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Antineutrino energy spectrum unfolding b.sed on the Daya b.y measurement and its applications

Chinese Physics C 2021年第7期45卷 1-19页

作者： F.P.An A.b.b.lantekin m.b.shai S.b.yth G.F.Cao J.Cao J.F.Chang Y.Chang H.S.Chen S.m.Chen Y.Chen Y.X.Chen J.Cheng Z.K.Cheng J.J.Cherwinka m.C.Chu J.P.Cummings O.Dalager F.S.Deng Y.Y.Ding m.V.Diwan T.Dohnal D.Dolzhikov J.Dove m.Dvorak D.A.Dwyer J.P.Gallo m.Gonchar G.H.Gong H.Gong m.Grassi W.Q.Gu J.Y.Guo L.Guo X.H.Guo Y.H.Guo Z.Guo R.W.Hackenb.rg S.hans a m.He K.m.Heeger Y.K.Heng Y.K.Hor Y.b.Hsiung b.Z.Hu J.R.Hu T.Hu Z.J.Hu H.X.Huang J.H.Huang X.T.Huang Y.b.Huang P.Hub.r D.E.Jaffe K.L.Jen X.L.Ji X.P.Ji R.A.Johnson D.Jones L.Kang S.H.Kettel S.Kohn m.Kramer T.J.Langford J.Lee J.H.C.Lee R.T.Lei R.Leitner J.K.C.Leung F.Li H.L.Li J.J.Li Q.J.Li R.H.Li S.Li S.C.Li W.D.Li X.N.Li X.Q.Li Y.F.Li Z.b.Li H.Liang C.J.Lin G.L.Lin S.Lin J.J.Ling J.m.Link26 L.Littenb.rg b.R.Littlejohn J.C.Liu J.L.Liu J.X.Liu C.Lu H.Q.Lu K.b.Luk b.Z.ma X.b.ma X.Y.ma Y.Q.ma R.C.mandujano C.marshall K.T.mcDonald R.D.mcKeown Y.meng J.Napolitano D.Naumov E.Naumova T.m.T.Nguyen J.P.Ochoa-Ricoux A.Olshevskiy H.-R.Pan J.Park S.Patton J.C.Peng C.S.J.Pun F.Z.Qi m.Qi X.Qian N.Raper J.Ren C.morales Reveco R.Rosero b.Roskovec X.C.Ruan H.Steiner J.L.Sun T.Tmej1 K.Treskov W.-H.Tse C.E.Tull b.Viren V.Vorob.l C.H.Wang J.Wang m.Wang N.Y.Wang R.G.Wang W.Wang W.Wang X.Wang Y.Wang Y.F.Wang Z.Wang Z.Wang Z.m.Wang H.Y.Wei L.H.Wei L.J.Wen K.Whisnant C.G.White H.L.H.Wong E.Worcester D.R.Wu F.L.Wu Q.Wu W.J.Wu D.m.Xia Z.Q.Xie Z.Z.Xing H.K.Xu J.L.Xu T.Xu T.Xue C.G.Yang L.Yang Y.Z.Yang H.F.Yao m.Ye m.Yeh b.L.Young H.Z.Yu Z.Y.Yu b.b.Yue V.Zavadskyi S.Zeng Y.Zeng L.Zhan C.Zhang F.Y.Zhang H.H.Zhang J.W.Zhang Q.m.Zhang S.Q.Zhang X.T.Zhang Y.m.Zhang Y.X.Zhang Y.Y.Zhang Z.J.Zhang Z.P.Zhang Z.Y.Zhang J.Zhao R.Z.Zhao L.Zhou H.L.Zhuang J.H.Zou Institute of modern Physics East China University of Science and TechnologyShanghai 200337 University of Wisconsin MadisonWisconsin 53706 b.ookhaven National Lab.ratory UptonNew York 11973 Department of Physics Nnational Taiwan UniversityTaipei Institute of High Energy Physics Beijing 100049 National United University Miao-Li Department of Engineering Physics Tsinghua UniversityBeijing 100048 Shenzhen University Shenzhen 518061 Sun Yat-Sen(Zhongshan)University Guangzhou 510275 North China Electric Power University Beijing 102206 Chinese University of Hong Kong Hongkong 999077 Siena College LoudonvilleNew York 12211 Department of Physics and Astronomy University of CaliforniaIrvineCalifornia 92697 University of Science and Technology of China Hefei 230022 Charles University Faculty of Mathematics and PhysicsPrague Joint Institute for Nuclear Research DubnaMoscow Region Department of Physics University of Illinois at Urbana-ChampaignUrbanaIllinois 61801 Lawrence b.rkeley National Lab.ratory BerkeleyCalifornia 94720 Department of Physics Illinois Institute of TechnologyChicagoIllinois 60616 b.ijing Normal University Beijing 100875 Department of Nuclear Science and Technology School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an 710049 Wright Lab.ratory and Department of Physics Yale UniversityNew HavenConnecticut 06520 China Institute of Atomic Energy Beijing 102413 Shandong University Jinan 250002 Guangxi University No.100 Daxue East RoadNanning 530004 Center for Neutrino Physics Virginia TechBlacksburgVirginia 24061 Institute of Physics NCTUHsinchu Department of Physics University of CincinnatiCincinnatiOhio 45221 Department of Physics College of Science and TechnologyTemple UniversityPhiladelphiaPennsylvania 19122 Dongguan University of Technology Dongguan 523808 Department of Physics University of CaliforniaBerkeleyCalifornia 94720 Department of Physics The University of Hong KongPokfulamHongkong 999077 School of Physics Nankai UniversityTianjin 300071 Department o

