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Surgical approach affecting long-term urinary continence status after robot-assisted laparoscopic prostatectomy prospectively evaluated using self-reported functional status(Expanded Prostate Cancer Index Composite,EPIC-26)

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当代泌尿学（英文） 2024年第1期18卷 61-65页

作者： Mathias Reichert Ame Strauß Joost Wilhelm Voß Hans Christoph von Knobloch hannah maria neuenhofer Annemarie Uhlig Lutz Trojan Mirjam Naomi Mohr Department of Urology University Medical CenterGoettingenGermany Department of Pediatrics University HospitalBonnGermany

Purpose:The aim of the study was to examine the influence of the surgical approach for robot-assisted laparoscopic prostatectomy(RALP)on long-term urinary continence status in the era of self-reported functional status measures using the Expanded Prostate Can-cer Index Composite 26.Materials and methods:This is a prospective evaluation of 232 patients undergoing RALP between September,2019 and September,*** continence status and postoperative incontinence(pad usage)were evaluated 12 months after RALP using Expanded Prostate Cancer Index Composite 26 *** were categorized according to their surgical approach and outcome into the following groups:successful nerve sparing(NS),primarily without nerve sparing(***),and no nerve sparing by secondary resection(NNS by SR).The median levels of their questionnaire outcomes were evaluated and compared using the Wilcoxon rank sum test with continuity correction.Results:Urinary continence status 12 months after RALP differed significantly between the NS and ***(p=0.0071)and the NS and NNS by SR(p=0.0076)*** was no significant difference between the *** and NNS by SR(p=0.53)*** usage 12 months after RALP had no significant difference with regard to SR of the neurovascular bundle(p=0.14).Conclusions:Patient-reported outcomes of long-term urinary continence status seem to show no difference in postoperative conti-nence,regardless of whether a non-nerve-sparing result was planned or reached through ***,preservation of neurovascular bundle seems to lead to better long-term continence rates.

关键词： Expanded Prostate Cancer Index Composite 26 Nerve sparing Prostate cancer Robot-assisted radical prostatectomy Surgical approach Urinary incontinence

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Pancreatic cancer survival trends in the US from 2001 to 2014:a CONCORD-3 study

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Cancer Communications 2023年第1期43卷 87-99页

作者： Maja Nikšić Pamela Minicozzi hannah K Weir Heather Zimmerman maria J Schymura Judith R Rees Michel P Coleman Claudia Allemani 无 Cancer Survival Group Department of Non-Communicable Disease EpidemiologyLondon School of Hygiene&Tropical MedicineKeppel StreetLondon WC1E 7HTUK Centre for Health Services Studies University of KentCanterbury CT27NFUK Division of Cancer Prevention and Control Centers for Disease Control and PreventionAtlantaGA 30333USA Montana Central Tumor Registry Chronic Disease Prevention and Health Promotion BureauPO Box 2029511400 BroadwayHelenaMT 59620-2951USA Bureau of Cancer Epidemiology New York State Cancer RegistryNew York State Department of Health150 BroadwayAlbanyNY 12204-2719USA New Hampshire State Cancer Registry Norris Cotton Cancer Centerand Department of EpidemiologyGeisel School of MedicineDartmouth CollegeDartmouth-Hitchcock Medical CenterOne Medical Center DriveLebanonNH 03756USA Cancer Division University College London Hospitals NHS Foundation Trust250 Euston RoadLondon NW12PGUK US CONCORDWorking Group

Background:Survival from pancreatic cancer is low *** the US,the 5-year relative survival has been slightly higher for women,whites and younger patients than for their counterparts,and differences in age and stage at diagnosis[Corrections added Nov 16,2022,after first online publication:a new affiliation is added to Maja Nikšić]may contribute to this *** aimed to examine trends in survival by race,stage,age and sex for adults(15-99 years)diagnosed with pancreatic cancer in the ***:This population-based study included 399,427 adults registered with pancreatic cancer in 41 US state cancer registries during 2001-2014,with followup to December 31,*** estimated age-specific and age-standardized net survival at 1 and 5 ***:Overall,12.3%of patients were blacks,and 84.2%were *** 9.5%of patients were diagnosed with localized disease,but 50.5%were diagnosed at an advanced stage;slightly more among blacks,mainly among *** substantial changes were seen over time(2001-2003,2004-2008,2009-2014).In general,1-year net survival was higher in whites than in blacks(26.1%vs.22.1%during 2001-2003,35.1%vs.31.4%during 2009-2014).This difference was particularly evident among patients with localized disease(49.6%in whites vs.44.6%in blacks during 2001-2003,60.1%vs.55.3%during 2009-2014).The survival gap between blacks and whites with localized disease was persistent at 5 years after diagnosis,and it widened over time(from 24.0%vs.21.3%during 2001-2003 to 39.7%vs.31.0%during 2009-2014).The survival gap was wider among men than among ***:Gaps in 1-and 5-year survival between blacks and whites were persistent throughout 2001-2014,especially for patients diagnosed with a localized tumor,for which surgery is currently the only treatment modality with the potential for cure.

