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Proinflammatory cytokine TNFα promotes HPV-associated oral carcinogenesis by increasing cancer stemness

International Journal of Oral Science 2020年第1期12卷 40-49页

作者： hannah shong Jonathan Akhavan Sung Hee Lee Reuben HKim Mo KKang No-Hee Park Ki-Hyuk Shin The Shapiro Family Laboratory of Viral Oncology and Aging Research UCLA School of DentistryLos AngelesCAUSA UCLA Jonsson Comprehensive Cancer Center Los AngelesCAUSA Department of Medicine David Geffen School of Medicine at UCLALos AngelesCAUSA

High-risk human papillomaviruses(HPVs) are involved in the development of several human cancers, including oropharyngeal squamous cell carcinomas. However, many studies have demonstrated that HPV alone is not sufficient for the oncogenic transformation of normal human epithelial cells, indicating that additional cofactors are required for the oncogenic conversion of HPV-infected cells. Inasmuch as chronic inflammation is also closely associated with carcinogenesis, we investigated the effect of chronic exposure to tumor necrosis factor α(TNFα), the major proinflammatory cytokine, on oncogenesis in two immortalized oral keratinocyte cell lines, namely, HPV16-immortalized and human telomerase reverse transcriptase(h TERT)-immortalized cells. TNFαtreatment led to the acquisition of malignant growth properties in HPV16-immortalized cells, such as(1) calcium resistance,(2)anchorage independence, and(3) increased cell proliferation in vivo. Moreover, TNFα increased the cancer stem cell-like population and stemness phenotype in HPV16-immortalized cells. However, such transforming effects were not observed in h TERTimmortalized cells, suggesting an HPV-specific role in TNFα-promoted oncogenesis. We also generated h TERT-immortalized cells that express HPV16 E6 and E7. Chronic TNFα exposure successfully induced the malignant growth and stemness phenotype in the E6-expressing cells but not in the control and E7-expressing cells. We further demonstrated that HPV16 E6 played a key role in TNFα-induced cancer stemness via suppression of the stemness-inhibiting micro RNAs mi R-203 and mi R-200 c. Overexpression of mi R-203 and mi R-200 c suppressed cancer stemness in TNFα-treated HPV16-immortalized cells. Overall, our study suggests that chronic inflammation promotes cancer stemness in HPV-infected cells, thereby promoting HPV-associated oral carcinogenesis.

关键词： carcinogenesis cytokine cancer

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Effects of overburden, rock strength and pillar width on the safety of a three-parallel-hole tunnel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第11期10卷 1581-1588页

作者： shong-loong CHEN Guo-wei LI Meen-wah GUI Department of Civil Engineering National Taipei University of Technology Taipei Department of Civil Engineering National Chiao-Tung University Hsinchu

During the excavation of three-parallel-hole tunnel, the tunnel might collapse due to over-stress as a result of inadequate rock pillar width. Treating the rock overburden depth, rock strength, and rock pillar width as variables, a series of 3D numerical analysis was carried out to examine the effect of each variable on the safety of the tunnel, in particular the rock pillar. A stress strength ratio (SSR) was used to define whether the safety of the rock pillar was exceeded. A simple design chart for the case of three-parallel-hole tunnel, which took into account the influence of overburden depth, rock pillar width, and rock strength, was also proposed for used in the preliminary design stage.

关键词： Three-parallel-hole tunnel Tunnels interaction Rock pillar Numerical analysis Stress strength ratio (SSR)

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江西油菜产业竞争力分析及对策研究

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江西农业学报 2024年第8期36卷 101-105页

作者：黄微付江凡王长松江西省农业科学院农业经济与信息研究所江西南昌330200

采用熵值法从省域角度分析了2016—2020年江西省油菜产业的竞争力水平,同时依托江西省农业农村厅2013—2018年10~15个油菜主产县150位农户的油菜生产、成本收益状况监测数据,对江西省各主要产区的油菜产业竞争力进行了测算。结果表明:... 详细信息