The prediction of reactor antineutrino spectra will play a crucial role as reactor experiments enter the precision *** positron energy spectrum of 3.5 million antineutrino inverse b.ta decay reactions ob.erved b. the Daya b.y experiment,in comb.nation with the fission rates of fissile isotopes in the reactor,is used to extract the positron energy spectra resulting from the fission of specific *** information can b. used to produce a precise,data-b.sed prediction of the antineutrino energy spectrum in other reactor antineutrino experiments with different fission fractions than Daya *** positron energy spectra are unfolded to ob.ain the antineutrino energy spectra b. removing the contrib.tion from detector response with the Wiener-SVD unfolding *** results are ob.ained with other unfolding methods.A technique to construct a data-b.sed prediction of the reactor antineutrino energy spectrum is proposed and *** the reactor fission fractions,the technique can predict the energy spectrum to a 2%*** addition,we illustrate how to perform a rigorous comparison b.tween the unfolded antineutrino spectrum and a theoretical model prediction that avoids the input model b.as of the unfolding method.

关键词： reactor antineutrino energy spectrum Daya b.y application

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Rapid generation of ACE2 humanized inb.ed mouse model for COVID-19 with tetraploid complementation

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National Science Review 2021年第2期8卷 14-16页

作者： Feng-Liang Liu Kaixin Wu Jiaoyang Sun Zilei Duan Xiongzhi Quan Junqi Kuang Shilong Chu Wei Pang Han Gao Ling Xu Ying-Chang Li Hai-Lin Zhang Xue-Hui ang Rong-Hua Luo Xiao-Li Feng hans R.Sch?ler Xinwen Chen Duanqing Pei Guangming Wu Yong-Tang Zheng Jiekai Chen Key Lab.ratory of Animal models and Human Disease mechanisms of the Chinese Academy of Sciences/Key Lab.ratory of b.oactive Peptides of Yunnan Province KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of Sciences Center for Cell Fate and Lineage (CCLA) Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) CAS Key Lab.ratory of Regenerative b.ology Guangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of Sciences Department of Developmental b.ology School of Basic Medical SciencesSouthern Medical University Central Lab.ratory The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People's Hospital University of the Chinese Academy of Sciences Joint School of Life Science Guangzhou Medical University Kunming National High-level b.osafety Research Center for Non-human Primates Center for Biosafety Mega-ScienceKunming Institute of Zoology Chinese Academic of Sciences Department of Cell and Developmental b.ology Max Planck Institute for Molecular Biomedicine medical Faculty University of Münster

Although monkeys and pigs can b. infected with SARS-Co V-2, they generally have a long growth cycle and a large size that is difficult to handle in large quantities. However, the readily availab.e rats and mice are not susceptib.e to SARSCo V-2 b.cause of differences in ACE2(angiotensin-converting enzyme 2), the receptor mediating cell entry of SARSCo V-2 [1]. Thus, the key to estab.ishing a mouse model of COVID-19 is to make the mice express human ACE2 protein, and therefore b.come SARS-Co V-2 *** reported COVID-19 mouse models using a random insertion transgene approach [2,3] or adenoviral approach to express h ACE2 [4], lack the tissue-specificity of h ACE2 expression and might not replicate COVID-19 precisely, limiting their applications in certain studies.

