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A critical literature review of bioretention research for stormwater management in cold climate and future research recommendations

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Frontiers of Environmental Science & Engineering 2017年第4期11卷 23-37页

作者： hannah kratky Zhan Li Yijun Chen Chengjin Wang Xiangfei Li Tong Yu Department of Civil and Environmental Engineering University of Alberta Edmonton Alberta T6G 1H9 Canada City Planning City of Edmonton Edmonton Alberta T5J 0J4 Canada

Bioretention is a popular best management practice of low impact development that el/ecUvely restores urban hydrologic characteristics to those ofpredevelopment and improves water quality prior to conveyance to surface waters. This is achieved by utilizing an engineered system containing a surface layer of mulch, a thick soil media often amended with a variety of materials to improve water oualitv, a variety of vegetation, and underdrains, depending on the surrounding soil *** systems have been studied quite extensively for warm climate applications, but ctata strongly supporting their long-tema efficacy and application in cold climates is sparse. Although it is apparent that biorelention is an effective stormwater management system, its design in cold climate needs further research. Existing cold climate research has shown that coarser media is required to prevent concrete frost from forming. For spring, summer and fall seasons, if sufficient permeability exists to drain the system prior to freezing, peak flow and volume reduction can be maintained. Additionally. contaminants that are removed via filtration are also not impacted by cold climates. In contrary, dissolved contaminants, nutrients, and organics are significantly more variable in their ability to be removed or degraded via bioretention in colder temperatures. Winter road maintenance salts have been shown to negatively impact the removal of some contaminants and positively impact others, while their effects on properly selected vegetation or bacteria health are also not well understood. Research in these water quality aspects has been inconsistent and therefore requires further study.

关键词： Bioretention Cold climate Low impact development Stormwater

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Diet,lipids,and antitumor immunity

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Cellular & Molecular Immunology 2022年第3期19卷 432-444页

作者： hannah Prendeville Lydia Lynch Trinity Biomedical Sciences Institute Trinity College DublinDublinIreland Brigham and Women’s Hospital Harvard Medical SchoolBostonMAUSA

Tumour growth and dissemination is largely dependent on nutrient *** has recently emerged that the tumour microenvironment is rich in a diverse array of lipids that increase in abundance with tumour progression and play a role in promoting tumour growth and ***,we describe the pro-tumorigenic roles of lipid uptake,metabolism and synthesis and detail the therapeutic potential of targeting lipid metabolism in ***,we highlight new insights into the distinct immunosuppressive effects of lipids in the tumour *** threaten an anti-tumour environment whereby metabolic adaptation to lipid metabolism is linked to immune ***,we describe the differential effects of commondietary lipids on cancer growth which may uncover a role for specific dietary regimens in association with traditional cancer *** the relationship between dietary lipids,tumour,and immune cells is important in the context of obesity which may reveal a possibility to harness the diet in the treatment of cancers.

关键词： Lipids cancer obesity β-oxidation anti-tumour immunity

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Crosslinking of viral nanoparticles with “clickable” fluorescent crosslinkers at the interface

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Science China Chemistry 2010年第6期53卷 1287-1293,1459页

作者： KAUR Gagandeep BARNHILL hannah Department of Chemistry and Biochemistry and Nanocenter University of South Carolina

Cu (I) catalyzed alkyne-azide cycloaddition (CuAAC) reaction,a typical "click" reaction,is one of the modular synthetic approaches which has been broadly used in various organic syntheses,medicinal chemistry,materials development and bioconjugation *** have for the first time synthesized two dialkyne derivatized fluorescent crosslinkers which could be applied to crosslink two biomolecules using CuAAC *** yellow mosaic virus,a plant virus with unique structural and chemical properties,was used as a prototypical scaffold to form a 2D single layer at the interface of two immiscible liquids and crosslinked with these two linkers by the CuAAC *** crosslinking,the fluorescence of both linkers diminished,likely due to the distortion of the polymethylene backbone,which therefore could be used to indicate the completion of the reaction.

