检索结果-南通市图书馆

A seed and soil model of loneliness in Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第12期19卷 2575-2576页

作者： hannah L.Apostolou Ian m.mcDonough Department of Psychology The University of AlabamaTuscaloosaALUSA Department of Psychology Binghamton UniversityBinghamtonNYUSA

Loneliness is classically defined as a result of perceiving a discrepancy between the desired quantity and quality of one's social life and actual social relationships(Perlman and Peplau,1984).Lifespan research has indicated older adults are among the highest risk for experiencing loneliness because their social network size decreases more frequently than that of younger adults.

关键词： Alzheimer younger soil

O_(2)-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第7期35卷 394-399页

作者： Yu Qin mingyang Huang Chenlu Huang hannah LPerry Linhua Zhang Dunwan Zhu Tianjin Key Laboratory of Biomedical materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China molecular Sciences Research Hub Department of ChemistryWhite City CampusImperial College LondonLondon W120BZUnited Kingdom

Photothermal therapy(PTT)and photodynamic therapy(PDT)have received tremendous attention owing to their great potential for tumor ***,two main issues hamper the antitumor performance of PDT:overexpression of glutathione(GSH)in tumors,which consumes PDT-induced reactive oxygen species(ROS),and hypoxia within the tumor *** drawbacks of PTT include uneven temperature distribution and the upregulation of the heat-shock proteins in tumors,both of which result in ineffective *** address these issues,a mnO_(2)doped nano-delivery system(HTIm-Pms)was synthesized by one-step self-assembly of disulfide bond bridged copolymers for indocyanine green(ICG)and mnO_(2)*** surface of polymeric micelles was layered with hyaluronan(HA)and transactivator(TAT)peptides to improve active targeting and increase cell *** internalization,HTIm-Pms showed responsiveness to the tumor microenvironment(acid pH,high glutathione,high H_(2)O_(2)).Breaking the disulfide bond reduced the intratumoral GSH level and simultaneously released the mnO_(2)and *** released mnO_(2)further reduced the GSH level and promoted O_(2)generation,thus enhancing the PDT *** PTT-mediated hyperthermia accelerated blood flow,which is beneficial for O_(2)distribution,and promotes ROS *** PTT-mediated adjuvant effects further overcame the limitations of PDT and the robust PDT effect in turn compensated for the deficiency of *** promising platform exhibited a significant improvement in the PTT-PDT cancer treatment strategy compared to previously reported nanostructures.

关键词： Photodynamic therapy Photothermal therapy Oxygen generating One-step self-assembly Stimuli-responsive nanoparticles

Glyphosate Exposure Associated with Human Neurodegenerative Disorders: A Scoping Review

在线全文

学校读者我要写书评

暂无评论

Journal of Behavioral and Brain Science 2024年第7期14卷 187-209页

作者： hannah Hutchins David m. Compton Kris Dougherty Behavioral Neuroscience Program Palm Beach Atlantic University West Palm Beach Florida USA Department of Biology Palm Beach Atlantic University West Palm Beach Florida USA

Chemically engineered agricultural products such as pesticides, insecticides, and herbicides, although used considerably for both industrialized and personal agricultural use, have recently been associated with a number of serious human health disorders. This rapid literature review aims to accumulate and analyze research from the last ten years, focusing specifically on the effects of exposure to glyphosate-based herbicide products such as Roundup as associated with the formation of various neurological disorders. Specifically, this review focuses on laboratory research using animal models or human cell cultures as well as human population-based epidemiological studies. It associates exposure to glyphosate or glyphosate-based products with the formation or exacerbation of neurological disorders such as Parkinson’s disease, Alzheimer’s disease, seizures, and autism spectrum disorder. In addition, it examines the correlation between the gut-brain axis, exposure to glyphosate, and neurodegeneration.

关键词： Herbicide Glyphosate Roundup Neurodegeneration Neurodegenerative Disorder Parkinson’s Disease Alzheimer’s Disease Seizures Autism Spectrum Disorder Gut-Brain Axis

Speed and surface steepness affect internal tibial loading during running

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第1期13卷 118-124页

作者： hannah Rice markus Kurz Patrick mai Leon Robertz Kevin Bill Timothy R.Derrick Steffen Willwacher Department of Physical Performance Norwegian School of Sport SciencesOslo 0806Norway Sports Tech Research Centre Mid Sweden UniversityÖstersund SE-83125Sweden Department of mechanical and Process Engineering Offenburg University of Applied SciencesOffenburg 77652Germany Institute of Biomechanics and Orthopaedics German Sport University CologneCologne 50933Germany Department of Kinesiology Iowa State UniversityAmesIA 50011USA