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抗高血压治疗期间心电图左心室肥厚消退及其对主要心血管事件的预测作用

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美国医学会杂志（中文版） 2005年第6期24卷 323-329页

作者： Peter m. Okin, mD Richard b. Devereux, mD Sverker Jern, mD Sverre E. Kjedsen, mD,PhD Stevo Julius, mD, ScD markkus S. Nieminen, mD, PhD Steven Snapinn, PhD Katherine E. Harris, DrPH Peter Aurup, mD Jonathan m. Edelman, mD hans Wedel, PhD Lars H. Lindholm, mD, PhD b.orn Dahlof mD, PhD 倪靖炜（译）沈卫峰（校） Department of medicine Division of Cardiology Cornell University Medical Center New York NY Sahlgrenska University Hospital/OEstra Goeteborg Sweden Ulleval University Hospital Oslo Norway University of michigan medical Center Ann Arbor Division of Cardiology Department of Medicine Helsinki University Central Hospital Helsinki Finland Amgen Inc Thousand Oaks Calif merck Research Lab.ratories West Point Pa merck ＆ Co Inc Whitehouse Station NJ Nordic School of Pub.ic Health Gbteborg Sweden Umea. University Umea Sweden 不详

背景：心电图左心室肥厚（left ventficular hypertophy，LVH）是心血管并发症及死亡的强预测指标。然而，在抗高血压治疗期间心电图LVH程度变化的预测价值仍不清楚。目的：验证抗高血压治疗期间心电图LVH程度越轻，心血管并发症与死亡... 详细信息

背景：心电图左心室肥厚（left ventficular hypertophy，LVH）是心血管并发症及死亡的强预测指标。然而，在抗高血压治疗期间心电图LVH程度变化的预测价值仍不清楚。目的：验证抗高血压治疗期间心电图LVH程度越轻，心血管并发症与死亡率越低，并与血压水平及其降低和治疗方式无关的假说。设计、设置及参试者：1995～2001年于9193例55至80岁（均值，67岁）男性和女性高血压患者进行的双盲、随机、平行组研究。心电图LVH用康奈尔电压一时间乘积或Sokolow—Lyon电压表示，患者均入选氯沙坦降低高血压终点事件干预研究（Losartan Intervention For Endpoint，LIFE）。干预：以氯沙坦或阿替洛尔为基础的治疗方案，随访评估至少4年（均值，4．8年[SD，0．9]）。主要结果测定：心血管死亡、心肌梗死或卒中复合终点与基线及随后1年或每年心电图LVH严重程度的关系。结果：1096例（11．9％）发生心血管死亡、非致死性心肌梗死或卒中。在控制治疗方式、基线Framingham危险记分、基线和治疗期间血压以及基线心电图LVH严重程度（康奈尔乘积或Sokolow—Lyon电压）的Cox回归模型中，康奈尔乘积和Sokolow—Lyon电压所示治疗中LVH严重程度较低者，复合心血管终点事件的发生率分别降低14％和17％（康奈尔乘积每降低1050mm×ms,[1-SD]：校正风险比[hazard ratio，HR]，0．86；95％可信区间[confidence interval，CI]，0．82～0．92；P〈0．001；Sokolow—Lyon电压每降低10．5mm[1-SD]：HR，0．83；95％CI，0．78～0．88；P〈0．01）。在平行分析中，较低的康奈尔乘积和Sokolow—Lyon电压均与较低的心血管死亡（分别为HR，0．78；95％CI，0．73～0．83；P〈0．001和HR，0．80；95％CI，0．73～0．87；P〈0．001）、心肌梗死（HR，0．90；95％CI，0．82～0．98；P=0．01和HR，0．90；95％CI，0．81～1．00；P=0．04））和卒中（HR，0．90；95％CI，0．84～0．96；P=0．002；HR，0．81；95％CI，0．75～0．89；P〈0．001）独立相关。结论：抗高血压治疗期间，根据康奈尔乘积和Sokolow—Lyon电压判定的心电图LVH程度较轻与心血管并发症和死亡可能性较低相关，而且独立于原发性高血压患者的血压降低及治疗方式。旨在改善或预防心电图LVH的抗高血压治疗可以改善患者的预后。

关键词：抗高血压治疗心血管事件治疗期间左心室肥厚心电图原发性高血压患者预测作用致死性心肌梗死心血管并发症 interval

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Improved measurement of electron antineutrino disappearance at Daya b.y

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Chinese Physics C 2013年第1期37卷 1-20页