关键词： pickering emulsion crosslinking nanoparticles CuAAC reaction click chemistry interfacial assembly

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Understanding the timing of brain injury in fetal growth restriction:lessons from a model of spontaneous growth restriction in piglets

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Neural Regeneration Research 2023年第2期18卷 322-323页

作者： hannah Musco Julie A.Wixey UQ Centre for Clinical Research Faculty of MedicineUniversity of QueenslandQueenslandAustralia

Fetal growth restriction(FGR)is one of the most common contributors to increased risk of mortality in the fetal/neonatal period and long-term morbidity in the infant(Malhotra et al.,2019).FGR can arise from many pathophysiological processes associated with maternal,fetal,genetic,or placental compromise;however,placental insufficiency is the most common cause of *** insufficiency during pregnancy results in chronic fetal hypoxia where a lack of oxygen and nutrients supply to the developing fetus impacts normal development of the fetus.

关键词： fetal fetus insufficiency

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Sensitivity analysis for stochastic and deterministic models of nascent focal adhesion dynamics

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International Journal of Biomathematics 2017年第7期10卷 237-265页

作者： hannah R. Biegel Alex Quackenbush hannah Callender Highlander Departments of Mathematics and Biology University of Portland 5000 North Willamette Boulevard Portland Oregon 97203 USA Department of Mathematics University of Portland 5000 North Willamette Boulevard Portland Oregon 97203 USA

Sensitivity analysis （SA） is a critical part of modeling any biological system due to the inherent uncertainty in model output, as introduced by parameter values that have not been experimentally determined. SA therefore provides deeper understanding of the system by painting a picture of the extent to which certain model outputs vary in rela- tionship to changes in model parameters. Here we explore two types of global SA for recently developed models of nascent focal adhesion formation, a key step in cellular movement. While many SA methods have been used for deterministic methods, we uti- lize methods for both stochastic and deterministic models, providing a more complete description of the parameters to which the focal adhesion model is most sensitive. Spe- cific recommendations for further experimentation in the process of cellular motility are proposed in response to the SA.

关键词： Sensitivity analysis method of Morris FAST focal adhesion dynamics cel-lular motility stochastic models.

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The CUL4A ubiquitin ligase is a potential therapeutic target in skin cancer and other malignancies

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Chinese Journal of Cancer 2013年第9期32卷 478-482页

作者： Jeffrey hannah Peng-Bo Zhou Department of Pathology and Laboratory Medicine Weill Cornell Medical College and Weill Cornell Graduate School of Medical Sciences Department of Pathology and Laboratory Medicine Weill Cornell Medical College

Cullin 4A(CUL4A)is an E3 ubiquitin ligase that directly affects DNA repair and cell cycle progression by targeting substrates including damage-specific DNA-binding protein 2(DDB2),xeroderma pigmentosum complementation group C(XPC),chromatin licensing and DNA replication factor 1(Cdt1),and *** work from our laboratory has shown that Cul4a-deficient mice have greatly reduced rates of ultraviolet-induced skin *** a cellular level,Cul4a-deficient cells have great capacity for DNA repair and demonstrate a slow rate of proliferation due primarily to increased expression of DDB2 and p21,*** suggests that CUL4A promotes tumorigenesis(as well as accumulation of skin damage and subsequent premature aging)by limiting DNA repair activity and expediting S phase *** addition,CUL4A has been found to be up-regulated via gene amplification or overexpression in breast cancers,hepatocellular carcinomas,squamous cell carcinomas,adrenocortical carcinomas,childhood medulloblastomas,and malignant pleural *** of its oncogenic activity in skin cancer and up-regulation in other malignancies,CUL4A has arisen as a potential candidate for targeted therapeutic *** this review,we outline the established functions of CUL4A and discuss the E3ligase’s emergence as a potential driver of tumorigenesis.

关键词：泛素连接酶恶性肿瘤皮肤癌治疗 DNA修复 DNA结合蛋白靶点细胞水平

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Bile acid signaling and biliary functions

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Acta Pharmaceutica Sinica B 2015年第2期5卷 123-128页

作者： hannah Jones Gianfranco Alpini Heather Francis Baylor Scott & White Digestive Disease Research Center Division Research Central Texas Veterans Health Care System Department of Medicine Texas A&M University

This review focuses on various components of bile acid signaling in relation to cholangiocytes. Their roles as targets for potential therapies for cholangiopathies are also explored. While many factors are involved in these complex signaling pathways, this review emphasizes the roles of transmembrane G protein coupled receptor(TGR5), farnesoid X receptor(FXR), ursodeoxycholic acid(UDCA) and the bicarbonate umbrella. Following a general background on cholangiocytes and bile acids,we will expand the review and include sections that are most recently known(within 5–7 years) regarding the field of bile acid signaling and cholangiocyte function. These findings all demonstrate that bile acids influence biliary functions which can, in turn, regulate the cholangiocyte response during pathological events.

