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A general spatial-temporal framework for short-term building temperature forecasting at arbitrary locations with crowdsourcing weather data

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Building Simulation 2023年第6期16卷 963-982页

作者： Reisa F.Widjaja Wenbo Wu Zhi Zhou Renhao Sun hannah c.fontenot Bing Dong Department of Management Science&Statistics The University of Texas at San AntonioSan AntonioTX78249USA Energy Systems Division Argonne National LaboratoryLemontIL60439USA Department of Mechanical&Aerospace Engineering Syracuse UniversitySyracuseNY13244USA

Weather forecasting has been a critical component to predict and control building energy consumption for better building energy *** accessibility to other data sources,the onsite observed temperatures or the airport temperatures are used in forecast *** this paper,we present a novel approach by utilizing the crowdsourcing weather data from neighboring personal weather stations(PWS)to improve the weather forecast accuracy around buildings using a general spatial-temporal modeling *** final forecast is based on the ensemble of local forecasts for the target location using neighboring *** approach is distinguished from existing literature in various ***,we leverage the crowdsourcing weather data from PWS in addition to public data *** this way,the data is at much finer time resolution(e.g.,at 5-minute frequency)and spatial resolution(e.g.,arbitrary location vs grid).Second,our proposed model incorporates spatial-temporal correlation information of weather variables between the target building and a set of neighboring PWSs so that underlying correlations can be effectively captured to improve forecasting *** demonstrate the performance of the proposed framework by comparing to the benchmark models on temperature forecasting for a building located at an arbitrary location at San Antonio,Texas,*** general,the proposed model framework equipped with machine learning technique such as Random Forest can improve forecasting by 50%compares with persistent model and has 90%chance to outperform airport forecast in short-term *** a real-time setting,the proposed model framework can provide more accurate temperature forecasting results compared with using airport temperature forecast for most forecast ***,we analyze the sensitivity of model parameters to gain insights on how crowdsourcing data from the neighboring personal weather stations impacts forecasting ***,we implement

关键词： crowdsourcing data machine learning spatial temporal model weather forecasting

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Lipid nanoparticles deliver mRNA to the blood-brain barrier

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Nano Research 2024年第10期17卷 9126-9134页

作者： Yanina Kuzminich Avraham Shakked Randi calkins Sebastian Rudden camille Jones Jessie Doan Bora Jang Elisa Schrader Echeverri Ryan Zenhausern Liming Lian David Loughrey hannah E.Peck Rachelle Wiese Dorothy Koveal Philip J.Santangelo James E.Dahlman George c.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Parker H.Petit Institute for Bioengineering and Biosciences Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of TechnologyAtlantaGA 30332USA

Lipid nanoparticles(LNPs)have delivered RNA to hepatocytes in patients after intravenous *** clinical data support efforts to design LNPs that transfect cells in the central nervous system(cNS).However,delivery to the cNS has been difficult,in large part because quantifying on-target delivery alongside common off-target cell types in adult mice remains *** we report methods to isolate different cell types from the cNS,and subsequently present mRNA delivery readouts using a liver-detargeted *** data suggest that LNPs without targeting ligands can transfect cerebral endothelial cells in mice after intravenous *** the difficulty of crossing the blood-brain barrier,they also underscore the value of quantifying delivery in the cNS with cell-type resolution instead of whole-tissue resolution.

关键词： lipid nanoparticle mRNA nanomedicine central nervous system blood-brain barrier

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Why forefoot striking in minimal shoes might positively change the course of running injuries

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Journal of Sport and Health Science 2017年第2期6卷 154-161页

作者： Irene S.Davis hannah M.Rice Scott c.Wearing Spaulding National Running center Department of Physical Medicine and Rehabilitation Harvard Medical School Sport and Health Sciences University of Exeter Institute of Health and Biomedical Innovation Queensland University of Technology