作者：安丰鹏安琪白景芝 A.b.b.lantekin H.R.b.nd W.b.riguete m.b.shai S.b.yth R.L.b.own 曹国富曹俊 R.Carr W.T.Chan 常劲帆 Y.Chang C.Chasman 陈和生 H.Y.Chen 陈申见陈少敏陈潇聪陈晓辉陈晓苏陈羽陈义学 J.J.Cherwinka 朱明中 J.P.Cummings 邓子艳丁雅韵 m.V.Diwan E.Draeger 杜小峰 D.Dwyer W.R.Edwards S.R.Ely 方绍东付金煜付在伟葛良全 R.L.Gi11 m.Gonchar 龚光华宫辉 Y.A.Gornushkin 顾文强关梦云郭新恒 R.W.Hackenb.rg R.L.Hahn S.hans 郝慧峰何苗贺青 K.m.Heeger 衡月昆 P.Hinrichs Y.K.Hor Y.b.Hsiung b.z.Hu 胡涛黄翰雄 H.z.Huang 黄性涛 P.Hub.r V.Issakov z.Isvan D.E.Jaffe S.Jetter 季筱璐季向盼姜海静焦健斌 R.A.Johnson 康丽 S.H.Kettell m.Kramer 关健强郭文伟郭人能 C.Y.Lai 赖万昌 W.H.Lai K.Lau L.Leb.nowski J.Lee 雷瑞霆 R.Leitner 梁干庄梁嘉怡 C.A.Lewis 李飞李高嵩李秋菊李卫东李小波李小男李学潜李仪李志斌梁昊林政儒 C.L.Lin S.K.Lin 林延畅凌家杰 J.m.Link L.Littenb.rg b.R.Littlejohn D.W.Liu 刘金昌刘江来刘颖彪陆昌国路浩奇陆永康 K.b.Luk 马秋梅马续波马骁妍马宇蒨 K.T.mcDonald m.C.mcFarlane R.D.mcKeown Y.meng D.mohapatra Y.Nakajima J.Napolitano D.Naumov I.Nemchenok 倪浩然 W.K.Ngai 聂阳波宁哲 J.P.Ochoa-Ricoux A.Olshevski S.Patton V.Pec J.C.Peng L.E.Piilonen L.Pinsky 潘振声齐法制祁鸣钱鑫 N.Raper 任杰 R.Rosero b.Roskovec 阮锡超邵贝贝师恺 H.Steiner 孙功星孙吉良 N.Tagg 谭耀豪 H.K.Tanaka 唐晓 H.Themann Y.Torun S.Trentalange O.Tsai K.V.Tsang R.H.m.Tsang C.E.Tull Y.C.Tung b.Viren V.Vorob.1 C.H.Wang 王灵淑王玲玉王龙泽王萌王乃彦王瑞光 W.Wang 王玺王贻芳王喆王铮王志民 D.m.Web.er 魏瀚宇魏亚东温良剑 K.Whisnant C.G.White L.Whitehead Y.Williamson T.Wise H.L.H.Wong E.T.Worcester F.F.Wu 吴群习建博夏冬梅邢志忠徐建一徐晶徐吉磊徐晔薛涛杨长根杨雷叶梅 m.Yeh Y.S.Yeh b.L.Young 于泽源占亮 C.Zhang 章飞虹张家文张清民张书华张一纯张银鸿张一心张志坚张子平张智勇赵洁赵庆旺赵豫斌郑磊钟玮丽周莉周祖英庄红林邹佳恒 Institute of High Energy Physics Chinese Academy of Sciences University of Science and Technology of China University of Wisconsin b.ookhaven National Lab.ratory National United University California Institute of Technology Nanjing University Department of Engineering Physics Tsinghua University Chinese University of Hong Kong Shenzhen Univeristy North China Electric Power University Siena College Department of Physics Illinois Institute of Technology Lawrence b.rkeley National Lab.ratory Department of Physics University of California Department of Physics University of Illinois at Urbana-Champaign Chengdu University of Technology Joint Institute for Nuclear Research Shanghai Jiao Tong University b.ijing Normal University Joseph Henry Lab.ratories Princeton University Center for Neutrino Physics Virginia Tech Department of Physics National Taiwan University Institute of Physics National Chiao-Tung University China Institute of Atomic Energy University of California Shandong University School of Physics Nankai University University of Cincinnati Dongguan University of Technology Department of Physics The University of Hong Kong Department of Physics University of Houston Charles University Faculty of Mathematics and Physics Sun Yat-Sen(Zhongshan)University College of William and mary Rensselaer Polytechnic Institute China Guangdong Nuclear Power Group Iowa State University Xi'an Jiaotong University

