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Plasma Science and Technology 2013年第3期15卷 240-243页

作者： Takashi MINAMI Shohei ARAI Naoki kENMOCHI Hiroaki YASHIRO Chihiro TAkAHASHI Shinji kOBAYASHI Tohru MIZUUCHI Shinsuke OHSHIMA Satoshi YAMAMOTO Hiroyuki OkADA kazunobu NAGASAkI Yuji NAkAMURA kiyoshi HANATANI Shigeru kONOSHIMA Fumimichi sano Institute of Advanced Energy Kyoto University Graduate School of Energy Science Kyoto University Pioneering Research Unit for Next Generation Kyoto University

A new high repetition rate Nd：YAG Thomson scattering system is developed for the Heliotron J helical device. A main purpose of installing the new system is the temporal evolution measurement of a plasma profile for improved confinement physics such as the edge transport barrier （H-mode） or the internal transport barrier of the helical plasma. The system has 25 spatial points with -10 mm resolution. Two high repetition Nd：YAG lasers （〉 550 m J@ 50 Hz） realize the measurement of the time evolution of the plasma profile with ~10 ms time intervals. Scattered light is collected by a large concave mirror （D----800 mm, f/2.25） with a solid angle of -100 mstr and transferred to interference filter polychromators by optical fiber bundles in a staircase form. The signal is amplified by newly designed fast preamplifiers with DC and AC output, which reduces the low frequency background noise. The signals are digitized with a multi-event QDC, fast gated integrators. The data acquisition is performed by a VME-based system operated by the CINOS.

关键词： plasma diagnostic Nd:YAG laser Thomson scattering measurement plasma improved confinement

Shock wave phenomena in underwater laser peening

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Shock wave phenomena in underwater laser peening

New application of endocytoscope for histopathological diagnosis of colorectal lesions

The 24th International Symposium on Shock Waves

作者： k.Watanabe H.Torikai A.Sasoh Y.sano N.Mukai Institute of Fluid Science Tohoku UniversitySendai 980-8577Japan Institute for Energy Utilization AISTTsukuba 305-8569Japan Power and Industrial Systems Research and Development Center Toshiba CorporationYokohama 235-8523Japan

The propagation of pressure waves in water and metal generated by focusing of pulsed Nd:YAG laser beam on to the metal surface is studied. When a metal material is ablated in water, a pressure is enhanced near laser-irradiated area and some stress waves generate. The understanding of the process is the basis of laser peening. The effects of thickness of specimen (SUS304) ranging from 0.1mm to 10mm on wave generation in water were investigated using visualization with shadowgraph technique and measurement of over pressure in the water. The shape of a hemispherical shock wave and the peak pressure behind it were independent on thickness of the specimen. On the other hand, the shapes and the behaviors of visualized other waves depend on plate thickness.

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World Journal of Gastrointestinal Endoscopy 2022年第8期14卷 495-501页

作者： Fumihiro Inoue Daizen Hirata Mineo Iwatate Santa Hattori Mikio Fujita Wataru sano Tamotsu Sugai Hiroshi kawachi kazuhito Ichikawa Yasushi sano Gastrointestinal Center and Institute of Minimally-invasive Endoscopic Care(i-MEC) Sano HospitalKobe 655-0031HyogoJapan Molecular Diagnostic Pathology Iwate Medical University School of MedicineShiwa-gun 028-3694IwateJapan Department of Pathology Cancer Institute Hospital of Japanese Foundation for Cancer ResearchKoto 135-8550TokyoJapan Department of Pathology Noda HospitalNoda 270-0237ChibaJapan

BACkGROUND The endocytoscope with ultra-high magnification(x 520)allows us to observe the cellular structure of the colon epithelium during colonoscopy,known as virtual *** hypothesized that the endocytoscope could directly observe colorectal histopathological specimens and store them as endocyto-pathological images by the endoscopists without a microscope,potentially saving the burden on *** To assess the feasibility of endocyto-pathological images taken by an endoscopist as adequate materials for histopathological *** Three gastrointestinal pathologists were invited and asked to diagnose 40 cases of endocyto-pathological images of colorectal *** case contained seven endocyto-pathological images taken by an endoscopist,consisting of one loupe image,three low-magnification images,and three ultra-high magnification *** participants chose hyperplastic polyp or low-grade adenoma for 20 cases of endocyto-pathological images(10 hyperplastic polyps,and 10 Low-grade adenomas in conventional histopathology)in study 1 and high-grade adenoma/shallow invasive cancer or deep invasive cancer for 20 cases[10 tumor in situ/T1a and 10 T1b]in study *** investigated the agreement between the histopathological diagnosis using the endocyto-pathological images and conventional histopathological *** Agreement between the endocyto-pathological and conventional histopathological diagnosis by the three gastrointestinal pathologists was 100%(95%CI:94.0%–100%)in studies 1 and *** interobserver agreement among the three gastrointestinal pathologists was 100%,and theκcoefficient was 1.00 in both *** Endocyto-pathological images were adequate and reliable materials for histopathological diagnosis.