It is believed that human ancestors evolved the ability to run bipedally approximately 2 million years ago. This form of locomotion may have been important to our survival and likely has influenced the evolution of our body form. As our bodies have adapted to run, it seems unusual that up to 79% of modern day runners are injured annually. The etiology of these injuries is clearly multifactorial. However, 1 aspect of running that has significantly changed over the past 50 years is the footwear we use. Modern running shoes have become increasingly cushioned and supportive, and have changed the way we run. In particular, they have altered our footstrike pattern from a predominantly forefoot strike(FFS) landing to a predominantly rearfoot strike(RFS) landing. This change alters the way in which the body is loaded and may be contributing to the high rate of injuries runners experience while engaged in an activity for which they were adapted. In this paper, we will examine the benefits of barefoot running(typically an FFS pattern),and compare the lower extremity mechanics between FFS and RFS. The implications of these mechanical differences, in terms of injury, will be discussed. We will then provide evidence to support our contention that FFS provides an optimal mechanical environment for specific foot and ankle structures, such as the heel pad, the plantar fascia, and the Achilles tendon. The importance of footwear will then be addressed, highlighting its interaction with strike pattern on mechanics. This analysis will underscore why footwear matters when assessing mechanics. Finally, proper preparation and safe transition to an FFS pattern in minimal shoes will be emphasized. Through the discussion of the current literature, we will develop a justification for returning to running in the way for which we were adapted to reduce running-related injuries.

关键词： shoes running injuries strike predominantly landing tendon striking plantar locomotion

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The cUL4A ubiquitin ligase is a potential therapeutic target in skin cancer and other malignancies

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chinese Journal of cancer 2013年第9期32卷 478-482页

作者： Jeffrey hannah Peng-Bo Zhou Department of Pathology and Laboratory Medicine Weill Cornell Medical College and Weill Cornell Graduate School of Medical Sciences Department of Pathology and Laboratory Medicine Weill Cornell Medical College

cullin 4A(cUL4A)is an E3 ubiquitin ligase that directly affects DNA repair and cell cycle progression by targeting substrates including damage-specific DNA-binding protein 2(DDB2),xeroderma pigmentosum complementation group c(XPc),chromatin licensing and DNA replication factor 1(cdt1),and *** work from our laboratory has shown that cul4a-deficient mice have greatly reduced rates of ultraviolet-induced skin *** a cellular level,cul4a-deficient cells have great capacity for DNA repair and demonstrate a slow rate of proliferation due primarily to increased expression of DDB2 and p21,*** suggests that cUL4A promotes tumorigenesis(as well as accumulation of skin damage and subsequent premature aging)by limiting DNA repair activity and expediting S phase *** addition,cUL4A has been found to be up-regulated via gene amplification or overexpression in breast cancers,hepatocellular carcinomas,squamous cell carcinomas,adrenocortical carcinomas,childhood medulloblastomas,and malignant pleural *** of its oncogenic activity in skin cancer and up-regulation in other malignancies,cUL4A has arisen as a potential candidate for targeted therapeutic *** this review,we outline the established functions of cUL4A and discuss the E3ligase’s emergence as a potential driver of tumorigenesis.

关键词：泛素连接酶恶性肿瘤皮肤癌治疗 DNA修复 DNA结合蛋白靶点细胞水平

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Bile acid signaling and biliary functions

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Acta Pharmaceutica Sinica B 2015年第2期5卷 123-128页

作者： hannah Jones Gianfranco Alpini Heather Francis Baylor Scott & White Digestive Disease Research center Division Research Central Texas Veterans Health Care System Department of Medicine Texas A&M University

This review focuses on various components of bile acid signaling in relation to cholangiocytes. Their roles as targets for potential therapies for cholangiopathies are also explored. While many factors are involved in these complex signaling pathways, this review emphasizes the roles of transmembrane G protein coupled receptor(TGR5), farnesoid X receptor(FXR), ursodeoxycholic acid(UDcA) and the bicarbonate umbrella. Following a general background on cholangiocytes and bile acids,we will expand the review and include sections that are most recently known(within 5–7 years) regarding the field of bile acid signaling and cholangiocyte function. These findings all demonstrate that bile acids influence biliary functions which can, in turn, regulate the cholangiocyte response during pathological events.