关键词： pancreatic cancer race/ethnicity stage net survival population-based cancer registries

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Endoscopic ultrasound elastography for malignant pancreatic masses and associated lymph nodes:Critical evaluation of strain ratio cutoff value

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World Journal of Gastrointestinal Endoscopy 2022年第9期14卷 524-535页

作者： Miguel Puga-Tejada Raquel Del Valle Roberto Oleas maria Egas-Izquierdo Martha Arevalo-Mora Jorge Baquerizo-Burgos Jesenia Ospina Miguel Soria-Alcivar hannah Pitanga-Lukashok Carlos Robles-Medranda Endoscopy Division Instituto Ecuatoriano de Enfermedades DigestivasGuayaquil 090505GuayasEcuador Universidad de Guayaquil Guayaquil 090505GuayasEcuador

BACKGROUND Endoscopic ultrasound(EUS)can detect small lesions throughout the digestive tract;however,it remains challenging to accurately identify malignancies with this *** elastography measures tissue hardness,by which malignant and nonmalignant pancreatic masses(PMs)and lymph nodes(LNs)can be ***,there is currently little information regarding the strain ratio(SR)cutoff in Hispanic *** To determine the diagnostic accuracy of EUS elastography for PMs and LNs with an SR cutoff value in *** A retrospective study of patients who underwent EUS elastography for PMs between December 2013 and December 2014.A qualitative(analysis of color maps)and quantitative(SR)analysis of PMs and their associated LNs was *** accuracy of EUS elastography in identifying malignant PMs and LNs and cutoff value for SR were analyzed.A PM and/or its associated LNs were considered malignant based on histopathological findings from fine-needle aspiration biopsy *** A sample of 121 patients was included,45.4%of whom were female.69(57.0%)PMs were histologically malignant,with a median SR of 50.4 vs 33.0 for malignant vs nonmalignant masses(P21.5 yielded a sensitivity of 94.2%,while a cutoff value of>121 yielded a specificity of 96.2.2%.There were significant differences in the Giovannini scores,a previously established elastic score system,between the patients grouped by their final histology results(P14.0 and>155 yielded a sensitivity of 90.9%and a specificity of 95.2%,respectively,in detecting *** EUS elastography is a helpful technique for the diagnosis of solid PMs and their associated LNs.T

关键词： Ultrasound Elastography Pancreas Lymph nodes Neoplasm

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别让男孩在舞蹈课堂中成了弱势群体

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尚舞 2016年第1期 92-93页

作者： Ariel hannah maria Hayes

在笔者采访过的许多青海年中,每个男孩子学舞之初都会有些顾虑,这让舞蹈班中男孩儿的招生天然存在着难题。而对于国标舞来说,每一个女孩都在等待着属于她的那一个男孩。Adam Holms幼时曾是一个舞蹈工作室中唯一的男孩,为此他的老师一度... 详细信息

在笔者采访过的许多青海年中,每个男孩子学舞之初都会有些顾虑,这让舞蹈班中男孩儿的招生天然存在着难题。而对于国标舞来说,每一个女孩都在等待着属于她的那一个男孩。Adam Holms幼时曾是一个舞蹈工作室中唯一的男孩,为此他的老师一度十分头痛。"那时候班里都是女孩,所以每次汇演的编舞都是为女孩定制,我也只能跟着做同样的动作,"他说,"有一次,老师给我穿了一件廉价的爵士连体裤,上身是带亮片和蓝

关键词：舞蹈作品弱势群体

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Clinical impact of confocal laser endomicroscopy in the management of gastrointestinal lesions with an uncertain diagnosis

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World Journal of Gastrointestinal Endoscopy 2017年第8期9卷 389-395页

作者： Carlos Robles-Medranda maria Vargas Jesenia Ospina Miguel Puga-Tejada Manuel Valero Miguel Soria Gladys Bravo Carlos Robles-Jara hannah Pitanga Lukashok Gastroenterology and Endoscopy Division Instituto Ecuatoriano de Enfermedades DigestivasUniversity Hospital OMNIGuayaquil 090505Ecuador

AIM To evaluate the clinical impact of confocal laser endomicroscopy(CLE) in the diagnosis and management of patients with an uncertain *** A retrospective chart review was *** who underwent CLE between November 2013 and October 2015 and exhibited a poor correlation between endoscopic and histological findings were *** characteristics,indications,previous diagnostic studies,findings at the time of CLE,clinical management and histological results were *** based on CLE findings were also *** compared the diagnostic accuracy of CLE and target biopsies of surgical *** A total of 144 patients were *** these,51%(74/144) were *** mean age was 51 years *** all,41/144(28.4%) lesions were neoplastic(13 bile duct,10 gastric,8 esophageal,6 colonic,1 duodenal,1 rectal,1 ampulloma and 1 pancreatic).The sensitivity,specificity,positive predictive value,negative predictive value,and observed agreement when CLE was used to detect N-lesions were 85.37%,87.38%,72.92%,93.75% and 86.81%,***'s Kappa was 69.20%,thus indicating good *** in management were observed in 54% of the *** CLE is a new diagnostic tool that has a significant clinical impact on the diagnosis and treatment of patients with uncertain diagnosis.