关键词： Bile acids Cholangiocytes Receptors Signaling

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Deregulation of splicing factors and breast cancer development

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Journal of Molecular Cell Biology 2015年第5期7卷 388-401页

作者： Marco Silipo hannah Gautrey Alison Tyson-Capper Institute of Cellular Medicine Faculty of Medical SciencesNewcastle UniversityNewcastle upon Tyne NE24HHUK

It is well known that many genes implicated in the development and progression of breast cancer undergo aberrant alternative splicing events to produce *** changes in alternative splicingcan arise frommutations or single-nucleotide polymorphisms(SNPs)within the DNA sequences of cancer-related genes,which can strongly affect the activity of splicing factors and influence the splice site ***,it is important to note that absence of mutations is not sufficient to prevent misleading choices in splice site *** is nowincreasing evidence to demonstrate that the expression profile of ten splicing factors(including SRs and hnRNPs)and eight RNA-binding proteins changes in breast cancer cells compared with normal *** modifications strongly influence the alternative splicing pattern of many cancer-related genes despite the absence of any detrimental mutations within their DNA ***,a comprehensive assessment of the splicing factor status in breast cancer is important to provide insights into the mechanisms that lead to breast cancer development and *** most studies focus on mutations that affect alternative splicing in cancer-related genes,this review focuses on splicing factors and RNA-binding proteins that are themselves deregulated in breast cancer and implicated in cancer-related alternative splicing events.

关键词： alternative splicing splicing factors RNA-binding proteins breast cancer

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SPACE AND TOPOGRAPHY IN ANCIENT EGYPT

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Journal of Ancient Civilizations 2023年第1期38卷 69-124,127页

作者： hannah Pethen Honorary Fellow University of Liverpool

Introduction"Space"and "topography"have very specific meanings in the modern world. "Space"is an external void,an empty physical area to be acted upon. "Topography"is the "configuration of the surface relief"of the earth,a human body,or another *** words are technical terms implying the existence of externalities or abstractions;'spaces and topography that can be measured,recorded,observed,and acted *** this they are associated with the Enlightenment concept of "landscape"as external,viewable,and empirically understandable through objective scientific observation and recording,often for imperialist purposes.

关键词： SPACE recording earth

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Speech,language,and hearing function in twins with Alport syndrome:A seven-year retrospective case report

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Journal of Otology 2017年第2期12卷 86-96页

作者： Ramesh Kaipa hannah Tether Department of Communication Sciences and Disorders Oklahoma State UniversityUnited States

Alport syndrome is an X-linked syndrome that results in nephritis, renal failure, sensorineural hearing loss, and eye deficits. As a result of sensorineural hearing loss, these individuals are likely to experience difficulties in the area of speech and language. While studies in the past have examined the speech and language characteristics of children with syndromic sensorineural hearing loss, to our knowledge there are no previous studies to have documented the speech and language characteristics of these children on a long-term basis. The current study addresses this limitation by reporting speech, language, hearing, and function of twin brothers with X-linked Alport syndrome across a seven-year *** was collected by examining the medical records of the participants as well as through a verbal interview with the participants' guardian. Results revealed that the participants' hearing abilities gradually deteriorated over the seven-year period which affected their speech and language development as well. The kidney function tests revealed significant presence of hematuria(blood in the urine) as well as proteinuria(protein in the urine) suggesting chronic kidney dysfunction. This longitudinal study demonstrates the functional relationship between the kidneys and the cochlea, although they appear to be independent of one another. As individuals with Alport syndrome exhibit systemic complications, interdisciplinary collaboration is essential among health care providers including audiologists, speech-language pathologists,nephrologists, and ophthalmologist to promote evidence-based practice.

关键词： Alport syndrome Hearing loss Speech and language development Kidney function

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