关键词： Cancer Colon Endocytoscopy Histopathology Specimen

Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2018年第11期24卷 1239-1249页

作者： Naoyuki Fujimori Takeji Umemura Takefumi kimura Naoki Tanaka Ayumi Sugiura Tomoo Yamazaki Satoru Joshita Michiharu komatsu Yoko Usami kenji sano koji Igarashi Akihiro Matsumoto Eiji Tanaka Department of Internal Medicine Division of GastroenterologyShinshu University School of MedicineMatsumoto 390-8621Japan Department of Metabolic Regulation Shinshu University Graduate School of MedicineMatsumotoJapanand Research Center for Agricultural Food IndustryShinshu UniversityMatsumoto390-8621Japan Department of Laboratory Medicine Shinshu University HospitalMatsumoto 390-8621Japan Bioscience Division TOSOH CorporationKanagawa 252-1123Japan

AIM To examine the relationship between serum autotaxin(ATX) concentrations and clinicopathological findings in non-alcoholic fatty liver disease(NAFLD) *** One hundred eighty-six NAFLD patients who had undergone liver biopsy between 2008 and 2017 were retrospectively *** samples were collected at the time of biopsy and ATX was measured by enzyme *** obtained from 160 healthy,nonobese individuals were used as *** findings were graded according to an NAFLD scoring system and correlations with serum ATX were calculated by Spearman's *** accuracy was evaluated using the area under the receiver operating characteristic curve(AUC).Cut-off values were identified by the Youden index,and the nearest clinically applicable value to the cutoff was considered the optimal threshold for clinical *** Serum ATX levels were significantly higher in NAFLD patients than in controls(0.86 mg/L vs 0.76 mg/L,P kable relationships between ATX and serum alanine aminotransferase,lipid profiles,or steatosis *** AUC values of ATX for predicting the presence of fibrosis(≥ F1),significant fibrosis(≥ F2),severe fibrosis(≥ F3),and cirrhosis(F4),were all more than 0.70 in respective *** Serum ATX levels may at least partially reflect histological severity in NAFLD.

关键词： Autotaxin Non-alcoholic fatty liver disease Fibrosis Ballooning

Phylogenetic Relationships of Japanese Unionoida (Mollusca: Bivalvia) Based on Mitochondrial 16S rDNA Sequences

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Journal of Water Resource and Protection 2017年第5期9卷 493-509页

作者： Isao sano Akihisa Shirai Takaki kondo Jun-Ichi Miyazaki Faculty of Education University of Yamanashi Yamanashi Japan Musashi High School and Junior High School Tokyo Japan Division of Natural Science Osaka Kyoiku University Osaka Japan

Japanese unionoid mussels are classified into 2 families (Margaritiferidae and Unionidae), 12 genera, and 18 species based on the morphological characteristics of both adults and larvae;however, there are some debates regarding their systematics. In this study, we determined mitochondrial 16S ribosomal DNA sequences (347-bp) for 60 specimens belonging to 18 species and constructed trees to elucidate phylogenetic relationships and evaluate the current systematics of Japanese unionoid mussels. Almost all species formed clades, except for Inversiunio yanagawensis, Sinanodonta lauta, S. japonica, and Margaritifera laevis, even though two or more specimens were collected from distant localities. All genera formed highly supported clades with the exception of the genus Sinanodonta. Phylogenetic relationships obtained in this study supported systematics based on morphological and larval traits. Therefore, the current phylogenetic relationships and systematics of Japanese unionoid mussels are stronger than they were before;now that they are corroborated by genetic data.

关键词： Systematics Molecular Barcoding Endangered Species Conservation East Asian Mussels

Usefulness of Detailed Analysis with Operative Procedure of Total Laparoscopic Hysterectomy (TLH) Done a Single Surgeon, to Master the Surgical Technique of TLH and Gain Higher Proficiency

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Open Journal of Obstetrics and Gynecology 2022年第11期12卷 1183-1190页

作者： Tsutomu Muramoto Shin Takenaka Ryo koike Megumi sano kyosuke kamijo Reproductive Center Nagano Municipal Hospital Nagano Japan Department of Obstetrics and Gynecology Showa University Fujigaoka Hospital Yokohama Japan