Background:Internal tibial loading is influenced by modifiable factors with implications for the risk of stress *** encounter varied surface steepness(gradients)when running outdoors and may adapt their speed according to the *** study aimed to quantify tibial bending moments and stress at the anterior and posterior peripheries when running at different speeds on surfaces of different ***:Twenty recreational runners ran on a treadmill at 3 different speeds(2.5 m/s,3.0 m/s,and 3.5 m/s)and gradients(level:0%;uphill:+5%,+10%,and+15%;downhill:-5%,-10%,and-15%).Force and marker data were collected synchronously *** moments were estimated at the distal third centroid of the tibia about the medial-lateral axis by ensuring static equilibrium at each 1%of *** was derived from bending moments at the anterior and posterior peripheries by modeling the tibia as a hollow ***-way repeated-measures analysis of variance were conducted using both functional and discrete statistical ***:There were significant main effects for running speed and gradient on peak bending moments and peak anterior and posterior *** running speeds resulted in greater tibial *** uphill at+10%and+15%resulted in greater tibial loading than level *** downhill at-10%and-15%resulted in reduced tibial loading compared to level *** was no difference between+5%or-5%and level ***:Running at faster speeds and uphill on gradients≥+10%increased internal tibial loading,whereas slower running and downhill running on gradients≥-10%reduced internal *** running speed according to the gradient could be a protective mechanism,providing runners with a strategy to minimize the risk of tibial stress injuries.

关键词： Bending moments Gradient musculoskeletal modeling Overuse injury Tibial stress Training factors

尽享面包与全日餐饮的极致体验——宁波麦田工坊

在线全文

学校读者我要写书评

暂无评论

中国建筑装饰装修 2024年第20期 46-51页

作者： hannah Churchill

最新落地的麦田工坊，把众人目光吸引到宁波的中心地带，设计团队将280 m2的区域打造成一个结合烘焙和全日餐饮的综合体验空间。该项目以传统烘焙工艺为理念，为当地社区注入了独特氛围与魅力。该空间不仅创造了居民聚集的理想场所，也...

最新落地的麦田工坊，把众人目光吸引到宁波的中心地带，设计团队将280 m2的区域打造成一个结合烘焙和全日餐饮的综合体验空间。该项目以传统烘焙工艺为理念，为当地社区注入了独特氛围与魅力。该空间不仅创造了居民聚集的理想场所，也突显了设计在传播社区文化与品牌价值方面的重要性。在设计初期，设计师将现代工坊的简约时尚与传统法式面包店的经典风格相融合，特别强调了烘焙的纯手工品质和历史悠久的工艺传承。独特的设计理念使其在繁华都市中独具一格。

关键词：

3-Dimensional Kinematic Comparison of Arm movements between an Individual with NGLY1 Deficiency and a Neurotypical Individual

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Case Reports in Clinical medicine 2024年第4期13卷 122-146页

作者： Charles S. Layne Christopher A. malaya Brock Futrell Dacia martinez Diaz Christian Alfaro hannah E. Gustafson Subhalakshmi Chandrasekaran Rhea m. Phatak Bernhard Suter Department of Health and Human Performance University of Houston Houston TX USA Center for Neuromotor and Biomechanics Research University of Houston Houston TX USA Center for Neuro Engineering and Cognitive Science University of Houston Houston TX USA Department of Computer Science and Engineering Texas A&M University College Station TX USA Blue Bird Circle Rett Center Texas Children&#8217s Hospital Houston TX USA Baylor College of medicine Houston TX USA

NGLY1 Deficiency is an ultra-rare autosomal recessively inherited disorder. Characteristic symptoms include among others, developmental delays, movement disorders, liver function abnormalities, seizures, and problems with tear formation. movements are hyperkinetic and may include dysmetric, choreo-athetoid, myoclonic and dystonic movement elements. To date, there have been no quantitative reports describing arm movements of individuals with NGLY1 Deficiency. This report provides quantitative information about a series of arm movements performed by an individual with NGLY1 Deficiency and an aged-matched neurotypical participant. Three categories of arm movements were tested: 1) open ended reaches without specific end point targets;2) goal-directed reaches that included grasping an object;3) picking up small objects from a table placed in front of the participants. Arm movement kinematics were obtained with a camera-based motion analysis system and “initiation” and “maintenance” phases were identified for each movement. The combination of the two phases was labeled as a “complete” movement. Three-dimensional analysis techniques were used to quantify the movements and included hand trajectory pathlength, joint motion area, as well as hand trajectory and joint jerk cost. These techniques were required to fully characterize the movements because the NGLY1 individual was unable to perform movements only in the primary plane of progression instead producing motion across all three planes of movement. The individual with NGLY1 Deficiency was unable to pick up objects from a table or effectively complete movements requiring crossing the midline. The successfully completed movements were analyzed using the above techniques and the results of the two participants were compared statistically. Almost all comparisons revealed significant differences between the two participants, with a notable exception of the 3D initiation area as a percentage of the complete movement. The stati

