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Anti-spermatogenic Effects of Ethanol Extract of mucuna Urens

Journal of Reproduction and Contraception 2009年第3期20卷 161-168页

作者： hannah ed.m etta Udoh Paul Bassey Eneobong Effiom Eneobong Okon Bassey Okon Biological Science Department Cross River University of Technology Environmental Biology and Zoology Department University of Calabar Genetics and Biotechnology Department University of Calabar Animal Science Department Faculty of AgricultureUniversity of Calabar

Objective To investigate the age-long claim by the locales that the food thickener, m. urens seed, has antispermatogenic, hence, antifertility effects in man. methods Eight-week old male Albino rats were used as the mammalian model for this study. They were assigned to four groups of 6 rats each and treatment with the ethanol extract was for a period of 14 d. The treatment regimes were 70 mg/kg, 140 mg/kg, 210 mg/kg and 0 mg/kg BW in groups A, B, C and D, respectively. Extracts were prepared by Soxhlet extraction using 80% ethanol as the extracting solvent. The stock solution was prepared by dissolving 1 g of the paste extract in 10 ml corn oil （vehicle） to make up 100 mg/ml concentration. At the end of the treatment, sperm from the distal caudal epididymis was collected and analyzed for sperm count, sperm motility and sperm morphology. Results Significant reduction was observed in sperm count and sperm motility （P〈0.05）. The mean sperm count for group A was 6.27±0.02×10^6, for group B was 6.16±0.02×10^6 and group C had 6.0±0.0×10^6 sperm cells The control （group D） had a mean sperm count of 6.50±0.09×10^6 which was higher than that of any treated group. Results of the sperm motility test gave the following mean rates for motile sperm cells after treatment： group A, 57.6±% 2.1; group B, 50.0±4.0; group C, 45.0±4.0. The control had the highest mean motility rate of 72.3±2.1. The observed sperm abnormalities included unusual head with large acrosome, looped tailpiece, mid piece with distal droplet, pin head, pyriform head and long *** The anti-spermatogenic effects of the extract on the sperm in the Albino rat may lead to reduction of fertility.

关键词： mucuna urens anti-spermatogenic sperm count sperm motility sperm morphology

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足月臀先露妊娠行剖宫产术及阴道分娩术2年后产妇结局分析:足月臀先露国际随机试验

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 19-19页

作者： hannah m.E. Whyte H. hannah W.J. 朱晓明

This study was undertaken to compare maternal outcomes at2years postpartum after planned cesarean section and planned vaginal birth for the single ton fetus in breech pre-sentation at *** selected cente rs in the Term Breech Trial,mothers completed a structur ed questionnaire at 2or more years postpartumto determine t heir health in the pre-vious 3to 6months.A total of 917of 1159(79.1%)mothers from 85centers completed a f ollow -up question-naire at 2years *** we re no differences between groups in breast feeding,re lationship with child or partner,pain,subsequent pregnancy,incontinence,de-pression,urinary,menstrual or sexual problems,fatigue,or distressing memories of the birth *** cesarean section was associated with a higher risk of con-stipation(P =.02).maternal outcomes at 2years post-partum are similar after planned cesarean section and planned vaginal birth for the single ton breech fetus at term.

关键词：臀先露剖宫产术阴道分娩随机试验单胎妊娠母乳喂养大小便失禁记忆方面试验中心问卷调查

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足月臀先露妊娠行剖宫产术及阴道分娩后2年婴儿结局分析:足月臀先露国际随机试验

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 16-16页

作者： Whyte H. hannah m.E. Saigal S. 朱晓明

The purpose of this study was to determine whether planned cesarean delivery for the singleton fetus in breech presen-tation at term reduces the risk of dea th or neurodevelop-mental delay at 2years of *** sele cted centers in the Term Breech Trial,children were screened for abnormali-ties at≥2years of age with the Ages and Stages Ques-tionnaire,followed by a neurodevelopmental assessment if the Ages and Stages Questionnaire sc ore was abnormal.A total of 923of 1159children(79.6%)from 85centers were followed to 2years of *** risk of death or neu-rodevelopmental delay was no different for the planned ce-sarean than for the planned vaginal birth groups(14chil-dren3.1%vs 13children2.8%;relative risk,1.09;95%CI,0.52-2.30;P =.85;risk diffe rence,+0.3%;95%CI,-1.9%,+2.4%).Planned cesarean delivery is not associated with a red uction in risk of death or neurodevelopmental delay in childr en at 2years of age.

关键词：臀先露剖宫产术阴道分娩随机试验单胎妊娠神经发育筛检试验中心无显著性差异险度

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