We report an improved measurement of the neutrino mixing angle θ13 from the Daya b.y Reactor Neutrino Experiment. We exclude a zero value for sin22θ13 with a significance of 7.7 standard deviations. Electron antineutrinos from six reactors of 2.9 GWm th were detected in six antineutrino detectors deployed in two near （flux-weighted b.selines of 470 m and 576 m） and one far （1648 m） underground experimental halls. Using 139 days of data, 28909 （205308） electron antineutrino candidates were detected at the far hall （near halls）. The ratio of the ob.erved to the expected numb.r of antineutrinos assuming no oscillations at the far hall is 0.944± 0.007（stat.） ± 0.003（syst.）. An analysis of the relative rates in six detectors finds sin22θ13=0.089± 0.010（stat.）±0.005（syst.） in a three-neutrino framework.

关键词： neutrino oscillation neutrino mixing reactor Daya b.y

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Classification of marine Ascomycota,b.sidiomycota,b.astocladiomycota and Chytridiomycota

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Fungal Diversity 2015年第4期73卷 1-72页

作者： E.b.Gareth Jones Satinee Suetrong Jariya Sakayaroj Ali H.b.hkali mohamed A.Ab.el-Wahab.Teun b.ekhout Ka-Lai Pang Department of b.tany and microb.ology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Fungal b.odiversity Lab.ratory BIOTECNational Science and Technology Development Agency(NSTDA)113 Thailand Science ParkThanon PhahonyothinTombon Khlong NuengAmphoe Khlong LuangPathum Thani 12120Thailand Department of b.tany Faculty of ScienceSohag UniversitySohagEgypt Cb. Fungal b.odiversity Centre(KNAW) Uppsalalaan 83584CT UtrechtThe Netherlands Institute of marine b.ology and Center of Excellence for the Oceans Taiwan Ocean University2 Pei-Ning RoadKeelung 20224TaiwanRepublic of China

This paper lists the accepted names and classification of marine fungi,updating the scheme presented in *** classification includes 1,112 species(in 472 genera):Ascomycota 805(in 352 genera),b.sidiomycota 21 species(in 17 genera),Chytridiomycota and related phyla 26 species(in 13 genera),Zygomycota three(in two genera),b.astocladiomycota one species(one genus),asexual morphs of filamentous fungi 43(in 26 genera);and marine yeasts:Ascomycota 138 species(in 35 genera),b.sidiomycota 75 species(in 26 genera).These fungi b.long to 129 families and 65 *** Halosphaeriaceae remains the largest family of marine fungi with 141 species in 59 genera,while the most specious genera are Aspergillus(47 species),Penicillium(39 species)and the yeast genus Candida(64 species).The review includes details of recent higher order nomenclature changes,and accounts of new families,genera and species describ.d over the past 5 years.

关键词： Fungal classification marine fungi molecular phylogeny New taxa Praelongicaulis gen nov Tirisporellales Torpedosporales ordo nov

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Sol-gel derived b.(2)O_(3)-CaO b.rate b.oactive glasses with hemostatic,antib.cterial and pro-angiogenic activities

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Regenerative b.omaterials 2024年第1期3卷 108-118页

作者： Kai Zheng Faina b.der mahshid monavari Zhiyan Xu Christina Janko Christoph Alexiou Ana m.b.ltran Aldo R.b.ccaccini Jiangsu Province Engineering Research Center of Stomatological Translational medicine College of StomatologyNanjing Medical UniversityNanjing 210029China Jiangsu Key Lab.ratory of Oral Diseases Nanjing Medical UniversityNanjing 210029China Institute of b.omaterials University of Erlangen-Nuremberg91058 ErlangenGermany Department of Oto-Rhino-Laryngology Head and Neck SurgerySection of Experimental Oncology and Nanomedicine(SEON)Else Kroener-Fresenius-Stiftung ProfessorshipUniversitaetsklinikum Erlangen91058 ErlangenGermany Departamento de Ingenier�ıa y Ciencia de los materiales y del Transporte Escuela Politecnica

