铝源,合成了两类铝硅酸盐ITH沸石.X射线衍射、扫描电子显微镜以及氮气吸脱附表征结果表明,这两类分子筛具有相似的片状形貌和微孔性质.氨气程序升温脱附结果表明,具有相近硅铝比的两类ITH沸石具有相近的酸量.进一步采用27Al魔角旋转核磁共振(MAS NMR)、密度泛函理论计算和1-己烯裂解反应对两类ITH分子筛的铝分布进行研究.结果表明,两类分子筛具有不同的铝分布,LTA-ITH中有更多的铝进入ITH的正弦孔道与直孔道,而C-ITH中有更多的铝分布在交叉孔道.当前,研究者普遍认为MTO反应过程遵循双循环烃池机理,ITH交叉孔道由于具有较大的空间,相比于正弦孔道和直孔道,更有利于芳烃循环中间体的产生,从而有利于形成芳烃循环产物(乙烯),而正弦孔道和直孔道却更有利于烯烃循环过程,导致产生更多的丙烯.对两类ITH进行了MTO催化性能测试,结果表明,LTA-ITH比C-ITH表现出更高的丙烯选择性,并且表现出更高的丙烯与乙烯的比率,表明其烯烃循环过程得到加强,这与^(27)Al MAS NMR以及1-己烯裂解反应得到的结论一致,进一步证明ITH分子筛的铝分布得到有效调控.综上,本文阐明了ITH沸石中铝分布与其反应性能的关系,为调整沸石骨架中的Al位点提供一种新策略,为未来制备高效的MTO沸石基催化剂提供参考.

关键词：骨架铝分布硅铝ITH分子筛甲醇制烯烃铝核磁

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Anti-inflammatory and antinociceptive activities of Rhipicephalus microplus saliva

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Asian Pacific Journal of Tropical Biomedicine 2018年第4期8卷 194-200页

作者： DF.Buccini AA.Nunes GGO.Silva ON.Silva OL.Franco se.Moreno Programa de Pos-Graduacao em Biotecnologia e Biodiversidade Universidade Federal do Mato Grosso do Sul S-Inova Biotech Programa de Pos-Graduacao em Biotecnologia Universidade Catolica Dom Bosco Programa de Pos-Graduacao em Patologia Molecular Universidade de Brasilia Centro de Analises Proteomicas e Bioquimicas Programa de Pos-Graduacao em Ciencias Genomicas e Biotecnologia Universidade Catolica de Brasilia

To evaluate the antinociceptive and anti-inflammatory activities and the toxic effects of Rlhipicephalus microplus saliva for elucidating the modulation mechanism between arthropod saliva and ***:For saliva collection,engorged ticks were obtained from a controlled bovine infestation and collected by natural *** ticks were fixed and injected pilocarpine 0.2%for induction of *** was collected,lyophilized and stored at-80℃.Cytotoxic activity was assessed by the hemolysis method(25,50,100,200 and 300μg/mL)and MTT cell viability assay(2.5,5,10,20 and 40μg/mL)for 24,48 and 72 ***-inflammatory activity was evaluated using the method of neutrophil migration to the peritoneal cavity of mice at doses of l0,15 and 20 mg/kg;antinociceptive activity was assessed using the acetic acid-induced writhing test,and formalin-induced paw-licking in mice at dose of 15 mg/***:Saliva did not cause erythrocytes hemolysis at any concentration tested,as well as did not decrease cell viability in the MTT *** inhibited neutrophil migration by 87%and 73%at doses of l5 and 20 mg/kg,*** the nociceptive tests,saliva presented analgesic activity of69.96%in the abdominal writhing test,and of 84.41%in the formalin *** study proves that Rlhipiceplhalus microplus saliva has significant in vivo anti-inflammatory and antinociceptive *** data presented herein support the development of further studies to elucidate the active principles of Rhipicephalus microplus saliva and its mechanism of action and,in future,to develop novel anti-inflammatory and analgesic drugs.