关键词： NGLY1 Deficiency Developmental Disorders Kinematics 3 Dimensional Analyses

Glyphosate Exposure Associated with Human Neurodegenerative Disorders: A Scoping Review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quantifying Kinematic Tremor in an NGLY1-Deficient Individual: A Case Study

Journal of Behavioral and Brain Science（行为与脑科学期刊） 2024年第7期 187页

作者： hannah Hutchins David m. Compton Kris Dougherty

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Case Reports in Clinical medicine 2024年第1期13卷 25-36页

作者： Brock Futrell Christopher Alexander malaya Dacia martinez Diaz Christian Alfaro hannah Elizabeth Gustafson Subhalakshmi Chandrasekaran Rhea mohan Phatak Bernhard Suter Charles Shannon Layne Department of Health and Human Performance University of Houston Houston USA Center for Neuromotor and Biomechanics Research University of Houston Houston USA Department of Computer Science and Engineering Texas A&M University College Station USA Blue Bird Circle Rett Center Texas Children’s Hospital Houston USA Baylor College of medicine Houston USA Center for NeuroEngineering and Cognitive Science University of Houston Houston USA

NGLY1 Deficiency is an autosomal recessive congenital disorder that has been identified in less than 100 individuals. most individuals with NGLY1 Deficiency display hyperkinetic movement disorders, including choreiform, athetoid, dystonic myoclonic, dyskinetic, and dysmetric movements. Developing a consistent and concise consensus on the classification and evaluation of tremors is essential to forward the research and treatment of tremors. It has also been reported that some individuals with NGLY1 Deficiency demonstrate tremor, but such tremor has never been formally investigated. The primary objective of this study is to determine if an individual with NGLY1 Deficiency demonstrates an identifiable tremor during a series of arm movements and, if so, describe the frequency and power characteristics of that tremor. Arm movement kinematics were obtained using a 16-camera Vicon system, and time series trajectory waveforms for three planes of a marker placed on the hand were developed. Custom mATLAB scripts were utilized to compute Fast Fourier Transformations of the data within the identified waveform segments. A mean frequency of 2.30 Hz (SD = 1.05) with a mean power of 5.02 |P1(f)| (SD = 4.63) suggests that our participant’s kinematic data did display a persistent tremor in both hands across all tasks and movement planes. Analyses of the reaching hand and the non-reaching hand suggest the participant displayed an action tremor in both postural and intention (kinetic) tremors. Future directions should include assessing additional individuals with NGLY1 Deficiency to determine if the tremor is a distinguishable disorder behavior. Additionally, evaluating other anatomical sites, such as the elbow, head, and lower limbs, would provide further insights into the characteristics of this tremor.

关键词： Tremor NGLY Fast Fourier Transformation Reaching Hyperkinetic movement

Color change in a marine isopod is adaptive in reducing predation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2015年第4期61卷 739-748页

作者： Kristin m. HULTGREN hannah mITTELSTAEDT Department of Biology Seattle University 901 12^th ave. Seattle WA 98122

Although background matching is a common form of camouflage across a wide diversity of animals, there has been surprisingly little experimental work testing the fitness consequences of this camouflage strategy, especially in marine ecosystems. In this study, we tested whether color camouflage enhances survival of the intertidal marine isopod Pentidotea （Idotea） wosnesenskii, quantified patterns of camouflage in different algal habitats, and examined how algal diet affected color change and growth using laboratory assays. In the field, isopods collected from two differently colored algal habitats （the brown alga Fucus distichus and the red alga Odonthaliafloccosa） matched the color of their respective algal habitats, and also differed significantly in body size： smaller red isopods were found on red algae, while larger brown isopods were found on brown algae. Predation ex- periments demonstrated these color differences had fitness benefits： brown isopods that matched their brown algae habitats sur- vived at higher rates than red unmatched isopods. Surprisingly, despite the propensity of isopods to match their algal habitats, algal diet had no effect on color change in color change experiments. Instead, isopods in all treatments turned browner, matching the color of the algal habitat that many isopods are found on as adults. In summary, our data supported our hypothesis that back- ground matching serves an adaptive function in reducing predation, with important evolutionary implications for explaining the wide variation in color change mechanisms in idoteid isopods [Current Zoology 61 （4）： 739-748, 2015].

关键词： Isopod Pentidotea wosnesenskii. Camouflage Crypsis Background matching Color change