采用熵值法从省域角度分析了2016—2020年江西省油菜产业的竞争力水平,同时依托江西省农业农村厅2013—2018年10~15个油菜主产县150位农户的油菜生产、成本收益状况监测数据,对江西省各主要产区的油菜产业竞争力进行了测算。结果表明:江西省油菜产业仍具有较大的进步空间,发展势头向好,生产成本对油菜产业竞争力影响显著。并从政策专项补贴、市场要素流动、基础设施建设3个方面提出了一些关于江西油菜产业发展的政策建议。

关键词：油菜竞争力江西省熵值法

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Marine Environment around Taiwan Coast

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Journal of Civil Engineering and Architecture 2016年第11期10卷 1297-1303页

作者： Ho-shong Hou Graduate School of Civil and Ecological Engineering I-Shou University Kaohsiung Taiwan R.O.C.

Coastal erosion is an island-wide problem in Taiwan; about 80% of the island＇s sandy coastline had suffered from erosion over the past few decades. Historically, with the specific tectonic environment and rapid uplifting rate, lots of sediment had been yielded and transported to the coastal area that resulted in an advancing shoreline. Taiwan economically moved from a developing country to a developed one; a lot of human intervention had been made along the island coast. These are the major factors on recent coastal erosion. Even actions such as building of stabilization structures may inadvertently increase erosion. Some intervention examples are chosen to address how human-induced change made the profound impact on coastal erosion in Taiwan. All the information serves to provide a better understanding of the coastal processes, and a better response to the erosion problem.

关键词： Erosion sediment protection construction.

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Choroid Plexus Carcinoma: A Rare Tumor in Adult

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Surgical Science 2014年第4期5卷 146-149页

作者： Chi-Man Yip Hui-Hwa Tseng Shu-shong Shu-shong Hsu Department of Pathology Kaohsiung Veterans General Hospital Kaohsiung Taiwan Division of Neurosurgery Kaohsiung Veterans General Hospital Kaohsiung Taiwan

Background: Choroid plexus carcinoma is a highly aggressive malignant, infrequent tumor with poor prognosis. About 80% of choroid plexus carcinoma occurs in children, but it is uncommon in adults. Because of the rarity of the choroid plexus carcinoma, there is no established treatment protocol for this malignancy. Case Description: A 21-year-old man with past medical history of asthma presented to us with the chief complaint of morning headache for one month. His brain magnetic resonance imaging (MRI) showed a mass in the trigone and occipital horn of the left lateral ventricle. He had undergone a left occipitoparietal craniotomy, posterior interhemispheric precuneus approach with grossly total removal of the tumor. The histology examination of the tumor proved to be choroid plexus carcinoma. This patient achieved a favorable outcome after having a grossly complete surgical resection followed by postoperative adjuvant radiotherapy and chemotherapy. Conclusions: Choroid plexus carcinoma is aggressive and is associated with dismal prognosis. The 5-year survival rates for choroid plexus carcinoma vary between 10% and 50%. Currently, there is no established treatment protocol for choroid plexus carcinoma. Complete resection of this malignant tumor is the primary goal of treatment since it allows best chance of survival and improves the overall prognosis.

关键词： Choroid Plexus Carcinoma Surgical Resection Adjuvant Radiotherapy and Chemotherapy

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PARTIAL OXIDATION OF METHANE TO FORMALDEHYDE OVER VARIOUS SILICA GELS

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Journal of Energy Chemistry 1994年第4期 459-467页

作者： DAI Han-shong QIU Fa-LiChengdu Institute of Organic Chemistry,Academa Sinica Chengdu, Sichuan 610015

Partial oxidation of methane over various silica gels using oxygenas an oxidant has been investigated. The results showed that different silica gelshad different activities for formation of HCHO over verious silica gels. Thehighest yield of HCHO is 2.14% (output is 49.72g·m·h) on the silicagel-1. The results of IR, TGA and XPS indicated that the-OH group amountwas different on various silica gels, which is considered to be related to theactivity difference for partial oxidation of methane to HCHO, and the reactionmechnism is discussed.