关键词： Rhipicephalus microplus Saliva Tick Antinociceptive Anti-inflammatory

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基于ISO 26262安全要求的汽车电子电气架构优化模型

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同济大学学报（自然科学版） 2022年第S1期50卷 247-251页

作者： Dorsa ZAHeRI hans⁃Christian ReUSS 斯图加特大学汽车工程学院(IFS) 德国斯图加特70569

在开发汽车电子电气(e/e)架构时,考虑安全要求是实现未来技术(如自动驾驶)的先决条件之一。按照ISO 26262标准,安全分析必须在产品开发生命周期的早期阶段进行,以检测设计缺陷并采取行动改善设计。本文提出了一种基于模型的方法,在汽车... 详细信息

在开发汽车电子电气(e/e)架构时,考虑安全要求是实现未来技术(如自动驾驶)的先决条件之一。按照ISO 26262标准,安全分析必须在产品开发生命周期的早期阶段进行,以检测设计缺陷并采取行动改善设计。本文提出了一种基于模型的方法,在汽车e/e架构的设计阶段解决符合ISO 26262的安全要求;同时,基于这些要求,提取了一组与安全相关的约束条件,并通过整数线性规划(ILP)模型将这些约束用于e/e架构的优化。

关键词：汽车电子电气电子电气架构优化模型安全要求 ISO 26262标准

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Prognosis and Survival of Nasopharyngeal Cancer in Cameroon

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International Journal of Otolaryngology and Head & Neck Surgery 2021年第1期10卷 6-19页

作者： Jean Paul engbang Amadou Njifou Therè se Daphné e Tjomb Maurice Mpessa Louis Richard Njock Faculty of Medicine and Pharmaceutical Sciences The University of Douala Douala Cameroon Douala Laquintinie hospital Douala Cameroon

Background: Nasopharyngeal carcinoma (NPC) is an entity belonging to up-per aerodigestive tract Cancers. NPC is more widespread in Southern China and South east Asia. In our country, it is the leading cause of head and neck cancers. Its prognosis remains bleak because of the late stage at diagnostic. Objectives: The objectives of this study were to determine the prognostic fac-tors and survival rate of patients with nasopharyngeal cancer in six reference hospitals in Cameroon. Material and Methods: It was a retrospective analytic study, conducted from January 2009 to December 2018. It was conducted in oncology, surgery and ear Nose and Throat (eNT) units of six reference hos-pitals. Data from 114 files meeting the inclusion were collected. We have drawn survival curves and determined the different survival probabilities with the help of Kaplan-Meier Method. The different survival curves were compared using the Log-Rank Test (P es that were statistically associated with the 5% cut off were introduced into the Cox regression model for multivariate analysis, thus allowing us to bring out the prognostic factors significantly associated with survival. Results: The mean age at the time of diagnosis of the 114 patients recruited was 45.30 ± 17.14 years. The predominant histological type was the UCNT (Undifferentiated Carcinoma of the NasoPharynx) representing 84.2%. According to the WHO classification, 2 patients were classified as stage I (1.8%), 33 as stage II (28.9%), 42 as stage III (36.8%), 25 as stage IV A (21.9%) and 12 as stage IV B (10.5%). At the end of the survival assessment period, 34 patients were dead and 73 patients (64%) were still alive. The median overall survival was 44 months. The overall survival rates at one, two, three, and four years were 80%;74%;68%;44%, respectively. The prognostic factors associated with poor survival were: late consultation time of more than 12

关键词： Nasopharyngeal Cancer Survival Prognostic Factors Detection Cameroon

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Advances in Climate Change Research 2015年第3期6卷 159-170页

作者： ZHANG Peng Deliang CHeN hans W.LINDeRHOLM ZHANG Qiong Regional Climate Group Department of Earth Sciences University of Gothenburg Bert Bolin Centre for Climate Research Department of Physical Geography and Quaternary Geology Stockholm University

