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A nanotherapeutic strategy to target drug-tolerant cells and overcome EGFR tyrosine kinase inhibitor resistance in lung cancer

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Cancer Communications 2023年第4期43卷 503-507页

作者： Tatiana Shaurova Lingyue Yan Yafei Su Laurie James Rich Vui King Vincent-Chong hannah calkins Saraswati Pokharel Martin Petkovich Mukund Seshadri Yun Wu Pamela Anne Hershberger Department of Pharmacology and Therapeutics Roswell Park Comprehensive Cancer CenterBuffaloNew YorkUSA Department of Biomedical Engineering University at Buffalothe State University of New YorkBuffaloNew YorkUSA Cell Stress and Biophysical Oncology Graduate Program Roswell Park Comprehensive Cancer CenterBuffaloNew YorkUSA Fujifilm-Visual Sonics Corporation TorontoOntarioCanada Department of Oral Oncology Roswell Park Comprehensive Cancer CenterBuffaloNew YorkUSA Department of Pathology Roswell Park Comprehensive Cancer CenterBuffaloNew YorkUSA Cancer Research Institute School of MedicineQueens UniversityKingstonOntarioCanada

Dear Editor,For patientswith epidermal growth factor receptor(EGFR)mutant non-small cell lung cancer(NSCLC),EGFR tyrosine kinase inhibitors(TKIs)are used as the first-line treatment[1,2].Despite initial therapeutic responses,patients invariably experience disease progression due to acquired drug resistance[3].Resistance arises,in part,because a subset of cancer cells undergoes epithelial-mesenchymal transition(EMT)and remains viable despite exposure to EGFR TKI concentrations that eliminate the bulk population[4].The surviving cells can be re-sensitized to treatment by prolonged culture in the absence of EGFR TKIs,indicating a transient.

关键词： therapeutic viable resistance

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Lipid nanoparticles deliver mRNA to the blood-brain barrier

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Nano Research 2024年第10期17卷 9126-9134页

作者： Yanina Kuzminich Avraham Shakked Randi calkins Sebastian Rudden Camille Jones Jessie Doan Bora Jang Elisa Schrader Echeverri Ryan Zenhausern Liming Lian David Loughrey hannah E.Peck Rachelle Wiese Dorothy Koveal Philip J.Santangelo James E.Dahlman George C.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Parker H.Petit Institute for Bioengineering and Biosciences Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of TechnologyAtlantaGA 30332USA

Lipid nanoparticles(LNPs)have delivered RNA to hepatocytes in patients after intravenous *** clinical data support efforts to design LNPs that transfect cells in the central nervous system(CNS).However,delivery to the CNS has been difficult,in large part because quantifying on-target delivery alongside common off-target cell types in adult mice remains *** we report methods to isolate different cell types from the CNS,and subsequently present mRNA delivery readouts using a liver-detargeted *** data suggest that LNPs without targeting ligands can transfect cerebral endothelial cells in mice after intravenous *** the difficulty of crossing the blood-brain barrier,they also underscore the value of quantifying delivery in the CNS with cell-type resolution instead of whole-tissue resolution.

关键词： lipid nanoparticle mRNA nanomedicine central nervous system blood-brain barrier

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