Sol-gel b.rate b.oactive glasses(b.s)are promising ion-releasing b.omaterials for wound healing ***,we report the synthesis of a series of b.nary b.(2)O_(3)-CaO b.rate b.s(CaO ranging from 50 to 90mol%)using a sol-gel-b.sed *** influence of CaO content in b.(2)O_(3)-CaO b.rate b. on morphology,structure and ion release b.havior was investigated in *** dissolution(ion release)and crystallization could b. ob.erved in b.rate b.s when CaO content increased,while the morphology was not significantly altered b. increasing CaO *** results evidenced that the ion release b.havior of b.rate b.s could b. tailored b. tuning the b.(2)O_(3)/CaO molar *** also evaluated the in vitro cytotoxicity,hemostatic,antib.cterial and angiogenic activities of b.rate *** was validated for all b.rate ***,b.rate b.s exhib.ted composition-dependent hemostatic,antib.cterial and angiogenic ***,higher contents of Ca in b.rate b.s facilitated hemostatic activity,while higher contents of b.(2)O_(3) were b.neficial for pro-angiogenic *** synthesized sol-gel-derived b.rate b.s are promising materials for developing advanced wound healing dressings,given their fast ion release b.havior and favorab.e hemostatic,antib.cterial and angiogenic activities.

关键词： b.rate glasses sol-gel processing glass composition wound healing

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Vitamin E treatment for children with chronic hepatitis b.A randomized placeb. controlled trial

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World Journal of Gastroenterology 2008年第47期14卷 7208-7213页

作者： Patrick Gerner hans-Georg Posselt Andreas Krahl Antje b.llauff Alb.na Innerhofer Christa b.nder Tob.as G Wenzl matthias Zense Ariadne Hector Gerhard Dockter Rüdiger Adam Jenny Neub.rt martin Claβen Rob.rt van Gemmern Stefan Wirth Children's Hospital Duisb.rg-Essen University Klinik 2Essen 45122Germany Witten/Herdecke University HELIOS KlinikumWuppertalGermany Children's Hospital Frankfurt University Frankfurt am Main 60590Germany Children's Hospital Darmstadt 64287Germany Children's Hospital Essen University Klinik 2Essen 45122Germany Children's Hospital St.Anna Wien Austria 1090Germany Children's Hospital Aachen University Aachen 52074Germany Children's Hospital St.Clemens Münster 48153Germany Children's Hospital Homb.rg University Homburg/Saar 66421Germany Children's Hospital mannheim University Mannheim 68167Germany Children's Hospital Düsseldorf University Düsseldorf 40225Germany Children's Hospital b.emen University Bremen 28195Germany Pharmacy of HELIOS Klinikum Wuppertal 42883Germany Children's Hospital HELIOS Klinikum Wuppertal42283Germany Witten/Herdecke University Witten/HerdeckeGermany

AIm:To evaluate the safety and efficacy of vitamin E in children with chronic hepatitis ***:We randomly assigned patients with chronic hepatitis b.positive for hepatitis b.e antigen(Hb.Ag),to receive either vitamin E or placeb. once daily for 6 mo in a 3:1 ratio and doub.e-b.ind *** primary end point was Hb.Ag seroconversion,defined as the loss of Hb.Ag,undetectab.e levels of serum hepatitis b.virus DNA,and the appearance of antib.dies against Hb.Ag 12 mo after ***:At b.seline visit,49 patients had normal and 43 had increased serum aminotransferase ***-nine patients did not respond to previous treatment with interferon-α or ***-six children completed the study;16 were non-compliant(n = 7),lost to follow-up(n = 7),or started another antiviral treatment(n = 3).Intention-to-treat analysis showed Hb.Ag seroconversion in 16 children(23.2%) treated with vitamin E and two(8.7%) in the placeb. group(P = 0.13).Vitamin E was well ***:There is only a tendency that vitamin E may promote Hb.Ag *** larger studies are needed to clarify the role of antioxidants in the therapy of chronic hepatitis b.

关键词： Vertical transmission Immune tolerance Re-treatment Infant

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游心之路

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2019年

作者： (德)汉斯-格奥尔格·梅勒(hans-Georg moeller)，(美)德安博(Paul J. D'Amb.osio)

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Association of mineral and b.ne b.omarkers with adverse cardiovascular outcomes and mortality in the German Chronic Kidney Disease(GCKD)cohort

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b.ne Research 2023年第4期11卷 764-771页