Tree-ring based temperature reconstructions have successfully inferred the past inter-annual to millennium scales summer temperature variability. A clear relationship between annual and summer temperatures can provide insights into tile variability of past annual mean tem- perature from the reconstructed summer temperature. However, how similar are summer and annual temperatures is to a large extent still unknown. This study aims at investigating the relationship between annual and summer temperatures at different timescales in central Sweden during the last millennium. The temperature variability in central Sweden can represent large parts of Scandinavia which has been a key region for dendroclimatological research. The observed annual and summer temperatures during 1901-2005 were firstly decomposed into different frequency bands using ensemble empirical mode decomposition （eeMD） method, and then the scale-dependent relationship was quantified using Pearson correlation coefficients. The relationship between the observed annual and summer temperatures determined by the instrumental data was subsequently used to evaluate 7 climate models. The model with the best performance was used to infer the relationship for the last millennium. The results show that the relationship between the observed annual and summer temperatures becomes stronger as the timescale increases, except for the 4--16 years timescales at which it does not show any relationship. The summer temperature variability at short timescales （2--4 years） shows much higher variance than the annual variability, while the annual temperature variability at long timescales （〉32 years） has a much higher variance than the summer one. During the last millennium, the simulated summer temperature also shows higher variance at the short timescales （2-4 years） and lower variance at the long timescales （〉1024 years） than those of the annual temperature. The relationship between the two temperatures is generally close at

关键词： Annual temperature Summer temperature Central Sweden Climate model simulation Scale-dependent similarity

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Design and Simulation of a Feedback Control System for a Steel Plate Storage

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厦门大学学报（自然科学版） 2002年第S1期41卷 199-200页

作者： Torben Feld Holmgaard Kristensen hans Holm Jesper hansen Department of Production Aalborg UniversityDepartment of Production Aalborg UniversityDepartm ent of Mathematical ModellingTechnical University of Denmark DenmarkDenmarkDenmark

A discrete event heuristic feedback control system fo r a steel plate storage at Odense Steel Shipyard Ltd is developed and implemente d in a computer-based simulation model. The plant is subject to stochastic dist urbances. The control system is able to handle this stochastic behaviour bec ause of the feedback design. The present simulation results indicate that a bene fit in the range of 30%～40% is reachable by modifying the plant. Plant description The steel plate storage is located at Odense Steel Shipyard Ltd, Denmark. The st eel plate storage contains steel plates used to build ship sections. The size of the storage is 600x35 meters. It consists of 32x8 stacks of plates. Plates are delivered and removed dynamically. The plate storage contains 5.000 steel plates in average. Over time, new plates delivered to the storage replace plates removed from the storage. The maximum si ze of a plate is 17x4 meters with a weight of up to 22 tons. The plates are uniq ue and dedicated to a specific purpose but in average the 5 000 plates consist o f 2 500 types. Plates are transported around the plate storage by two portal cranes. The cranes drive on a common rail and hence they cannot overtake each other. The cranes us e magnetic force to lift the plates. The crane can deliver the lifted plate to a conveyor belt or to another stack depending on whether the plate has been order ed for the current day or later. The plant is subject to different kinds of disturbances. The processes performed at the plant are stochastic. Furthermore, the due dates of the plates are frequ ently changed and hence the effect of previously sorting might be lost. The control task is to dispatch movements of plates to the two cranes. The overa ll goal is to minimize the costs at the plate storage and hence the two cranes a re used for executing the movements as fast as possible without colliding and re spect other physical constraints. Problem solution Different approaches have been investigated to s

关键词： Feedback stochastic heuristic deliver handle hence behaviour today replace removed

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利用强子探针研究奇特原子核的点质子分布半径及强子探针效应

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Science Bulletin 2024年第11期69卷 1647-1652页

作者：张寂潮孙保华 Isao Tanihata Rituparna Kanungo Christoph Scheidenberger Satoru Terashima 王枫 Frederic Ameil Joel Atkinson Yassid Ayyad Soumya Bagchi Dolores Cortina-Gil Iris Dillmann Alfredo estradé Alexey evdokimov Fabio Farinon hans Geissel Giulia Guastalla Rudolf Janik Satbir Kaur Ronja Knöbel Jan Kurcewicz Yury Litvinov Michele Marta Magdalena Mostazo Ivan Mukha Chiara Nociforo Hooi Jin Ong Stephane Pietri Andrej Prochazka Branislav Sitar Peter Strmen Maya Takechi Junki Tanaka Jossitt Vargas Helmut Weick John Stuart Winfield School of Physics Beihang UniversityBeijing 100191China Research Center for Nuclear Physics(RCNP) Osaka UniversityOsaka 567-0047Japan Astronomy and Physics Department Saint Mary’s UniversityHalifax B3H 3C3Canada TRIUMF Vancouver V6T 4A3Canada GSI Helmholtzzentrum für Schwerionenforschung Darmstadt D-64291Germany Justus-Liebig University Gießn 35392Germany Helmholtz Research Academy Hesse for FAIR(HFHF) GSI Helmholtz Center for Heavy Ion ResearchGießn 35392Germany Universidad de Santiago de Compostela Santiago de Compostella E-15706Spain Department of Physics Indian Institute of Technology(Indian School of Mines)Dhanbad 826004India Faculty of Mathematics and Physics Comenius UniversityBratislava 84215Slovakia Department of Physics and Atmospheric Science Dalhousie UniversityHalifax B3H 4R2Canada