关键词：共焦的激光 endomicroscopy 在 vivo 显微镜学小型帽子食管胃肠的癌症胰腺的包囊胆汁的苛评

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C-reactive protein and radiographic findings of lower respiratory tract infection in infants

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World Journal of Radiology 2017年第4期9卷 206-211页

作者： maria Twomey hannah Fleming Fiachra Moloney Kevin P Murphy Lee Crush Siobhan B O’Neill Oisin Flanagan Karl James Conor Bogue Owen J O’Connor Michael M Maher Department of Radiology Cork University HospitalWiltonT12 DC4A CorkIreland

AIM To evaluate the association between C-reactive protein(CRP) and radiological evidence of lower respiratory tract infection(LRTI) in *** All patients aged less than 4 years who presented with suspected lower respiratory tract infection,who received a peri-presentation chest radiograph and CRP blood measurement over an 18-mo period were included in the ***,gender,source of referral,CRP,white cell count,neutrophil count along with the patients' symptoms and radiologist's report were *** Three hundred and eleven patients met the *** chest radiographs were more common in patients with elevated CRP levels(P < 0.01).Radiologic signs of LRTI were identified in 73.7% of chest radiographs when a patient had a CRP level between 50-99 mg/*** levels were a better predictor of positive chest radiograph findings for those aged greater than I year compared to those 1 year or *** CRP may be used in patients with suspected LRTI diagnosis to select those who are likely to have positive findings on chest radiograph,thus reducing unnecessary chest radiographs.

关键词：胸拍 C 反应的蛋白质胸感染呼吸感染小儿科

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Phytosociology and Floristic Composition of the Infesting Community in Rice Crop Waterlogged

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American Journal of Plant Sciences 2018年第3期9卷 353-367页

作者： Bruna Penha Costa maria Rosangela Malheiros Silva Carlos Augusto Rocha de Moraes Rego Juan López de Herrera maria Soraia Fortado Vera Cruz Ana Carolina Pinguelli Ristau Marinez Carpiski Sampaio Thatiane Nepomuceno Alves Shirlene Souza Oliveira hannah Braz Nitalo Andre Farias Machado Center of Agrarian Sciences State University of Western Paraná Marechal Candido Rondon Brazil Center of Agrarian Sciences State University of Maranh&atilde o S&atilde o Luís Brazil University School of Agricultural Technical Engineering Polytechnic University of Madrid Madrid Spain

The objective of this study is to identify and quantify the floristic composition of the weed community in the rice crop waterlogged in the municipality of Arari-MA. The botanical material was obtained in three areas by randomly a hollow rectangle of 0.50 m × 0.30 m by forty five times in each plot. The aerial parts of weeds were harvested, identified, counted and oven dried with forced air ventilation at 333.15 K to 343.15 K. These data were used to determine the phytosociological parameters and the Shannon-Wiener diversity index was also calculated. A total of 6607 plants were collected, being 4115 (62.28%) in the vegetative phase and 2492 (37.72%) in the reproductive phase. The monocotyledonous group obtained the largest number of plants, 2882 in the vegetative phase and 1535 in the reproductive phase. The Cyperaceae family recorded nine species and four genera and the Poaceae, seven and four species in the vegetative and reproductive phases, respectively. The species of higher IVI in the vegetative phase was E. sellowiana in the area A1 with 82.86%, and in the reproductive F. dichotoma with IVI of 90.49% in the area A3. The individuals density and species richness were higher in the vegetative phase of the culture and the monocotyledonous group predominated with the Cyperaceae and Poaceae families, and the weed diversity among the areas was low.