关键词： HCHO CO PARTIAL OXIDATION OF METHANE TO FORMALDEHYDE OVER VARIOUS SILICA GELS over

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STUDIES ON TBP-NO_x——A NEW OXIDIZING AGENT PREPARED FROM NITROGEN OXIDES

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Chinese Chemical Letters 1992年第11期3卷 877-878页

作者： Shen shong ZHANG Ren Zhong QIAO Qing Zhi ZHANG Fu Gui LU Department of chemistry.Henan Normal University Xinxiang453002

Nitrogen oxides(NO_2 and NO)are absorbed by tributyl phosphorate(TBP)to fom a new complex mixture of TBP-NO_x. which is used as a selective oddizing agent to oxidize benzylalcohols to corresponding sldehydes or ketones In high yield. In the reaction process, nitrogen oxides are llberated mildly and mainly reduced to nitrogen, while tributyl phosphorate is recovered end recycled.

关键词： NO 目血 A NEW OXIDIZING AGENT PREPARED FROM NITROGEN OXIDES STUDIES ON TBP-NO_x AGENT TBP

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MICROCALORIMETRY ON BACILLUS ***-61

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Chinese Chemical Letters 1991年第9期2卷 709-710页

作者： Wei Hong XIE Chang Li XIE shong Sheng QU Department of Chemistry,Wuhan University,Wuhan 430072

The fundamental growth thermograms of Bacillus ***-61 have been de- termined by microcalorimetric *** these growth curves we got some thermo- kinetics data of its growth and its thermodynamic properties.

关键词： TT SP MICROCALORIMETRY ON BACILLUS SP.NTT-61

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一种改进的直方图均衡化

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光学技术 2008年第S1期34卷 141-142页

作者：乔闹生湖南文理学院物理与电子科学学院湖南常德415000

从理论上分析了直方图均衡化过程中灰度级合并的原因,给出了简单的物理解释和解析推导,并讨论了该算法的缺点。为了使图像保留更多的细节信息、消除虚假轮廓且保持连续性,提出了保留灰度级的直方图均衡化算法,并分析了其基本原理。实验... 详细信息

从理论上分析了直方图均衡化过程中灰度级合并的原因,给出了简单的物理解释和解析推导,并讨论了该算法的缺点。为了使图像保留更多的细节信息、消除虚假轮廓且保持连续性,提出了保留灰度级的直方图均衡化算法,并分析了其基本原理。实验结果表明:通过该算法处理的图像比采用传统直方图均衡化算法处理的图像效果好。

关键词：图像增强直方图均衡化灰度级

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台北市软弱地基改良后之深开挖分析

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岩土工程学报 2008年第2期30卷 185-192页

作者：何政道陈水龙台北科技大学工程科技研究所中国台湾台北超伟工程顾问有限公司中国台湾台北台北科技大学土木与防灾研究所中国台湾台北金门技术学院中国台湾金门

为降低于软弱黏土层开挖可能引起挡土壁及地表沉陷过大之问题,常搭配辅助性之挡土措施。其中地基改良方法,实务上大都简化假设改良之复合土壤平均强度来进行分析。为求能更进一步探讨台北市软弱黏土层地基改良后之深开挖行为,本研究系... 详细信息

为降低于软弱黏土层开挖可能引起挡土壁及地表沉陷过大之问题,常搭配辅助性之挡土措施。其中地基改良方法,实务上大都简化假设改良之复合土壤平均强度来进行分析。为求能更进一步探讨台北市软弱黏土层地基改良后之深开挖行为,本研究系以台北市内湖重划区已开挖完成案例,再利用二维有限元法程序PLAXIS来进行分析,并与现地监测数据比较分析,藉以探讨软弱黏土层地基改良后之深开挖特性。

关键词：深开挖地基改良有限元法

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