We report the charge-changing cross sections(σ_(cc))of 24 p-shell nuclides on both hydrogen and carbon at about 900A MeV,of which^(8,9)Li,^(10–12)Be,^(10,14,15)B,^(14,15,17–22)N and^(16)O on hydrogen and^(8,9)Li on carbon are for the first *** from the data set,we found a new and robust relationship between the scaling factor of the Glauber model calculations and the separation energies of the nuclei of interest on both *** allows us to deduce proton radii(R_p)for the first time from the cross sections on *** identical R_p values are deduced from both target data for the neutron-rich carbon isotopes;however,the R_p from the hydrogen target is systematically smaller in the neutron-rich nitrogen *** calls for further experimental and theoretical investigations.

关键词： exotic nuclei Nuclear size Reaction cross section Glauber model Radioactive ion beam

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Multidimensional thermally-induced transformation of nest-structured complex Au-Fe nanoalloys towards equilibrium

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Nano Research 2022年第1期15卷 581-592页

作者： Jacob Johny Oleg Prymak Marius Kamp Florent Calvo se-Ho Kim Anna Tymoczko Ayman el-Zoka Christoph Rehbock Ulrich Schurmann Baptiste Gault Lorenz Kienle Stephan Barcikowski Technical Chemistry I and Center for Nanointegration Duisburg-essen(CeNIDe) University of Duisburg-EssenEssen 45141Germany Inorganic Chemistry and Center for Nanointegration Duisburg-essen(CeNIDe) University of Duisburg-EssenEssen 45141Germany Institute for Materials Science Synthesis and Real StructureKiel UniversityKiel 24143Germany University Grenoble Alpes CNRSLiPhyGrenoble 38000France Max-Planck-Institut fur eisenforschurtg GmbH Diisseldorf40237Germany Department of Materials Royal School of MineImperial College LondonLondon SW72AZUK

Bimetallic nanoparticles are often superior candidates for a wide range of technological and biomedical applications owing to their enhanced catalytic,optical,and magnetic properties,which are often better than their monometallic *** of their properties strongly depend on their chemical composition,crystallographic structure,and phase ***,little is known of how their crystal structure,on the nanoscale,transforms over time at elevated temperatures,even though this knowledge is highly relevant in case nanoparticles are used in,e.g.,high-temperature ***-Fe is a promising bimetallic system where the low-cost and magnetic Fe is combined with catalytically active and plasmonic ***,we report on the in s/fi;temporal evolution of the crystalline ordering in Au-Fe nanoparticles,obtained from a modern laser ablation in liquids *** in-depth analysis,complemented by dedicated atomistic simulations,includes a detailed structural characterization by X-ray diffraction and transmission electron microscopy as well as atom probe tomography to reveal elemental distributions down to a single atom *** show that the Au-Fe nanoparticles initially exhibit highly complex internal nested nanostructures with a wide range of compositions,phase distributions,and size-depended *** elevated temperature induces a diffusion-controlled recrystallization and phase merging,resulting in the formation of a single face-centered-cubic ultrastructure in contact with a body-centered cubic phase,which demonstrates the metastability of these *** these unique nanostructures with nested features could be highly attractive from a fundamental viewpoint as they could give further insights into the nanoparticle formation mechanism under non-equilibrium ***,the in situ evaluation of the crystal structure changes upon heating is potentially relevant for high-temperature process utilization of bimetallic na

关键词： nanoparticles in situ atom probe tomography diffusion recrystallization atomistic simulation

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