关键词： Bile acids cholangiocytes Receptors Signaling

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Visualizing the importance of oxide-metal phase transitions in the production of synthesis gas over Ni catalysts

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Journal of Energy chemistry 2020年第11期29卷 178-186页

作者： Luis Sandoval-Diaz Milivoj Plodinec Danail Ivanov Stephane Poitel Adnan Hammud hannah c.Nerl Robert Schldgl Thomas Lunkenbein Department of Inorganic chemistry Fritz-Haber-Institut der Max-Planck-GesellschaftFaradayweg 4-614195 BerlinGermany Electron Spectrometry and Microscopy Laboratory School of Basic SciencesEcole Polytechnique Federale de Lausanne1015 LausanneSwitzerland Max Planck Institute for chemical Energy conversion StiftstraJSe 34-3645470 Miihlheim a.d.RuhrGermany

Synthesis gas, composed of H2 and cO, is an important fuel which serves as feedstock for industrially relevant processes, such as methanol or ammonia synthesis. The efficiency of these reactions depends on the H2: cO ratio, which can be controlled by a careful choice of reactants and catalyst surface ***, using a combination of environmental scanning electron microscopy(ESEM) and online mass spectrometry, direct visualization of the surface chemistry of a Ni catalyst during the production of synthesis gas was achieved for the first time. The insertion of a homebuilt quartz tube reactor in the modified ESEM chamber was key to success of the setup. The nature of chemical dynamics was revealed in the form of reversible oxide-metal phase transitions and surface transformations which occurred on the performing catalyst. The oxide-metal phase transitions were found to control the production of synthesis gas in the temperature regime between 700 and 900 ℃ in an atmosphere relevant for dry reforming of methane(DRM, cO2: cH4=0.75). This was confirmed using high resolution transmission electron microscopy imaging, electron energy loss spectroscopy, thermal analysis, and c18O2 labelled *** dedicated operando approach of simultaneously studying the surface processes of a catalyst and its activity allowed to uncover how phase transitions can steer catalytic reactions.

关键词： Dry reforming of methane Partial oxidation of methane Environmental scanning electron microscopy Synthesis gas Operando

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Assessing global Sentinel-2 coverage dynamics and data availability for operational Earth observation(EO)applications using the EO-compass

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International Journal of Digital Earth 2020年第7期13卷 768-784页

作者： Martin Sudmanns Dirk Tiede hannah Augustin Stefan Lang Department of Geoinformatics University of SalzburgSalzburgAustria

Sentinel-2 scenes are increasingly being used in operational Earth observation(EO)applications at regional,continental and global scales,in near-real time applications,and with multi-temporal *** a broader scale,they are therefore one of the most important facilitators of the Digital ***,the data quality and availability are not spatially and temporally homogeneous due to effects related to cloudiness,the position on the Earth or the acquisition *** spatiotemporal inhomogeneity of the underlying data may therefore affect any big remote sensing analysis and is important to *** study presents an assessment of the metadata for all accessible Sentinel-2 Level-1c scenes acquired in 2017,enabling the spatio-temporal coverage and availability to be quantified,including scene availability and *** exploratory analysis of the global,multi-temporal metadata also reveals that higher acquisition frequencies do not necessarily yield more cloud-free scenes and exposes metadata quality issues,*** incorrect cloud cover estimation in high,nonvegetated *** continuously updated datasets and analysis results are accessible as a Web application called *** contributes to a better understanding and selection of Sentinel-2 scenes,and improves the planning and interpretation of remote sensing analyses.

关键词： Sentinel-2 metadata cloud cover scene coverage global analysis big Earth data digital earth

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A machine learning approach for regional geochemical data:Platinum-group element geochemistry vs geodynamic settings of the North Atlantic Igneous Province

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Geoscience Frontiers 2021年第3期12卷 42-59页

作者： Jordan J.Lindsay hannah S.R.Hughes christopher M.Yeomans Jens c.Ø.Andersen Iain McDonald camborne School of Mines University of ExeterPenryn CampusPenrynCornwall TR109FEUnited Kingdom School of Earth and Ocean Sciences Main CollegeCardiff UniversityPark PlaceCardiff CF103ATUnited Kingdom