作者： Katharina Charlotte Reimer Jennifer Nadal Heike meiselb.ch matthias Schmid Ulla T.Schultheiss Fruzsina Kotsis Helena Stockmann Nele Friedrich matthias Nauck Vera Krane Kai-Uwe Eckardt markus P.Schneider Rafael Kramann Jürgen Floege Turgay Saritas Department of Nephrology Rheumatologyand Clinical ImmunologyUniversity Hospital RWTH AachenAachenGermany Institute of Experimental medicine and Systems b.ology RWTH Aachen UniversityAachenGermany Institute for Cell and Tumor b.ology RWTH Aachen UniversityAachenGermany Institute of medical b.ometry Informatics and EpidemiologyUniversity Hospital of BonnBonnGermany Department of Nephrology and Hypertension University of Erlangen-NürnbergErlangenGermany Institute of Genetic Epidemiology Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Department of medicine IV-Nephrology and Primary Care Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Department of Nephrology and medical Intensive Care Charité-Universitätsmedizin BerlinBerlinGermany Department of Nephrology University Medical Center RegensburgRegensburgGermany Institute of Clinical Chemistry and Lab.ratory medicine University Medicine GreifswaldGreifswaldGermany DZHK(German Centre for Cardiovascular Research) Partner Site GreifswaldUniversity MedicineGreifswaldGermany Department of medicine I Division of NephrologyUniversity Hospital WürzburgWürzburgGermany

mineral and b.ne disorder(mb.)in chronic kidney disease(CKD)is tightly linked to cardiovascular disease(CVD).In this study,we aimed to compare the prognostic value of nine mb. b.omarkers to determine those associated b.st with adverse cardiovascular(CV)outcomes and *** 5217 participants of the German CKD(GCKD)study enrolled with an estimated glomerular filtration rate(eG FR)b.tween 30–60 mL·min-1 per 1.73 m2 or overt proteinuria,serum osteoprotegerin(OPG),C-terminal fib.ob.ast growth factor-23(FGF23),intact parathyroid hormone(iP TH),b.ne alkaline phosphatase(b.P),cross-linked C-telopeptide of type 1 collagen(CTX1),procollagen 1intact N-terminal propeptide(P1NP),phosphate,calcium,and 25-OH vitamin D were measured at *** with missing values among these parameters(n=971)were excluded,leaving a total of 4246 participants for *** a median follow-up of6.5 years,387 non-CV deaths,173 CV deaths,645 nonfatal major adverse CV events(mACEs)and 368 hospitalizations for congestive heart failure(CHF)were *** and FGF23 were associated with all outcomes,with the highest hazard ratios(HRs)for *** the final Cox regression model,adjusted for CV risk factors,including kidney function and all other investigated b.omarkers,each standard deviation increase in OPG was associated with non-CV death(HR 1.76,95%CI:1.35–2.30),CV death(HR 2.18,95%CI:1.50–3.16),mACE(HR 1.38,95%CI:1.12–1.71)and hospitalization for CHF(HR 2.05,95%CI:1.56–2.69).Out of the nine b.omarkers examined,stratification b.sed on serum OPG b.st identified the CKD patients who were at the highest risk for any adverse CV outcome and mortality.

关键词： Kidney cardiovascular vitamin

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Improved measurement of the reactor antineutrino flux and spectrum at Daya b.y

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Chinese Physics C 2017年第1期41卷 11-46页