Objective: To analyze the relationship between the numbers of cases experienced and the operation time for a single surgeon aiming to master the TLH surgical technique. Material and Methods: Retrospective data analysis of women who underwent TLH for benign diseases between April, 2014 and March, 2016 was conducted by a single surgeon in a single hospital (Showa University of Fujigaoka Hospital). We divided the main procedures of the TLH operation into five sections, and measured the time required for each section. These cases were divided into three groups, group 1, 2, and 3. Results: There were 54 cases of TLH over two years for a single surgeon, and 21 cases that included essential operative procedures were divided into three groups of seven cases each. The average duration of the surgery (min.) was 178.3 ± 48.2 in the group 1, 128.3 ± 15.6 in the group 2, and 111.3 ± 15.9 in the group 3. A significant reduction in the required time was observed between group 1, 2, and 3 groups. As the number of cases increased, the operation time became statistically significantly shorter for every section except B and D. The skill growth rate was different at each section. Conclusion: For a single surgeon, as the number of surgical cases increased, we recognized the increased skill with the procedure in every section and the rate of skill growth differed for different sections. The difference of growth rate for each section implied that the number of operative cases required for a surgeon in each section was different.

关键词： Total Laparoscopic Hysterectomy on the Job Training Learning Curve Surgical Technique of TLH

Identification and Pre-distortion for GaN-PA

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Identification and Pre-distortion for GaN-PA

用氧化镁铝热还原原位产生的镁蒸气改善铁水脱氧效率

The 2011 International Conference on Electric and Electronics(EEIC 2011)

作者： Yuanming Ding Yan Wang Akira sano Liaoning key Laboratory of Communication Networks and Information Processing Department of Information Engineering Dalian University Department of System Design Engineering Keio University

A memory polynomial model（MPM） is adopted to describe the characteristics of Ga N power amplifiers（Ga N-PA） in orthogonal frequency division multiplexing（OFDM） communication systems, and the RLS algorithm is used to estimate the MPM parameters in on-line manner. The MPM with odd-even orders is considered in choosing models. Furthermore, the orders and memory length of MPM are decided by the final prediction error（FPE）. Finally, an adaptive pre-distorter is designed besed on the achieved MPM, and its effectiveness is proved by numerical simulation.

关键词： GaN Power Amplifier Pre-Distortion Memory Polynomial Model

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钢铁 2003年第Z1期38卷 116-119页

作者： Jiayi SHAN Takashi ITOH kuniyuki kITAGAWA Masamichi sano 名古屋大学名古屋大学名古屋大学名古屋大学

提出了一种用氧化镁铝热还原原位产生的镁蒸气进行铁水脱氧的新方法.建立了反应模型来研究控速机理和镁蒸气的脱氧效率.模型计算结果显示,要获得高脱氧效率,必须控制喷吹气泡中的镁蒸气压力.

关键词：脱氧铁水镁蒸气铝热还原洁净钢

Inhibitory Effects of Pu-erh Tea Leaves on Mouse Type IV Allergy

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Food and Nutrition Sciences 2012年第3期3卷 394-400页

作者： katsuko Yamazaki kyoji Yoshino Chihiro Yagi Toshio Miyase Mitsuaki sano Department of Chemistry and Biochem- istry Numazu National College of Technology Shizuoka Japan Department of Food Science and Nutrition Nagoya Women’s University Nagoya Japan School of Pharmaceutical Sciences University of Shizuoka Shi- zuoka Japan.

Pu-erh tea is one of post fermented tea manufactured through oxidative maturing by microorganisms. We investigated the preventive effects of pu-erh tea extract on oxazolone-induced type IV allergy in male (ICR) mice. Oral administration of 50 mg/kg water extract of pu-erh tea leaves resulted in significant preventive effects against mouse type IV allergy. The hydrophilic Theabrownin-like fraction (TBW-ND), with a high molecular weight of approximately 12,000 or higher, was prepared from pu-erh tea leaves by a solvent-extraction method, followed by Diaion HP-20 column chro-matography and dialysis. Oral and percutaneous administrations of TBW-ND at doses of 18.7 mg/kg and 0.037 mg/ear also resulted in significant preventive effects, which included preventing increases in levels of the proinflam-matory cytokine interleukin-12. The anti-allergic ingredients in TBW-ND were predicted to be highly complex compounds containing of polyphenols, polysaccharides and/or proteins. The results suggest pu-erh tea leaves could be a beneficial food for protecting against delayed-type allergy.

关键词： Pu-erh Tea Type IV Allergy Cytokines Theabrownin Polyphenol

Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer

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World Journal of Gastroenterology 2016年第44期22卷 9765-9774页

作者： kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito ken Nakayama Tomohiro kurokawa Naoki sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi Department of Surgery and Organ Transplantation Faculty of Medicine University of Tsukuba Regenerative Medicine Research Center Jiangsu University Hospital Department of Regenerative Medicine Graduate School of Medicine Yokohama City University Department of Gastroenterology Faculty of Medicine University of Tsukuba Faculty of Life and Environmental Sciences Alliance of Research on North Africa University of Tsukuba

AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer *** The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo *** Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy.

关键词： Colorectal cancer Linalool Oxidative stress Electron spin resonance Lipid peroxidation