Whilst traditional approaches to geochemistry provide valuable insights into magmatic processes such as melting and element fractionation,by considering entire regional data sets on an objective basis using machine learning algorithms(MLAs),we can highlight new facets within the broader data structure and significantly enhance previous geochemical *** platinum-group element(PGE)budget of lavas in the North Atlantic Igneous Province(NAIP)has been shown to vary systematically according to age,geographic location and geodynamic *** the large multi-element geochemical data set available for the region,MLAs were employed to explore the magmatic controls on these shifting *** key advantage of using machine learning in analysis is its ability to cluster samples across multi-dimensional(i.e.,multi-element)*** NAIP data set is manipulated using Principal component Analysis(PcA)and t-Distributed Stochastic Neighbour Embedding(t-SNE)techniques to increase separability in the data alongside clustering using the k-means *** new multi-element classification is compared to the original geographic classification to assess the performance of both *** workflow provides a means for creating an objective high-dimensional investigation on a geochemical data set and particularly enhances the identification of metallogenic anomalies across the *** techniques used highlight three distinct multi-element end-members which successfully capture the variability of the majority of elements included as input *** end-members are seen to fluctuate in prominence throughout the NAIP,which we propose reflects the changing geodynamic environment and melting ***,the variability of Pt and Pd are not reflected in MLA-based clustering trends,suggesting that they vary independently through controls not readily demonstrated by the NAIP major or trace element data structure(i.e.,other proxies for magmatic differe

关键词： Platinum-group elements Machine learning Plume Geochemistry Metallogenesis Mantle

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Direct Measurement of cO_2 Retention in Arable Soils with pH Above 6.5 During Barometric Process Separation Incubation

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Pedosphere 2018年第5期28卷 726-738页

作者： hannah cONRADS Joachim INGWERSEN JU Xiaotang Thilo STREcK Institute of Soil Science and Land Evaluation Biogeophysics SectionUniversity of Hohenheim college of Agricultural Resources and Environmental Sciences China Agricultural University

The barometric process separation(BaPS)technique is a well-established incubation method to simultaneously measure gross nitrification and respiration rates in *** application,however,is still critical in soils with pH above ***,a substantial part of microbial cO_2 production is retained in soil solution(cO_2,aq)due to shifts in the carbonate *** may lead to substantial errors in gas balance ***,utilization of the BaPS technique is only reliable if the critical term is adequately *** present an easy,inexpensive,and direct method,the sterilization-cO_2-injection(ScI)method,to measure cO_2 retention during soil *** soil was incubated in the BaPS system,and defined volumes of cO_2 were injected to stepwise increase cO_2partial pressure(p cO_2)inside the chamber and to analyse the physicochemical equilibration *** exemplary agricultural soils from Northeast china and Southwest Germany were used for method establishment,presenting pH values between 4.4 and 7.6 and carbonate contents between 0% and 3.9%.We observed that in soils with pH>6.5,70%–90% of the injected cO_2 was taken up by the soil until the equilibrium inside the chamber was *** expected,in soils with low pH(cO_2 retention was ***_2 retention patterns were sensitive to incubation temperature with tri-fold dissolution capacity at 5~?c compared to 25?c,but insensitive to variations in soil water *** resulting soil-specific relationship between p cO_2 and cO_2,aq concentration allowed the quantification of cO_2,aq concentration as a function of headspace p cO_2.

关键词： carbonate equilibrium cO2 dissolution capacity cO_2 partial pressure microbial cO2 production soil pH sterilization-cO2-injection method volume of headspace air volume of soil solution

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Engineering porous organic polymers for carbon dioxide capture

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Science china chemistry 2017年第8期60卷 1007-1014页

作者： Ning Huang Gregory Day Xinyu Yang hannah Drake Hong-cai Zhou Department of chemistry Texas A＆M University College Station TX 77843 US

As atmospheric cO_2 levels rise, the development of physical or chemical adsorbents for cO_2 capture and separation is of great importance on the way towards a sustainable low-carbon future. Porous organic polymers are promising candidates for cO_2 capture materials owing to their structural flexibility, high surface area, and high stability. In this review, we highlight high-performance porous organic polymers for cO_2 capture and summarize the strategies to enhance cO_2 uptake and selectivity, such as increasing surface area, increasing interaction between porous organic polymers and cO_2, and pore surface functionalization.

关键词： porous organic polymers c02 capture nanomaterials post-synthesis polymer

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