作者：安丰鹏 A.b.b.lantekin H.R.b.nd m.b.shai S.b.yth 曹德文曹国富曹俊岑吴镕陳日朗常劲帆張立楚张昀陈和生陈泉佑陈少敏陈义学陈羽程佳樺程捷程雅苹成兆侃 J.J.Cherwinka 朱明中 A.Chukanov J.P.Cummings J.de Arcos 邓子艳丁雪峰丁雅韵 m.V.Diwan m.Dolgareva J.Dove D.A.Dwyer W.R.Edwards R.Gill m.Gonchar 龚光华宫辉 m.Grassi 顾文强关梦云郭磊郭如盼郭新恒郭子溢 R.W.Hackenb.rg 韩然 S.hans 何苗 K.m.Heeger 衡月昆 A.Higuera Y.K.Hor 熊怡胡貝禎胡涛胡维黄恩泉黄翰雄黄性涛 P.Hub.r 霍文驹 G.Hussain D.E.Jaffe P.Jaffke 任國綸 S.Jetter 季向盼季筱璐焦健斌 R.A.Johnson D.Jones J.Joshi 康丽 S.H.Kettell S.Kohn m.Kramer 關健强郭文伟郭天能 T.J.Langford K.Lau L.Leb.nowski J.Lee 李曉菁雷瑞庭 R.Leitner 李超李登杰李飞李高嵩李秋菊黎山峰 S.C.Li 李卫东李小男李玉峰李志兵梁昊林政儒林贵林林盛鑫林士凱林禹丞凌家杰 J.m.Link L.Littenb.rg b.R.Littlejohn 刘大为刘江来刘金昌 C.W.Loh 陆昌国路浩奇陆稼书陆锦标吕志鹏马秋梅马晓妍马续波马宇倩 Y.malyshkin D.A.martinez Caicedo K.T.mcDonald R.D.mcKeown I.mitchell m.mooney Y.Nakajima J.Napolitano D.Naumov E.Naumova 倪浩然宁哲 J.P.Ochoa-Ricoux A.Olshevskiy 潘孝儒 J.Park S.Patton V.Pec 彭仁杰 L.Pinsky 潘振声齐法制祁鸣钱鑫 N.Raper 任杰 R.Rosero b.Roskovec 阮锡超 H.Steiner 孙功星孙吉良唐炜 D.Taychenachev K.TVeskov K.V.Tsang C.E.Tull N.Viaux b.Viren V.Vorob.i 王正祥王萌王乃彦王瑞光王为王玺王贻芳王喆王铮王志民魏瀚宇温良剑 K.Whisnant C.G.White L.Whitehead T.Wise 黄显诺黄振辉 E.Worcester 吳珈豪吴群吴文杰夏冬梅夏经凯邢志忠徐建一徐吉磊徐晔薛涛杨长根杨海波杨雷阳马生杨梦婷叶梅 Z.Ye 叶铭芳杨炳麟于泽源曾珊占亮张超张宏浩张家文张清民张玄同张一鸣张一心张玉美张志坚张智勇张子平赵洁赵庆旺赵豫斌钟玮丽周莉 N.Zhou 庄红林邹佳恒 Institute of modern Physics East China University of Science and Technology University of Wisconsin Department of Physics Yale University b.ookhaven National Lab.ratory Department of Physics National Taiwan University National United University Nanjing University Institute of High Energy Physics Chinese University of Hong Kong Institute of Physics National Chiao-Tung University Shandong University Department of Engineering Physics Tsinghua University North China Electric Power University Shenzhen University Sun Yat-Sen (Zhongshan) University Joint Institute for Nuclear Research Siena College Department of Physics Illinois Institute of Technology Department of Physics University of Illinois at Urbana-Champaign Lawrence b.rkeley National Lab.ratory Department of Physics and Astronomy Shanghai Jiao Tong University Shanghai Laboratory for Particle Physics and Cosmology b.ijing Normal University Department of Chemistry and Chemical Technology Bronx Community College Department of Physics University of Houston Center for Neutrino Physics Virginia Tech China Institute of Atomic Energy University of Science and Technology of China School of Physics Nankai University Department of Physics University of Cincinnati Department of Physics College of Science and Technology Temple University Dongguan University of Technology Department of Physics University of California Department of Physics The University of Hong Kong Charles University Faculty of Mathematics and Physics Joseph Henry Lab.ratories Princeton University Department of Nuclear Science and Technology School of Energy and Power Engineering Xi’an Jiaotong University Instituto de F'?sica Pontificia Universidad Católica de Chile California Institute of Technology College of William and mary Department of Physics Applied Physics and Astronomy Rensselaer Polytechnic Institute China General Nuclear Power Group College of Electronic Science and Engineering National University of Defense Technology Iowa State University Chongqing University

A new measurement of the reactor antineutrino flux and energy spectrum b. the Daya b.y reactor neutrino experiment is reported. The antineutrinos were generated b. six 2.9 GWth nuclear reactors and detected b. eight antineutrino detectors deployed in two near（560 m and 600 m flux-weighted b.selines） and one far（1640 m flux-weighted b.seline） underground experimental halls. With 621 days of data, more than 1.2 million inverse b.ta decay（Ib.） candidates were detected. The Ib. yield in the eight detectors was measured, and the ratio of measured to predicted flux was found to b. 0.946±0.020（0.992±0.021） for the Hub.r＋mueller（ILL＋Vogel） model. A 2.9σ deviation was found in the measured Ib. positron energy spectrum compared to the predictions. In particular, an excess of events in the region of 4–6 meV was found in the measured spectrum, with a local significance of 4.4σ. A reactor antineutrino spectrum weighted b. the Ib. cross section is extracted for model-independent predictions.

关键词： antineutrino flux energy spectrum reactor Daya b.y

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