关键词： Diversity Oryza sativa L. Weeds

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Automated Cell Detection and Morphometry on Growth Plate Images of Mouse Bone

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Applied Mathematics 2014年第18期5卷 2866-2880页

作者： maria-Grazia Ascenzi Xia Du James I. Harding Emily N. Beylerian Brian M. de Silva Ben J. Gross hannah K. Kastein Weiguang Wang Karen M. Lyons Hayden Schaeffer Department of Orthopaedic Surgery University of California Los Angeles California USA Department of Mathematics University of California Los Angeles California USA Department of Mathematics University of California Irvine California USA

Microscopy imaging of mouse growth plates is extensively used in biology to understand the effect of specific molecules on various stages of normal bone development and on bone disease. Until now, such image analysis has been conducted by manual detection. In fact, when existing automated detection techniques were applied, morphological variations across the growth plate and heterogeneity of image background color, including the faint presence of cells (chondrocytes) located deeper in tissue away from the image’s plane of focus, and lack of cell-specific features, interfered with identification of cells. We propose the first method of automated detection and morphometry applicable to images of cells in the growth plate of long bone. Through ad hoc sequential application of the Retinex method, anisotropic diffusion and thresholding, our new cell detection algorithm (CDA) addresses these challenges on bright-field microscopy images of mouse growth plates. Five parameters, chosen by the user in respect of image characteristics, regulate our CDA. Our results demonstrate effectiveness of the proposed numerical method relative to manual methods. Our CDA confirms previously established results regarding chondrocytes’ number, area, orientation, height and shape of normal growth plates. Our CDA also confirms differences previously found between the genetic mutated mouse Smad1/5CKO and its control mouse on fluorescence images. The CDA aims to aid biomedical research by increasing efficiency and consistency of data collection regarding arrangement and characteristics of chondrocytes. Our results suggest that automated extraction of data from microscopy imaging of growth plates can assist in unlocking information on normal and pathological development, key to the underlying biological mechanisms of bone growth.

关键词： Anisotropic Diffusion Cell Detection Growth Plate Mouse Retinex

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Production of Lettuce Seedlings with Association of Diazotrophic Bacteria and Humic Acids

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American Journal of Plant Sciences 2018年第5期9卷 946-957页

作者： Carlos Augusto Rocha de Moraes Rego Bruna Penha Costa Marinez Carpiski Sampaio Marcos Massuo Kashiwaqui Joao Henrique Silva Caetano Vandeir Francisco Guimaraes Juan López de Herrera Pablo Wenderson Ribeiro Coutinho Cláudio Yuji Tsutsumi maria Soraia Fortado Vera Cruz Thatiane Nepomuceno Alves Shirlene Souza Oliveira Ana Carolina Pinguelli Ristau hannah Braz Center of Agrarian Sciences State University of Western ParanáMarechal Candido RondonBrazil University School of Agricultural Technical Engineering Polytechnic University of MadridMadridSpain

The objective of this work was to verify the responses in agronomic and physiological characters of lettuce seedlings when submitted to different doses of humic acids and the presence or absence of inoculation of the bacterium Azospirillum brasilense. The experiment was carried out at the Protected Cultivation Station and Biological Control Teacher Mário César Lopes, belonging to the Experimental Stations Nucleus of the State University of the West of Paraná. The experimental design was a randomized block design, in a 5 × 2 factorial scheme, with four repetitions, totaling 40 plots. The first factor consisted of five solutions containing humic acid (100%, 75%, 50%, 25% and 0%) and the second factor was the presence or absence of the diazotrophic bacterium Azospirillum brasilense obtained by commercial product. Germination tests were carried out in addition to the determination of agronomic characters such as the number of fully expanded leaves, plant height, stem diameter, main root length, shoot dry mass, root dry mass, total dry mass, and Dickson quality index. The association of diazotrophic bacteria and humic acids did not influence the emergency rate, mean emergence time, mean speed of emergency, emergence speed index, plant height, and root length of lettuce seedlings. The dilutions of humic acids, regardless of inoculation with bacteria diazotrophic favored the development of the number of leaves, stem diameter and Dickson quality index. Inoculation of lettuce seeds with diazotrophic bacteria associated with the addition of humic acids, favored the development of the dry mass of root and total dry matter.

关键词： Azospirillum brasilense Humic Substances Lactuca sativa L. Productive Characteristics

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钾通道J亚家族成员5基因嵌合导致双侧肾上腺皮质增生进而引起的早期原发性醛固酮增多症

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中华高血压杂志 2020年第12期28卷 1234-1234页

作者： maria AG Suzuki M Berthon A Kamilaris C Demidowich A Lack J Zilbermint M hannah-Shmouni F Faucz FR Stratakis CA 周卫(译) 叶鹏(审校) 不详

钾通道J亚家族成员5(potassium voltage-gated channel subfamily J member 5,KCNJ5)的体细胞变异最易导致原发性醛固酮增多症(primary aldosteronism,PA),有部分患者因KCNJ5钾通道基因的生殖细胞突变而患该病[家族性醛固酮增多症Ⅲ型(familial hyperaldosteronismⅢ,FH-Ⅲ)]。方法:1998年,美国国立卫生研究院临床中心发现一名11岁的白人男孩,患有早期严重高血压。

关键词：原发性醛固酮增多症双侧肾上腺临床中心严重高血压钾通道体细胞变异美国国立卫生研究院

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